Telomere and TRF2/MTBP localization in respect to satellite DNA during the cell cycle of mouse cell line L929.

abstract：:Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments ...

journal_title：Rejuvenation research

authors： Fortney K,Morgen EK,Kotlyar M,Jurisica I

更新日期：2012-04-01 00:00:00

abstract：:Osteoarthritis is the most common disabling condition of humans in the western world. It has been known for a very long time that aging is the most prominent risk factor for the initiation and progression of the disease, but the explanations for this phenomenon have changed over time. The most longstanding theory is t...

journal_title：Rejuvenation research

authors： Aigner T,Rose J,Martin J,Buckwalter J

更新日期：2004-07-01 00:00:00

abstract：:Human growth hormone-2 (GH-2) is a 191-amino-acid protein also known as human placental hormone. During pregnancy, continuous secretion of GH-2 appears to have important implications for physiological adjustment to gestation, especially in controlling levels of maternal insulin-like growth factor 1. To compare the phy...

journal_title：Rejuvenation research

authors： Kim SH,Lee EY,Cho KH

更新日期：2015-02-01 00:00:00

abstract：:The progeroid Werner's syndrome (WS) represents the best current model of human aging. It is caused by loss of the WRN helicase/exonuclease, resulting in high levels of replication fork stalling and genomic instability. Current models suggest that characteristic WS phenotypes of poor S phase progression, low prolifera...

journal_title：Rejuvenation research

authors： Rodriguez-Lopez AM,Whitby MC,Borer CM,Bachler MA,Cox LS

更新日期：2007-03-01 00:00:00

abstract：:Alzheimer's Disease (AD) is the most common age-related dementia, with a current prevalence in excess of five million individuals in the United States. The aggregation of amyloid-beta (A beta) into fibrillar amyloid plaques is a key pathological event in the development of the disease. Microglial proinflammatory activ...

journal_title：Rejuvenation research

authors： Zhu Y,Bickford PC,Sanberg P,Giunta B,Tan J

更新日期：2008-10-01 00:00:00

abstract：:The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, because these are a key technology to systematically integrate heterogeneous information about the aging process. Related t...

journal_title：Rejuvenation research

authors： Fuellen G,Boerries M,Busch H,de Grey A,Hahn U,Hiller T,Hoeflich A,Jansen L,Janssens GE,Kaleta C,Meinema AC,Schäuble S,Simm A,Schofield PN,Smith B,Sühnel J,Vera J,Wagner W,Wönne EC,Wuttke D

更新日期：2013-12-01 00:00:00

abstract：:We developed a new model for initiating, coordinating, funding, and managing biomedical research projects. The concept involves engaging the patients with chronic conditions with no known cures into goal-oriented research activities. In this model, the patient seeks the help of a research organization to bring togethe...

journal_title：Rejuvenation research

authors： Zhavoronkov A,Cantor CR

更新日期：2013-10-01 00:00:00

abstract：:To evaluate a possible involvement of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism in susceptibility to Parkinson's disease (PD), we performed a meta-analysis of all studies on the topic published from 2002 to 2014. This article reviews and compares the data from two previous meta-analyses, inclu...

journal_title：Rejuvenation research

authors： Mariani S,Ventriglia M,Simonelli I,Bucossi S,Siotto M,R RS

更新日期：2015-02-01 00:00:00

abstract：:Lysosomes are involved in degrading and recycling cellular ingredients, and their disruption with age may contribute to amyloidogenesis, paired helical filaments (PHFs), and α-synuclein and mutant huntingtin aggregation. Lysosomal cathepsins are upregulated by accumulating proteins and more so by the modulator Z-Phe-A...

journal_title：Rejuvenation research

authors： Bahr BA,Wisniewski ML,Butler D

更新日期：2012-04-01 00:00:00

abstract：:A family of constitutive cell surface ECTO-NOX proteins capable of oxidizing reduced quinones, initially described as NADH oxidases, has offered an opportunity to formulate, for the first time, a complete electron transport chain from the cytosol to oxygen at the cell surface with the ECTO-NOX proteins acting as the t...

journal_title：Rejuvenation research

authors： Morré DJ,Morré DM

更新日期：2006-07-01 00:00:00

abstract：:Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human popu...

journal_title：Rejuvenation research

authors： Balistreri CR,Candore G,Mirabile M,Lio D,Caimi G,Incalcaterra E,Caruso M,Hoffmann E,Caruso C

更新日期：2008-04-01 00:00:00

abstract：:Previously, other groups and our team consistently have demonstrated that the possible origination of liver cancer stem cells (LCSCs) is the malignant transformation from liver normal stem cells (LNSCs). However, this complex and multi-step process is far from clear due to the accumulation of various gene dysregulatio...

journal_title：Rejuvenation research

authors： Ye P,Wang T,Liu WH,Li XC,Tang LJ,Tian FZ

更新日期：2015-08-01 00:00:00

abstract：:The human mitochondrion contains a small circular genome that codes for 13 proteins, 22 tRNAs, and 2 rRNAs. The proteins are all inner membrane bound components of complexes involved in the electron transport system and ATP formation. Mutations to any of the 13 proteins affect cellular behavior because energy producti...

journal_title：Rejuvenation research

authors： Mukhopadhyay A,Zullo SJ,Weiner H

更新日期：2006-07-01 00:00:00

abstract：:Theses reviewed in this issue include "Downregulation of the Apelinergic Axis Accelerates Aging, Whereas Its Systemic Restoration Improves the Mammalian Healthspan," "Intracellular Delivery of Exogenous Molecules Via an Ultrahigh Throughput Mechanoporation Microdevice," "Intrinsic and Extrinsic Drivers of Treg Fragili...

journal_title：Rejuvenation research

authors： Zealley B,de Grey ADNJ

更新日期：2019-08-01 00:00:00

abstract：:Treadmills are often used as rehabilitation devices to improve gait in Parkinson's disease (PD). Kinematic differences between treadmill and overground gait have been reported. However, electromyographic (EMG) patterns during treadmill and overground walking have not been systematically compared. The aim of this study...

journal_title：Rejuvenation research

authors： Bello O,Marquez G,Fernandez-Del-Olmo M

更新日期：2019-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common form of dementia and amyloid-β peptide (Aβ) aggregation is considered to be one of its main causes. Paeoniflorin has been previously shown to attenuate cognitive damage inflicted by exogenous Aβ protein. Using transgenic Caenorhabditis elegans models expressing human Aβ1-42, we dem...

journal_title：Rejuvenation research

authors： Ai L,Yang F,Song J,Chen Y,Xiao L,Wang Q,Wang L,Li H,Lei T,Huang Z

更新日期：2018-08-01 00:00:00

abstract：:Astaxanthin (AST), a xanthophyll belonging to the family of carotenoids, is a potent antioxidant. The effect of AST on longevity and its physiological and molecular mechanism are still unclear. In this study, we proved that AST could prolong the life span of Caenorhabditis elegans. To uncover whether AST could delay a...

journal_title：Rejuvenation research

authors： Fu M,Zhang X,Zhang X,Yang L,Luo S,Liu H

更新日期：2020-11-30 00:00:00

abstract：:This review discusses the role of estrogens as pro- or antiinflammatory players in immune-inflammatory responses. In particular, their role in Alzheimer's disease (AD), an example of immune-inflammatory disease, is discussed briefly. AD is a progressive neurodegenerative disease, which in Western societies accounts fo...

journal_title：Rejuvenation research

authors： Candore G,Balistreri CR,Colonna-Romano G,Lio D,Listì F,Vasto S,Caruso C

更新日期：2010-04-01 00:00:00

abstract：:The relationships among lipoprotein metabolism, genetic vascular factors, vascular disease, and Alzheimer's disease suggest that the examination of centenarian populations in relation to certain genes or lipoprotein metabolism provide insights into human longevity. The findings on the higher frequency of the apolipopr...

journal_title：Rejuvenation research

authors： Panza F,D'introno A,Capurso C,Colacicco AM,Seripa D,Pilotto A,Santamato A,Capurso A,Solfrizzi V

更新日期：2007-12-01 00:00:00

abstract：:Walnuts kernels (Juglans regia L.) have rich antioxidants content and have been used in both cosmetic and pharmaceutical industry. This study dealt with the protective role of walnut kernels extracts (WK) on isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Rats were pretreated with WK extracts (300 mg/k...

journal_title：Rejuvenation research

authors： Sun Y,Qi G,Li D,Meng H,Zhu Z,Zhao Y,Qi Y,Zhang X

更新日期：2019-08-01 00:00:00

abstract：:Physical exercise is a potential intervention to revert or attenuate frailty syndrome, which may be accomplished by traditional center-based and home-based programs. This study aimed to compare the effectiveness of a home-based and center-based exercise program on frailty status, physical and muscle function of frail ...

journal_title：Rejuvenation research

authors： Garcia RNSA,Costa SN,Garcia EDSA,Bento PCB

更新日期：2020-05-26 00:00:00

abstract：:Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in d-galactose (d-gal)-induced aging rat model by integration of behavior examination, biochemical detection, and 1H nuclear magnetic resonance ...

journal_title：Rejuvenation research

authors： Duan DD,Wang KX,Zhou YZ,Qin XM,Gao L,Du GH

更新日期：2017-12-01 00:00:00

abstract：:The United States has the most expensive healthcare system worldwide. Yet measures of health span and life expectancy are well below the major industrialized nations. With the U.S. population aged 65 years and older projected to double by mid-century, a healthcare crisis is looming. Within this context, huge interest ...

journal_title：Rejuvenation research

authors： Larrick JW,Mendelsohn AR

更新日期：2018-06-01 00:00:00

abstract：:Aristotle described the study of politics as an "architectonic" science that aspires to bring together insights from different fields of scientific inquiry to ensure that citizens have the opportunities to flourish. To meet the health and economic challenges of aging populations, we must revive this Aristotelian visio...

journal_title：Rejuvenation research

authors： Farrelly C

更新日期：2010-10-01 00:00:00

abstract：:Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has b...

journal_title：Rejuvenation research

authors： Sjöberg JS,Bulterijs S

更新日期：2009-04-01 00:00:00

abstract：:The pineal hormone melatonin plays a major role in circadian sleep-wake rhythm in many mammals, including humans. Patients with acute confusional state or delirium, especially those with underlying cognitive impairment, frequently suffer from sleep disturbances and disturbed circadian rhythm. In this review, an overvi...

journal_title：Rejuvenation research

authors： de Rooij SE,van Munster BC

更新日期：2013-08-01 00:00:00

abstract：:Evidence suggests association of red blood cell distribution width (RDW) with cardiovascular diseases (CVDs). On the contrary, we underline that the sole RDW values cannot represent a valid CVD biomarker. High RDW values are expression of biological effects of a lot of both endogenous and exogenous factors (i.e., age,...

journal_title：Rejuvenation research

authors： Poz D,De Falco E,Pisano C,Madonna R,Ferdinandy P,Balistreri CR

更新日期：2019-04-01 00:00:00

abstract：:We investigated the prognostic role of the Short Physical Performance Battery (SPPB) in elderly patients discharged from the acute care hospital. Our series consisted of 506 patients aged 70 years or more enrolled in a multicenter collaborative observational study. We considered three main outcomes: 1-year survival af...

journal_title：Rejuvenation research

authors： Corsonello A,Lattanzio F,Pedone C,Garasto S,Laino I,Bustacchini S,Pranno L,Mazzei B,Passarino G,Incalzi RA,Pharmacosurveillance In The Elderly Care Pvc Study Investigators.

更新日期：2012-02-01 00:00:00

abstract：:d-galactose (d-gal) is widely used to induce aging. However, it is still unclear whether long-term injection of d-gal affects the gastrointestinal functions of aging rats, and how. In this study, we investigated the effects of d-gal on the gastrointestinal functions of aging rats, especially from the perspective of fe...

journal_title：Rejuvenation research

authors： Zhao D,Liu X,Zhao S,Li Z,Qin X

更新日期：2020-09-29 00:00:00

abstract：:Abnormalities of gene structure or expression are commonly found in cancers, where they are used as prognostic markers, predicting the likely severity of disease or chances of response to therapy. An odds ratio (OR) of <1 indicates that a marker's presence is correlated with better outcome. An OR of <1 is also often t...

journal_title：Rejuvenation research

authors： Bains W

更新日期：2004-10-01 00:00:00