In silico drug screen in mouse liver identifies candidate calorie restriction mimetics.

abstract：BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...

journal_title：Rejuvenation research

authors： Xiong Y,Xiong Y,Zhou S,Sun Y,Zhao Y,Ren X,Zhang Y,Zhang N

更新日期：2017-04-01 00:00:00

abstract：:The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of calo...

journal_title：Rejuvenation research

authors： Prokopov AF,Reinmuth J

更新日期：2010-04-01 00:00:00

abstract：:The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, an...

journal_title：Rejuvenation research

authors： Pishel I,Shytikov D,Orlova T,Peregudov A,Artyuhov I,Butenko G

更新日期：2012-04-01 00:00:00

abstract：:Diminished integrity of the intestinal epithelial barrier with advanced age is believed to contribute to aging-associated dysfunction and pathologies in animals. In mammals, diminished gut integrity contributes to inflammaging, the increase in inflammatory processes observed in old age. Recent work suggests that expre...

journal_title：Rejuvenation research

authors： Larrick JW,Mendelsohn AR

更新日期：2020-04-01 00:00:00

abstract：:Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...

journal_title：Rejuvenation research

authors： Szwergold BS

更新日期：2013-08-01 00:00:00

abstract：:Older patients often suffer from multiple co-morbid conditions. Few co-morbidity indices are valid and reliable in elderly patients and comparison between them is rare. Our objective was to compare the performance, relevance, and abilities of six widely used and validated co-morbidity indices--the Charlson Cumulative ...

journal_title：Rejuvenation research

authors： Zekry D,Valle BH,Michel JP,Esposito F,Gold G,Krause KH,Herrmann FR

更新日期：2010-12-01 00:00:00

abstract：:The aim of this study was to evaluate the role of magnesium levels on 3-year survival in the elderly with congestive heart failure (CHF) admitted to the Rehabilitative Cardiology Unit of S. Maugeri Foundation Scientific Institute of Telese/Campoli. All elderly patients > or = 65 years old with a diagnosis of CHF under...

journal_title：Rejuvenation research

authors： Corbi G,Acanfora D,Iannuzzi GL,Longobardi G,Cacciatore F,Furgi G,Filippelli A,Rengo G,Leosco D,Ferrara N

更新日期：2008-02-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...

journal_title：Rejuvenation research

authors： Ganie SA,Dar TA,Bhat AH,Dar KB,Anees S,Zargar MA,Masood A

更新日期：2016-02-01 00:00:00

abstract：:We examined the impact of strong co-presence and function of glutathione peroxidase-1 (GPX-1) and glial cell line-derived neurotrophic factor (GDNF) on protecting the rat dopaminergic pheochromocytoma cell line PC12 against 6-hydroxydopamine (6-OHDA) and hydrogen peroxide (H₂O₂) toxicities. Primarily, GPX-1 over-expre...

journal_title：Rejuvenation research

authors： Gharib E,Gardaneh M,Shojaei S

更新日期：2013-06-01 00:00:00

abstract：:Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2017-08-01 00:00:00

abstract：:Obese older adults are particularly susceptible to sarcopenia and have a higher prevalence of disability than their peers of normal weight. Interventions to improve body composition in late life are crucial to maintaining independence. The main mechanisms underlying sarcopenia have not been determined conclusively, bu...

journal_title：Rejuvenation research

authors： Wohlgemuth SE,Lees HA,Marzetti E,Manini TM,Aranda JM,Daniels MJ,Pahor M,Perri MG,Leeuwenburgh C,Anton SD

更新日期：2011-06-01 00:00:00

abstract：:New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumu...

journal_title：Rejuvenation research

authors： Bahr BA

更新日期：2014-08-01 00:00:00

abstract：:Aging plays a central role in the occurrence of neurodegenerative diseases. Caloric restriction (CR) mitigates oxidative stress by decreasing the rate of generation of endogenous damage, a mechanism that can contribute to the slowing of the aging rate induced by this intervention. Various reports have recently linked ...

journal_title：Rejuvenation research

authors： Naudí A,Caro P,Jové M,Gómez J,Boada J,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2007-12-01 00:00:00

abstract：:To determine the prognostic value of frailty and comorbidity for outdoor mobility loss and mortality in the elderly. The retrospective study was conducted among outpatients aged ≥60 years. Patients with ≥3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The outdoor low-mobilit...

journal_title：Rejuvenation research

authors： Tkacheva ON,Runikhina NK,Merkusheva LI,Lysenkov SN,Ostapenko VS,Sharashkina NV,Press Y

更新日期：2020-07-14 00:00:00

abstract：:Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...

journal_title：Rejuvenation research

authors： Kulminski AM,Culminskaya I,Arbeev KG,Ukraintseva SV,Arbeeva L,Yashin AI

更新日期：2013-02-01 00:00:00

abstract：:Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent prolif...

journal_title：Rejuvenation research

authors： Carter AR,Meinert E,Brindley DA

更新日期：2019-06-01 00:00:00

abstract：:Theses reviewed in this issue include "Characterization and Purification of Putative Stem Cells from the Adult Murine Pancreas," "Inhibition of TLR4 Minimizes Islet Damage due to Sterile Inflammation and Improves Islet Transplant Outcomes," "Liquefaction of the Brain Following Stroke Shares Multiple Characteristics wi...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...

journal_title：Rejuvenation research

authors： Stipic I,Polasek O,Vulic M,Punda H,Grandic L,Strinic T

更新日期：2012-12-01 00:00:00

abstract：:Inflammation and oxidative stress (OS) are key points in age progression. Both processes impact negatively in cognition and in brain functions. Resveratrol (RV) has been postulated as a potent antioxidant natural compound, with rejuvenating properties. Inducing a metabolic stress by high-fat (HF) diet in aged C56/BL6 ...

journal_title：Rejuvenation research

authors： Palomera-Ávalos V,Griñán-Ferré C,Izquierdo V,Camins A,Sanfeliu C,Pallàs M

更新日期：2017-06-01 00:00:00

abstract：:Homocysteine (Hcy) could induce amyloid β (Aβ) accumulation, synaptic dysfunction, and memory impairment as seen in Alzheimer disease (AD), the most prevalent neurodegenerative disorder, which affects more than 25 million people worldwide. Here we investigated the protective effect of hydroxysafflor yellow A (HSYA) on...

journal_title：Rejuvenation research

authors： Lu YQ,Luo Y,He ZF,Chen J,Yan BL,Wang Y,Yu Q

更新日期：2013-12-01 00:00:00

abstract：:The relationships among lipoprotein metabolism, genetic vascular factors, vascular disease, and Alzheimer's disease suggest that the examination of centenarian populations in relation to certain genes or lipoprotein metabolism provide insights into human longevity. The findings on the higher frequency of the apolipopr...

journal_title：Rejuvenation research

authors： Panza F,D'introno A,Capurso C,Colacicco AM,Seripa D,Pilotto A,Santamato A,Capurso A,Solfrizzi V

更新日期：2007-12-01 00:00:00

abstract：:Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has b...

journal_title：Rejuvenation research

authors： Sjöberg JS,Bulterijs S

更新日期：2009-04-01 00:00:00

abstract：:Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain bar...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2016-12-01 00:00:00

abstract：:A hypothetical mechanism of 14C-generated influence on a person's rate of aging is offered. The mathematical description and the following approbation of the radiocarbon mechanism of aging made it possible to coordinate the Gompertz and Strehler-Mildvan laws and predict the existence of one more, till-now unknown, int...

journal_title：Rejuvenation research

authors： Germansky AM,Germanskaia AA

更新日期：2006-07-01 00:00:00

abstract：:This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...

journal_title：Rejuvenation research

authors： Cancela Carral JM,Pallin E,Orbegozo A,Ayán Pérez C

更新日期：2017-10-01 00:00:00

abstract：:Frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in a rehabilitation setting for the treatment of pain, especially in diabetic patients. In a randomized clinical trial, we tested the hypothesis that FREMS is effective in the treatment of chronic and pa...

journal_title：Rejuvenation research

authors： Santamato A,Panza F,Fortunato F,Portincasa A,Frisardi V,Cassatella G,Valente M,Seripa D,Ranieri M,Fiore P

更新日期：2012-06-01 00:00:00

abstract：:Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous system. Previously, we showed a drastic decline in the expression of glial and neuronal proteins in myelinated peripher...

journal_title：Rejuvenation research

authors： Opalach K,Rangaraju S,Madorsky I,Leeuwenburgh C,Notterpek L

更新日期：2010-02-01 00:00:00

abstract：:Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscl...

journal_title：Rejuvenation research

authors： Picca A,Lezza AMS,Leeuwenburgh C,Pesce V,Calvani R,Bossola M,Manes-Gravina E,Landi F,Bernabei R,Marzetti E

更新日期：2018-08-01 00:00:00

abstract：:With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...

journal_title：Rejuvenation research

authors： Cai HB,Wu GL,Huang CH,Huang ZS,Chen YB,Wang Q

更新日期：2016-08-01 00:00:00