abstract：:The century-old tuberculosis vaccine BCG has been the focus of renewed interest due to its well-documented ability to protect against various non-TB pathogens. Much of these broad spectrum protective effects are attributed to trained immunity, the epigenetic and metabolic reprogramming of innate immune cells. As BCG v...

journal_title：Immunobiology

authors： Moulson AJ,Av-Gay Y

更新日期：2020-12-24 00:00:00

abstract：:Acute Myeloid Leukaemia (AML) is a neoplasia characterised by rapid proliferation and an increased rate of relapses. The AML blasts display features of antigen-presenting cells (APC), and thus can directly modulate the anti-tumour T cell responses. The bone marrow of a group consisting of 30 newly diagnosed patients a...

journal_title：Immunobiology

authors： Antohe I,Tanasa MP,Dăscălescu A,Dănăilă C,Titieanu A,Zlei M,Ivanov I,Sireteanu A,Cianga P

更新日期：2020-12-03 00:00:00

abstract：:Regulatory properties of macrophages associated with alternative activation serve to limit the exaggerated inflammatory response during pneumonia caused by Pseudomonas aeruginosa infection. Arginase-1 is an important effector of these macrophages believed to play an essential role in decreasing injury and promoting re...

journal_title：Immunobiology

authors： Haydar D,Gonzalez R,Garvy BA,Garneau-Tsodikova S,Thamban Chandrika N,Bocklage TJ,Feola DJ

更新日期：2020-11-24 00:00:00

abstract：:Atypical hemolytic uremic syndrome (aHUS) is caused mainly by complement dysregulation. Although various defects in the complement system explaining pathophysiology have been described in recent years, the etiology still remains unclear in about thirty percent of cases. In exploring other causes, similar to anti- comp...

journal_title：Immunobiology

authors： Govindarajan S,Rawat A,Ramachandran R,Hans R,Dawman L,Tiewsoh K

更新日期：2020-09-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) is an environmental sensor and ligand-activated transcription factor that is critically involved in the regulation of inflammatory responses and the induction of tolerance by modulating immune cells. As dendritic cells (DCs) express high AhR levels, they are efficient to induce immu...

journal_title：Immunobiology

authors： Michalski J,Deinzer A,Stich L,Zinser E,Steinkasserer A,Knippertz I

更新日期：2020-07-01 00:00:00

abstract：:Numerous studies have shown that over-activation of microglia could cause neuroinflammation and release pro-inflammatory mediators, which could result in neurodegenerative diseases, like Parkinson's disease, Alzheimer's disease etc. Beta-naphthoflavone (BNF) has anti-oxidant and anti-inflammatory effects in borderline...

journal_title：Immunobiology

authors： Gao X,He D,Liu D,Hu G,Zhang Y,Meng T,Su Y,Zhou A,Huang B,Du J,Fu S

更新日期：2020-07-01 00:00:00

abstract：:Natural killer (NK) cells are the main population of leukocytes in decidua during the first trimester of pregnancy. NK cells can have contact with trophoblast cells during pregnancy, which raises the possibility of mutual influence. This research aimed to evaluate the proliferation and phenotype of peripheral blood NK...

journal_title：Immunobiology

authors： Mikhailova VA,Kudryavtsev IV,Serebryakova MK,Milyutina YP,Demidova ES,Panina AN,Bazhenov DO,Belikova ME,Selkov SA,Sokolov DI

更新日期：2020-05-01 00:00:00

abstract：:NK-92 cell line has been used as anti-tumor cytotoxic effector cells in immunotherapy. Leucine-rich repeats and calponin homology domain containing 1 (LRCH1) is a novel gene of which the function is unclear. In the present study, we investigated the role of LRCH1 in NK-92 cell cytotoxicity. LRCH1 was ablated in NK-92 ...

journal_title：Immunobiology

authors： Dai K,Chen Z,She S,Shi J,Zhu J,Huang Y

更新日期：2020-05-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside bronchodilators that prevent disease progression. Levels of both...

journal_title：Immunobiology

authors： Douaoui S,Djidjik R,Boubakeur M,Ghernaout M,Touil-Boukoffa C,Oumouna M,Derrar F,Amrani Y

更新日期：2020-05-01 00:00:00

abstract：:Asthma is characterized by inflammation, pulmonary remodeling and bronchial hyperresponsiveness. We have previously shown that treatment with angiotensin-(1-7) [Ang-(1-7)] promotes resolution of eosinophilic inflammation and prevents chronic allergic lung inflammation. Here, we evaluated the effect of treatment with t...

journal_title：Immunobiology

authors： Magalhães GS,Gregório JF,Ramos KE,Cançado-Ribeiro ATP,Baroni IF,Barcelos LS,Pinho V,Teixeira MM,Santos RAS,Rodrigues-Machado MG,Campagnole-Santos MJ

更新日期：2020-05-01 00:00:00

abstract：:Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the TLRs are of considerable interest. Here we seek to determine the molecular mechanism by ...

journal_title：Immunobiology

authors： Zsengellér ZK,Gerard NP

更新日期：2020-03-01 00:00:00

abstract：:The goal of our work was to titer the IgG, IgM and IgA in Pentaglobin® (a preparation enriched in IgM), targeting specific surface antigens of Gram-positive and Gram-negative bacteria as well as a C. albicans strain. Lipopolysaccharides from Gram-negative bacteria, peptidoglycan and lipoteichoic acid from the other mi...

journal_title：Immunobiology

authors： Stracquadanio S,Lo Verde F,Cialfi A,Zega A,Stefani S,Cafiso V

更新日期：2020-03-01 00:00:00

abstract：:Chronic rhinosinusitis is an inflammatory process of the mucous membrane of the nasal cavity and paranasal sinuses, presenting with two phenotypes that differ in symptoms and inflammatory profiles: either with or without polyps. Natural killer (NK) cells are involved in both the innate and acquired immune response, an...

journal_title：Immunobiology

authors： Kaczmarek M,Wasicka K,Tin-Tsen Chou J,Popowicz P,Rzetelska Z,Łagiedo-Żelazowska M,Piwowarczyk K,Leszczyńska M

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:NK cells as a part of innate immune system, are controlled by a set of activating and inhibitory KIR receptors (aKIR, iKIR) which are implicated in tumor microenvironment immunity through a variety of activating and inhibitory immune signals. KIRs are multi gene family receptors that differ in the number and...

journal_title：Immunobiology

authors： Barani S,Taghipour M,Ghaderi A

更新日期：2020-03-01 00:00:00

abstract：:Individuals infected with Strongyloides stercoralis have been reported to produce different immunoglobulins isotypes, yet few studies have evaluated their use in strongyloidiasis diagnosis. The aim of this work was to evaluate the immunoreactivity of different classes and subclasses of anti-S. stercoralis circulating ...

journal_title：Immunobiology

authors： De Souza JN,Cruz ADV,Araújo WAC,Sampaio LM,Allegretti SM,Teixeira MCA,Handali S,Galvão-Castro B,Soares NM

更新日期：2020-03-01 00:00:00

abstract：:Glypican-3 (GPC3) is an attractive target for chimeric antigen receptor (CAR)-T cell therapy, as it is overexpressed in most hepatocellular carcinoma (HCC) tissues but shows restricted expression in healthy adult tissues. Herein, we generated GPC3-specific CAR-T cells for HCC therapy by electroporation with plasmid DN...

journal_title：Immunobiology

authors： Wang P,Qin W,Liu T,Jiang D,Cui L,Liu X,Fang Y,Tang X,Jin H,Qian Q

更新日期：2020-01-01 00:00:00

abstract：:Details of the "Trojan Horse" mechanism by which Zika virus (ZIKV) crosses the blood-brain barrier (BBB) remain unclear. However, the migration of ZIKV-infected monocytes to the brain is thought to be dependent on both pattern-recognition and chemokine receptors. In this study, we investigated whether the migration of...

journal_title：Immunobiology

authors： de Carvalho GC,Borget MY,Bernier S,Garneau D,da Silva Duarte AJ,Dumais N

更新日期：2019-11-01 00:00:00

abstract：:Acute lung injury (ALI) is an acute inflammatory disorder. Toll-like receptor-4 (TLR-4) and Stanniocalcin -1 (STC-1) had roles in lung endothelial protection. This study aims to assess TLR-4 and SCT-1 genes expressions in peripheral blood of ALI patients. Total RNA was extracted from peripheral blood of 48 subjects (2...

journal_title：Immunobiology

authors： Esawy MM,Shabana MA,Baioumy SA,Ismail NA

更新日期：2019-11-01 00:00:00

abstract：:Asthma is an airway inflammatory disorder. Vitamin (Vit) D is a potent immuno-modulator. It suppresses Interleukin (IL)-17 and induces IL-10. This study aims to investigate the role of IL-17A and IL-10 in predicting asthma control in case of Vit D supplementation. Seventy-nine patients enrolled in this study (42 patie...

journal_title：Immunobiology

authors： Shabana MA,Esawy MM,Ismail NA,Said AM

更新日期：2019-11-01 00:00:00

abstract：:Mugwort pollen allergy is frequent in parts of Europe. As mugwort pollen contains only one major allergen, Art v 1, which harbors only one T cell epitope, we employed mugwort pollen allergy as a model to study allergen-specific T cell responses. However, after 2004, we noticed a drastic decrease in the T cell response...

journal_title：Immunobiology

authors： Van Hemelen D,Hemmer W,Kmenta M,Berger UB,Kinaciyan T,Bohle B,Jahn-Schmid B

更新日期：2019-09-01 00:00:00

abstract：:The tumor suppressor protein P53 is strongly involved in orchestrating cellular defenses in the diverse variety of human tissues. Anomalies to lung endothelium permeability are streaming severe consequences towards human health, often associated with fatal outcomes. Ongoing investigations suggest that P53 exerts a pro...

journal_title：Immunobiology

authors： Uddin MA,Akhter MS,Siejka A,Catravas JD,Barabutis N

更新日期：2019-07-01 00:00:00

abstract：:IFN-γ produced during viral infections activates the IFN-γ receptor (IFNGR) complex for STAT1 transcriptional activity leading to expression of Interferon Regulatory Factors (IRF). Simultaneous activation of TBK/IKKε via TLR3 during viral infections activates the transcription factor IRF3. Together these transcription...

journal_title：Immunobiology

authors： Guinn ZP,Petro TM

更新日期：2019-07-01 00:00:00

abstract：:Peptide immunotherapy (PIT) represents a safe and efficacious therapeutic modality for allergic diseases. Present study evaluates immunotherapeutic potential of T cell peptides of major cockroach allergen, Per a 10 in murine model of airway allergy. Treatment with peptides T-P8 and T-P10 demonstrated maximal resolutio...

journal_title：Immunobiology

authors： Govindaraj D,Sharma S,Singh N,Arora N

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:An association between Tako-Tsubo cardiomyopathy (TTC) and underlying malignancies has been observed, suggesting that TTC might be the consequence of paraneoplastic phenomena. This study investigates the presence of autoantibodies against cardiomyocytes as well as adrenergic (β1, β2) and muscarinic (M2) rece...

journal_title：Immunobiology

authors： Juenemann M,Nef H,Möllmann H,Singh P,Troidl C,Schramm P,Kaps M,Gerriets T,Blaes F,Tschernatsch M

更新日期：2019-03-01 00:00:00

abstract：:Leukocytes found at the human maternal-fetal interface participate in the inflammatory process associated with both preterm and term labor; therein, effective methods for their isolation that allow further phenotypic and functional analyses are necessary. Leukocyte isolation is usually carried out through scraping or ...

journal_title：Immunobiology

authors： MacDonald-Ramos K,Arenas-Hernandez M,Mancilla-Herrera I,Rangel-Escareño C,Vega-Sanchez R

更新日期：2019-01-01 00:00:00

abstract：:Prior work demonstrated that a splice variant of SCN5A, a voltage-gated sodium channel gene, acts as a cytoplasmic sensor for viral dsRNA in human macrophages. Expression of this channel also polarizes macrophages to an anti-inflammatory phenotype in vitro and in vivo. Here we utilized global expression analysis of sp...

journal_title：Immunobiology

authors： White CR,Dungan M,Carrithers MD

更新日期：2019-01-01 00:00:00

abstract：:To investigate the role of IL-13 during a severe systemic Candida albicans infection, BALB/c control and IL-13-/- mice were examined for colony forming units (CFU) in the kidneys and survival days after intravenous infection. Proinflammatory mediators and cell recruitment into the tissue were measured by quantitative ...

journal_title：Immunobiology

authors： Abe Y,Yamamoto N,Nakamura K,Arai K,Sakurai C,Hatsuzawa K,Ogura Y,Iseki K,Tase C,Kanemitsu K

更新日期：2019-01-01 00:00:00

abstract：:Complement assays have for many years utilised buffers based on barbitone (veronal) despite the well-recognised toxicity of this agent and the tight regulations on its use in most countries. The use of barbitone in complement assay buffers is steeped in history, from a time when no other suitable buffers were availabl...

journal_title：Immunobiology

authors： Zelek WM,Harris CL,Morgan BP

更新日期：2018-12-01 00:00:00

abstract：:To date, numerable reviews are found in the literature prominent to the effect of caffeine on the immune system, with the latest review published in 2006. Database screening reveals around three thousand articles that have been published during the last decade. Interestingly, less than hundred articles involved humans...

journal_title：Immunobiology

authors： Al Reef T,Ghanem E

更新日期：2018-12-01 00:00:00

abstract：:Macrophage functions in the immune response depend on their ability to infiltrate tissues and organs. The penetration between and within the tissues requires degradation of extracellular matrix (ECM), a function performed by the specialized, endopeptidase- and actin filament- rich organelles located at the ventral sur...

journal_title：Immunobiology

authors： Chen W,Ghobrial RM,Li XC,Kloc M

更新日期：2018-11-01 00:00:00

abstract：:Based on the goat genome database, we have annotated the genomic organization of the goat immunoglobulin heavy chain variable region. The goat IgH locus is present on seven genome scaffolds, and contains ten VH, three DH and six JH segments. After the exclusion of three shorter segments, the VH genes were divided into...

journal_title：Immunobiology

authors： Du L,Wang S,Zhu Y,Zhao H,Basit A,Yu X,Li Q,Sun X

更新日期：2018-11-01 00:00:00

abstract：:Pythiosis is a life-threatening disease caused by the fungus-like microorganism Pythium insidiosum that can lead to death if not treated. Since P. insidiosum has particular cell wall characteristics, pythiosis is difficult to treat, as it does not respond well to traditional antifungal drugs. In our study, we investig...

journal_title：Immunobiology

authors： Ledur PC,Tondolo JSM,Jesus FPK,Verdi CM,Loreto ÉS,Alves SH,Santurio JM

更新日期：2018-03-01 00:00:00

abstract：:Successful reconstitution of T lymphocytes after allogeneic haematopoietic stem cell transplantation (HSCT) is needed to establish the graft-versus-leukaemia effect and an effective anti-microbial defense, but the ratio between functionally different T-cell subsets needs to be balanced to avoid graft-versus-host disea...

journal_title：Immunobiology

authors： Kielsen K,Ryder LP,Lennox-Hvenekilde D,Gad M,Nielsen CH,Heilmann C,Ifversen M,Pedersen AE,Müller K

更新日期：2018-02-01 00:00:00

abstract：:Immunological mechanisms of hygiene hypothesis are expected to develop a novel strategy for allergy prevention. Although a large number of studies has investigated the relation between allergies and infection, little is known about the influence of the exposure to infections on antigen uptake by dendritic cells (DCs)....

journal_title：Immunobiology

authors： Mizuno N,Sasaki Y,Segawa R,Asakawa S,Hiratsuka M,Hirasawa N

更新日期：2018-01-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are heterogeneous cells capable of abrogating T and B cells responses and have been identified in numerous cancers. As with other regulatory cell populations, they aim to maintain balance between host-defence-associated inflammation and ensuing tissue pathology. MDSC accumulati...

journal_title：Immunobiology

authors： Tamadaho RSE,Hoerauf A,Layland LE

更新日期：2018-01-01 00:00:00

abstract：:Although there have been numerous attempts to develop a successful vaccine against leishmaniasis, based on the clinical trial in this field, no vaccine against Leishmania in routine way can be found for globally effective vaccination in human. Amongst, first generation vaccines consisting of parasite fractions or whol...

journal_title：Immunobiology

authors： Jafari I,Heravi Shargh V,Shahryari M,Abbasi A,Jaafari MR,Khamesipour A,Badiee A

更新日期：2018-01-01 00:00:00

abstract：:Mast cells serve important roles as sentinels against bacterial infection by secreting mediators stored in granules. Much of their effectiveness depends upon recruiting and/or modulating other immune cells. The location of mast cells implies that they recognize pathogens invading tissues or mucosal tissues. Acinetobac...

journal_title：Immunobiology

authors： Kikuchi-Ueda T,Kamoshida G,Ubagai T,Nakano R,Nakano A,Akuta T,Hikosaka K,Tansho-Nagakawa S,Kikuchi H,Ono Y

更新日期：2017-11-01 00:00:00

abstract：:Propranolol is a widely-known beta-blocker approved for treating infantile hemangiomas (IH). The mechanisms behind the spectacular IH involution after propranolol treatment remain unclear. Recently, there is strong evidence of overexpression of numerous angiogenic factors in IH tissues, and it is reported that propran...

journal_title：Immunobiology

authors： Taran K,Wnęk A,Kobos J,Andrzejewska E,Przewratil P

更新日期：2017-11-01 00:00:00

abstract：:The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inflammatory environment in the obese adipose tissue and pancreatic β-cell islets ...

journal_title：Immunobiology

authors： Ahmed M,de Winther MPJ,Van den Bossche J

更新日期：2017-10-01 00:00:00

abstract：:Airway remodeling is a characteristic of bronchial asthma. The process involves the expression of many genes, such as transforming growth factor-beta (TGF-β), tissue inhibitors of metalloproteinases (TIMP-1), MMP and arginase. Human rhinovirus (HRV) is known to cause asthma exacerbations, and viral infections might be...

journal_title：Immunobiology

authors： Wieczfinska J,Pawliczak R

更新日期：2017-08-01 00:00:00