The concept of telomeric non-reciprocal recombination (TENOR) applied to human fibroblasts grown in serial cultures: concordance with genealogical data.

abstract：:Aging plays a central role in the occurrence of neurodegenerative diseases. Caloric restriction (CR) mitigates oxidative stress by decreasing the rate of generation of endogenous damage, a mechanism that can contribute to the slowing of the aging rate induced by this intervention. Various reports have recently linked ...

journal_title：Rejuvenation research

authors： Naudí A,Caro P,Jové M,Gómez J,Boada J,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2007-12-01 00:00:00

abstract：:The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm in many mammals, including humans. Patients with acute confusional state or delirium, especially those with underlying cognitive impairment, frequently suffer from sleep disturbances and disturbed circadian rhythm. In this review, an overvi...

journal_title：Rejuvenation research

authors： de Rooij SE,van Munster BC

更新日期：2013-08-01 00:00:00

abstract：:Interruption of insulin-like growth factor I (IGF-1) signaling has been demonstrated to prolong life span although the underlying mechanism has not been elucidated. The aim of this study was to examine the influence of severe IGF-1 deficiency on survival rate, cardiomyocyte viability, contractile function, and intrace...

journal_title：Rejuvenation research

authors： Li Q,Yang X,Sreejayan N,Ren J

更新日期：2007-12-01 00:00:00

abstract：:The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the fi...

journal_title：Rejuvenation research

authors： Kyriazis M

更新日期：2014-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) are chemically reactive molecules with impaired electrons that make them unstable and able to react easily with a great variety of molecules. The main targets of ROS are DNA, proteins, and membrane phospholipids. In the skin, ROS are able to affect the production of collagen and elastin, ...

journal_title：Rejuvenation research

authors： Avantaggiato A,Palmieri A,Bertuzzi G,Carinci F

更新日期：2014-06-01 00:00:00

abstract：:This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...

journal_title：Rejuvenation research

authors： Candore G,Balistreri CR,Colonna-Romano G,Lio D,Listì F,Vasto S,Caruso C

更新日期：2010-04-01 00:00:00

abstract：:Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...

journal_title：Rejuvenation research

authors： Ye P,Wang T,Liu WH,Li XC,Tang LJ,Tian FZ

更新日期：2015-08-01 00:00:00

abstract：:Aristotle described the study of politics as an "architectonic" science that aspires to bring together insights from different fields of scientific inquiry to ensure that citizens have the opportunities to flourish. To meet the health and economic challenges of aging populations, we must revive this Aristotelian visio...

journal_title：Rejuvenation research

authors： Farrelly C

更新日期：2010-10-01 00:00:00

abstract：:The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of calo...

journal_title：Rejuvenation research

authors： Prokopov AF,Reinmuth J

更新日期：2010-04-01 00:00:00

abstract：:The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients > or = 65 years old with a diagnosis of CHF under...

journal_title：Rejuvenation research

authors： Corbi G,Acanfora D,Iannuzzi GL,Longobardi G,Cacciatore F,Furgi G,Filippelli A,Rengo G,Leosco D,Ferrara N

更新日期：2008-02-01 00:00:00

abstract：:Thrombolytic therapy (TT) is applied in patients (<75 years of age) with acute myocardial infarction (AMI) with ST-segment elevation. It is recommended for elderly patients who have percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery. For PTCA and bypass surgery a cardiosurgery medical team, which ...

journal_title：Rejuvenation research

authors： Taneva E

更新日期：2006-07-01 00:00:00

abstract：:Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...

journal_title：Rejuvenation research

authors： Kim SH,Lee EY,Cho KH

更新日期：2015-02-01 00:00:00

abstract：:Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...

journal_title：Rejuvenation research

authors： Balietti M,Giuli C,Casoli T,Fabbietti P,Conti F

更新日期：2020-10-01 00:00:00

abstract：:The vicious cycle theory postulates that typical mitochondrial DNA (mtDNA) mutations cause their host mitochondria to generate more superoxide and other reactive oxygen species (ROS) than do normal mitochondria, thereby promoting the occurrence of additional mtDNA mutations at an ever-accelerating rate. However, nearl...

journal_title：Rejuvenation research

authors： de Grey AD

更新日期：2005-04-01 00:00:00

abstract：:The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...

journal_title：Rejuvenation research

authors： Mukhopadhyay A,Zullo SJ,Weiner H

更新日期：2006-07-01 00:00:00

abstract：:Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...

journal_title：Rejuvenation research

authors： Tokarz P,Kaarniranta K,Blasiak J

更新日期：2016-04-01 00:00:00

abstract：:We examined the impact of strong co-presence and function of glutathione peroxidase-1 (GPX-1) and glial cell line-derived neurotrophic factor (GDNF) on protecting the rat dopaminergic pheochromocytoma cell line PC12 against 6-hydroxydopamine (6-OHDA) and hydrogen peroxide (H₂O₂) toxicities. Primarily, GPX-1 over-expre...

journal_title：Rejuvenation research

authors： Gharib E,Gardaneh M,Shojaei S

更新日期：2013-06-01 00:00:00

abstract：:Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse along the surface of the primary myotubes, giving rise to a population...

journal_title：Rejuvenation research

authors： Matsakas A,Otto A,Elashry MI,Brown SC,Patel K

更新日期：2010-12-01 00:00:00

abstract：:Alzheimer's Disease (AD) is the most common age-related dementia, with a current prevalence in excess of five million individuals in the United States. The aggregation of amyloid-beta (A beta) into fibrillar amyloid plaques is a key pathological event in the development of the disease. Microglial proinflammatory activ...

journal_title：Rejuvenation research

authors： Zhu Y,Bickford PC,Sanberg P,Giunta B,Tan J

更新日期：2008-10-01 00:00:00

abstract：:The relationships among lipoprotein metabolism, genetic vascular factors, vascular disease, and Alzheimer's disease suggest that the examination of centenarian populations in relation to certain genes or lipoprotein metabolism provide insights into human longevity. The findings on the higher frequency of the apolipopr...

journal_title：Rejuvenation research

authors： Panza F,D'introno A,Capurso C,Colacicco AM,Seripa D,Pilotto A,Santamato A,Capurso A,Solfrizzi V

更新日期：2007-12-01 00:00:00

abstract：:The aim of the current study was to develop fitness standards associated with maintaining physical capacity in older adults at two different levels-that needed for advanced functioning and that needed for maintaining moderate (independent) functional ability. This was a cross-sectional study of 406 Chilean adults aged...

journal_title：Rejuvenation research

authors： Merellano-Navarro E,Collado-Mateo D,García-Rubio J,Gusi N,Olivares PR

更新日期：2017-12-01 00:00:00

abstract：:Telomeres are specialized DNA structures located at the ends of chromosomes. Their length is reduced at each cell cycle, especially when the cumulative burden of oxidative stress is high. The purpose of this study was to determine the associations between telomere length and clinical and biological risk factors in isc...

journal_title：Rejuvenation research

authors： Biotti D,Aho S,Béjot Y,Giroud M,Caillier M,Ragot S,Osseby GV,Moreau T,Teyssier JR

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities, such as antioxidative, antiinflammatory, anticancer, chemopreventive, and antineurodegenerative properties. We ev...

journal_title：Rejuvenation research

authors： Lee KS,Lee BS,Semnani S,Avanesian A,Um CY,Jeon HJ,Seong KM,Yu K,Min KJ,Jafari M

更新日期：2010-10-01 00:00:00

abstract：:To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...

journal_title：Rejuvenation research

authors： Ko KM,Chiu PY,Leung HY,Siu AH,Chen N,Leong EP,Poon MK

更新日期：2010-04-01 00:00:00

abstract：:The full power of gene modification in higher eukaryotes, including its potential to correct disease-causing mutations, has so far been limited by its low efficiency. Now that power looks set to be released through the use of customized endonuclease "hands," DNA-binding zinc fingers linked to nuclease "thumbs," capabl...

journal_title：Rejuvenation research

authors： Porter AC

更新日期：2005-01-01 00:00:00

abstract：:The release of mitochondrial cytochrome c followed by activation of caspase cascade has been reported with aging in various tissues, whereas little is known about the caspase-independent pathway involved in mitochondrial dysfunction. To determine the functional impact of cytochrome c loss on mitochondrial respiratory ...

journal_title：Rejuvenation research

authors： Tamilselvan J,Sivarajan K,Anusuyadevi M,Panneerselvam C

更新日期：2007-09-01 00:00:00

abstract：:Pulses up to 11 Tesla magnetic fields may generate pockets of currents along the walls of cellular material and may interfere with the overall ability of cell division. We used prokaryotic cells (Escherichia coli) and eukaryotic cells (murine fibroblasts) and exposed them to magnetic pulses of intensities ranging from...

journal_title：Rejuvenation research

authors： Kletetschka G,Zila V,Klimova L

更新日期：2014-04-01 00:00:00

abstract：:Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...

journal_title：Rejuvenation research

authors： Zhang M,Hwang E,Lin P,Gao W,Ngo HTT,Yi TH

更新日期：2018-08-01 00:00:00

abstract：:Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...

journal_title：Rejuvenation research

authors： Fortney K,Morgen EK,Kotlyar M,Jurisica I

更新日期：2012-04-01 00:00:00

abstract：:Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there is no endogenous mechanism to eliminate it. This ultimately results in progressive dysfunction and loss of vision either in advanced age for genetically normal patients (age-related macular degeneration) or...

journal_title：Rejuvenation research

authors： Moody KJ,Tinklepaugh J,Obert E,Grohn K,DeRosa JR,Lumen E,Moyer BS,Campbell S,Wolfe AJ,Sleeper MB,Bianchi AH,Fisher C,Applegate J,Leary E,LeClair N,Wortel D,Doyle RP,Rohrer B,Blanden AR

更新日期：2018-12-01 00:00:00