The Association Between Comorbidity, Frailty, and Outdoor Mobility Loss Among Community-Dwelling Individuals 60 Years of Age and Above in Moscow.

abstract：:Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...

journal_title：Rejuvenation research

authors： Badreh F,Joukar S,Badavi M,Rashno M

更新日期：2020-08-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, because these are a key technology to systematically integrate heterogeneous information about the aging process. Related t...

journal_title：Rejuvenation research

authors： Fuellen G,Boerries M,Busch H,de Grey A,Hahn U,Hiller T,Hoeflich A,Jansen L,Janssens GE,Kaleta C,Meinema AC,Schäuble S,Simm A,Schofield PN,Smith B,Sühnel J,Vera J,Wagner W,Wönne EC,Wuttke D

更新日期：2013-12-01 00:00:00

abstract：:Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...

journal_title：Rejuvenation research

authors： Poz D,De Falco E,Pisano C,Madonna R,Ferdinandy P,Balistreri CR

更新日期：2019-04-01 00:00:00

abstract：:Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and 1H nuclear magnetic resonance ...

journal_title：Rejuvenation research

authors： Duan DD,Wang KX,Zhou YZ,Qin XM,Gao L,Du GH

更新日期：2017-12-01 00:00:00

abstract：:Pulses up to 11 Tesla magnetic fields may generate pockets of currents along the walls of cellular material and may interfere with the overall ability of cell division. We used prokaryotic cells (Escherichia coli) and eukaryotic cells (murine fibroblasts) and exposed them to magnetic pulses of intensities ranging from...

journal_title：Rejuvenation research

authors： Kletetschka G,Zila V,Klimova L

更新日期：2014-04-01 00:00:00

abstract：:To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...

journal_title：Rejuvenation research

authors： Ko KM,Chiu PY,Leung HY,Siu AH,Chen N,Leong EP,Poon MK

更新日期：2010-04-01 00:00:00

abstract：:This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...

journal_title：Rejuvenation research

authors： Cancela Carral JM,Pallin E,Orbegozo A,Ayán Pérez C

更新日期：2017-10-01 00:00:00

abstract：:I propose a new model, called the "RNA memory" model, for the possible role of RNAs in the maintenance and establishment of cell identity. This is cytoplasmic memory obtained by the transmission of mother noncoding (nc) RNAs to daughter cells. These RNAs are able to activate transcription via sequence homology in daug...

journal_title：Rejuvenation research

authors： Arancio W

更新日期：2010-04-01 00:00:00

abstract：:The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low prolifera...

journal_title：Rejuvenation research

authors： Rodriguez-Lopez AM,Whitby MC,Borer CM,Bachler MA,Cox LS

更新日期：2007-03-01 00:00:00

abstract：:Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...

journal_title：Rejuvenation research

authors： Szwergold BS

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities, such as antioxidative, antiinflammatory, anticancer, chemopreventive, and antineurodegenerative properties. We ev...

journal_title：Rejuvenation research

authors： Lee KS,Lee BS,Semnani S,Avanesian A,Um CY,Jeon HJ,Seong KM,Yu K,Min KJ,Jafari M

更新日期：2010-10-01 00:00:00

abstract：:New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumu...

journal_title：Rejuvenation research

authors： Bahr BA

更新日期：2014-08-01 00:00:00

abstract：:It is known that dietary restriction (DR) increases maximum longevity in rodents, but the mechanisms involved remain unknown. Among the possible mechanisms, several lines of evidence support the idea that decreases in mitochondrial oxidative stress and in insulin signaling are involved but it is not known if they are ...

journal_title：Rejuvenation research

authors： Caro P,Gómez J,López-Torres M,Sánchez I,Naudi A,Portero-Otín M,Pamplona R,Barja G

更新日期：2008-06-01 00:00:00

abstract：:The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...

journal_title：Rejuvenation research

authors： Mukhopadhyay A,Zullo SJ,Weiner H

更新日期：2006-07-01 00:00:00

abstract：:Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent prolif...

journal_title：Rejuvenation research

authors： Carter AR,Meinert E,Brindley DA

更新日期：2019-06-01 00:00:00

abstract：:Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...

journal_title：Rejuvenation research

authors： Kim SH,Lee EY,Cho KH

更新日期：2015-02-01 00:00:00

abstract：:It is known that weakness in the lower limbs is associated with recurrent falls in old people. Among the tests routinely used to assess lower extremity strength, the Short Physical Performance Battery (SPPB) is one of those used most often, but its relationship with recurrent falls is poorly investigated. We aimed to ...

journal_title：Rejuvenation research

authors： Veronese N,Bolzetta F,Toffanello ED,Zambon S,De Rui M,Perissinotto E,Coin A,Corti MC,Baggio G,Crepaldi G,Sergi G,Manzato E

更新日期：2014-06-01 00:00:00

abstract：:Older patients often suffer from multiple co-morbid conditions. Few co-morbidity indices are valid and reliable in elderly patients and comparison between them is rare. Our objective was to compare the performance, relevance, and abilities of six widely used and validated co-morbidity indices--the Charlson Cumulative ...

journal_title：Rejuvenation research

authors： Zekry D,Valle BH,Michel JP,Esposito F,Gold G,Krause KH,Herrmann FR

更新日期：2010-12-01 00:00:00

abstract：:We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...

journal_title：Rejuvenation research

authors： Kikkawa K,Okada H,Mori T

更新日期：2010-04-01 00:00:00

abstract：:Osteoporosis is a silent disease caused by low bone mineral density and is complicated by fractures. This study was designed to examine the differentiation of uterine stem cell-derived osteoprogenitor cells (UOPCs) both in vitro and in vivo, assessing their effectiveness in treating osteoporosis. CD271+/CD45- UOPCs we...

journal_title：Rejuvenation research

authors： Wang Z,Wang D,Liu Y,Liu D,Ren Y,Liu Z,Yu B,Hao M,Xie J

更新日期：2020-11-03 00:00:00

abstract：:Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...

journal_title：Rejuvenation research

authors： Tokarz P,Kaarniranta K,Blasiak J

更新日期：2016-04-01 00:00:00

abstract：:Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...

journal_title：Rejuvenation research

authors： Ganie SA,Dar TA,Bhat AH,Dar KB,Anees S,Zargar MA,Masood A

更新日期：2016-02-01 00:00:00

abstract：:As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old and young mice are connected, the old mice experience increased neurogenesi...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2011-12-01 00:00:00

abstract：:Pursuance of longevity is not only combating decrepitude but it is also extending the health span; otherwise longevity would result in a universal medical and social burden. As revealed by the literature, the attainment of a healthy life could be impacted by the social milieu. An inquiry of this kind could hardly be s...

journal_title：Rejuvenation research

authors： Lai WF,Chan ZC

更新日期：2011-02-01 00:00:00

abstract：:Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...

journal_title：Rejuvenation research

authors： Fortney K,Morgen EK,Kotlyar M,Jurisica I

更新日期：2012-04-01 00:00:00

abstract：:Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...

journal_title：Rejuvenation research

authors： Roat E,Prada N,Lugli E,Nasi M,Ferraresi R,Troiano L,Giovenzana C,Pinti M,Biagioni O,Mariotti M,Di Iorio A,Consolo U,Balli F,Cossarizza A

更新日期：2008-06-01 00:00:00

abstract：:Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous system. Previously, we showed a drastic decline in the expression of glial and neuronal proteins in myelinated peripher...

journal_title：Rejuvenation research

authors： Opalach K,Rangaraju S,Madorsky I,Leeuwenburgh C,Notterpek L

更新日期：2010-02-01 00:00:00

abstract：:This study was designed to elucidate the molecular mechanism underlying lysophosphatidic acid (LPA) and adenylyl cyclase inhibitor SQ22536 (ACI)-induced senescent human diploid fibroblast (HDF) proliferation. Because adenosine monophosphate (AMP)-activated protein kinase (AMPK) is known to inhibit cell proliferation, ...

journal_title：Rejuvenation research

authors： Rhim JH,Jang IS,Song KY,Ha MK,Cho SC,Yeo EJ,Park SC

更新日期：2008-08-01 00:00:00

abstract：:With advancing age, the mammalian thymus undergoes involution, a progressive loss of architectural integrity and lymphoid cellularity that results in reduced T lymphopoiesis. Thymic involution also is associated with extreme malnutrition and states of immune deficiency, such as active HIV infection, after chemotherapy...

journal_title：Rejuvenation research

authors： Virts EL,Phillips JA,Thoman ML

更新日期：2006-04-01 00:00:00