Abstract:
:New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumulation events. Shoji-Kawata et al. (Nature 2013;494:201-206) describe a new autophagy-inducing peptide, Tat-Beclin 1, that enhances the clearance of polyglutamine aggregates related to Huntington's disease and, interestingly, suppresses viral and bacterial infections. Savolainen et al. (Neurobiol Dis 2014;68:1-15) describe a prolyl oligopeptidase inhibitor that reduces α-synuclein species related to Parkinson's disease and other α-synucleinopathies, and this inhibitor caused a concomitant increase in autophagic activation markers. Previous studies have also linked the autophagy-lysosomal pathway to the protective clearing of the Aβ peptides of Alzheimer's disease and tau species of tauopathies. Enhancing autophagy-lysosomal efficiency may provide a therapeutic avenue for diverse types of proteinopathies, including the most common neurodegenerative disorders of the elderly.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Bahr BAdoi
10.1089/rej.2014.1585subject
Has Abstractpub_date
2014-08-01 00:00:00pages
382-4issue
4eissn
1549-1684issn
1557-8577journal_volume
17pub_type
评论,杂志文章abstract::Since the discovery of the limited life span of human fibroblasts some 50 years ago, many genealogical studies have been undertaken to describe growth kinetics of fibroblasts in serial cultures by their individual division behavior. It is now accepted that proliferation capacities of human fibroblasts strongly depend ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2005.8.154
更新日期:2005-10-01 00:00:00
abstract::With advancing age, the mammalian thymus undergoes involution, a progressive loss of architectural integrity and lymphoid cellularity that results in reduced T lymphopoiesis. Thymic involution also is associated with extreme malnutrition and states of immune deficiency, such as active HIV infection, after chemotherapy...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.134
更新日期:2006-04-01 00:00:00
abstract::The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of calo...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0946
更新日期:2010-04-01 00:00:00
abstract::No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a...
journal_title:Rejuvenation research
pub_type: 临床试验,杂志文章
doi:10.1089/rej.2012.1380
更新日期:2013-04-01 00:00:00
abstract::The United States has the most expensive healthcare system worldwide. Yet measures of health span and life expectancy are well below the major industrialized nations. With the U.S. population aged 65 years and older projected to double by mid-century, a healthcare crisis is looming. Within this context, huge interest ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2088
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1835
更新日期:2017-04-01 00:00:00
abstract::Lysosomes are involved in degrading and recycling cellular ingredients, and their disruption with age may contribute to amyloidogenesis, paired helical filaments (PHFs), and α-synuclein and mutant huntingtin aggregation. Lysosomal cathepsins are upregulated by accumulating proteins and more so by the modulator Z-Phe-A...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1282
更新日期:2012-04-01 00:00:00
abstract::Lysosomal storage diseases occur due to incomplete metabolic degradation of macromolecules by various hydrolytic enzymes in the lysosome. Despite structural differences, most of the lysosomal enzymes share many common features including a lysosomal targeting motif and phosphotransferase recognition sites. β-Glucuronid...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2013.1407
更新日期:2013-10-01 00:00:00
abstract::Alzheimer's Disease (AD) is the most common age-related dementia, with a current prevalence in excess of five million individuals in the United States. The aggregation of amyloid-beta (A beta) into fibrillar amyloid plaques is a key pathological event in the development of the disease. Microglial proinflammatory activ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0757
更新日期:2008-10-01 00:00:00
abstract::Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes....
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1834
更新日期:2017-02-01 00:00:00
abstract::Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.2001
更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2012.1337
更新日期:2012-12-01 00:00:00
abstract::Twenty years have passed since Kadenbach and Müller-Höcker first proposed that the age-related accumulation of mutant mitochondrial DNA is caused by its clonal expansion, rather than by a "vicious cycle" of de novo mutational events caused by the disruptive metabolic impact of prior ones. Proof that they were correct ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0879
更新日期:2009-06-01 00:00:00
abstract::The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low prolifera...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.0503
更新日期:2007-03-01 00:00:00
abstract::Frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in a rehabilitation setting for the treatment of pain, especially in diabetic patients. In a randomized clinical trial, we tested the hypothesis that FREMS is effective in the treatment of chronic and pa...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2011.1236
更新日期:2012-06-01 00:00:00
abstract::The article is a presentation at the 4th Conference of ESAAM, which took place on October 30-31, 2015, in Athens, Greece. Its purpose was not to cover all aspects of cellular aging but to share with the audience of the Conference, in a 15-minute presentation, current knowledge about the rejuvenating and repairing soma...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1809
更新日期:2017-02-01 00:00:00
abstract::Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has b...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0846
更新日期:2009-04-01 00:00:00
abstract::Thrombolytic therapy (TT) is applied in patients (<75 years of age) with acute myocardial infarction (AMI) with ST-segment elevation. It is recommended for elderly patients who have percutaneous transluminal coronary angioplasty (PTCA) or bypass surgery. For PTCA and bypass surgery a cardiosurgery medical team, which ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.358
更新日期:2006-07-01 00:00:00
abstract::Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1594
更新日期:2015-02-01 00:00:00
abstract::Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2018.2140
更新日期:2019-08-01 00:00:00
abstract::Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.1971
更新日期:2018-08-01 00:00:00
abstract::The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, an...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1331
更新日期:2012-04-01 00:00:00
abstract::We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0921
更新日期:2010-04-01 00:00:00
abstract::Our recent studies have shown that Huogu (HG) formula was effective both in clinic experience and in experimental osteonecrosis of the femoral head (ONFH). Given that defective of bone marrow stromal cells (MSCs) contribute to the development of osteonecrosis and MSCs show enormous potential in the treatment of ONFH, ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1795
更新日期:2016-12-01 00:00:00
abstract::Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1717
更新日期:2016-04-01 00:00:00
abstract::Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2254
更新日期:2020-08-01 00:00:00
abstract::Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1362
更新日期:2013-02-01 00:00:00
abstract::A new consensus of gerontologists proposes that delay of biological senescence is the most potent public health measure for preventing chronic disease in late life. At the most fundamental level, cellular aging is characterized by a decline in repair and homeostatic systems. Thus, interventions that protect or rejuven...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0793
更新日期:2008-12-01 00:00:00
abstract::Aristotle described the study of politics as an "architectonic" science that aspires to bring together insights from different fields of scientific inquiry to ensure that citizens have the opportunities to flourish. To meet the health and economic challenges of aging populations, we must revive this Aristotelian visio...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1023
更新日期:2010-10-01 00:00:00
abstract::Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2307
更新日期:2020-10-01 00:00:00