Recombinant Manganese Peroxidase Reduces A2E Burden in Age-Related and Stargardt's Macular Degeneration Models.

abstract：:Abnormalities of gene structure or expression are commonly found in cancers, where they are used as prognostic markers, predicting the likely severity of disease or chances of response to therapy. An odds ratio (OR) of <1 indicates that a marker's presence is correlated with better outcome. An OR of <1 is also often t...

journal_title：Rejuvenation research

authors： Bains W

更新日期：2004-10-01 00:00:00

abstract：:Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral...

journal_title：Rejuvenation research

authors： Rutledge GA,Phang HJ,Le MN,Bui L,Rose MR,Mueller LD,Jafari M

更新日期：2020-10-20 00:00:00

abstract：:New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumu...

journal_title：Rejuvenation research

authors： Bahr BA

更新日期：2014-08-01 00:00:00

abstract：:We investigated the prognostic role of the Short Physical Performance Battery (SPPB) in elderly patients discharged from the acute care hospital. Our series consisted of 506 patients aged 70 years or more enrolled in a multicenter collaborative observational study. We considered three main outcomes: 1-year survival af...

journal_title：Rejuvenation research

authors： Corsonello A,Lattanzio F,Pedone C,Garasto S,Laino I,Bustacchini S,Pranno L,Mazzei B,Passarino G,Incalzi RA,Pharmacosurveillance In The Elderly Care Pvc Study Investigators.

更新日期：2012-02-01 00:00:00

abstract：:Astaxanthin (AST), a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of AST on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that AST could prolong the life span of Caenorhabditis elegans. To uncover whether AST could delay a...

journal_title：Rejuvenation research

authors： Fu M,Zhang X,Zhang X,Yang L,Luo S,Liu H

更新日期：2020-11-30 00:00:00

abstract：:Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...

journal_title：Rejuvenation research

authors： Ganie SA,Dar TA,Bhat AH,Dar KB,Anees S,Zargar MA,Masood A

更新日期：2016-02-01 00:00:00

abstract：:Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent prolif...

journal_title：Rejuvenation research

authors： Carter AR,Meinert E,Brindley DA

更新日期：2019-06-01 00:00:00

abstract：:A hypothetical mechanism of 14C-generated influence on a person's rate of aging is offered. The mathematical description and the following approbation of the radiocarbon mechanism of aging made it possible to coordinate the Gompertz and Strehler-Mildvan laws and predict the existence of one more, till-now unknown, int...

journal_title：Rejuvenation research

authors： Germansky AM,Germanskaia AA

更新日期：2006-07-01 00:00:00

abstract：:The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the fi...

journal_title：Rejuvenation research

authors： Kyriazis M

更新日期：2014-08-01 00:00:00

abstract：:There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and...

journal_title：Rejuvenation research

authors： Mansilla E,Roque G,Sosa YE,Tarditti A,Goya RG

更新日期：2016-08-01 00:00:00

abstract：:Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...

journal_title：Rejuvenation research

authors： Zhang M,Hwang E,Lin P,Gao W,Ngo HTT,Yi TH

更新日期：2018-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) are chemically reactive molecules with impaired electrons that make them unstable and able to react easily with a great variety of molecules. The main targets of ROS are DNA, proteins, and membrane phospholipids. In the skin, ROS are able to affect the production of collagen and elastin, ...

journal_title：Rejuvenation research

authors： Avantaggiato A,Palmieri A,Bertuzzi G,Carinci F

更新日期：2014-06-01 00:00:00

abstract：:Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...

journal_title：Rejuvenation research

authors： Szwergold BS

更新日期：2013-08-01 00:00:00

abstract：:Twenty years have passed since Kadenbach and Müller-Höcker first proposed that the age-related accumulation of mutant mitochondrial DNA is caused by its clonal expansion, rather than by a "vicious cycle" of de novo mutational events caused by the disruptive metabolic impact of prior ones. Proof that they were correct ...

journal_title：Rejuvenation research

authors： de Grey AD

更新日期：2009-06-01 00:00:00

abstract：:The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels-that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. This was a cross-sectional study of 406 Chilean adults aged...

journal_title：Rejuvenation research

authors： Merellano-Navarro E,Collado-Mateo D,García-Rubio J,Gusi N,Olivares PR

更新日期：2017-12-01 00:00:00

abstract：:Alzheimer's Disease (AD) is the most common age-related dementia, with a current prevalence in excess of five million individuals in the United States. The aggregation of amyloid-beta (A beta) into fibrillar amyloid plaques is a key pathological event in the development of the disease. Microglial proinflammatory activ...

journal_title：Rejuvenation research

authors： Zhu Y,Bickford PC,Sanberg P,Giunta B,Tan J

更新日期：2008-10-01 00:00:00

abstract：:Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes....

journal_title：Rejuvenation research

authors： Musacchio E,Perissinotto E,Sartori L,Veronese N,Punzi L,Zambon S,Manzato E,Baggio G,Corti MC,Crepaldi G,Ramonda R

更新日期：2017-02-01 00:00:00

abstract：:The mouse Mus musculus chromosomes are all acrocentric; each centromere (CEN) is adjacent to a telomere. The aim of the current work is to find out if at least half of the mouse telomeres (Tel) always follow satellite DNA sequences and if membrane telomere binding protein TRF2/MTBP is always in association with the Te...

journal_title：Rejuvenation research

authors： Kuznetsova IS,Voronin AP,Podgornaya OI

更新日期：2006-10-01 00:00:00

abstract：:Since the discovery of the limited life span of human fibroblasts some 50 years ago, many genealogical studies have been undertaken to describe growth kinetics of fibroblasts in serial cultures by their individual division behavior. It is now accepted that proliferation capacities of human fibroblasts strongly depend ...

journal_title：Rejuvenation research

authors： Hasenmaile S,Pawelec G

更新日期：2005-10-01 00:00:00

abstract：:The release of mitochondrial cytochrome c followed by activation of caspase cascade has been reported with aging in various tissues, whereas little is known about the caspase-independent pathway involved in mitochondrial dysfunction. To determine the functional impact of cytochrome c loss on mitochondrial respiratory ...

journal_title：Rejuvenation research

authors： Tamilselvan J,Sivarajan K,Anusuyadevi M,Panneerselvam C

更新日期：2007-09-01 00:00:00

abstract：:Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...

journal_title：Rejuvenation research

authors： Roat E,Prada N,Lugli E,Nasi M,Ferraresi R,Troiano L,Giovenzana C,Pinti M,Biagioni O,Mariotti M,Di Iorio A,Consolo U,Balli F,Cossarizza A

更新日期：2008-06-01 00:00:00

abstract：:The article is a presentation at the 4th Conference of ESAAM, which took place on October 30-31, 2015, in Athens, Greece. Its purpose was not to cover all aspects of cellular aging but to share with the audience of the Conference, in a 15-minute presentation, current knowledge about the rejuvenating and repairing soma...

journal_title：Rejuvenation research

authors： Koliakos G

更新日期：2017-02-01 00:00:00

abstract：:I propose a new model, called the "RNA memory" model, for the possible role of RNAs in the maintenance and establishment of cell identity. This is cytoplasmic memory obtained by the transmission of mother noncoding (nc) RNAs to daughter cells. These RNAs are able to activate transcription via sequence homology in daug...

journal_title：Rejuvenation research

authors： Arancio W

更新日期：2010-04-01 00:00:00

abstract：:Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...

journal_title：Rejuvenation research

authors： Fortney K,Morgen EK,Kotlyar M,Jurisica I

更新日期：2012-04-01 00:00:00

abstract：:Pluripotent stem cells offer unique opportunities for curing debilitating diseases. However, further comprehensive research is needed to better understand cell signaling during the differentiation of pluripotent cells into different cell lineages and accordingly to develop clinically applicable protocols. One of the l...

journal_title：Rejuvenation research

authors： Sharma S,Szurek EA,Rzucidlo JS,Liour SS,Eroglu A

更新日期：2011-12-01 00:00:00

abstract：:Pursuance of longevity is not only combating decrepitude but it is also extending the health span; otherwise longevity would result in a universal medical and social burden. As revealed by the literature, the attainment of a healthy life could be impacted by the social milieu. An inquiry of this kind could hardly be s...

journal_title：Rejuvenation research

authors： Lai WF,Chan ZC

更新日期：2011-02-01 00:00:00

abstract：:Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2020-08-01 00:00:00

abstract：:The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of calo...

journal_title：Rejuvenation research

authors： Prokopov AF,Reinmuth J

更新日期：2010-04-01 00:00:00

abstract：:Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...

journal_title：Rejuvenation research

authors： Poz D,De Falco E,Pisano C,Madonna R,Ferdinandy P,Balistreri CR

更新日期：2019-04-01 00:00:00

abstract：:Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain bar...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2016-12-01 00:00:00