abstract：:Astaxanthin (AST), a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of AST on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that AST could prolong the life span of Caenorhabditis elegans. To uncover whether AST could delay a...

journal_title：Rejuvenation research

authors： Fu M,Zhang X,Zhang X,Yang L,Luo S,Liu H

更新日期：2020-11-30 00:00:00

abstract：:Osteoporosis is a silent disease caused by low bone mineral density and is complicated by fractures. This study was designed to examine the differentiation of uterine stem cell-derived osteoprogenitor cells (UOPCs) both in vitro and in vivo, assessing their effectiveness in treating osteoporosis. CD271+/CD45- UOPCs we...

journal_title：Rejuvenation research

authors： Wang Z,Wang D,Liu Y,Liu D,Ren Y,Liu Z,Yu B,Hao M,Xie J

更新日期：2020-11-03 00:00:00

abstract：:Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral...

journal_title：Rejuvenation research

authors： Rutledge GA,Phang HJ,Le MN,Bui L,Rose MR,Mueller LD,Jafari M

更新日期：2020-10-20 00:00:00

abstract：:Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...

journal_title：Rejuvenation research

authors： Balietti M,Giuli C,Casoli T,Fabbietti P,Conti F

更新日期：2020-10-01 00:00:00

abstract：:d-galactose (d-gal) is widely used to induce aging. However, it is still unclear whether long-term injection of d-gal affects the gastrointestinal functions of aging rats, and how. In this study, we investigated the effects of d-gal on the gastrointestinal functions of aging rats, especially from the perspective of fe...

journal_title：Rejuvenation research

authors： Zhao D,Liu X,Zhao S,Li Z,Qin X

更新日期：2020-09-29 00:00:00

abstract：:Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...

journal_title：Rejuvenation research

authors： Badreh F,Joukar S,Badavi M,Rashno M

更新日期：2020-08-01 00:00:00

abstract：:Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2020-08-01 00:00:00

abstract：:To determine the prognostic value of frailty and comorbidity for outdoor mobility loss and mortality in the elderly. The retrospective study was conducted among outpatients aged ≥60 years. Patients with ≥3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The outdoor low-mobilit...

journal_title：Rejuvenation research

authors： Tkacheva ON,Runikhina NK,Merkusheva LI,Lysenkov SN,Ostapenko VS,Sharashkina NV,Press Y

更新日期：2020-07-14 00:00:00

abstract：:Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by traditional center-based and home-based programs. This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frail ...

journal_title：Rejuvenation research

authors： Garcia RNSA,Costa SN,Garcia EDSA,Bento PCB

更新日期：2020-05-26 00:00:00

abstract：:The senescence of the immune system contributes considerably to the age-related diseases that are the main causes of death after the age of 65. In this study, we present an appealing option for the prevention of immune senescence and slowing or reversing the aging process, which can be achieved by heterochronous autol...

journal_title：Rejuvenation research

authors： Rožman P

更新日期：2020-04-01 00:00:00

abstract：:Diminished integrity of the intestinal epithelial barrier with advanced age is believed to contribute to aging-associated dysfunction and pathologies in animals. In mammals, diminished gut integrity contributes to inflammaging, the increase in inflammatory processes observed in old age. Recent work suggests that expre...

journal_title：Rejuvenation research

authors： Larrick JW,Mendelsohn AR

更新日期：2020-04-01 00:00:00

abstract：:Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...

journal_title：Rejuvenation research

authors： Sun Y,Qi G,Li D,Meng H,Zhu Z,Zhao Y,Qi Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:Theses reviewed in this issue include "Downregulation of the Apelinergic Axis Accelerates Aging, Whereas Its Systemic Restoration Improves the Mammalian Healthspan," "Intracellular Delivery of Exogenous Molecules Via an Ultrahigh Throughput Mechanoporation Microdevice," "Intrinsic and Extrinsic Drivers of Treg Fragili...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2019-08-01 00:00:00

abstract：:Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent prolif...

journal_title：Rejuvenation research

authors： Carter AR,Meinert E,Brindley DA

更新日期：2019-06-01 00:00:00

abstract：:Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...

journal_title：Rejuvenation research

authors： Poz D,De Falco E,Pisano C,Madonna R,Ferdinandy P,Balistreri CR

更新日期：2019-04-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. This ultimately results in progressive dysfunction and loss of vision either in advanced age for genetically normal patients (age-related macular degeneration) or...

journal_title：Rejuvenation research

authors： Moody KJ,Tinklepaugh J,Obert E,Grohn K,DeRosa JR,Lumen E,Moyer BS,Campbell S,Wolfe AJ,Sleeper MB,Bianchi AH,Fisher C,Applegate J,Leary E,LeClair N,Wortel D,Doyle RP,Rohrer B,Blanden AR

更新日期：2018-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ1-42, we dem...

journal_title：Rejuvenation research

authors： Ai L,Yang F,Song J,Chen Y,Xiao L,Wang Q,Wang L,Li H,Lei T,Huang Z

更新日期：2018-08-01 00:00:00

abstract：:Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscl...

journal_title：Rejuvenation research

authors： Picca A,Lezza AMS,Leeuwenburgh C,Pesce V,Calvani R,Bossola M,Manes-Gravina E,Landi F,Bernabei R,Marzetti E

更新日期：2018-08-01 00:00:00

abstract：:Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...

journal_title：Rejuvenation research

authors： Zhang M,Hwang E,Lin P,Gao W,Ngo HTT,Yi TH

更新日期：2018-08-01 00:00:00

abstract：:The United States has the most expensive healthcare system worldwide. Yet measures of health span and life expectancy are well below the major industrialized nations. With the U.S. population aged 65 years and older projected to double by mid-century, a healthcare crisis is looming. Within this context, huge interest ...

journal_title：Rejuvenation research

authors： Larrick JW,Mendelsohn AR

更新日期：2018-06-01 00:00:00

abstract：:The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels-that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. This was a cross-sectional study of 406 Chilean adults aged...

journal_title：Rejuvenation research

authors： Merellano-Navarro E,Collado-Mateo D,García-Rubio J,Gusi N,Olivares PR

更新日期：2017-12-01 00:00:00

abstract：:Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and 1H nuclear magnetic resonance ...

journal_title：Rejuvenation research

authors： Duan DD,Wang KX,Zhou YZ,Qin XM,Gao L,Du GH

更新日期：2017-12-01 00:00:00

abstract：:This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...

journal_title：Rejuvenation research

authors： Cancela Carral JM,Pallin E,Orbegozo A,Ayán Pérez C

更新日期：2017-10-01 00:00:00

abstract：:Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2017-08-01 00:00:00

abstract：:Inflammation and oxidative stress (OS) are key points in age progression. Both processes impact negatively in cognition and in brain functions. Resveratrol (RV) has been postulated as a potent antioxidant natural compound, with rejuvenating properties. Inducing a metabolic stress by high-fat (HF) diet in aged C56/BL6 ...

journal_title：Rejuvenation research

authors： Palomera-Ávalos V,Griñán-Ferré C,Izquierdo V,Camins A,Sanfeliu C,Pallàs M

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...

journal_title：Rejuvenation research

authors： Xiong Y,Xiong Y,Zhou S,Sun Y,Zhao Y,Ren X,Zhang Y,Zhang N

更新日期：2017-04-01 00:00:00

abstract：:The article is a presentation at the 4th Conference of ESAAM, which took place on October 30-31, 2015, in Athens, Greece. Its purpose was not to cover all aspects of cellular aging but to share with the audience of the Conference, in a 15-minute presentation, current knowledge about the rejuvenating and repairing soma...

journal_title：Rejuvenation research

authors： Koliakos G

更新日期：2017-02-01 00:00:00

abstract：:Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes....

journal_title：Rejuvenation research

authors： Musacchio E,Perissinotto E,Sartori L,Veronese N,Punzi L,Zambon S,Manzato E,Baggio G,Corti MC,Crepaldi G,Ramonda R

更新日期：2017-02-01 00:00:00

abstract：:Our recent studies have shown that Huogu (HG) formula was effective both in clinic experience and in experimental osteonecrosis of the femoral head (ONFH). Given that defective of bone marrow stromal cells (MSCs) contribute to the development of osteonecrosis and MSCs show enormous potential in the treatment of ONFH, ...

journal_title：Rejuvenation research

authors： Kong X,Li X,Zhang C,Zhu L,Wan H,Zhu J,Liu C,Su H,Qin Q,Chen W,Lin N

更新日期：2016-12-01 00:00:00

abstract：:Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain bar...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2016-12-01 00:00:00

abstract：:With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...

journal_title：Rejuvenation research

authors： Cai HB,Wu GL,Huang CH,Huang ZS,Chen YB,Wang Q

更新日期：2016-08-01 00:00:00

abstract：:There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and...

journal_title：Rejuvenation research

authors： Mansilla E,Roque G,Sosa YE,Tarditti A,Goya RG

更新日期：2016-08-01 00:00:00

abstract：:Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...

journal_title：Rejuvenation research

authors： Tokarz P,Kaarniranta K,Blasiak J

更新日期：2016-04-01 00:00:00

abstract：:Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...

journal_title：Rejuvenation research

authors： Ganie SA,Dar TA,Bhat AH,Dar KB,Anees S,Zargar MA,Masood A

更新日期：2016-02-01 00:00:00

abstract：:Can memory be retained after cryopreservation? Our research has attempted to answer this long-standing question by using the nematode worm Caenorhabditis elegans, a well-known model organism for biological research that has generated revolutionary findings but has not been tested for memory retention after cryopreserv...

journal_title：Rejuvenation research

authors： Vita-More N,Barranco D

更新日期：2015-10-01 00:00:00

abstract：:Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...

journal_title：Rejuvenation research

authors： Ye P,Wang T,Liu WH,Li XC,Tang LJ,Tian FZ

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Human growth hormone-1 (GH-1), somatotropin, is a peptide hormone that stimulates cell division in tissues such as bone and cartilage. METHODS:To compare physiological activities in lipid-free and lipid-bound states, we expressed and incorporated GH-1 in reconstituted high-density lipoprotein (rHDL). RESUL...

journal_title：Rejuvenation research

authors： Lee EY,Kim SH,Cho KH

更新日期：2015-06-01 00:00:00

abstract：:Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...

journal_title：Rejuvenation research

authors： Kim SH,Lee EY,Cho KH

更新日期：2015-02-01 00:00:00

abstract：:To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, inclu...

journal_title：Rejuvenation research

authors： Mariani S,Ventriglia M,Simonelli I,Bucossi S,Siotto M,R RS

更新日期：2015-02-01 00:00:00