A Rat Treated with Mesenchymal Stem Cells Lives to 44 Months of Age.

abstract：:Pursuance of longevity is not only combating decrepitude but it is also extending the health span; otherwise longevity would result in a universal medical and social burden. As revealed by the literature, the attainment of a healthy life could be impacted by the social milieu. An inquiry of this kind could hardly be s...

journal_title：Rejuvenation research

authors： Lai WF,Chan ZC

更新日期：2011-02-01 00:00:00

abstract：:The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm in many mammals, including humans. Patients with acute confusional state or delirium, especially those with underlying cognitive impairment, frequently suffer from sleep disturbances and disturbed circadian rhythm. In this review, an overvi...

journal_title：Rejuvenation research

authors： de Rooij SE,van Munster BC

更新日期：2013-08-01 00:00:00

abstract：:Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...

journal_title：Rejuvenation research

authors： Sun Y,Qi G,Li D,Meng H,Zhu Z,Zhao Y,Qi Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:A new consensus of gerontologists proposes that delay of biological senescence is the most potent public health measure for preventing chronic disease in late life. At the most fundamental level, cellular aging is characterized by a decline in repair and homeostatic systems. Thus, interventions that protect or rejuven...

journal_title：Rejuvenation research

authors： Perez FP,Zhou X,Morisaki J,Ilie J,James T,Jurivich DA

更新日期：2008-12-01 00:00:00

abstract：:A hypothetical mechanism of 14C-generated influence on a person's rate of aging is offered. The mathematical description and the following approbation of the radiocarbon mechanism of aging made it possible to coordinate the Gompertz and Strehler-Mildvan laws and predict the existence of one more, till-now unknown, int...

journal_title：Rejuvenation research

authors： Germansky AM,Germanskaia AA

更新日期：2006-07-01 00:00:00

abstract：:Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...

journal_title：Rejuvenation research

authors： Ganie SA,Dar TA,Bhat AH,Dar KB,Anees S,Zargar MA,Masood A

更新日期：2016-02-01 00:00:00

abstract：:Can memory be retained after cryopreservation? Our research has attempted to answer this long-standing question by using the nematode worm Caenorhabditis elegans, a well-known model organism for biological research that has generated revolutionary findings but has not been tested for memory retention after cryopreserv...

journal_title：Rejuvenation research

authors： Vita-More N,Barranco D

更新日期：2015-10-01 00:00:00

abstract：:Telomeres are specialized DNA structures located at the ends of chromosomes. Their length is reduced at each cell cycle, especially when the cumulative burden of oxidative stress is high. The purpose of this study was to determine the associations between telomere length and clinical and biological risk factors in isc...

journal_title：Rejuvenation research

authors： Biotti D,Aho S,Béjot Y,Giroud M,Caillier M,Ragot S,Osseby GV,Moreau T,Teyssier JR

更新日期：2012-06-01 00:00:00

abstract：:To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...

journal_title：Rejuvenation research

authors： Ko KM,Chiu PY,Leung HY,Siu AH,Chen N,Leong EP,Poon MK

更新日期：2010-04-01 00:00:00

abstract：:Interruption of insulin-like growth factor I (IGF-1) signaling has been demonstrated to prolong life span although the underlying mechanism has not been elucidated. The aim of this study was to examine the influence of severe IGF-1 deficiency on survival rate, cardiomyocyte viability, contractile function, and intrace...

journal_title：Rejuvenation research

authors： Li Q,Yang X,Sreejayan N,Ren J

更新日期：2007-12-01 00:00:00

abstract：:This study was designed to elucidate the molecular mechanism underlying lysophosphatidic acid (LPA) and adenylyl cyclase inhibitor SQ22536 (ACI)-induced senescent human diploid fibroblast (HDF) proliferation. Because adenosine monophosphate (AMP)-activated protein kinase (AMPK) is known to inhibit cell proliferation, ...

journal_title：Rejuvenation research

authors： Rhim JH,Jang IS,Song KY,Ha MK,Cho SC,Yeo EJ,Park SC

更新日期：2008-08-01 00:00:00

abstract：:Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...

journal_title：Rejuvenation research

authors： Ye P,Wang T,Liu WH,Li XC,Tang LJ,Tian FZ

更新日期：2015-08-01 00:00:00

abstract：:It is known that weakness in the lower limbs is associated with recurrent falls in old people. Among the tests routinely used to assess lower extremity strength, the Short Physical Performance Battery (SPPB) is one of those used most often, but its relationship with recurrent falls is poorly investigated. We aimed to ...

journal_title：Rejuvenation research

authors： Veronese N,Bolzetta F,Toffanello ED,Zambon S,De Rui M,Perissinotto E,Coin A,Corti MC,Baggio G,Crepaldi G,Sergi G,Manzato E

更新日期：2014-06-01 00:00:00

abstract：:Thrombolytic therapy (TT) is applied in patients (<75 years of age) with acute myocardial infarction (AMI) with ST-segment elevation. It is recommended for elderly patients who have percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery. For PTCA and bypass surgery a cardiosurgery medical team, which ...

journal_title：Rejuvenation research

authors： Taneva E

更新日期：2006-07-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:Astaxanthin (AST), a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of AST on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that AST could prolong the life span of Caenorhabditis elegans. To uncover whether AST could delay a...

journal_title：Rejuvenation research

authors： Fu M,Zhang X,Zhang X,Yang L,Luo S,Liu H

更新日期：2020-11-30 00:00:00

abstract：:Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...

journal_title：Rejuvenation research

authors： Tokarz P,Kaarniranta K,Blasiak J

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Human growth hormone-1 (GH-1), somatotropin, is a peptide hormone that stimulates cell division in tissues such as bone and cartilage. METHODS:To compare physiological activities in lipid-free and lipid-bound states, we expressed and incorporated GH-1 in reconstituted high-density lipoprotein (rHDL). RESUL...

journal_title：Rejuvenation research

authors： Lee EY,Kim SH,Cho KH

更新日期：2015-06-01 00:00:00

abstract：:Twenty years have passed since Kadenbach and Müller-Höcker first proposed that the age-related accumulation of mutant mitochondrial DNA is caused by its clonal expansion, rather than by a "vicious cycle" of de novo mutational events caused by the disruptive metabolic impact of prior ones. Proof that they were correct ...

journal_title：Rejuvenation research

authors： de Grey AD

更新日期：2009-06-01 00:00:00

abstract：:We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...

journal_title：Rejuvenation research

authors： Kikkawa K,Okada H,Mori T

更新日期：2010-04-01 00:00:00

abstract：:As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old and young mice are connected, the old mice experience increased neurogenesi...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2011-12-01 00:00:00

abstract：:This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...

journal_title：Rejuvenation research

authors： Cancela Carral JM,Pallin E,Orbegozo A,Ayán Pérez C

更新日期：2017-10-01 00:00:00

abstract：:Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by traditional center-based and home-based programs. This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frail ...

journal_title：Rejuvenation research

authors： Garcia RNSA,Costa SN,Garcia EDSA,Bento PCB

更新日期：2020-05-26 00:00:00

abstract：:Aging plays a central role in the occurrence of neurodegenerative diseases. Caloric restriction (CR) mitigates oxidative stress by decreasing the rate of generation of endogenous damage, a mechanism that can contribute to the slowing of the aging rate induced by this intervention. Various reports have recently linked ...

journal_title：Rejuvenation research

authors： Naudí A,Caro P,Jové M,Gómez J,Boada J,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2007-12-01 00:00:00

abstract：:Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral...

journal_title：Rejuvenation research

authors： Rutledge GA,Phang HJ,Le MN,Bui L,Rose MR,Mueller LD,Jafari M

更新日期：2020-10-20 00:00:00

abstract：:Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...

journal_title：Rejuvenation research

authors： Kulminski AM,Culminskaya I,Arbeev KG,Ukraintseva SV,Arbeeva L,Yashin AI

更新日期：2013-02-01 00:00:00

abstract：:This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...

journal_title：Rejuvenation research

authors： Candore G,Balistreri CR,Colonna-Romano G,Lio D,Listì F,Vasto S,Caruso C

更新日期：2010-04-01 00:00:00

abstract：:Since the discovery of the limited life span of human fibroblasts some 50 years ago, many genealogical studies have been undertaken to describe growth kinetics of fibroblasts in serial cultures by their individual division behavior. It is now accepted that proliferation capacities of human fibroblasts strongly depend ...

journal_title：Rejuvenation research

authors： Hasenmaile S,Pawelec G

更新日期：2005-10-01 00:00:00

abstract：:Lysosomes are involved in degrading and recycling cellular ingredients, and their disruption with age may contribute to amyloidogenesis, paired helical filaments (PHFs), and α-synuclein and mutant huntingtin aggregation. Lysosomal cathepsins are upregulated by accumulating proteins and more so by the modulator Z-Phe-A...

journal_title：Rejuvenation research

authors： Bahr BA,Wisniewski ML,Butler D

更新日期：2012-04-01 00:00:00

abstract：:No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a...

journal_title：Rejuvenation research

authors： Mahmood T,Akhtar N

更新日期：2013-04-01 00:00:00