Two hands make light work of gene modification.


:The full power of gene modification in higher eukaryotes, including its potential to correct disease-causing mutations, has so far been limited by its low efficiency. Now that power looks set to be released through the use of customized endonuclease "hands," DNA-binding zinc fingers linked to nuclease "thumbs," capable of grasping and cutting any chosen genomic target locus. Once cleaved, the target locus is efficiently repaired by endogenous mechanisms, using an exogenous DNA template that carries the chosen modification. These helping hands are likely to touch many areas of biological and clinical endeavor.


Rejuvenation Res


Rejuvenation research


Porter AC





Has Abstract


2005-01-01 00:00:00












  • Hydroxysafflor yellow A ameliorates homocysteine-induced Alzheimer-like pathologic dysfunction and memory/synaptic disorder.

    abstract::Homocysteine (Hcy) could induce amyloid β (Aβ) accumulation, synaptic dysfunction, and memory impairment as seen in Alzheimer disease (AD), the most prevalent neurodegenerative disorder, which affects more than 25 million people worldwide. Here we investigated the protective effect of hydroxysafflor yellow A (HSYA) on...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Lu YQ,Luo Y,He ZF,Chen J,Yan BL,Wang Y,Yu Q

    更新日期:2013-12-01 00:00:00

  • Commentary on Some Recent Theses Relevant to Combating Aging: August 2017.

    abstract::Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Zealley B,de Grey ADNJ

    更新日期:2017-08-01 00:00:00

  • Restoration of the Renin-Angiotensin System Balance Is a Part of the Effect of Fasting on Cardiovascular Rejuvenation: Role of Age and Fasting Models.

    abstract::Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Badreh F,Joukar S,Badavi M,Rashno M

    更新日期:2020-08-01 00:00:00

  • Prospective comparison of six co-morbidity indices as predictors of 5 years post hospital discharge survival in the elderly.

    abstract::Older patients often suffer from multiple co-morbid conditions. Few co-morbidity indices are valid and reliable in elderly patients and comparison between them is rare. Our objective was to compare the performance, relevance, and abilities of six widely used and validated co-morbidity indices--the Charlson Cumulative ...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Zekry D,Valle BH,Michel JP,Esposito F,Gold G,Krause KH,Herrmann FR

    更新日期:2010-12-01 00:00:00

  • Overcoming the aging systemic milieu to restore neural stem cell function.

    abstract::As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old and young mice are connected, the old mice experience increased neurogenesi...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Mendelsohn AR,Larrick JW

    更新日期:2011-12-01 00:00:00

  • Efficiency of cellular growth when creating small pockets of electric current along the walls of cells.

    abstract::Pulses up to 11 Tesla magnetic fields may generate pockets of currents along the walls of cellular material and may interfere with the overall ability of cell division. We used prokaryotic cells (Escherichia coli) and eukaryotic cells (murine fibroblasts) and exposed them to magnetic pulses of intensities ranging from...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Kletetschka G,Zila V,Klimova L

    更新日期:2014-04-01 00:00:00

  • Accelerated aging versus rejuvenation of the immune system in heterochronic parabiosis.

    abstract::The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, an...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Pishel I,Shytikov D,Orlova T,Peregudov A,Artyuhov I,Butenko G

    更新日期:2012-04-01 00:00:00

  • In silico drug screen in mouse liver identifies candidate calorie restriction mimetics.

    abstract::Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Fortney K,Morgen EK,Kotlyar M,Jurisica I

    更新日期:2012-04-01 00:00:00

  • Characteristics, formation, and pathophysiology of glucosepane: a major protein cross-link.

    abstract::Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has b...

    journal_title:Rejuvenation research

    pub_type: 杂志文章,评审


    authors: Sjöberg JS,Bulterijs S

    更新日期:2009-04-01 00:00:00

  • Supplementation with Brush Border Enzyme Alkaline Phosphatase Slows Aging.

    abstract::Diminished integrity of the intestinal epithelial barrier with advanced age is believed to contribute to aging-associated dysfunction and pathologies in animals. In mammals, diminished gut integrity contributes to inflammaging, the increase in inflammatory processes observed in old age. Recent work suggests that expre...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Larrick JW,Mendelsohn AR

    更新日期:2020-04-01 00:00:00

  • Global aging, well-ordered science, and prospection.

    abstract::Aristotle described the study of politics as an "architectonic" science that aspires to bring together insights from different fields of scientific inquiry to ensure that citizens have the opportunities to flourish. To meet the health and economic challenges of aging populations, we must revive this Aristotelian visio...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Farrelly C

    更新日期:2010-10-01 00:00:00

  • Inhibitory effect of encapsulated curcumin on ultraviolet-induced photoaging in mice.

    abstract::Photoaging is the superposition of photodamage (ultraviolet [UV] radiation-induced) on the aging process. It is a major damaging consequence of free radical action. Curcumin (diferuloylmethane) is a phytochemical with diverse antioxidant and antiinflammatory properties. However, it shows a poor topical bioavailability...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Agrawal R,Kaur IP

    更新日期:2010-08-01 00:00:00

  • Trade-offs between anti-aging dietary supplementation and exercise.

    abstract::In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Mendelsohn AR,Larrick JW

    更新日期:2013-10-01 00:00:00

  • Baicalein Exerts Beneficial Effects in d-Galactose-Induced Aging Rats Through Attenuation of Inflammation and Metabolic Dysfunction.

    abstract::Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and 1H nuclear magnetic resonance ...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Duan DD,Wang KX,Zhou YZ,Qin XM,Gao L,Du GH

    更新日期:2017-12-01 00:00:00

  • 1H NMR-Based Fecal Metabolomics Reveals Changes in Gastrointestinal Function of Aging Rats Induced by d-Galactose.

    abstract::d-galactose (d-gal) is widely used to induce aging. However, it is still unclear whether long-term injection of d-gal affects the gastrointestinal functions of aging rats, and how. In this study, we investigated the effects of d-gal on the gastrointestinal functions of aging rats, especially from the perspective of fe...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Zhao D,Liu X,Zhao S,Li Z,Qin X

    更新日期:2020-09-29 00:00:00

  • Vitamin C and E Supplements Enhance the Antioxidant Capacity of Erythrocytes Obtained from Aged Rats.

    abstract:BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Xiong Y,Xiong Y,Zhou S,Sun Y,Zhao Y,Ren X,Zhang Y,Zhang N

    更新日期:2017-04-01 00:00:00

  • Commentary on Some Recent Theses Relevant to Combating Aging: August 2019.

    abstract::Theses reviewed in this issue include "Downregulation of the Apelinergic Axis Accelerates Aging, Whereas Its Systemic Restoration Improves the Mammalian Healthspan," "Intracellular Delivery of Exogenous Molecules Via an Ultrahigh Throughput Mechanoporation Microdevice," "Intrinsic and Extrinsic Drivers of Treg Fragili...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Zealley B,de Grey ADNJ

    更新日期:2019-08-01 00:00:00

  • Pharmaceutical Rejuvenation of Age-Associated Decline in Spatial Memory.

    abstract::Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain bar...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Mendelsohn AR,Larrick JW

    更新日期:2016-12-01 00:00:00

  • Association between Short Physical Performance Battery and falls in older people: the Progetto Veneto Anziani Study.

    abstract::It is known that weakness in the lower limbs is associated with recurrent falls in old people. Among the tests routinely used to assess lower extremity strength, the Short Physical Performance Battery (SPPB) is one of those used most often, but its relationship with recurrent falls is poorly investigated. We aimed to ...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Veronese N,Bolzetta F,Toffanello ED,Zambon S,De Rui M,Perissinotto E,Coin A,Corti MC,Baggio G,Crepaldi G,Sergi G,Manzato E

    更新日期:2014-06-01 00:00:00

  • The impracticality of biomedical rejuvenation therapies: translational and pharmacological barriers.

    abstract::The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the fi...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Kyriazis M

    更新日期:2014-08-01 00:00:00

  • Diagnostic and Prognostic Relevance of Red Blood Cell Distribution Width for Vascular Aging and Cardiovascular Diseases.

    abstract::Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...

    journal_title:Rejuvenation research

    pub_type: 杂志文章,评审


    authors: Poz D,De Falco E,Pisano C,Madonna R,Ferdinandy P,Balistreri CR

    更新日期:2019-04-01 00:00:00

  • Enhancing HOTAIR/MiR-10b Drives Normal Liver Stem Cells Toward a Tendency to Malignant Transformation Through Inducing Epithelial- to-Mesenchymal Transition.

    abstract::Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Ye P,Wang T,Liu WH,Li XC,Tang LJ,Tian FZ

    更新日期:2015-08-01 00:00:00

  • Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.

    abstract::Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Kulminski AM,Culminskaya I,Arbeev KG,Ukraintseva SV,Arbeeva L,Yashin AI

    更新日期:2013-02-01 00:00:00

  • Combined topical application of lotus and green tea improves facial skin surface parameters.

    abstract::No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a...

    journal_title:Rejuvenation research

    pub_type: 临床试验,杂志文章


    authors: Mahmood T,Akhtar N

    更新日期:2013-04-01 00:00:00

  • Biotechnology Governance 2.0: A Proposal for Minimum Standards in Biotechnology Corporate Governance.

    abstract::Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent prolif...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Carter AR,Meinert E,Brindley DA

    更新日期:2019-06-01 00:00:00

  • Human β-glucuronidase: structure, function, and application in enzyme replacement therapy.

    abstract::Lysosomal storage diseases occur due to incomplete metabolic degradation of macromolecules by various hydrolytic enzymes in the lysosome. Despite structural differences, most of the lysosomal enzymes share many common features including a lysosomal targeting motif and phosphotransferase recognition sites. β-Glucuronid...

    journal_title:Rejuvenation research

    pub_type: 杂志文章,评审


    authors: Naz H,Islam A,Waheed A,Sly WS,Ahmad F,Hassan I

    更新日期:2013-10-01 00:00:00

  • Telomere and TRF2/MTBP localization in respect to satellite DNA during the cell cycle of mouse cell line L929.

    abstract::The mouse Mus musculus chromosomes are all acrocentric; each centromere (CEN) is adjacent to a telomere. The aim of the current work is to find out if at least half of the mouse telomeres (Tel) always follow satellite DNA sequences and if membrane telomere binding protein TRF2/MTBP is always in association with the Te...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Kuznetsova IS,Voronin AP,Podgornaya OI

    更新日期:2006-10-01 00:00:00

  • Paradoxes of non-trivial gene networks: how cancer-causing mutations can appear to be cancer-protective.

    abstract::Abnormalities of gene structure or expression are commonly found in cancers, where they are used as prognostic markers, predicting the likely severity of disease or chances of response to therapy. An odds ratio (OR) of <1 indicates that a marker's presence is correlated with better outcome. An OR of <1 is also often t...

    journal_title:Rejuvenation research

    pub_type: 杂志文章,评审


    authors: Bains W

    更新日期:2004-10-01 00:00:00

  • Estrogen replacement therapy improves pulmonary function in postmenopausal women with genital prolapse.

    abstract:OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...

    journal_title:Rejuvenation research

    pub_type: 杂志文章,随机对照试验


    authors: Stipic I,Polasek O,Vulic M,Punda H,Grandic L,Strinic T

    更新日期:2012-12-01 00:00:00

  • Commentary on Some Recent Theses Relevant to Combating Aging: August 2020.

    abstract::Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...

    journal_title:Rejuvenation research

    pub_type: 杂志文章


    authors: Zealley B,de Grey ADNJ

    更新日期:2020-08-01 00:00:00