Abstract:
:We investigated the prognostic role of the Short Physical Performance Battery (SPPB) in elderly patients discharged from the acute care hospital. Our series consisted of 506 patients aged 70 years or more enrolled in a multicenter collaborative observational study. We considered three main outcomes: 1-year survival after discharge, functional decline, and hospitalization during follow-up. Independent predictors/correlates of the outcomes were investigated by Cox regression or logistic regression analysis when appropriate. The diagnostic accuracy of SPPB in relation to study outcomes was investigated by receiver operating characteristic (ROC) curve. SPPB score was associated with reduced mortality (hazard ratio [HR]=0.86, 95% confidence interval [CI] 0.78-0.95). When the analysis was adjusted for functional status at discharge, such an association was still near significant only for SPPB values >8 (HR=0.51; 95% CI 0.30-1.05). An SPPB score<5 could identify patients who died during follow-up with fair sensitivity (0.66), specificity (0.62), and area under the ROC curve (0.66). SPPB also qualified as independent correlate of functional decline (odds ratio [OR]=0.82; 95% CI 0.70-0.96), but not of rehospitalization or combined end-point death or rehospitalization. An SPPB score <5 could identify patients experiencing functional decline during follow-up with lower sensitivity (0.60), but higher specificity (0.69), and area under the ROC curve (0.69) with respect to mortality. In conclusion, SPPB can be considered a valid instrument to identify patients at major risk of functional decline and death after discharge from acute care hospital. However, it could more efficiently target patients at risk of functional decline than those at risk of death.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Corsonello A,Lattanzio F,Pedone C,Garasto S,Laino I,Bustacchini S,Pranno L,Mazzei B,Passarino G,Incalzi RA,Pharmacosurveillance In The Elderly Care Pvc Study Investigators.doi
10.1089/rej.2011.1215subject
Has Abstractpub_date
2012-02-01 00:00:00pages
41-8issue
1eissn
1549-1684issn
1557-8577journal_volume
15pub_type
杂志文章abstract::We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0921
更新日期:2010-04-01 00:00:00
abstract::Diminished integrity of the intestinal epithelial barrier with advanced age is believed to contribute to aging-associated dysfunction and pathologies in animals. In mammals, diminished gut integrity contributes to inflammaging, the increase in inflammatory processes observed in old age. Recent work suggests that expre...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2335
更新日期:2020-04-01 00:00:00
abstract::Let us define human aging as the random accumulation of damage in the human organism's cells, tissues, or whole organism during life that increases the probability of death. This definition opens ways to postpone aging via risk factors to health. Studies show that changes in aging have postponed aging 0.15-0.20 years ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2008.0675
更新日期:2008-04-01 00:00:00
abstract::Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2378
更新日期:2020-08-01 00:00:00
abstract::To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0893
更新日期:2010-04-01 00:00:00
abstract::The release of mitochondrial cytochrome c followed by activation of caspase cascade has been reported with aging in various tissues, whereas little is known about the caspase-independent pathway involved in mitochondrial dysfunction. To determine the functional impact of cytochrome c loss on mitochondrial respiratory ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0541
更新日期:2007-09-01 00:00:00
abstract::Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has b...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0846
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities, such as antioxidative, antiinflammatory, anticancer, chemopreventive, and antineurodegenerative properties. We ev...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1031
更新日期:2010-10-01 00:00:00
abstract::Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2140
更新日期:2019-08-01 00:00:00
abstract::Osteoarthritis is the most common disabling condition of humans in the western world. It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of the disease, but the explanations for this phenomenon have changed over time. The most longstanding theory is t...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/1549168041552964
更新日期:2004-07-01 00:00:00
abstract::We have reported the isolation of a unique subpopulation of human stromal cells from bone marrow termed marrow-isolated adult multilineage inducible (MIAMI) cells. The expression of embryonic stem cell markers SSEA-4, Oct-4, Rex-1, and telomerase reverse transcriptase indicates the developmentally immature status of t...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.10
更新日期:2006-04-01 00:00:00
abstract::Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2012.1401
更新日期:2013-08-01 00:00:00
abstract::Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2018.2094
更新日期:2019-04-01 00:00:00
abstract::With advancing age, the mammalian thymus undergoes involution, a progressive loss of architectural integrity and lymphoid cellularity that results in reduced T lymphopoiesis. Thymic involution also is associated with extreme malnutrition and states of immune deficiency, such as active HIV infection, after chemotherapy...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.134
更新日期:2006-04-01 00:00:00
abstract::With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1751
更新日期:2016-08-01 00:00:00
abstract::Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2015.1704
更新日期:2016-02-01 00:00:00
abstract::Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human popu...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0666
更新日期:2008-04-01 00:00:00
abstract::Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1362
更新日期:2013-02-01 00:00:00
abstract::This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0942
更新日期:2010-04-01 00:00:00
abstract::Abnormalities of gene structure or expression are commonly found in cancers, where they are used as prognostic markers, predicting the likely severity of disease or chances of response to therapy. An odds ratio (OR) of <1 indicates that a marker's presence is correlated with better outcome. An OR of <1 is also often t...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2004.7.199
更新日期:2004-10-01 00:00:00
abstract::To determine the prognostic value of frailty and comorbidity for outdoor mobility loss and mortality in the elderly. The retrospective study was conducted among outpatients aged ≥60 years. Patients with ≥3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The outdoor low-mobilit...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2289
更新日期:2020-07-14 00:00:00
abstract::Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.2001
更新日期:2017-08-01 00:00:00
abstract::No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a...
journal_title:Rejuvenation research
pub_type: 临床试验,杂志文章
doi:10.1089/rej.2012.1380
更新日期:2013-04-01 00:00:00
abstract::This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2017.1924
更新日期:2017-10-01 00:00:00
abstract::Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ1-42, we dem...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.1966
更新日期:2018-08-01 00:00:00
abstract::The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2006.9.182
更新日期:2006-07-01 00:00:00
abstract::The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low prolifera...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.0503
更新日期:2007-03-01 00:00:00
abstract::In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1484
更新日期:2013-10-01 00:00:00
abstract::Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.1971
更新日期:2018-08-01 00:00:00
abstract::We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring togethe...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1471
更新日期:2013-10-01 00:00:00