Abstract:
:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study was to assess the effects of treadmill gait on the magnitude of the EMG activity of the lower limb muscles in PD. We measured EMG activity of the tibialis anterior, gastrocnemius medialis, vastus lateralis, and biceps femoris of nine individuals with PD and nine healthy matched controls. Comparisons between walking overground with walking on a treadmill and with walking with a treadmill simulator were carried out. The treadmill simulator is a device that simulates treadmill conditions with the exception of the belt. Our results have shown that treadmill walking is associated with several EMG differences compared with overground walking. The key finding of the study is that coactivation of the thigh muscles was significantly decreased (37%; p = 0.008) in PD subjects when walking on the treadmill in comparison with overground walking. The changes observed in the coactivation level may be related to the belt movement, since no changes were reported during walking with the treadmill simulator. Understanding the differences between treadmill and overground gait as well as the mechanisms that result in improvement of gait disturbances may optimize rehabilitative protocols for patients with PD.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Bello O,Marquez G,Fernandez-Del-Olmo Mdoi
10.1089/rej.2018.2084subject
Has Abstractpub_date
2019-02-01 00:00:00pages
71-78issue
1eissn
1549-1684issn
1557-8577journal_volume
22pub_type
杂志文章abstract::The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low prolifera...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.0503
更新日期:2007-03-01 00:00:00
abstract::New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumu...
journal_title:Rejuvenation research
pub_type: 评论,杂志文章
doi:10.1089/rej.2014.1585
更新日期:2014-08-01 00:00:00
abstract::d-galactose (d-gal) is widely used to induce aging. However, it is still unclear whether long-term injection of d-gal affects the gastrointestinal functions of aging rats, and how. In this study, we investigated the effects of d-gal on the gastrointestinal functions of aging rats, especially from the perspective of fe...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2352
更新日期:2020-09-29 00:00:00
abstract::Older patients often suffer from multiple co-morbid conditions. Few co-morbidity indices are valid and reliable in elderly patients and comparison between them is rare. Our objective was to compare the performance, relevance, and abilities of six widely used and validated co-morbidity indices--the Charlson Cumulative ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1037
更新日期:2010-12-01 00:00:00
abstract::We examined the impact of strong co-presence and function of glutathione peroxidase-1 (GPX-1) and glial cell line-derived neurotrophic factor (GDNF) on protecting the rat dopaminergic pheochromocytoma cell line PC12 against 6-hydroxydopamine (6-OHDA) and hydrogen peroxide (H₂O₂) toxicities. Primarily, GPX-1 over-expre...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1390
更新日期:2013-06-01 00:00:00
abstract::Alzheimer disease (AD), the most common form of dementia, is without an effective cure or preventive treatment. Recently, amyloid-beta protein (Abeta) has become a major therapeutic target. Many efforts are underway to either reduce the production of Abeta or enhance its clearance. In 1999, Schenk and colleagues first...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2006.9.77
更新日期:2006-04-01 00:00:00
abstract::Our recent studies have shown that Huogu (HG) formula was effective both in clinic experience and in experimental osteonecrosis of the femoral head (ONFH). Given that defective of bone marrow stromal cells (MSCs) contribute to the development of osteonecrosis and MSCs show enormous potential in the treatment of ONFH, ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1795
更新日期:2016-12-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2010.1132
更新日期:2011-06-01 00:00:00
abstract::Pursuance of longevity is not only combating decrepitude but it is also extending the health span; otherwise longevity would result in a universal medical and social burden. As revealed by the literature, the attainment of a healthy life could be impacted by the social milieu. An inquiry of this kind could hardly be s...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2010.1071
更新日期:2011-02-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2378
更新日期:2020-08-01 00:00:00
abstract::To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0893
更新日期:2010-04-01 00:00:00
abstract::The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2006.9.182
更新日期:2006-07-01 00:00:00
abstract::Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1717
更新日期:2016-04-01 00:00:00
abstract::The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients > or = 65 years old with a diagnosis of CHF under...
journal_title:Rejuvenation research
pub_type: 杂志文章,多中心研究
doi:10.1089/rej.2007.0583
更新日期:2008-02-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1186
更新日期:2011-12-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1263
更新日期:2012-04-01 00:00:00
abstract::Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by traditional center-based and home-based programs. This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frail ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2292
更新日期:2020-05-26 00:00:00
abstract::There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1777
更新日期:2016-08-01 00:00:00
abstract::Since the discovery of the limited life span of human fibroblasts some 50 years ago, many genealogical studies have been undertaken to describe growth kinetics of fibroblasts in serial cultures by their individual division behavior. It is now accepted that proliferation capacities of human fibroblasts strongly depend ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2005.8.154
更新日期:2005-10-01 00:00:00
abstract::The vicious cycle theory postulates that typical mitochondrial DNA (mtDNA) mutations cause their host mitochondria to generate more superoxide and other reactive oxygen species (ROS) than do normal mitochondria, thereby promoting the occurrence of additional mtDNA mutations at an ever-accelerating rate. However, nearl...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2005.8.13
更新日期:2005-04-01 00:00:00
abstract::Osteoporosis is a silent disease caused by low bone mineral density and is complicated by fractures. This study was designed to examine the differentiation of uterine stem cell-derived osteoprogenitor cells (UOPCs) both in vitro and in vivo, assessing their effectiveness in treating osteoporosis. CD271+/CD45- UOPCs we...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2262
更新日期:2020-11-03 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2307
更新日期:2020-10-01 00:00:00
abstract::Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2140
更新日期:2019-08-01 00:00:00
abstract::A new consensus of gerontologists proposes that delay of biological senescence is the most potent public health measure for preventing chronic disease in late life. At the most fundamental level, cellular aging is characterized by a decline in repair and homeostatic systems. Thus, interventions that protect or rejuven...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0793
更新日期:2008-12-01 00:00:00
abstract::It is known that weakness in the lower limbs is associated with recurrent falls in old people. Among the tests routinely used to assess lower extremity strength, the Short Physical Performance Battery (SPPB) is one of those used most often, but its relationship with recurrent falls is poorly investigated. We aimed to ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1491
更新日期:2014-06-01 00:00:00
abstract::Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. This ultimately results in progressive dysfunction and loss of vision either in advanced age for genetically normal patients (age-related macular degeneration) or...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2146
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities, such as antioxidative, antiinflammatory, anticancer, chemopreventive, and antineurodegenerative properties. We ev...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1031
更新日期:2010-10-01 00:00:00
abstract::We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0921
更新日期:2010-04-01 00:00:00
abstract::Abnormalities of gene structure or expression are commonly found in cancers, where they are used as prognostic markers, predicting the likely severity of disease or chances of response to therapy. An odds ratio (OR) of <1 indicates that a marker's presence is correlated with better outcome. An OR of <1 is also often t...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2004.7.199
更新日期:2004-10-01 00:00:00
abstract::I propose a new model, called the "RNA memory" model, for the possible role of RNAs in the maintenance and establishment of cell identity. This is cytoplasmic memory obtained by the transmission of mother noncoding (nc) RNAs to daughter cells. These RNAs are able to activate transcription via sequence homology in daug...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0957
更新日期:2010-04-01 00:00:00