Abstract:
:Older patients often suffer from multiple co-morbid conditions. Few co-morbidity indices are valid and reliable in elderly patients and comparison between them is rare. Our objective was to compare the performance, relevance, and abilities of six widely used and validated co-morbidity indices--the Charlson Cumulative Illness Rating Scale-Geriatrics (CIRS), Index of Co-Existent Disease, Kaplan Scale, Geriatrics Index of Co-morbidity (GIC), and Chronic Disease Score--to predict 5 years of survival after hospital discharge. Data came from a prospective study with yearly follow up, conducted 2004-2009 in 444 patients (mean age 85 years; 74% female) discharged from the acute geriatric hospital of the Geneva University Hospitals. In univariate analysis, mortality was significantly associated with age; each supplementary year added 7% of additional risk; and with sex, being male increased the risk by 1.5-fold. The best prognostic predictor was the GIC class 4 followed by the CIRS quartile 4 multiplying the risk of death by 4 and 3, respectively. After 1 year of discharge, for both scores approximately 50% of the high-score patients were already deceased and 80% were deceased after 5 years, compared with <5% in the lowest scores after 1 year and <40% after 5 years. When we entered all of the significant independent variables in a stepwise backward analysis, the best multiple regression model retained the CIRS quartile 4 as the strongest risk predictor followed by the GIC class 4. We conclude that the CIRS and the GIC may improve hospital discharge planning as being useful for clinical decision-making purposes and for clinical research in older patients.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Zekry D,Valle BH,Michel JP,Esposito F,Gold G,Krause KH,Herrmann FRdoi
10.1089/rej.2010.1037subject
Has Abstractpub_date
2010-12-01 00:00:00pages
675-82issue
6eissn
1549-1684issn
1557-8577journal_volume
13pub_type
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journal_title:Rejuvenation research
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journal_title:Rejuvenation research
pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1594
更新日期:2015-02-01 00:00:00
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journal_title:Rejuvenation research
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doi:10.1089/rej.2014.1644
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journal_title:Rejuvenation research
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journal_title:Rejuvenation research
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journal_title:Rejuvenation research
pub_type: 杂志文章
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更新日期:2006-04-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0892
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journal_title:Rejuvenation research
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doi:10.1089/rej.2017.1971
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journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2007.0537
更新日期:2007-12-01 00:00:00
abstract::Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0648
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abstract::Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1717
更新日期:2016-04-01 00:00:00
abstract::This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0942
更新日期:2010-04-01 00:00:00