Role of the Cell Cycle Re-Initiation in DNA Damage Response of Post-Mitotic Cells and Its Implication in the Pathogenesis of Neurodegenerative Diseases.

abstract：:Reactive oxygen species (ROS) are chemically reactive molecules with impaired electrons that make them unstable and able to react easily with a great variety of molecules. The main targets of ROS are DNA, proteins, and membrane phospholipids. In the skin, ROS are able to affect the production of collagen and elastin, ...

journal_title：Rejuvenation research

authors： Avantaggiato A,Palmieri A,Bertuzzi G,Carinci F

更新日期：2014-06-01 00:00:00

abstract：:We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...

journal_title：Rejuvenation research

authors： Kikkawa K,Okada H,Mori T

更新日期：2010-04-01 00:00:00

abstract：:The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels-that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. This was a cross-sectional study of 406 Chilean adults aged...

journal_title：Rejuvenation research

authors： Merellano-Navarro E,Collado-Mateo D,García-Rubio J,Gusi N,Olivares PR

更新日期：2017-12-01 00:00:00

abstract：:It is known that weakness in the lower limbs is associated with recurrent falls in old people. Among the tests routinely used to assess lower extremity strength, the Short Physical Performance Battery (SPPB) is one of those used most often, but its relationship with recurrent falls is poorly investigated. We aimed to ...

journal_title：Rejuvenation research

authors： Veronese N,Bolzetta F,Toffanello ED,Zambon S,De Rui M,Perissinotto E,Coin A,Corti MC,Baggio G,Crepaldi G,Sergi G,Manzato E

更新日期：2014-06-01 00:00:00

abstract：:Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...

journal_title：Rejuvenation research

authors： Ye P,Wang T,Liu WH,Li XC,Tang LJ,Tian FZ

更新日期：2015-08-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ1-42, we dem...

journal_title：Rejuvenation research

authors： Ai L,Yang F,Song J,Chen Y,Xiao L,Wang Q,Wang L,Li H,Lei T,Huang Z

更新日期：2018-08-01 00:00:00

abstract：:We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring togethe...

journal_title：Rejuvenation research

authors： Zhavoronkov A,Cantor CR

更新日期：2013-10-01 00:00:00

abstract：:Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...

journal_title：Rejuvenation research

authors： Poz D,De Falco E,Pisano C,Madonna R,Ferdinandy P,Balistreri CR

更新日期：2019-04-01 00:00:00

abstract：:Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes....

journal_title：Rejuvenation research

authors： Musacchio E,Perissinotto E,Sartori L,Veronese N,Punzi L,Zambon S,Manzato E,Baggio G,Corti MC,Crepaldi G,Ramonda R

更新日期：2017-02-01 00:00:00

abstract：:With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...

journal_title：Rejuvenation research

authors： Cai HB,Wu GL,Huang CH,Huang ZS,Chen YB,Wang Q

更新日期：2016-08-01 00:00:00

abstract：:Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...

journal_title：Rejuvenation research

authors： Szwergold BS

更新日期：2013-08-01 00:00:00

abstract：:The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients > or = 65 years old with a diagnosis of CHF under...

journal_title：Rejuvenation research

authors： Corbi G,Acanfora D,Iannuzzi GL,Longobardi G,Cacciatore F,Furgi G,Filippelli A,Rengo G,Leosco D,Ferrara N

更新日期：2008-02-01 00:00:00

abstract：:Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous system. Previously, we showed a drastic decline in the expression of glial and neuronal proteins in myelinated peripher...

journal_title：Rejuvenation research

authors： Opalach K,Rangaraju S,Madorsky I,Leeuwenburgh C,Notterpek L

更新日期：2010-02-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:Aristotle described the study of politics as an "architectonic" science that aspires to bring together insights from different fields of scientific inquiry to ensure that citizens have the opportunities to flourish. To meet the health and economic challenges of aging populations, we must revive this Aristotelian visio...

journal_title：Rejuvenation research

authors： Farrelly C

更新日期：2010-10-01 00:00:00

abstract：:Older patients often suffer from multiple co-morbid conditions. Few co-morbidity indices are valid and reliable in elderly patients and comparison between them is rare. Our objective was to compare the performance, relevance, and abilities of six widely used and validated co-morbidity indices--the Charlson Cumulative ...

journal_title：Rejuvenation research

authors： Zekry D,Valle BH,Michel JP,Esposito F,Gold G,Krause KH,Herrmann FR

更新日期：2010-12-01 00:00:00

abstract：:The senescence of the immune system contributes considerably to the age-related diseases that are the main causes of death after the age of 65. In this study, we present an appealing option for the prevention of immune senescence and slowing or reversing the aging process, which can be achieved by heterochronous autol...

journal_title：Rejuvenation research

authors： Rožman P

更新日期：2020-04-01 00:00:00

abstract：:In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2013-10-01 00:00:00

abstract：:The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the fi...

journal_title：Rejuvenation research

authors： Kyriazis M

更新日期：2014-08-01 00:00:00

abstract：:Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...

journal_title：Rejuvenation research

authors： Ganie SA,Dar TA,Bhat AH,Dar KB,Anees S,Zargar MA,Masood A

更新日期：2016-02-01 00:00:00

abstract：:Osteoarthritis is the most common disabling condition of humans in the western world. It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of the disease, but the explanations for this phenomenon have changed over time. The most longstanding theory is t...

journal_title：Rejuvenation research

authors： Aigner T,Rose J,Martin J,Buckwalter J

更新日期：2004-07-01 00:00:00

abstract：:Diminished integrity of the intestinal epithelial barrier with advanced age is believed to contribute to aging-associated dysfunction and pathologies in animals. In mammals, diminished gut integrity contributes to inflammaging, the increase in inflammatory processes observed in old age. Recent work suggests that expre...

journal_title：Rejuvenation research

authors： Larrick JW,Mendelsohn AR

更新日期：2020-04-01 00:00:00

abstract：:Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...

journal_title：Rejuvenation research

authors： Sun Y,Qi G,Li D,Meng H,Zhu Z,Zhao Y,Qi Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...

journal_title：Rejuvenation research

authors： Roat E,Prada N,Lugli E,Nasi M,Ferraresi R,Troiano L,Giovenzana C,Pinti M,Biagioni O,Mariotti M,Di Iorio A,Consolo U,Balli F,Cossarizza A

更新日期：2008-06-01 00:00:00

abstract：:Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse along the surface of the primary myotubes, giving rise to a population...

journal_title：Rejuvenation research

authors： Matsakas A,Otto A,Elashry MI,Brown SC,Patel K

更新日期：2010-12-01 00:00:00

abstract：:Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2020-08-01 00:00:00

abstract：:Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...

journal_title：Rejuvenation research

authors： Balietti M,Giuli C,Casoli T,Fabbietti P,Conti F

更新日期：2020-10-01 00:00:00

abstract：:The vicious cycle theory postulates that typical mitochondrial DNA (mtDNA) mutations cause their host mitochondria to generate more superoxide and other reactive oxygen species (ROS) than do normal mitochondria, thereby promoting the occurrence of additional mtDNA mutations at an ever-accelerating rate. However, nearl...

journal_title：Rejuvenation research

authors： de Grey AD

更新日期：2005-04-01 00:00:00

abstract：:Our recent studies have shown that Huogu (HG) formula was effective both in clinic experience and in experimental osteonecrosis of the femoral head (ONFH). Given that defective of bone marrow stromal cells (MSCs) contribute to the development of osteonecrosis and MSCs show enormous potential in the treatment of ONFH, ...

journal_title：Rejuvenation research

authors： Kong X,Li X,Zhang C,Zhu L,Wan H,Zhu J,Liu C,Su H,Qin Q,Chen W,Lin N

更新日期：2016-12-01 00:00:00

abstract：:I propose a new model, called the "RNA memory" model, for the possible role of RNAs in the maintenance and establishment of cell identity. This is cytoplasmic memory obtained by the transmission of mother noncoding (nc) RNAs to daughter cells. These RNAs are able to activate transcription via sequence homology in daug...

journal_title：Rejuvenation research

authors： Arancio W

更新日期：2010-04-01 00:00:00