abstract：:Intrahepatic ductular reaction is a pathologic proliferation of phenotypical biliary channels. Ductular reactions aim to restore compromised physiological function after liver injury and are one of the archetypal responses of the liver to a wide variety of etiologies, among them are parenchymal loss, biliary tract dis...

journal_title：Advances in anatomic pathology

authors： Jain R,Clark I

更新日期：2021-01-19 00:00:00

abstract：:Salivary gland neoplasms are an uncommon and widely heterogeneous group of tumors. In recent years, there has been considerable progress in efforts to reveal the molecular landscape of these tumors, although it is still limited and appears to be only the tip of the iceberg. Genomic aberrations, especially specific chr...

journal_title：Advances in anatomic pathology

authors： Toper MH,Sarioglu S

更新日期：2021-01-04 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is an intermediate-grade malignancy of follicular dendritic cells, which are derived from mesenchymal stem cells. Nodal FDCS is well-recognized. However, when it occurs at an extranodal site, it may not be recognized and is often misdiagnosed. These tumors exhibit a variable sp...

journal_title：Advances in anatomic pathology

authors： Kaur R,Mehta J,Borges A

更新日期：2021-01-01 00:00:00

abstract：:Endometriosis is a relatively common condition in which endometrial tissue is established in locations outside the uterus where, like the eutopic endometrium, it responds to hormonal stimuli and develops internal bleeding, inflammation, and fibrosis. These changes are associated with chronic and often debilitating cyc...

journal_title：Advances in anatomic pathology

authors： Arafah M,Rashid S,Akhtar M

更新日期：2021-01-01 00:00:00

abstract：:Pathology has benefited from advanced innovation with novel technology to implement a digital solution. Whole slide imaging is a disruptive technology where glass slides are scanned to produce digital images. There have been significant advances in whole slide scanning hardware and software that have allowed for ready...

journal_title：Advances in anatomic pathology

authors： Hanna MG,Parwani A,Sirintrapun SJ

更新日期：2020-07-01 00:00:00

abstract：:As genomic characterization becomes increasingly necessary for accurate diagnosis of tumors of the central nervous system, identification of rapidly assessible biomarkers is equally important to avoid excessive cost and delay in initiation of therapy. This article reviews novel immunohistochemical markers that may be ...

journal_title：Advances in anatomic pathology

authors： Meredith DM

更新日期：2020-05-01 00:00:00

abstract：:Immunohistochemistry (IHC) is routinely performed in most laboratories, and other than purchase of commercially available antibodies, requires no additional equipment or reagents. As such, IHC is an accessible and relatively inexpensive test and one that can be performed quite quickly. This is in sharp contrast to gen...

journal_title：Advances in anatomic pathology

authors： Oh KS,Mahalingam M

更新日期：2019-11-01 00:00:00

abstract：:Inflammatory skin diseases encompass a vast array of conditions. The field continues to expand and evolve with resurgence of conditions, through newly recognized medication adverse effects, and via more detailed descriptions of known dermatoses. The importance of clinicopathologic correlation and an up to date knowled...

journal_title：Advances in anatomic pathology

authors： Penn L,Rothman L,Sutton AM,Brinster NK,Vidal CI

更新日期：2019-01-01 00:00:00

abstract：:Gastric-type endocervical adenocarcinoma (GAS) is a recently described diagnostic entity originally characterized as a tumor with (1) voluminous cytoplasm that is (2) clear or pale eosinophilic, and (3) cells showing distinct cell borders. Since the initial tumor description there has been accumulating experience that...

journal_title：Advances in anatomic pathology

authors： Pirog EC,Park KJ,Kiyokawa T,Zhang X,Chen W,Jenkins D,Quint W

更新日期：2019-01-01 00:00:00

abstract：:This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly dif...

journal_title：Advances in anatomic pathology

authors： Guilmette JM,Nosé V

更新日期：2019-01-01 00:00:00

abstract：:This manuscript presents a review of infectious causes of gastritis aimed at the practicing anatomic pathologist. We shall highlight unique histologic findings and clinical attributes that will assist those analyzing endoscopically obtained mucosal biopsies of the stomach or resection specimens. ...

journal_title：Advances in anatomic pathology

authors： Yee EU,Kuo E,Goldsmith JD

更新日期：2018-07-01 00:00:00

abstract：:Pancreatic cancer is an aggressive disease with a dismal prognosis in dire need of novel diagnostic and therapeutic approaches. The past decade has witnessed an explosion of data on the genetic alterations that occur in pancreatic cancer, as comprehensive next-generation sequencing analyses have been performed on samp...

journal_title：Advances in anatomic pathology

authors： Felsenstein M,Hruban RH,Wood LD

更新日期：2018-03-01 00:00:00

abstract：:A variety of arthropods, protozoa, and helminths infect the skin and subcutaneous tissues and may be identified by anatomic pathologists in standard cytology and histology preparations. The specific organisms seen vary greatly with the patient's exposure history, including travel to or residence in endemic countries. ...

journal_title：Advances in anatomic pathology

authors： Norgan AP,Pritt BS

更新日期：2018-03-01 00:00:00

abstract：:The topic of hereditary gynecologic malignancies readily evokes associations between Lynch syndrome and endometrial adenocarcinoma, or between BRCA mutations and tubo-ovarian serous carcinoma, but other familial associations are less well-known. Two hereditary syndromes are known to be related to uterine mesenchymal t...

journal_title：Advances in anatomic pathology

authors： Joehlin-Price AS,Garg K

更新日期：2018-03-01 00:00:00

abstract：:Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reach...

journal_title：Advances in anatomic pathology

authors： Iczkowski KA,Paner GP,Van der Kwast T

更新日期：2018-01-01 00:00:00

abstract：:The encapsulated and noninvasive follicular variant of papillary thyroid carcinoma has been recently reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). These tumors demonstrate indolent behavior. This change in nomenclature will have great clinical impact by avoiding ...

journal_title：Advances in anatomic pathology

authors： Basolo F,Macerola E,Ugolini C,Poller DN,Baloch Z

更新日期：2017-09-01 00:00:00

abstract：:The differential diagnosis of neuroendocrine neoplasms of the larynx is broad and includes lesions of epithelial, mesenchymal, and neuroectodermal origin. These lesions have overlapping clinical and pathologic aspects and must be carefully considered in the differential diagnosis of laryngeal neoplasms. The prognosis ...

journal_title：Advances in anatomic pathology

authors： Hunt JL,Ferlito A,Hellquist H,Rinaldo A,Skálová A,Slootweg PJ,Willems SM,Cardesa A

更新日期：2017-05-01 00:00:00

abstract：:Collecting duct carcinoma (CDC) and related tumors [ie, renal medullary carcinoma (RMC)] are rare types of highly aggressive renal cell carcinomas (RCC) with poor prognosis. Because of the rarity and diagnostic uncertainty of them, their molecular pathology and significance have not yet been fully elucidated. CDC, RMC...

journal_title：Advances in anatomic pathology

authors： Seo AN,Yoon G,Ro JY

更新日期：2017-03-01 00:00:00

abstract：:The diagnosis of minimal prostatic adenocarcinoma can be challenging on prostate needle biopsy, and immunohistochemistry may be used to support the diagnosis of cancer. The International Society of Urologic Pathology currently recommends the use of the basal cell markers high-molecular-weight cytokeraratin and p63, an...

journal_title：Advances in anatomic pathology

authors： Giannico GA,Arnold SA,Gellert LL,Hameed O

更新日期：2017-01-01 00:00:00

abstract：:Our understanding of the natural history of breast cancer has evolved alongside technologies to study its genomic, transcriptomic, proteomic, and metabolomics landscapes. These technologies have helped decipher multiple molecular pathways dysregulated in breast cancer. First-generation 'omics analyses considered each ...

journal_title：Advances in anatomic pathology

authors： Kalita-de Croft P,Al-Ejeh F,McCart Reed AE,Saunus JM,Lakhani SR

更新日期：2016-11-01 00:00:00

abstract：:The main purpose of urine cytology is to detect high-grade urothelial carcinoma. With this principle in mind, The Paris System (TPS) Working Group, composed of cytopathologists, surgical pathologists, and urologists, has proposed and published a standardized reporting system that includes specific diagnostic categorie...

journal_title：Advances in anatomic pathology

authors： Barkan GA,Wojcik EM,Nayar R,Savic-Prince S,Quek ML,Kurtycz DF,Rosenthal DL

更新日期：2016-07-01 00:00:00

abstract：:Well-differentiated liposarcoma (WDL) and dedifferentiated liposarcoma (DDL) form the largest subgroup of liposarcomas, and represent a morphologic and behavioral spectrum of 1 disease entity, which arises typically in middle to late adult life, most frequently within the retroperitoneum or extremities. DDL is defined...

journal_title：Advances in anatomic pathology

authors： Thway K,Jones RL,Noujaim J,Zaidi S,Miah AB,Fisher C

更新日期：2016-01-01 00:00:00

abstract：:In this review, a recently published pattern-based risk stratification system of endocervical adenocarcinoma (EAC) is presented. This novel system evaluates the morphologic features of the tumor and establishes patterns that are associated with a particular tumor behavior. Patients with pattern A EAC do not develop ly...

journal_title：Advances in anatomic pathology

authors： Roma AA

更新日期：2015-11-01 00:00:00

abstract：:Pheochromocytomas are uncommon neuroendocrine tumors arising in the adrenal medulla, whereas paragangliomas arise from chromaffin cells in sympathetic and parasympathetic locations outside of the adrenal gland. Molecular genetic studies in the past few years have identified >10 genes involved in the pathogenesis of ph...

journal_title：Advances in anatomic pathology

authors： Guo Z,Lloyd RV

更新日期：2015-09-01 00:00:00

abstract：:Desmoplastic melanoma (DM) is a relatively rare cytomorphologic variant of melanoma with a marked propensity for perineural invasion (PNI). Historically, DMs that display PNI have been grouped under the umbrella term of neurotropic melanoma (NM). However, definitions for NM and desmoplastic NM are not consistent in th...

journal_title：Advances in anatomic pathology

authors： Frydenlund N,Mahalingam M

更新日期：2015-07-01 00:00:00

abstract：:We report a case of a 14-year-old female with primary adenocarcinoma of the transverse colon. She was hospitalized after presenting with abdominal pain and signs of intestinal obstruction. There was no health antecedent or family history of neoplasia. Physical examination revealed a distended abdomen. Tenderness was e...

journal_title：Advances in anatomic pathology

authors： Galliani CA,Sanchez IC,D'Errico MM,Bisceglia M

更新日期：2015-05-01 00:00:00

abstract：:Gliomas are a large and diverse group of primary brain tumors that include those that are diffusely infiltrative and others that are well-circumscribed and low grade. Diffuse gliomas are currently classified by the World Health Organization as astrocytomas, oligodendrogliomas, or oligoastrocytomas and range in grade f...

journal_title：Advances in anatomic pathology

authors： Appin CL,Brat DJ

更新日期：2015-01-01 00:00:00

abstract：:Myoepithelial neoplasms represent a heterogeneous group of tumors of which classification is incomplete and evolving. Those of the soft tissues often form genetically distinct subgroups that differ from those arising within salivary glands. Soft-tissue myoepithelial tumors (including mixed tumors that show true glandu...

journal_title：Advances in anatomic pathology

authors： Thway K,Fisher C

更新日期：2014-11-01 00:00:00

abstract：:Epithelioid hemangioendothelioma is a vascular tumor of low to intermediate malignancy that was initially described in the soft tissue. Since then, epithelioid hemangioendothelioma has been described in various anatomic sites including parenchymal tissues and the bone. In the bone, these tumors must not only be distin...

journal_title：Advances in anatomic pathology

authors： Weissferdt A,Moran CA

更新日期：2014-07-01 00:00:00

abstract：:IMP3 is a member of a family of RNA-binding proteins that consists of IMP1, IMP2 and IMP3. These proteins contain 2 RNA recognition motifs and 4 K-homology domains that allow them to bind RNAs strongly and specifically. IMP3 is an oncofetal protein involved in embryogenesis and its expression is associated with a numb...

journal_title：Advances in anatomic pathology

authors： Gong Y,Woda BA,Jiang Z

更新日期：2014-05-01 00:00:00

abstract：:This paper reviews the pathologic features of lesions which are oncocytic and involve classic endocrine organs. The history of the oncocytic cell, its morphologic and ultrastructural features, and important immunohistochemical findings are reviewed. Oncocytic proliferations including non-neoplastic and neoplastic of t...

journal_title：Advances in anatomic pathology

authors： Canberk S,LiVolsi VA,Baloch Z

更新日期：2014-03-01 00:00:00

abstract：:Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of n...

journal_title：Advances in anatomic pathology

authors： Amaral AT,Ordóñez JL,Otero-Motta AP,García-Domínguez DJ,Sevillano MV,de Álava E

更新日期：2014-01-01 00:00:00

abstract：:Gastrointestinal (GI) tract tumors with melanocytic differentiation may present significant diagnostic challenges both for the pathologist and the clinician. This comprehensive review discusses the relatively common as well as rare entities that have melanocytic differentiation in the GI tract. Clinical, histologic, i...

journal_title：Advances in anatomic pathology

authors： Karamchandani DM,Patil DT,Goldblum JR

更新日期：2013-11-01 00:00:00

abstract：:This article reviews the recent dermatopathology literature regarding cutaneous adnexal neoplasms, with emphasis on new and underrecognized entities, "old entities" with new findings, advances in immunohistochemistry, and new findings in relation to inherited disorders associated with cutaneous adnexal neoplasms. ...

journal_title：Advances in anatomic pathology

authors： Ali SM,Sangueza OP

更新日期：2013-09-01 00:00:00

abstract：:Endometrial endometrioid adenocarcinoma (EEC) is the most common malignancy of the female genital tract, partly attributable to chronic estrogen exposure secondary to increased obesity rates. Tumor stage, which in most cases is based on depth of invasion (DOI), is of critical importance in determining if additional tr...

journal_title：Advances in anatomic pathology

authors： Cole AJ,Quick CM

更新日期：2013-05-01 00:00:00

abstract：:Tissue microarrays (TMAs) provide unique resources for rapid evaluation and validation of tissue biomarkers. The Canary Foundation Retrospective Prostate Tissue Microarray Resource used a rigorous statistical design, quota sampling, a variation of the case-cohort study, to select patients for inclusion in a multicente...

journal_title：Advances in anatomic pathology

authors： Hawley S,Fazli L,McKenney JK,Simko J,Troyer D,Nicolas M,Newcomb LF,Cowan JE,Crouch L,Ferrari M,Hernandez J,Hurtado-Coll A,Kuchinsky K,Liew J,Mendez-Meza R,Smith E,Tenggara I,Zhang X,Carroll PR,Chan JM,Gleave M,L

更新日期：2013-01-01 00:00:00

abstract：:The Bethesda System for Reporting Thyroid Cytopathology is a standardized reporting system for classifying thyroid fine-needle aspiration results comprising of 6 diagnostic categories with unique risks of malignancy and recommendations for clinical management. The majority of thyroid nodules are benign; however, up to...

journal_title：Advances in anatomic pathology

authors： Wong LQ,Baloch ZW

更新日期：2012-09-01 00:00:00

abstract：:Atypical cribriform lesions of the prostate gland consist of cribriform and rarely solid proliferation of prostate glands populated with cytologically atypical cells with partial or complete basal cell lining. It may represent cribriform "high-grade prostatic intraepithelial neoplasia" (HGPIN) or "intraductal carcinom...

journal_title：Advances in anatomic pathology

authors： Shah RB,Zhou M

更新日期：2012-07-01 00:00:00

abstract：:Digital pathology systems offer pathologists an alternate, emerging mechanism to manage and interpret information. They offer increasingly fast and scalable hardware platforms for slide scanning and software that facilitates remote viewing, slide conferencing, archiving, and image analysis. Deployed initially and vali...

journal_title：Advances in anatomic pathology

authors： Cornish TC,Swapp RE,Kaplan KJ

更新日期：2012-05-01 00:00:00

abstract：:Distinction between endometrioid and serous carcinomas of the endometrium has important prognostic and therapeutic implications. Misdiagnosing a serous carcinoma as endometrioid can have significant consequences for the patient and pathologist. Although many cases are straightforward and easy to classify, there are oc...

journal_title：Advances in anatomic pathology

authors： Garg K,Soslow RA

更新日期：2012-01-01 00:00:00