Abstract:
:Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral diet results in improved functional health, particularly at later ages. Meanwhile, pharmaceutical studies have demonstrated that botanical extracts have potent antiaging properties, capable of extending the mean lifespan of D. melanogaster by up to 25%, without a decrease in early fecundity. In this study, we combine these two different approaches to healthspan extension to examine whether a combination of such treatments results in a synergistic or antagonistic effect on Drosophila healthspan. One botanical extract, derived from Rhodiola rosea, mimicked the effects of the ancestral apple diet with better performance at later ages compared with the control. Another extract, derived from Rosa damascena, decreased age-specific survivorship when combined with the apple diet providing support for the "Poisoned Chalice" hypothesis that combinations of various supplements or diets can elicit adverse physiological responses. More experiments in model organisms should be completed researching the effects of combining healthspan-extending substances in various diet backgrounds.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Rutledge GA,Phang HJ,Le MN,Bui L,Rose MR,Mueller LD,Jafari Mdoi
10.1089/rej.2020.2361subject
Has Abstractpub_date
2020-10-20 00:00:00eissn
1549-1684issn
1557-8577pub_type
杂志文章abstract::Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2012.1401
更新日期:2013-08-01 00:00:00
abstract::Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2254
更新日期:2020-08-01 00:00:00
abstract::Thrombolytic therapy (TT) is applied in patients (<75 years of age) with acute myocardial infarction (AMI) with ST-segment elevation. It is recommended for elderly patients who have percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery. For PTCA and bypass surgery a cardiosurgery medical team, which ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.358
更新日期:2006-07-01 00:00:00
abstract::The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, an...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1331
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities, such as antioxidative, antiinflammatory, anticancer, chemopreventive, and antineurodegenerative properties. We ev...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1031
更新日期:2010-10-01 00:00:00
abstract::We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring togethe...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1471
更新日期:2013-10-01 00:00:00
abstract::Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1263
更新日期:2012-04-01 00:00:00
abstract::The release of mitochondrial cytochrome c followed by activation of caspase cascade has been reported with aging in various tissues, whereas little is known about the caspase-independent pathway involved in mitochondrial dysfunction. To determine the functional impact of cytochrome c loss on mitochondrial respiratory ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0541
更新日期:2007-09-01 00:00:00
abstract::I propose a new model, called the "RNA memory" model, for the possible role of RNAs in the maintenance and establishment of cell identity. This is cytoplasmic memory obtained by the transmission of mother noncoding (nc) RNAs to daughter cells. These RNAs are able to activate transcription via sequence homology in daug...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0957
更新日期:2010-04-01 00:00:00
abstract::This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0942
更新日期:2010-04-01 00:00:00
abstract::Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2307
更新日期:2020-10-01 00:00:00
abstract::d-galactose (d-gal) is widely used to induce aging. However, it is still unclear whether long-term injection of d-gal affects the gastrointestinal functions of aging rats, and how. In this study, we investigated the effects of d-gal on the gastrointestinal functions of aging rats, especially from the perspective of fe...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2352
更新日期:2020-09-29 00:00:00
abstract::Alzheimer disease (AD), the most common form of dementia, is without an effective cure or preventive treatment. Recently, amyloid-beta protein (Abeta) has become a major therapeutic target. Many efforts are underway to either reduce the production of Abeta or enhance its clearance. In 1999, Schenk and colleagues first...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2006.9.77
更新日期:2006-04-01 00:00:00
abstract::A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the t...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.231
更新日期:2006-07-01 00:00:00
abstract::Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2378
更新日期:2020-08-01 00:00:00
abstract::The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients > or = 65 years old with a diagnosis of CHF under...
journal_title:Rejuvenation research
pub_type: 杂志文章,多中心研究
doi:10.1089/rej.2007.0583
更新日期:2008-02-01 00:00:00
abstract::Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.1971
更新日期:2018-08-01 00:00:00
abstract::Pulses up to 11 Tesla magnetic fields may generate pockets of currents along the walls of cellular material and may interfere with the overall ability of cell division. We used prokaryotic cells (Escherichia coli) and eukaryotic cells (murine fibroblasts) and exposed them to magnetic pulses of intensities ranging from...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1487
更新日期:2014-04-01 00:00:00
abstract::The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2006.9.182
更新日期:2006-07-01 00:00:00
abstract::We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0921
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Human growth hormone-1 (GH-1), somatotropin, is a peptide hormone that stimulates cell division in tissues such as bone and cartilage. METHODS:To compare physiological activities in lipid-free and lipid-bound states, we expressed and incorporated GH-1 in reconstituted high-density lipoprotein (rHDL). RESUL...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1644
更新日期:2015-06-01 00:00:00
abstract::To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, inclu...
journal_title:Rejuvenation research
pub_type: 杂志文章,meta分析,评审
doi:10.1089/rej.2014.1612
更新日期:2015-02-01 00:00:00
abstract::Astaxanthin (AST), a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of AST on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that AST could prolong the life span of Caenorhabditis elegans. To uncover whether AST could delay a...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2355
更新日期:2020-11-30 00:00:00
abstract::No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a...
journal_title:Rejuvenation research
pub_type: 临床试验,杂志文章
doi:10.1089/rej.2012.1380
更新日期:2013-04-01 00:00:00
abstract::Alzheimer's Disease (AD) is the most common age-related dementia, with a current prevalence in excess of five million individuals in the United States. The aggregation of amyloid-beta (A beta) into fibrillar amyloid plaques is a key pathological event in the development of the disease. Microglial proinflammatory activ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0757
更新日期:2008-10-01 00:00:00
abstract::Twenty years have passed since Kadenbach and Müller-Höcker first proposed that the age-related accumulation of mutant mitochondrial DNA is caused by its clonal expansion, rather than by a "vicious cycle" of de novo mutational events caused by the disruptive metabolic impact of prior ones. Proof that they were correct ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0879
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2012.1337
更新日期:2012-12-01 00:00:00
abstract::The article is a presentation at the 4th Conference of ESAAM, which took place on October 30-31, 2015, in Athens, Greece. Its purpose was not to cover all aspects of cellular aging but to share with the audience of the Conference, in a 15-minute presentation, current knowledge about the rejuvenating and repairing soma...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1809
更新日期:2017-02-01 00:00:00
abstract::With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1751
更新日期:2016-08-01 00:00:00
abstract::Lysosomes are involved in degrading and recycling cellular ingredients, and their disruption with age may contribute to amyloidogenesis, paired helical filaments (PHFs), and α-synuclein and mutant huntingtin aggregation. Lysosomal cathepsins are upregulated by accumulating proteins and more so by the modulator Z-Phe-A...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1282
更新日期:2012-04-01 00:00:00