Inhibition of Abeta Proteotoxicity by Paeoniflorin in Caenorhabditis elegans Through Regulation of Oxidative and Heat Shock Stress Responses.

abstract：:The article is a presentation at the 4th Conference of ESAAM, which took place on October 30-31, 2015, in Athens, Greece. Its purpose was not to cover all aspects of cellular aging but to share with the audience of the Conference, in a 15-minute presentation, current knowledge about the rejuvenating and repairing soma...

journal_title：Rejuvenation research

authors： Koliakos G

更新日期：2017-02-01 00:00:00

abstract：:Lysosomes are involved in degrading and recycling cellular ingredients, and their disruption with age may contribute to amyloidogenesis, paired helical filaments (PHFs), and α-synuclein and mutant huntingtin aggregation. Lysosomal cathepsins are upregulated by accumulating proteins and more so by the modulator Z-Phe-A...

journal_title：Rejuvenation research

authors： Bahr BA,Wisniewski ML,Butler D

更新日期：2012-04-01 00:00:00

abstract：:The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, because these are a key technology to systematically integrate heterogeneous information about the aging process. Related t...

journal_title：Rejuvenation research

authors： Fuellen G,Boerries M,Busch H,de Grey A,Hahn U,Hiller T,Hoeflich A,Jansen L,Janssens GE,Kaleta C,Meinema AC,Schäuble S,Simm A,Schofield PN,Smith B,Sühnel J,Vera J,Wagner W,Wönne EC,Wuttke D

更新日期：2013-12-01 00:00:00

abstract：:Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2017-08-01 00:00:00

abstract：:We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring togethe...

journal_title：Rejuvenation research

authors： Zhavoronkov A,Cantor CR

更新日期：2013-10-01 00:00:00

abstract：:Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...

journal_title：Rejuvenation research

authors： Sun Y,Qi G,Li D,Meng H,Zhu Z,Zhao Y,Qi Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:Thrombolytic therapy (TT) is applied in patients (<75 years of age) with acute myocardial infarction (AMI) with ST-segment elevation. It is recommended for elderly patients who have percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery. For PTCA and bypass surgery a cardiosurgery medical team, which ...

journal_title：Rejuvenation research

authors： Taneva E

更新日期：2006-07-01 00:00:00

abstract：:Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...

journal_title：Rejuvenation research

authors： Zhang M,Hwang E,Lin P,Gao W,Ngo HTT,Yi TH

更新日期：2018-08-01 00:00:00

abstract：:The full power of gene modification in higher eukaryotes, including its potential to correct disease-causing mutations, has so far been limited by its low efficiency. Now that power looks set to be released through the use of customized endonuclease "hands," DNA-binding zinc fingers linked to nuclease "thumbs," capabl...

journal_title：Rejuvenation research

authors： Porter AC

更新日期：2005-01-01 00:00:00

abstract：:The release of mitochondrial cytochrome c followed by activation of caspase cascade has been reported with aging in various tissues, whereas little is known about the caspase-independent pathway involved in mitochondrial dysfunction. To determine the functional impact of cytochrome c loss on mitochondrial respiratory ...

journal_title：Rejuvenation research

authors： Tamilselvan J,Sivarajan K,Anusuyadevi M,Panneerselvam C

更新日期：2007-09-01 00:00:00

abstract：:Our recent studies have shown that Huogu (HG) formula was effective both in clinic experience and in experimental osteonecrosis of the femoral head (ONFH). Given that defective of bone marrow stromal cells (MSCs) contribute to the development of osteonecrosis and MSCs show enormous potential in the treatment of ONFH, ...

journal_title：Rejuvenation research

authors： Kong X,Li X,Zhang C,Zhu L,Wan H,Zhu J,Liu C,Su H,Qin Q,Chen W,Lin N

更新日期：2016-12-01 00:00:00

abstract：:Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral...

journal_title：Rejuvenation research

authors： Rutledge GA,Phang HJ,Le MN,Bui L,Rose MR,Mueller LD,Jafari M

更新日期：2020-10-20 00:00:00

abstract：:We examined the impact of strong co-presence and function of glutathione peroxidase-1 (GPX-1) and glial cell line-derived neurotrophic factor (GDNF) on protecting the rat dopaminergic pheochromocytoma cell line PC12 against 6-hydroxydopamine (6-OHDA) and hydrogen peroxide (H₂O₂) toxicities. Primarily, GPX-1 over-expre...

journal_title：Rejuvenation research

authors： Gharib E,Gardaneh M,Shojaei S

更新日期：2013-06-01 00:00:00

abstract：:The senescence of the immune system contributes considerably to the age-related diseases that are the main causes of death after the age of 65. In this study, we present an appealing option for the prevention of immune senescence and slowing or reversing the aging process, which can be achieved by heterochronous autol...

journal_title：Rejuvenation research

authors： Rožman P

更新日期：2020-04-01 00:00:00

abstract：:This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...

journal_title：Rejuvenation research

authors： Cancela Carral JM,Pallin E,Orbegozo A,Ayán Pérez C

更新日期：2017-10-01 00:00:00

abstract：:Telomeres are specialized DNA structures located at the ends of chromosomes. Their length is reduced at each cell cycle, especially when the cumulative burden of oxidative stress is high. The purpose of this study was to determine the associations between telomere length and clinical and biological risk factors in isc...

journal_title：Rejuvenation research

authors： Biotti D,Aho S,Béjot Y,Giroud M,Caillier M,Ragot S,Osseby GV,Moreau T,Teyssier JR

更新日期：2012-06-01 00:00:00

abstract：:Pluripotent stem cells offer unique opportunities for curing debilitating diseases. However, further comprehensive research is needed to better understand cell signaling during the differentiation of pluripotent cells into different cell lineages and accordingly to develop clinically applicable protocols. One of the l...

journal_title：Rejuvenation research

authors： Sharma S,Szurek EA,Rzucidlo JS,Liour SS,Eroglu A

更新日期：2011-12-01 00:00:00

abstract：:The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low prolifera...

journal_title：Rejuvenation research

authors： Rodriguez-Lopez AM,Whitby MC,Borer CM,Bachler MA,Cox LS

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Human growth hormone-1 (GH-1), somatotropin, is a peptide hormone that stimulates cell division in tissues such as bone and cartilage. METHODS:To compare physiological activities in lipid-free and lipid-bound states, we expressed and incorporated GH-1 in reconstituted high-density lipoprotein (rHDL). RESUL...

journal_title：Rejuvenation research

authors： Lee EY,Kim SH,Cho KH

更新日期：2015-06-01 00:00:00

abstract：:A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the t...

journal_title：Rejuvenation research

authors： Morré DJ,Morré DM

更新日期：2006-07-01 00:00:00

abstract：:Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous system. Previously, we showed a drastic decline in the expression of glial and neuronal proteins in myelinated peripher...

journal_title：Rejuvenation research

authors： Opalach K,Rangaraju S,Madorsky I,Leeuwenburgh C,Notterpek L

更新日期：2010-02-01 00:00:00

abstract：:The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...

journal_title：Rejuvenation research

authors： Mukhopadhyay A,Zullo SJ,Weiner H

更新日期：2006-07-01 00:00:00

abstract：:Theses reviewed in this issue include "Downregulation of the Apelinergic Axis Accelerates Aging, Whereas Its Systemic Restoration Improves the Mammalian Healthspan," "Intracellular Delivery of Exogenous Molecules Via an Ultrahigh Throughput Mechanoporation Microdevice," "Intrinsic and Extrinsic Drivers of Treg Fragili...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2019-08-01 00:00:00

abstract：:The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients > or = 65 years old with a diagnosis of CHF under...

journal_title：Rejuvenation research

authors： Corbi G,Acanfora D,Iannuzzi GL,Longobardi G,Cacciatore F,Furgi G,Filippelli A,Rengo G,Leosco D,Ferrara N

更新日期：2008-02-01 00:00:00

abstract：:Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscl...

journal_title：Rejuvenation research

authors： Picca A,Lezza AMS,Leeuwenburgh C,Pesce V,Calvani R,Bossola M,Manes-Gravina E,Landi F,Bernabei R,Marzetti E

更新日期：2018-08-01 00:00:00

abstract：:Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...

journal_title：Rejuvenation research

authors： Roat E,Prada N,Lugli E,Nasi M,Ferraresi R,Troiano L,Giovenzana C,Pinti M,Biagioni O,Mariotti M,Di Iorio A,Consolo U,Balli F,Cossarizza A

更新日期：2008-06-01 00:00:00

abstract：:Let us define human aging as the random accumulation of damage in the human organism's cells, tissues, or whole organism during life that increases the probability of death. This definition opens ways to postpone aging via risk factors to health. Studies show that changes in aging have postponed aging 0.15-0.20 years ...

journal_title：Rejuvenation research

authors： Kristjuhan U

更新日期：2008-04-01 00:00:00

abstract：:The mouse Mus musculus chromosomes are all acrocentric; each centromere (CEN) is adjacent to a telomere. The aim of the current work is to find out if at least half of the mouse telomeres (Tel) always follow satellite DNA sequences and if membrane telomere binding protein TRF2/MTBP is always in association with the Te...

journal_title：Rejuvenation research

authors： Kuznetsova IS,Voronin AP,Podgornaya OI

更新日期：2006-10-01 00:00:00

abstract：:Interruption of insulin-like growth factor I (IGF-1) signaling has been demonstrated to prolong life span although the underlying mechanism has not been elucidated. The aim of this study was to examine the influence of severe IGF-1 deficiency on survival rate, cardiomyocyte viability, contractile function, and intrace...

journal_title：Rejuvenation research

authors： Li Q,Yang X,Sreejayan N,Ren J

更新日期：2007-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) are chemically reactive molecules with impaired electrons that make them unstable and able to react easily with a great variety of molecules. The main targets of ROS are DNA, proteins, and membrane phospholipids. In the skin, ROS are able to affect the production of collagen and elastin, ...

journal_title：Rejuvenation research

authors： Avantaggiato A,Palmieri A,Bertuzzi G,Carinci F

更新日期：2014-06-01 00:00:00