Persistence of Long-Term Memory in Vitrified and Revived Caenorhabditis elegans.

abstract：:To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increa...

journal_title：Rejuvenation research

authors： Ko KM,Chiu PY,Leung HY,Siu AH,Chen N,Leong EP,Poon MK

更新日期：2010-04-01 00:00:00

abstract：:Decades of studies of candidate genes show their complex role in aging-related traits. We focus on apolipoprotein E e2/3/4 polymorphism and ages at onset of cardiovascular diseases (CVD) and cancer in the parental and offspring generations of the Framingham Heart Study participants to gain insights on the role of age ...

journal_title：Rejuvenation research

authors： Kulminski AM,Culminskaya I,Arbeev KG,Ukraintseva SV,Arbeeva L,Yashin AI

更新日期：2013-02-01 00:00:00

abstract：:Alzheimer disease (AD), the most common form of dementia, is without an effective cure or preventive treatment. Recently, amyloid-beta protein (Abeta) has become a major therapeutic target. Many efforts are underway to either reduce the production of Abeta or enhance its clearance. In 1999, Schenk and colleagues first...

journal_title：Rejuvenation research

authors： Lemere CA,Maier M,Jiang L,Peng Y,Seabrook TJ

更新日期：2006-04-01 00:00:00

abstract：:Spatial memory and cognition decline during aging. Montelukast, an FDA approved drug for the treatment of asthma, can restore spatial memory in old rats to levels similar to those of young animals. Treatment improves three hallmarks of aging in the brain: reducing microglial-mediated neuroinflammation, blood-brain bar...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2016-12-01 00:00:00

abstract：:Skeletal muscle fiber generation occurs principally in two myogenic phases: (1) Primary (embryonic) myogenesis when myoblasts proliferate and fuse to form primary myotubes and (2) secondary (fetal) myogenesis when successive waves of myoblasts fuse along the surface of the primary myotubes, giving rise to a population...

journal_title：Rejuvenation research

authors： Matsakas A,Otto A,Elashry MI,Brown SC,Patel K

更新日期：2010-12-01 00:00:00

abstract：:As mammals age, the rate of neurogenesis in the brain declines with a concomitant reduction in cognitive ability. Recent data suggest that plasma-borne factors are responsible for inhibition of neurogenesis. When the circulatory systems of old and young mice are connected, the old mice experience increased neurogenesi...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2011-12-01 00:00:00

abstract：:Homocysteine (Hcy) could induce amyloid β (Aβ) accumulation, synaptic dysfunction, and memory impairment as seen in Alzheimer disease (AD), the most prevalent neurodegenerative disorder, which affects more than 25 million people worldwide. Here we investigated the protective effect of hydroxysafflor yellow A (HSYA) on...

journal_title：Rejuvenation research

authors： Lu YQ,Luo Y,He ZF,Chen J,Yan BL,Wang Y,Yu Q

更新日期：2013-12-01 00:00:00

abstract：:Intermittent fasting (IF) is an intervention that can be beneficial for health span and mitigate the risk of developing age-related cardiovascular diseases; however, the involved mechanisms are not well understood. The present study investigated the effects of IF regimens on the plasma level of angiotensin II (Ang II)...

journal_title：Rejuvenation research

authors： Badreh F,Joukar S,Badavi M,Rashno M

更新日期：2020-08-01 00:00:00

abstract：:We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring togethe...

journal_title：Rejuvenation research

authors： Zhavoronkov A,Cantor CR

更新日期：2013-10-01 00:00:00

abstract：:Lysosomal storage diseases occur due to incomplete metabolic degradation of macromolecules by various hydrolytic enzymes in the lysosome. Despite structural differences, most of the lysosomal enzymes share many common features including a lysosomal targeting motif and phosphotransferase recognition sites. β-Glucuronid...

journal_title：Rejuvenation research

authors： Naz H,Islam A,Waheed A,Sly WS,Ahmad F,Hassan I

更新日期：2013-10-01 00:00:00

abstract：:Osteoporosis is a silent disease caused by low bone mineral density and is complicated by fractures. This study was designed to examine the differentiation of uterine stem cell-derived osteoprogenitor cells (UOPCs) both in vitro and in vivo, assessing their effectiveness in treating osteoporosis. CD271+/CD45- UOPCs we...

journal_title：Rejuvenation research

authors： Wang Z,Wang D,Liu Y,Liu D,Ren Y,Liu Z,Yu B,Hao M,Xie J

更新日期：2020-11-03 00:00:00

abstract：:Photoaging is the superposition of photodamage (ultraviolet [UV] radiation-induced) on the aging process. It is a major damaging consequence of free radical action. Curcumin (diferuloylmethane) is a phytochemical with diverse antioxidant and antiinflammatory properties. However, it shows a poor topical bioavailability...

journal_title：Rejuvenation research

authors： Agrawal R,Kaur IP

更新日期：2010-08-01 00:00:00

abstract：:This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...

journal_title：Rejuvenation research

authors： Candore G,Balistreri CR,Colonna-Romano G,Lio D,Listì F,Vasto S,Caruso C

更新日期：2010-04-01 00:00:00

abstract：:This study aimed at comparing the effects of three chair-based exercise programs on people older than 80 years. Thirty-six participants (87.91 ± 4.70 years) were randomly allocated to an aerobic, muscular resistance, or joint mobility exercise program. The participants exercised 3 days per week during 3 months. A hand...

journal_title：Rejuvenation research

authors： Cancela Carral JM,Pallin E,Orbegozo A,Ayán Pérez C

更新日期：2017-10-01 00:00:00

abstract：:Maillard reactions are an unavoidable feature of life that appear to be damaging to cell and organisms. Consequently, all living systems must have ways to protect themselves against this process. As of 2012, several such defense mechanisms have been identified. They are all enzymatic and were found in mesophilic organ...

journal_title：Rejuvenation research

authors： Szwergold BS

更新日期：2013-08-01 00:00:00

abstract：:New avenues to modulate the autophagy-lysosomal route of protein clearance have the potential to help treat several disease states to which the elderly are particularly vulnerable. Two recent papers identified distinct ways to tap into the lysosomal degradation pathway of autophagy to reduce age-related protein accumu...

journal_title：Rejuvenation research

authors： Bahr BA

更新日期：2014-08-01 00:00:00

abstract：:I propose a new model, called the "RNA memory" model, for the possible role of RNAs in the maintenance and establishment of cell identity. This is cytoplasmic memory obtained by the transmission of mother noncoding (nc) RNAs to daughter cells. These RNAs are able to activate transcription via sequence homology in daug...

journal_title：Rejuvenation research

authors： Arancio W

更新日期：2010-04-01 00:00:00

abstract：:Based on experience and the existing limited research literature in biotechnology corporate governance, the authors propose potential attributes of minimum corporate governance standards for biotechnology companies, as a basis for further quantitative and qualitative research. The authors assert that the recent prolif...

journal_title：Rejuvenation research

authors： Carter AR,Meinert E,Brindley DA

更新日期：2019-06-01 00:00:00

abstract：:Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous system. Previously, we showed a drastic decline in the expression of glial and neuronal proteins in myelinated peripher...

journal_title：Rejuvenation research

authors： Opalach K,Rangaraju S,Madorsky I,Leeuwenburgh C,Notterpek L

更新日期：2010-02-01 00:00:00

abstract：:In otherwise healthy adults, moderate aerobic exercise extends life span and likely health span by 2-6 years. Exercise improves blood sugar regulation, and resistance exercise increases or maintains muscle mass and is associated with improved cognitive function. On the other hand, evidence for anti-oxidant supplements...

journal_title：Rejuvenation research

authors： Mendelsohn AR,Larrick JW

更新日期：2013-10-01 00:00:00

abstract：:The mouse Mus musculus chromosomes are all acrocentric; each centromere (CEN) is adjacent to a telomere. The aim of the current work is to find out if at least half of the mouse telomeres (Tel) always follow satellite DNA sequences and if membrane telomere binding protein TRF2/MTBP is always in association with the Te...

journal_title：Rejuvenation research

authors： Kuznetsova IS,Voronin AP,Podgornaya OI

更新日期：2006-10-01 00:00:00

abstract：:The United States has the most expensive healthcare system worldwide. Yet measures of health span and life expectancy are well below the major industrialized nations. With the U.S. population aged 65 years and older projected to double by mid-century, a healthcare crisis is looming. Within this context, huge interest ...

journal_title：Rejuvenation research

authors： Larrick JW,Mendelsohn AR

更新日期：2018-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ1-42, we dem...

journal_title：Rejuvenation research

authors： Ai L,Yang F,Song J,Chen Y,Xiao L,Wang Q,Wang L,Li H,Lei T,Huang Z

更新日期：2018-08-01 00:00:00

abstract：:The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical "repair-oriented" approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the fi...

journal_title：Rejuvenation research

authors： Kyriazis M

更新日期：2014-08-01 00:00:00

abstract：:Theses reviewed in this issue include "Downregulation of the Apelinergic Axis Accelerates Aging, Whereas Its Systemic Restoration Improves the Mammalian Healthspan," "Intracellular Delivery of Exogenous Molecules Via an Ultrahigh Throughput Mechanoporation Microdevice," "Intrinsic and Extrinsic Drivers of Treg Fragili...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2019-08-01 00:00:00

abstract：:Prunella vulgaris L., a well-known traditional Chinese herbal medicine, has anti-inflammatory and antioxidant activities. In the present study, the underlying molecular mechanisms of the protective effect of P. vulgaris extract (PVE) were investigated in UVB-irradiated normal human dermal fibroblasts (NHDFs). The mRNA...

journal_title：Rejuvenation research

authors： Zhang M,Hwang E,Lin P,Gao W,Ngo HTT,Yi TH

更新日期：2018-08-01 00:00:00

abstract：:A hypothetical mechanism of 14C-generated influence on a person's rate of aging is offered. The mathematical description and the following approbation of the radiocarbon mechanism of aging made it possible to coordinate the Gompertz and Strehler-Mildvan laws and predict the existence of one more, till-now unknown, int...

journal_title：Rejuvenation research

authors： Germansky AM,Germanskaia AA

更新日期：2006-07-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:With advancing age, the mammalian thymus undergoes involution, a progressive loss of architectural integrity and lymphoid cellularity that results in reduced T lymphopoiesis. Thymic involution also is associated with extreme malnutrition and states of immune deficiency, such as active HIV infection, after chemotherapy...

journal_title：Rejuvenation research

authors： Virts EL,Phillips JA,Thoman ML

更新日期：2006-04-01 00:00:00

abstract：:Frequency rhythmic electrical modulation system (FREMS) is an innovative type of transcutaneous electrotherapy used in a rehabilitation setting for the treatment of pain, especially in diabetic patients. In a randomized clinical trial, we tested the hypothesis that FREMS is effective in the treatment of chronic and pa...

journal_title：Rejuvenation research

authors： Santamato A,Panza F,Fortunato F,Portincasa A,Frisardi V,Cassatella G,Valente M,Seripa D,Ranieri M,Fiore P

更新日期：2012-06-01 00:00:00