Efficiency of cellular growth when creating small pockets of electric current along the walls of cells.

abstract：:Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...

journal_title：Rejuvenation research

authors： Balietti M,Giuli C,Casoli T,Fabbietti P,Conti F

更新日期：2020-10-01 00:00:00

abstract：:This study was designed to elucidate the molecular mechanism underlying lysophosphatidic acid (LPA) and adenylyl cyclase inhibitor SQ22536 (ACI)-induced senescent human diploid fibroblast (HDF) proliferation. Because adenosine monophosphate (AMP)-activated protein kinase (AMPK) is known to inhibit cell proliferation, ...

journal_title：Rejuvenation research

authors： Rhim JH,Jang IS,Song KY,Ha MK,Cho SC,Yeo EJ,Park SC

更新日期：2008-08-01 00:00:00

abstract：:A hypothetical mechanism of 14C-generated influence on a person's rate of aging is offered. The mathematical description and the following approbation of the radiocarbon mechanism of aging made it possible to coordinate the Gompertz and Strehler-Mildvan laws and predict the existence of one more, till-now unknown, int...

journal_title：Rejuvenation research

authors： Germansky AM,Germanskaia AA

更新日期：2006-07-01 00:00:00

abstract：:The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, an...

journal_title：Rejuvenation research

authors： Pishel I,Shytikov D,Orlova T,Peregudov A,Artyuhov I,Butenko G

更新日期：2012-04-01 00:00:00

abstract：:Lysosomal storage diseases occur due to incomplete metabolic degradation of macromolecules by various hydrolytic enzymes in the lysosome. Despite structural differences, most of the lysosomal enzymes share many common features including a lysosomal targeting motif and phosphotransferase recognition sites. β-Glucuronid...

journal_title：Rejuvenation research

authors： Naz H,Islam A,Waheed A,Sly WS,Ahmad F,Hassan I

更新日期：2013-10-01 00:00:00

abstract：:In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2013-10-01 00:00:00

abstract：:Mitochondrial structural and functional integrity is maintained through the coordination of several processes (e.g., biogenesis, dynamics, mitophagy), collectively referred to as mitochondrial quality control (MQC). Dysfunctional MQC and inflammation are hallmarks of aging and are involved in the pathogenesis of muscl...

journal_title：Rejuvenation research

authors： Picca A,Lezza AMS,Leeuwenburgh C,Pesce V,Calvani R,Bossola M,Manes-Gravina E,Landi F,Bernabei R,Marzetti E

更新日期：2018-08-01 00:00:00

abstract：:With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...

journal_title：Rejuvenation research

authors： Cai HB,Wu GL,Huang CH,Huang ZS,Chen YB,Wang Q

更新日期：2016-08-01 00:00:00

abstract：:The relationships among lipoprotein metabolism, genetic vascular factors, vascular disease, and Alzheimer's disease suggest that the examination of centenarian populations in relation to certain genes or lipoprotein metabolism provide insights into human longevity. The findings on the higher frequency of the apolipopr...

journal_title：Rejuvenation research

authors： Panza F,D'introno A,Capurso C,Colacicco AM,Seripa D,Pilotto A,Santamato A,Capurso A,Solfrizzi V

更新日期：2007-12-01 00:00:00

abstract：:Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...

journal_title：Rejuvenation research

authors： Poz D,De Falco E,Pisano C,Madonna R,Ferdinandy P,Balistreri CR

更新日期：2019-04-01 00:00:00

abstract：:Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse along the surface of the primary myotubes, giving rise to a population...

journal_title：Rejuvenation research

authors： Matsakas A,Otto A,Elashry MI,Brown SC,Patel K

更新日期：2010-12-01 00:00:00

abstract：:To determine the prognostic value of frailty and comorbidity for outdoor mobility loss and mortality in the elderly. The retrospective study was conducted among outpatients aged ≥60 years. Patients with ≥3 chronic illnesses were treated by doctors who had undergone a 72-hour geriatric training. The outdoor low-mobilit...

journal_title：Rejuvenation research

authors： Tkacheva ON,Runikhina NK,Merkusheva LI,Lysenkov SN,Ostapenko VS,Sharashkina NV,Press Y

更新日期：2020-07-14 00:00:00

abstract：BACKGROUND:Human growth hormone-1 (GH-1), somatotropin, is a peptide hormone that stimulates cell division in tissues such as bone and cartilage. METHODS:To compare physiological activities in lipid-free and lipid-bound states, we expressed and incorporated GH-1 in reconstituted high-density lipoprotein (rHDL). RESUL...

journal_title：Rejuvenation research

authors： Lee EY,Kim SH,Cho KH

更新日期：2015-06-01 00:00:00

abstract：:This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...

journal_title：Rejuvenation research

authors： Candore G,Balistreri CR,Colonna-Romano G,Lio D,Listì F,Vasto S,Caruso C

更新日期：2010-04-01 00:00:00

abstract：:Alzheimer disease (AD), the most common form of dementia, is without an effective cure or preventive treatment. Recently, amyloid-beta protein (Abeta) has become a major therapeutic target. Many efforts are underway to either reduce the production of Abeta or enhance its clearance. In 1999, Schenk and colleagues first...

journal_title：Rejuvenation research

authors： Lemere CA,Maier M,Jiang L,Peng Y,Seabrook TJ

更新日期：2006-04-01 00:00:00

abstract：:Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and 1H nuclear magnetic resonance ...

journal_title：Rejuvenation research

authors： Duan DD,Wang KX,Zhou YZ,Qin XM,Gao L,Du GH

更新日期：2017-12-01 00:00:00

abstract：:We have reported the isolation of a unique subpopulation of human stromal cells from bone marrow termed marrow-isolated adult multilineage inducible (MIAMI) cells. The expression of embryonic stem cell markers SSEA-4, Oct-4, Rex-1, and telomerase reverse transcriptase indicates the developmentally immature status of t...

journal_title：Rejuvenation research

authors： D'Ippolito G,Howard GA,Roos BA,Schiller PC

更新日期：2006-04-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...

journal_title：Rejuvenation research

authors： Szwergold BS

更新日期：2013-08-01 00:00:00

abstract：:We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring togethe...

journal_title：Rejuvenation research

authors： Zhavoronkov A,Cantor CR

更新日期：2013-10-01 00:00:00

abstract：:Healthspan science aims to add healthy, functional years to human life. Many different methods of improving healthspan have been investigated, chiefly focusing on just one aspect of an organism's health such as survival. Studies in Drosophila melanogaster have demonstrated that a reversal to a long-abandoned ancestral...

journal_title：Rejuvenation research

authors： Rutledge GA,Phang HJ,Le MN,Bui L,Rose MR,Mueller LD,Jafari M

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND/AIMS:The main purpose of the present study was to investigate the effects of vitamin C and E supplements on the antioxidant capacity of erythrocytes obtained from young and aged rats. METHODS:Male Wistar rats aged 3 and 24 months were used. Vitamins C and E were injected at doses of 200 mg/kg (day) intraper...

journal_title：Rejuvenation research

authors： Xiong Y,Xiong Y,Zhou S,Sun Y,Zhao Y,Ren X,Zhang Y,Zhang N

更新日期：2017-04-01 00:00:00

abstract：:New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumu...

journal_title：Rejuvenation research

authors： Bahr BA

更新日期：2014-08-01 00:00:00

abstract：:Theses reviewed in this issue include "Engineering Cellular Input-Output for the Robust Control of Mammalian Cell-Based Therapies"; "Enzyme-Instructed Self-Assembly (EISA) Selectively Targets Cancer Cells"; "Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2017-08-01 00:00:00

abstract：:The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low prolifera...

journal_title：Rejuvenation research

authors： Rodriguez-Lopez AM,Whitby MC,Borer CM,Bachler MA,Cox LS

更新日期：2007-03-01 00:00:00

abstract：:Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...

journal_title：Rejuvenation research

authors： Sun Y,Qi G,Li D,Meng H,Zhu Z,Zhao Y,Qi Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:With advancing age, the mammalian thymus undergoes involution, a progressive loss of architectural integrity and lymphoid cellularity that results in reduced T lymphopoiesis. Thymic involution also is associated with extreme malnutrition and states of immune deficiency, such as active HIV infection, after chemotherapy...

journal_title：Rejuvenation research

authors： Virts EL,Phillips JA,Thoman ML

更新日期：2006-04-01 00:00:00

abstract：:Aging plays a central role in the occurrence of neurodegenerative diseases. Caloric restriction (CR) mitigates oxidative stress by decreasing the rate of generation of endogenous damage, a mechanism that can contribute to the slowing of the aging rate induced by this intervention. Various reports have recently linked ...

journal_title：Rejuvenation research

authors： Naudí A,Caro P,Jové M,Gómez J,Boada J,Ayala V,Portero-Otín M,Barja G,Pamplona R

更新日期：2007-12-01 00:00:00

abstract：:Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by traditional center-based and home-based programs. This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frail ...

journal_title：Rejuvenation research

authors： Garcia RNSA,Costa SN,Garcia EDSA,Bento PCB

更新日期：2020-05-26 00:00:00

abstract：OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...

journal_title：Rejuvenation research

authors： Stipic I,Polasek O,Vulic M,Punda H,Grandic L,Strinic T

更新日期：2012-12-01 00:00:00