Abstract:
:Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent proliferation of biotechnology start-up organizations is substantively changing inter- and intraorganizational cultures throughout the health care sector via a "cascade of governance." Therefore, governance decisions and actions-both positive and negative-that are instituted in start-up biotech companies may set new norms for other start-up biotech companies, the larger (bio)pharmaceutical companies by which they are acquired and the range of health care subsector actors that interact with biotechnology companies. The authors stress the importance of appropriate, proportionate, and consistent biotech corporate governance throughout company lifecycles, not simply to support value inflection or as a response to a crisis. Fail to govern, fail to succeed-for investors and, most importantly, for patients.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
Carter AR,Meinert E,Brindley DAdoi
10.1089/rej.2018.2122subject
Has Abstractpub_date
2019-06-01 00:00:00pages
254-260issue
3eissn
1549-1684issn
1557-8577journal_volume
22pub_type
杂志文章abstract::Osteoarthritis is the most common disabling condition of humans in the western world. It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of the disease, but the explanations for this phenomenon have changed over time. The most longstanding theory is t...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/1549168041552964
更新日期:2004-07-01 00:00:00
abstract::Diminished integrity of the intestinal epithelial barrier with advanced age is believed to contribute to aging-associated dysfunction and pathologies in animals. In mammals, diminished gut integrity contributes to inflammaging, the increase in inflammatory processes observed in old age. Recent work suggests that expre...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2335
更新日期:2020-04-01 00:00:00
abstract::The Strategies for Engineered Negligible Senescence (SENS) agenda contemplates specialized centers that offer a periodic rejuvenation and biogerontological maintenance for their clients. Although high-tech interventions are still in an early research phase, well-proven natural techniques, such as various forms of calo...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0946
更新日期:2010-04-01 00:00:00
abstract::It is known that weakness in the lower limbs is associated with recurrent falls in old people. Among the tests routinely used to assess lower extremity strength, the Short Physical Performance Battery (SPPB) is one of those used most often, but its relationship with recurrent falls is poorly investigated. We aimed to ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2013.1491
更新日期:2014-06-01 00:00:00
abstract::New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumu...
journal_title:Rejuvenation research
pub_type: 评论,杂志文章
doi:10.1089/rej.2014.1585
更新日期:2014-08-01 00:00:00
abstract::This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2017.1924
更新日期:2017-10-01 00:00:00
abstract::Can memory be retained after cryopreservation? Our research has attempted to answer this long-standing question by using the nematode worm Caenorhabditis elegans, a well-known model organism for biological research that has generated revolutionary findings but has not been tested for memory retention after cryopreserv...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1636
更新日期:2015-10-01 00:00:00
abstract::Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1594
更新日期:2015-02-01 00:00:00
abstract::Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1362
更新日期:2013-02-01 00:00:00
abstract::Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1263
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2012.1337
更新日期:2012-12-01 00:00:00
abstract::Let us define human aging as the random accumulation of damage in the human organism's cells, tissues, or whole organism during life that increases the probability of death. This definition opens ways to postpone aging via risk factors to health. Studies show that changes in aging have postponed aging 0.15-0.20 years ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2008.0675
更新日期:2008-04-01 00:00:00
abstract::No study has yet determined the anti-wrinkle efficacy of green tea plus lotus in Asian subjects using skin image analysis technique. In this study, the efficacy of two cosmetic active formulations intended for the treatment of facial wrinkles (green tea and lotus extract) has been evaluated in healthy subjects using a...
journal_title:Rejuvenation research
pub_type: 临床试验,杂志文章
doi:10.1089/rej.2012.1380
更新日期:2013-04-01 00:00:00
abstract::The relationships among lipoprotein metabolism, genetic vascular factors, vascular disease, and Alzheimer's disease suggest that the examination of centenarian populations in relation to certain genes or lipoprotein metabolism provide insights into human longevity. The findings on the higher frequency of the apolipopr...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2007.0537
更新日期:2007-12-01 00:00:00
abstract::To determine the prognostic value of frailty and comorbidity for outdoor mobility loss and mortality in the elderly. The retrospective study was conducted among outpatients aged ≥60 years. Patients with ≥3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The outdoor low-mobilit...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2289
更新日期:2020-07-14 00:00:00
abstract::Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2012.1401
更新日期:2013-08-01 00:00:00
abstract::Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes....
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1834
更新日期:2017-02-01 00:00:00
abstract::Telomeres are specialized DNA structures located at the ends of chromosomes. Their length is reduced at each cell cycle, especially when the cumulative burden of oxidative stress is high. The purpose of this study was to determine the associations between telomere length and clinical and biological risk factors in isc...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1243
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1835
更新日期:2017-04-01 00:00:00
abstract::Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2254
更新日期:2020-08-01 00:00:00
abstract::Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and 1H nuclear magnetic resonance ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.1919
更新日期:2017-12-01 00:00:00
abstract::The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the fi...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1588
更新日期:2014-08-01 00:00:00
abstract::This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0942
更新日期:2010-04-01 00:00:00
abstract::It is known that dietary restriction (DR) increases maximum longevity in rodents, but the mechanisms involved remain unknown. Among the possible mechanisms, several lines of evidence support the idea that decreases in mitochondrial oxidative stress and in insulin signaling are involved but it is not known if they are ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2008.0704
更新日期:2008-06-01 00:00:00
abstract::Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ1-42, we dem...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2017.1966
更新日期:2018-08-01 00:00:00
abstract::Down syndrome (DS), the most common chromosomal abnormality in humans, is characterized by precocious immunologic aging that results, among other things, in alterations of B and T lymphocyte subsets and natural killer cells, defective phagocytosis, and chemotaxis of polymorphonuclear leukocytes. We studied 30 children...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0648
更新日期:2008-06-01 00:00:00
abstract::Photoaging is the superposition of photodamage (ultraviolet [UV] radiation-induced) on the aging process. It is a major damaging consequence of free radical action. Curcumin (diferuloylmethane) is a phytochemical with diverse antioxidant and antiinflammatory properties. However, it shows a poor topical bioavailability...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0906
更新日期:2010-08-01 00:00:00
abstract::Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1642
更新日期:2015-08-01 00:00:00
abstract::Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has b...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2009.0846
更新日期:2009-04-01 00:00:00
abstract::The mouse Mus musculus chromosomes are all acrocentric; each centromere (CEN) is adjacent to a telomere. The aim of the current work is to find out if at least half of the mouse telomeres (Tel) always follow satellite DNA sequences and if membrane telomere binding protein TRF2/MTBP is always in association with the Te...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2006.9.391
更新日期:2006-10-01 00:00:00