Abstract:
:No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a non-invasive device, the Visioscan(®) VC, and software for surface evaluation of living skin (SELS). Thirty-three healthy Asian subjects, all men, were enrolled after consent in a placebo-controlled comparative study with a split face design. One group applied multiple emulsions with green tea. The second group applied multiple emulsions with lotus extract, while a third group applied a multiple emulsion with a combination of both extracts. In all three groups, active formulations were applied to one side of the face and the placebo to the other side, once daily over the 60-day treatment course. Non-invasive measurements were performed at baseline and on days 30 and 60. Interesting and significant improvements were observed for the treatment effects on skin roughness (SEr), scaliness (SEsc), smoothness (SEsm), and wrinkling (SEw). For example, a 49.99% improvement in skin smoothness (SEsm) from baseline value and -23.22% and perfection in facial wrinkles (SEw) substantiated that combined treatment is superior over single treatments. Green tea and lotus combined in multiple emulsions brought a superior synergistic anti-aging effect. We conclude that diverse anti-oxidant constituents in both plants have a potential influence on skin surface parameters, thus indicating these plants as the future of new anti-aging products.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Mahmood T,Akhtar Ndoi
10.1089/rej.2012.1380subject
Has Abstractpub_date
2013-04-01 00:00:00pages
91-7issue
2eissn
1549-1684issn
1557-8577journal_volume
16pub_type
临床试验,杂志文章abstract::The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of calo...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0946
更新日期:2010-04-01 00:00:00
abstract::Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscl...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2017.1989
更新日期:2018-08-01 00:00:00
abstract::As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old and young mice are connected, the old mice experience increased neurogenesi...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1301
更新日期:2011-12-01 00:00:00
abstract::There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1777
更新日期:2016-08-01 00:00:00
abstract::Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.1971
更新日期:2018-08-01 00:00:00
abstract::It is known that dietary restriction (DR) increases maximum longevity in rodents, but the mechanisms involved remain unknown. Among the possible mechanisms, several lines of evidence support the idea that decreases in mitochondrial oxidative stress and in insulin signaling are involved but it is not known if they are ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0704
更新日期:2008-06-01 00:00:00
abstract::The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2006.9.182
更新日期:2006-07-01 00:00:00
abstract::Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2361
更新日期:2020-10-20 00:00:00
abstract::Let us define human aging as the random accumulation of damage in the human organism's cells, tissues, or whole organism during life that increases the probability of death. This definition opens ways to postpone aging via risk factors to health. Studies show that changes in aging have postponed aging 0.15-0.20 years ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2008.0675
更新日期:2008-04-01 00:00:00
abstract::The full power of gene modification in higher eukaryotes, including its potential to correct disease-causing mutations, has so far been limited by its low efficiency. Now that power looks set to be released through the use of customized endonuclease "hands," DNA-binding zinc fingers linked to nuclease "thumbs," capabl...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2005.8.211
更新日期:2005-01-01 00:00:00
abstract::Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2307
更新日期:2020-10-01 00:00:00
abstract::Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1594
更新日期:2015-02-01 00:00:00
abstract::Lysosomal storage diseases occur due to incomplete metabolic degradation of macromolecules by various hydrolytic enzymes in the lysosome. Despite structural differences, most of the lysosomal enzymes share many common features including a lysosomal targeting motif and phosphotransferase recognition sites. β-Glucuronid...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2013.1407
更新日期:2013-10-01 00:00:00
abstract::Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human popu...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0666
更新日期:2008-04-01 00:00:00
abstract::The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the fi...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1588
更新日期:2014-08-01 00:00:00
abstract::Pursuance of longevity is not only combating decrepitude but it is also extending the health span; otherwise longevity would result in a universal medical and social burden. As revealed by the literature, the attainment of a healthy life could be impacted by the social milieu. An inquiry of this kind could hardly be s...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2010.1071
更新日期:2011-02-01 00:00:00
abstract::With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1751
更新日期:2016-08-01 00:00:00
abstract::The United States has the most expensive healthcare system worldwide. Yet measures of health span and life expectancy are well below the major industrialized nations. With the U.S. population aged 65 years and older projected to double by mid-century, a healthcare crisis is looming. Within this context, huge interest ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2088
更新日期:2018-06-01 00:00:00
abstract::Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0648
更新日期:2008-06-01 00:00:00
abstract::Osteoarthritis is the most common disabling condition of humans in the western world. It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of the disease, but the explanations for this phenomenon have changed over time. The most longstanding theory is t...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/1549168041552964
更新日期:2004-07-01 00:00:00
abstract::To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, inclu...
journal_title:Rejuvenation research
pub_type: 杂志文章,meta分析,评审
doi:10.1089/rej.2014.1612
更新日期:2015-02-01 00:00:00
abstract::Inflammation and oxidative stress (OS) are key points in age progression. Both processes impact negatively in cognition and in brain functions. Resveratrol (RV) has been postulated as a potent antioxidant natural compound, with rejuvenating properties. Inducing a metabolic stress by high-fat (HF) diet in aged C56/BL6 ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1885
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1835
更新日期:2017-04-01 00:00:00
abstract::Since the discovery of the limited life span of human fibroblasts some 50 years ago, many genealogical studies have been undertaken to describe growth kinetics of fibroblasts in serial cultures by their individual division behavior. It is now accepted that proliferation capacities of human fibroblasts strongly depend ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2005.8.154
更新日期:2005-10-01 00:00:00
abstract::The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients > or = 65 years old with a diagnosis of CHF under...
journal_title:Rejuvenation research
pub_type: 杂志文章,多中心研究
doi:10.1089/rej.2007.0583
更新日期:2008-02-01 00:00:00
abstract::Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2018.2094
更新日期:2019-04-01 00:00:00
abstract::Osteoporosis is a silent disease caused by low bone mineral density and is complicated by fractures. This study was designed to examine the differentiation of uterine stem cell-derived osteoprogenitor cells (UOPCs) both in vitro and in vivo, assessing their effectiveness in treating osteoporosis. CD271+/CD45- UOPCs we...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2262
更新日期:2020-11-03 00:00:00
abstract::Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.2001
更新日期:2017-08-01 00:00:00
abstract::Twenty years have passed since Kadenbach and Müller-Höcker first proposed that the age-related accumulation of mutant mitochondrial DNA is caused by its clonal expansion, rather than by a "vicious cycle" of de novo mutational events caused by the disruptive metabolic impact of prior ones. Proof that they were correct ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0879
更新日期:2009-06-01 00:00:00
abstract::The release of mitochondrial cytochrome c followed by activation of caspase cascade has been reported with aging in various tissues, whereas little is known about the caspase-independent pathway involved in mitochondrial dysfunction. To determine the functional impact of cytochrome c loss on mitochondrial respiratory ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0541
更新日期:2007-09-01 00:00:00