The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers.

abstract：:There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and...

journal_title：Rejuvenation research

authors： Mansilla E,Roque G,Sosa YE,Tarditti A,Goya RG

更新日期：2016-08-01 00:00:00

abstract：:Older patients often suffer from multiple co-morbid conditions. Few co-morbidity indices are valid and reliable in elderly patients and comparison between them is rare. Our objective was to compare the performance, relevance, and abilities of six widely used and validated co-morbidity indices--the Charlson Cumulative ...

journal_title：Rejuvenation research

authors： Zekry D,Valle BH,Michel JP,Esposito F,Gold G,Krause KH,Herrmann FR

更新日期：2010-12-01 00:00:00

abstract：:Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse along the surface of the primary myotubes, giving rise to a population...

journal_title：Rejuvenation research

authors： Matsakas A,Otto A,Elashry MI,Brown SC,Patel K

更新日期：2010-12-01 00:00:00

abstract：:The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of calo...

journal_title：Rejuvenation research

authors： Prokopov AF,Reinmuth J

更新日期：2010-04-01 00:00:00

abstract：:The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm in many mammals, including humans. Patients with acute confusional state or delirium, especially those with underlying cognitive impairment, frequently suffer from sleep disturbances and disturbed circadian rhythm. In this review, an overvi...

journal_title：Rejuvenation research

authors： de Rooij SE,van Munster BC

更新日期：2013-08-01 00:00:00

abstract：:Osteoarthritis is the most common disabling condition of humans in the western world. It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of the disease, but the explanations for this phenomenon have changed over time. The most longstanding theory is t...

journal_title：Rejuvenation research

authors： Aigner T,Rose J,Martin J,Buckwalter J

更新日期：2004-07-01 00:00:00

abstract：:The mouse Mus musculus chromosomes are all acrocentric; each centromere (CEN) is adjacent to a telomere. The aim of the current work is to find out if at least half of the mouse telomeres (Tel) always follow satellite DNA sequences and if membrane telomere binding protein TRF2/MTBP is always in association with the Te...

journal_title：Rejuvenation research

authors： Kuznetsova IS,Voronin AP,Podgornaya OI

更新日期：2006-10-01 00:00:00

abstract：:Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...

journal_title：Rejuvenation research

authors： Fortney K,Morgen EK,Kotlyar M,Jurisica I

更新日期：2012-04-01 00:00:00

abstract：:I propose a new model, called the "RNA memory" model, for the possible role of RNAs in the maintenance and establishment of cell identity. This is cytoplasmic memory obtained by the transmission of mother noncoding (nc) RNAs to daughter cells. These RNAs are able to activate transcription via sequence homology in daug...

journal_title：Rejuvenation research

authors： Arancio W

更新日期：2010-04-01 00:00:00

abstract：:The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...

journal_title：Rejuvenation research

authors： Mukhopadhyay A,Zullo SJ,Weiner H

更新日期：2006-07-01 00:00:00

abstract：:We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...

journal_title：Rejuvenation research

authors： Kikkawa K,Okada H,Mori T

更新日期：2010-04-01 00:00:00

abstract：:Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. This ultimately results in progressive dysfunction and loss of vision either in advanced age for genetically normal patients (age-related macular degeneration) or...

journal_title：Rejuvenation research

authors： Moody KJ,Tinklepaugh J,Obert E,Grohn K,DeRosa JR,Lumen E,Moyer BS,Campbell S,Wolfe AJ,Sleeper MB,Bianchi AH,Fisher C,Applegate J,Leary E,LeClair N,Wortel D,Doyle RP,Rohrer B,Blanden AR

更新日期：2018-12-01 00:00:00

abstract：:Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes....

journal_title：Rejuvenation research

authors： Musacchio E,Perissinotto E,Sartori L,Veronese N,Punzi L,Zambon S,Manzato E,Baggio G,Corti MC,Crepaldi G,Ramonda R

更新日期：2017-02-01 00:00:00

abstract：:A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the t...

journal_title：Rejuvenation research

authors： Morré DJ,Morré DM

更新日期：2006-07-01 00:00:00

abstract：:With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...

journal_title：Rejuvenation research

authors： Cai HB,Wu GL,Huang CH,Huang ZS,Chen YB,Wang Q

更新日期：2016-08-01 00:00:00

abstract：:This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...

journal_title：Rejuvenation research

authors： Cancela Carral JM,Pallin E,Orbegozo A,Ayán Pérez C

更新日期：2017-10-01 00:00:00

abstract：:The senescence of the immune system contributes considerably to the age-related diseases that are the main causes of death after the age of 65. In this study, we present an appealing option for the prevention of immune senescence and slowing or reversing the aging process, which can be achieved by heterochronous autol...

journal_title：Rejuvenation research

authors： Rožman P

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...

journal_title：Rejuvenation research

authors： Xiong Y,Xiong Y,Zhou S,Sun Y,Zhao Y,Ren X,Zhang Y,Zhang N

更新日期：2017-04-01 00:00:00

abstract：:The full power of gene modification in higher eukaryotes, including its potential to correct disease-causing mutations, has so far been limited by its low efficiency. Now that power looks set to be released through the use of customized endonuclease "hands," DNA-binding zinc fingers linked to nuclease "thumbs," capabl...

journal_title：Rejuvenation research

authors： Porter AC

更新日期：2005-01-01 00:00:00

abstract：:We have reported the isolation of a unique subpopulation of human stromal cells from bone marrow termed marrow-isolated adult multilineage inducible (MIAMI) cells. The expression of embryonic stem cell markers SSEA-4, Oct-4, Rex-1, and telomerase reverse transcriptase indicates the developmentally immature status of t...

journal_title：Rejuvenation research

authors： D'Ippolito G,Howard GA,Roos BA,Schiller PC

更新日期：2006-04-01 00:00:00

abstract：:Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...

journal_title：Rejuvenation research

authors： Kulminski AM,Culminskaya I,Arbeev KG,Ukraintseva SV,Arbeeva L,Yashin AI

更新日期：2013-02-01 00:00:00

abstract：:Diminished integrity of the intestinal epithelial barrier with advanced age is believed to contribute to aging-associated dysfunction and pathologies in animals. In mammals, diminished gut integrity contributes to inflammaging, the increase in inflammatory processes observed in old age. Recent work suggests that expre...

journal_title：Rejuvenation research

authors： Larrick JW,Mendelsohn AR

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...

journal_title：Rejuvenation research

authors： Stipic I,Polasek O,Vulic M,Punda H,Grandic L,Strinic T

更新日期：2012-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) are chemically reactive molecules with impaired electrons that make them unstable and able to react easily with a great variety of molecules. The main targets of ROS are DNA, proteins, and membrane phospholipids. In the skin, ROS are able to affect the production of collagen and elastin, ...

journal_title：Rejuvenation research

authors： Avantaggiato A,Palmieri A,Bertuzzi G,Carinci F

更新日期：2014-06-01 00:00:00

abstract：:To determine the prognostic value of frailty and comorbidity for outdoor mobility loss and mortality in the elderly. The retrospective study was conducted among outpatients aged ≥60 years. Patients with ≥3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The outdoor low-mobilit...

journal_title：Rejuvenation research

authors： Tkacheva ON,Runikhina NK,Merkusheva LI,Lysenkov SN,Ostapenko VS,Sharashkina NV,Press Y

更新日期：2020-07-14 00:00:00

abstract：:Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2017-08-01 00:00:00

abstract：:In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2013-10-01 00:00:00

abstract：:d-galactose (d-gal) is widely used to induce aging. However, it is still unclear whether long-term injection of d-gal affects the gastrointestinal functions of aging rats, and how. In this study, we investigated the effects of d-gal on the gastrointestinal functions of aging rats, especially from the perspective of fe...

journal_title：Rejuvenation research

authors： Zhao D,Liu X,Zhao S,Li Z,Qin X

更新日期：2020-09-29 00:00:00

abstract：:Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ1-42, we dem...

journal_title：Rejuvenation research

authors： Ai L,Yang F,Song J,Chen Y,Xiao L,Wang Q,Wang L,Li H,Lei T,Huang Z

更新日期：2018-08-01 00:00:00

abstract：:Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and 1H nuclear magnetic resonance ...

journal_title：Rejuvenation research

authors： Duan DD,Wang KX,Zhou YZ,Qin XM,Gao L,Du GH

更新日期：2017-12-01 00:00:00