Abstract:
:Astaxanthin (AST), a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of AST on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that AST could prolong the life span of Caenorhabditis elegans. To uncover whether AST could delay aging by upregulating autophagy, we measured the expression of autophagy gene and the life span of autophagy gene bec-1 mutant nematodes, and the results showed that the expression of autophagy gene was upregulated after AST intervention and the disruption of bec-1 weakened the extension of the life span. To explore the molecular mechanism of AST-induced autophagy upregulation, we knocked out the daf-16 or hlh-30 (key genes of insulin/insulin growth factor-1 [IGF-1] signal pathway or target of rapamycin [TOR] signal pathway) by RNA interference, and the expression of autophagy gene lgg-1 decreased. Collectively, our results strongly suggest that autophagy, which is both the insulin/IGF-1 signal pathway dependent and TOR signal pathway dependent, plays a role in the prolongation of the life span of Caenorhabditis elegans by AST.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Fu M,Zhang X,Zhang X,Yang L,Luo S,Liu Hdoi
10.1089/rej.2020.2355subject
Has Abstractpub_date
2020-11-30 00:00:00eissn
1549-1684issn
1557-8577pub_type
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journal_title:Rejuvenation research
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journal_title:Rejuvenation research
pub_type: 杂志文章
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journal_title:Rejuvenation research
pub_type: 杂志文章,评审
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journal_title:Rejuvenation research
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pub_type: 杂志文章
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journal_title:Rejuvenation research
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journal_title:Rejuvenation research
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