Abstract:
:We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The range of motion (ROM) of knee and hip and step length are the stable parameters in age-predictive models for both genders. Although the model achieved the Minimum Akaike's Information Criterion Estimate (MAICE), it did not reflect sufficiently the regimes of variable selection.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Kikkawa K,Okada H,Mori Tdoi
10.1089/rej.2009.0921subject
Has Abstractpub_date
2010-04-01 00:00:00pages
335-8issue
2-3eissn
1549-1684issn
1557-8577journal_volume
13pub_type
杂志文章abstract::Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has b...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0846
更新日期:2009-04-01 00:00:00
abstract::The relationships among lipoprotein metabolism, genetic vascular factors, vascular disease, and Alzheimer's disease suggest that the examination of centenarian populations in relation to certain genes or lipoprotein metabolism provide insights into human longevity. The findings on the higher frequency of the apolipopr...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2007.0537
更新日期:2007-12-01 00:00:00
abstract::Aristotle described the study of politics as an "architectonic" science that aspires to bring together insights from different fields of scientific inquiry to ensure that citizens have the opportunities to flourish. To meet the health and economic challenges of aging populations, we must revive this Aristotelian visio...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1023
更新日期:2010-10-01 00:00:00
abstract::Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1717
更新日期:2016-04-01 00:00:00
abstract::Homocysteine (Hcy) could induce amyloid β (Aβ) accumulation, synaptic dysfunction, and memory impairment as seen in Alzheimer disease (AD), the most prevalent neurodegenerative disorder, which affects more than 25 million people worldwide. Here we investigated the protective effect of hydroxysafflor yellow A (HSYA) on...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1451
更新日期:2013-12-01 00:00:00
abstract::Thrombolytic therapy (TT) is applied in patients (<75 years of age) with acute myocardial infarction (AMI) with ST-segment elevation. It is recommended for elderly patients who have percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery. For PTCA and bypass surgery a cardiosurgery medical team, which ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.358
更新日期:2006-07-01 00:00:00
abstract::The senescence of the immune system contributes considerably to the age-related diseases that are the main causes of death after the age of 65. In this study, we present an appealing option for the prevention of immune senescence and slowing or reversing the aging process, which can be achieved by heterochronous autol...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2164
更新日期:2020-04-01 00:00:00
abstract::With advancing age, the mammalian thymus undergoes involution, a progressive loss of architectural integrity and lymphoid cellularity that results in reduced T lymphopoiesis. Thymic involution also is associated with extreme malnutrition and states of immune deficiency, such as active HIV infection, after chemotherapy...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.134
更新日期:2006-04-01 00:00:00
abstract::Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1263
更新日期:2012-04-01 00:00:00
abstract::Pulses up to 11 Tesla magnetic fields may generate pockets of currents along the walls of cellular material and may interfere with the overall ability of cell division. We used prokaryotic cells (Escherichia coli) and eukaryotic cells (murine fibroblasts) and exposed them to magnetic pulses of intensities ranging from...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1487
更新日期:2014-04-01 00:00:00
abstract::In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1484
更新日期:2013-10-01 00:00:00
abstract::The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels-that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. This was a cross-sectional study of 406 Chilean adults aged...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1913
更新日期:2017-12-01 00:00:00
abstract::Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1642
更新日期:2015-08-01 00:00:00
abstract::Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2084
更新日期:2019-02-01 00:00:00
abstract::Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2012.1401
更新日期:2013-08-01 00:00:00
abstract::Frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in a rehabilitation setting for the treatment of pain, especially in diabetic patients. In a randomized clinical trial, we tested the hypothesis that FREMS is effective in the treatment of chronic and pa...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2011.1236
更新日期:2012-06-01 00:00:00
abstract::Photoaging is the superposition of photodamage (ultraviolet [UV] radiation-induced) on the aging process. It is a major damaging consequence of free radical action. Curcumin (diferuloylmethane) is a phytochemical with diverse antioxidant and antiinflammatory properties. However, it shows a poor topical bioavailability...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0906
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1835
更新日期:2017-04-01 00:00:00
abstract::Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2254
更新日期:2020-08-01 00:00:00
abstract::Twenty years have passed since Kadenbach and Müller-Höcker first proposed that the age-related accumulation of mutant mitochondrial DNA is caused by its clonal expansion, rather than by a "vicious cycle" of de novo mutational events caused by the disruptive metabolic impact of prior ones. Proof that they were correct ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0879
更新日期:2009-06-01 00:00:00
abstract::The mouse Mus musculus chromosomes are all acrocentric; each centromere (CEN) is adjacent to a telomere. The aim of the current work is to find out if at least half of the mouse telomeres (Tel) always follow satellite DNA sequences and if membrane telomere binding protein TRF2/MTBP is always in association with the Te...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.391
更新日期:2006-10-01 00:00:00
abstract::Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by traditional center-based and home-based programs. This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frail ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2292
更新日期:2020-05-26 00:00:00
abstract::There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1777
更新日期:2016-08-01 00:00:00
abstract::Interruption of insulin-like growth factor I (IGF-1) signaling has been demonstrated to prolong life span although the underlying mechanism has not been elucidated. The aim of this study was to examine the influence of severe IGF-1 deficiency on survival rate, cardiomyocyte viability, contractile function, and intrace...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0552
更新日期:2007-12-01 00:00:00
abstract::The United States has the most expensive healthcare system worldwide. Yet measures of health span and life expectancy are well below the major industrialized nations. With the U.S. population aged 65 years and older projected to double by mid-century, a healthcare crisis is looming. Within this context, huge interest ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2088
更新日期:2018-06-01 00:00:00
abstract::Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2378
更新日期:2020-08-01 00:00:00
abstract::As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old and young mice are connected, the old mice experience increased neurogenesi...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1301
更新日期:2011-12-01 00:00:00
abstract::To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0893
更新日期:2010-04-01 00:00:00
abstract::Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0648
更新日期:2008-06-01 00:00:00
abstract::No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a...
journal_title:Rejuvenation research
pub_type: 临床试验,杂志文章
doi:10.1089/rej.2012.1380
更新日期:2013-04-01 00:00:00