Abstract:
:We have reported the isolation of a unique subpopulation of human stromal cells from bone marrow termed marrow-isolated adult multilineage inducible (MIAMI) cells. The expression of embryonic stem cell markers SSEA-4, Oct-4, Rex-1, and telomerase reverse transcriptase indicates the developmentally immature status of these cells. They resemble primitive stem cells in their capacity to differentiate, at least in vitro, into mature-like cells from all three germ layers. MIAMI cells are characterized by a unique molecular profile that distinguishes them from other marrow stromal cell populations. Although the frequency of MIAMI cells, among all marrow nucleated cells, decreases from 0.01% at age 3 to 0.0018% at age 45, their numbers remain unchanged after age 45. The level of expression of the markers characteristic of MIAMI cells remains constant independent of age and gender. In long-term in vitro expansion experiments aging increased the population doubling time by about 30%, whereas specific in vitro differentiation of MIAMI cells toward osteoblastic cells was unaffected. Because the oxygen tension in bone marrow ranges from 1% to 7%, we examined the role of oxygen tension in regulating the capacity of MIAMI cells to self-renew and maintain their pluripotentiality during long-term culture. Low oxygen tension upregulated mRNAs for primitive embryonic stem cell markers. Our results suggest that maintaining developmentally primitive human cells in vitro at low oxygen tension is more physiologic and favors stemness. For osteoblastic differentiation, gap-junctional communication mediated by connexin43 is required. Its inhibition not only blocked osteoblastic differentiation but stimulated the adipocytic differentiation.
journal_name
Rejuvenation Resjournal_title
Rejuvenation researchauthors
D'Ippolito G,Howard GA,Roos BA,Schiller PCdoi
10.1089/rej.2006.9.10subject
Has Abstractpub_date
2006-04-01 00:00:00pages
10-9issue
1eissn
1549-1684issn
1557-8577journal_volume
9pub_type
杂志文章abstract::We investigated the prognostic role of the Short Physical Performance Battery (SPPB) in elderly patients discharged from the acute care hospital. Our series consisted of 506 patients aged 70 years or more enrolled in a multicenter collaborative observational study. We considered three main outcomes: 1-year survival af...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1215
更新日期:2012-02-01 00:00:00
abstract::Availability of reliable prognostic biomarkers that are also able to monitor preventive/therapeutic interventions in patients with mild cognitive impairment (MCI) is crucial. Cerebral brain-derived neurotrophic factor (BDNF) alterations were evidenced in Alzheimer's disease, but the value of blood BDNF in MCI is uncle...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2307
更新日期:2020-10-01 00:00:00
abstract::We examined the impact of strong co-presence and function of glutathione peroxidase-1 (GPX-1) and glial cell line-derived neurotrophic factor (GDNF) on protecting the rat dopaminergic pheochromocytoma cell line PC12 against 6-hydroxydopamine (6-OHDA) and hydrogen peroxide (H₂O₂) toxicities. Primarily, GPX-1 over-expre...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1390
更新日期:2013-06-01 00:00:00
abstract::There is a growing interest in the potential of mesenchymal stem cells (MSCs) for implementing regenerative medicine. We assessed the effect of intravenous administration of human bone marrow-derived MSC on the life span of a single Sprague-Dawley female rat. The treatment was started when the rat was 6 months old and...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1777
更新日期:2016-08-01 00:00:00
abstract::Mitochondria play a central role in cellular physiology. Besides their classic function of energy metabolism, mitochondria are involved in multiple cell functions, including energy distribution through the cell, energy/heat modulation, regulation of reactive oxygen species (ROS), calcium homeostasis, and control of ap...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2015.1704
更新日期:2016-02-01 00:00:00
abstract::Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse along the surface of the primary myotubes, giving rise to a population...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1065
更新日期:2010-12-01 00:00:00
abstract::Aging plays a central role in the occurrence of neurodegenerative diseases. Caloric restriction (CR) mitigates oxidative stress by decreasing the rate of generation of endogenous damage, a mechanism that can contribute to the slowing of the aging rate induced by this intervention. Various reports have recently linked ...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0538
更新日期:2007-12-01 00:00:00
abstract::This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2017.1924
更新日期:2017-10-01 00:00:00
abstract::Frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in a rehabilitation setting for the treatment of pain, especially in diabetic patients. In a randomized clinical trial, we tested the hypothesis that FREMS is effective in the treatment of chronic and pa...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2011.1236
更新日期:2012-06-01 00:00:00
abstract::To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, inclu...
journal_title:Rejuvenation research
pub_type: 杂志文章,meta分析,评审
doi:10.1089/rej.2014.1612
更新日期:2015-02-01 00:00:00
abstract::Astaxanthin (AST), a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of AST on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that AST could prolong the life span of Caenorhabditis elegans. To uncover whether AST could delay a...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2020.2355
更新日期:2020-11-30 00:00:00
abstract::Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous system. Previously, we showed a drastic decline in the expression of glial and neuronal proteins in myelinated peripher...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0892
更新日期:2010-02-01 00:00:00
abstract::The emergence of immune disorders in aging is explained by many factors, including thymus dysfunction, decrease in the proportion and function of naïve T cells, and so forth. There are several approaches to preventing these changes, such as thymus rejuvenation, stem cells recovery, modulation of hormone production, an...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2012.1331
更新日期:2012-04-01 00:00:00
abstract::Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1594
更新日期:2015-02-01 00:00:00
abstract::Alzheimer disease (AD), the most common form of dementia, is without an effective cure or preventive treatment. Recently, amyloid-beta protein (Abeta) has become a major therapeutic target. Many efforts are underway to either reduce the production of Abeta or enhance its clearance. In 1999, Schenk and colleagues first...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2006.9.77
更新日期:2006-04-01 00:00:00
abstract::To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0893
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia. It has been suggested to have many biological activities, such as antioxidative, antiinflammatory, anticancer, chemopreventive, and antineurodegenerative properties. We ev...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2010.1031
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:This study examined the impact of estrogen replacement therapy with spirometry on pulmonary function in surgically castrated (salpingo-oophorectomy) postmenopausal women with genital prolapse. METHODS:The study included 60 postmenopausal women with pelvic organ prolapse. The study received institutional Ethi...
journal_title:Rejuvenation research
pub_type: 杂志文章,随机对照试验
doi:10.1089/rej.2012.1337
更新日期:2012-12-01 00:00:00
abstract::Lysosomes are involved in degrading and recycling cellular ingredients, and their disruption with age may contribute to amyloidogenesis, paired helical filaments (PHFs), and α-synuclein and mutant huntingtin aggregation. Lysosomal cathepsins are upregulated by accumulating proteins and more so by the modulator Z-Phe-A...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2011.1282
更新日期:2012-04-01 00:00:00
abstract::Since the discovery of the limited life span of human fibroblasts some 50 years ago, many genealogical studies have been undertaken to describe growth kinetics of fibroblasts in serial cultures by their individual division behavior. It is now accepted that proliferation capacities of human fibroblasts strongly depend ...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2005.8.154
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Human growth hormone-1 (GH-1), somatotropin, is a peptide hormone that stimulates cell division in tissues such as bone and cartilage. METHODS:To compare physiological activities in lipid-free and lipid-bound states, we expressed and incorporated GH-1 in reconstituted high-density lipoprotein (rHDL). RESUL...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2014.1644
更新日期:2015-06-01 00:00:00
abstract::With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present stu...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1751
更新日期:2016-08-01 00:00:00
abstract::Osteoarthritis is the most common disabling condition of humans in the western world. It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of the disease, but the explanations for this phenomenon have changed over time. The most longstanding theory is t...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/1549168041552964
更新日期:2004-07-01 00:00:00
abstract::Hyperuricemia (HU) is growing worldwide and associates with several medical conditions in the elderly. However, data about older people and possible gender differences are sparse. The aim of this study was to compare HU prevalence rates and association with relevant medical disorders in elderly subjects of both sexes....
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1834
更新日期:2017-02-01 00:00:00
abstract::Theses reviewed in this issue include "Downregulation of the Apelinergic Axis Accelerates Aging, Whereas Its Systemic Restoration Improves the Mammalian Healthspan," "Intracellular Delivery of Exogenous Molecules Via an Ultrahigh Throughput Mechanoporation Microdevice," "Intrinsic and Extrinsic Drivers of Treg Fragili...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2019.2248
更新日期:2019-08-01 00:00:00
abstract::We tried to establish an age-predictive equation from kinematic and kinetic parameters during walking using the 2007 Okada database of Japanese elderly. Some predictive equations were established for each gender (109 males and 139 females)--once for all variables, second for the stepwise variable selection method. The...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2009.0921
更新日期:2010-04-01 00:00:00
abstract::Interruption of insulin-like growth factor I (IGF-1) signaling has been demonstrated to prolong life span although the underlying mechanism has not been elucidated. The aim of this study was to examine the influence of severe IGF-1 deficiency on survival rate, cardiomyocyte viability, contractile function, and intrace...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2007.0552
更新日期:2007-12-01 00:00:00
abstract::Lysosomal storage diseases occur due to incomplete metabolic degradation of macromolecules by various hydrolytic enzymes in the lysosome. Despite structural differences, most of the lysosomal enzymes share many common features including a lysosomal targeting motif and phosphotransferase recognition sites. β-Glucuronid...
journal_title:Rejuvenation research
pub_type: 杂志文章,评审
doi:10.1089/rej.2013.1407
更新日期:2013-10-01 00:00:00
abstract::Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain bar...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2016.1903
更新日期:2016-12-01 00:00:00
abstract::Neurodegenerative diseases are often associated with both normal and premature aging. Resumption of the cell cycle by neurons induced by DNA damage may lead to their apoptosis, which contributes to the degeneration of neuronal tissue. Cell cycle and DNA replication proteins are frequently found in patients with neurod...
journal_title:Rejuvenation research
pub_type: 杂志文章
doi:10.1089/rej.2015.1717
更新日期:2016-04-01 00:00:00