Abstract:
:Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscle wasting disorders, including sarcopenia and cachexia. One of the consequences of failing MQC is the release of mitochondria-derived damage-associated molecular patterns (DAMPs). By virtue of their bacterial ancestry, these molecules can trigger an inflammatory response by interacting with receptors similar to those involved in pathogen-associated responses. Mitochondria-derived DAMPs, especially cell-free mitochondrial DNA, have recently been associated with conditions characterized by chronic inflammation, such as aging and degenerative diseases. Yet, their actual implication in the aging process and muscle wasting disorders is at an early stage of investigation. Here, we review the contribution of mitochondria-derived DAMPs to age-related systemic inflammation. We also provide arguments in support of the exploitation of such signaling pathways for the management of muscle wasting conditions.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Picca A,Lezza AMS,Leeuwenburgh C,Pesce V,Calvani R,Bossola M,Manes-Gravina E,Landi F,Bernabei R,Marzetti Edoi
10.1089/rej.2017.1989subject
Has Abstractpub_date
2018-08-01 00:00:00pages
350-359issue
4eissn
1549-1684issn
1557-8577journal_volume
21pub_type
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journal_title:Rejuvenation research
pub_type: 杂志文章
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journal_title:Rejuvenation research
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pub_type: 杂志文章
doi:10.1089/rej.2013.1484
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journal_title:Rejuvenation research
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1487
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journal_title:Rejuvenation research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1282
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pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 评论,杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章,多中心研究
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更新日期:2008-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-02-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1834
更新日期:2017-02-01 00:00:00
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journal_title:Rejuvenation research
pub_type: 杂志文章
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