Anti-complement factor I antibody associated atypical hemolytic uremic syndrome - A new insight for future perspective!

abstract：:Splenic B cells of BALB/c mice were stimulated in vitro either with lipopolysaccharide (LPS), dextran sulphate (DxS), or with both LPS and DxS. The absolute frequency of B cells that differentiate into clones of immunoglobulin (Ig)-secreting cells upon activation with these mitogens was determined by means of limiting...

journal_title：Immunobiology

authors： Bos NA,Meeuwsen CG,de Visser H,Benner R

更新日期：1988-02-01 00:00:00

abstract：:To differentiate severe congenital neutropenia (SCN) from autoimmune neutropenia (AIN) in patients with persistent neutropenia ≤1000/mm(3) over three months, we evaluated anti-neutrophil auto-antibodies, candidate genes of ELANA, HAX1 and GCSFR, and neutrophil elastase (NE) activity in 38 patients (21 females; average...

journal_title：Immunobiology

authors： Lee WI,Chen SH,Huang JL,Jaing TH,Chung HT,Yeh KW,Chen LC,Yao TC,Hsieh MY,Lin SJ,Kuo ML

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to evaluate some immunological patterns involved in natural and acquired resistance against MHV3 using the original model of genetically modified lines of mice selected for high (HIII) and low (LIII) antibody responsiveness. As previously shown, a lower pre-existing anti-MHV antibody level wa...

journal_title：Immunobiology

authors： Vassão RC,Consales CA,Sant'Anna OA,Pereira CA

更新日期：2003-01-01 00:00:00

abstract：:Human cell lines of myelo/monocytic origin express the cellular receptor for urokinase-type plasminogen activator (uPA-R). The receptor localizes urokinase-type plasminogen activator (uPA) to the surface of the cell, where it can convert plasminogen to the active serine proteinase plasmin. Plasmin may subsequently acc...

journal_title：Immunobiology

authors： Herijgers N,Vettel U,Schaefer B,Spring H,Todd RF 3rd,Kramer MD

更新日期：1995-11-01 00:00:00

abstract：:Macrophages located in airways and the alveolar space are continually exposed to different signals from the respiratory mucosa. In this respect, epithelial cells represent an important source of cytokines and mediators modulating the state of activation and/or differentiation of mononuclear phagocytes. Many of the pro...

journal_title：Immunobiology

authors： Striz I,Brabcova E,Kolesar L,Liu XD,Brabcova I,Sekerkova A,Poole JA,Jaresova M,Slavcev A,Rennard SI

更新日期：2011-10-01 00:00:00

abstract：:A soluble form of complement receptor number 2 (sCR2) found in human serum closely resembles that produced in culture by B lymphoblastoid cells. Epitope analysis with a panel of CD21 monoclonal antibodies revealed only minor differences between antigen from the two sources. Purified sCR2 from both sources bound to C3d...

journal_title：Immunobiology

authors： Ling NR,Brown B

更新日期：1992-08-01 00:00:00

abstract：:NK-92 cell line has been used as anti-tumor cytotoxic effector cells in immunotherapy. Leucine-rich repeats and calponin homology domain containing 1 (LRCH1) is a novel gene of which the function is unclear. In the present study, we investigated the role of LRCH1 in NK-92 cell cytotoxicity. LRCH1 was ablated in NK-92 ...

journal_title：Immunobiology

authors： Dai K,Chen Z,She S,Shi J,Zhu J,Huang Y

更新日期：2020-05-01 00:00:00

abstract：:The Fc gamma RIII receptor (CD16) has been described on natural killer cells and a small subset of T lymphocytes. CD16+bright lymphocytes represent the typical population of peripheral blood CD3- NK cells. In these studies in addition to CD16+bright NK cells Fc gamma RIII expressing cytotoxic T lymphocytes in peripher...

journal_title：Immunobiology

authors： Uciechowski P,Werfel T,Leo R,Gessner JE,Schubert J,Schmidt RE

更新日期：1992-06-01 00:00:00

abstract：UNLABELLED:The lymphoid tissue of the appendix is considered as part of the gut-associated lymphoid tissue (GALT). In order to understand better the immunological significance of the appendix we analyzed the cellular composition of normal and inflamed human appendix tissue by flow cytometer with special attention to ex...

journal_title：Immunobiology

authors： Somekh E,Serour F,Gorenstein A,Vohl M,Lehman D

更新日期：2000-01-01 00:00:00

abstract：:Vaccines capable of inducing mucosal immunity in early postnatal life until adulthood, protecting early sexual initiation, should be considered as strategies to vaccination against HIV. The HIV-1 GAG protein as a chimera with the lysosome-associated membrane protein (LAMP/gag), encoded by a DNA vaccine, is targeted to...

journal_title：Immunobiology

authors： Goldoni AL,Maciel M Jr,Rigato PO,Piubelli O,de Brito CA,Melo A,Marques ET,August JT,Duarte AJ,Sato MN

更新日期：2011-04-01 00:00:00

abstract：:The anticonvulsant drug phenytoin, in less than cytotoxic concentrations, caused significant reductions in Ig secretion by unstimulated or EBV-stimulated normal MNC, as measured by PFC or secretion of Ig into the culture medium. Isotype-specific LBL varied in their sensitivity, the secretion of IgA (1 line) and IgG (3...

journal_title：Immunobiology

authors： Wangel AG,Arvilommi H,Jokinen I

更新日期：1985-09-01 00:00:00

abstract：:Intestinal epithelial cells produce cytokines in response to bacterial peptidoglycan (PGN), which is detected by several classes of pattern-recognition receptors (PRRs) as peptidoglycan recognition proteins (PGlyRPs), Toll-like receptor 2 (TLR2) and NOD receptors. All types of PGlyRPs recognize bacterial peptidoglycan...

journal_title：Immunobiology

authors： Zenhom M,Hyder A,de Vrese M,Heller KJ,Roeder T,Schrezenmeir J

更新日期：2012-04-01 00:00:00

abstract：:To recognize patients with inhibitory and neutralizing auto-antibodies to interferon-γ (AutoAbs-IFN-γ) presenting with the sporadic phenotype of Mendelian Susceptibility to Mycobacterial Disease (MSMD) mainly characterized by recurrent intracellular mycobacterium or/and salmonella infections, we comprehensively invest...

journal_title：Immunobiology

authors： Lee WI,Huang JL,Wu TS,Lee MH,Chen IJ,Yu KH,Liu CY,Yang CH,Hsieh MY,Lin YL,Shih YF,Jaing TH,Huang SC,Kuo TT,Ku CL

更新日期：2013-05-01 00:00:00

abstract：:Cytotoxicity and production of cytokines are two important functions of NK cells. These two different NK functions were studied in a syngeneic rat model in relation to MHC class I expression. We focussed on the mechanism by which NK cells modulate MHC class I expression on target cells and how this interferes with NK ...

journal_title：Immunobiology

authors： Jonges LE,Giezeman-Smits KM,van Vlierberghe RL,Ensink NG,Hagenaars M,Joly E,Eggermont AM,van de Velde CJ,Fleuren GJ,Kuppen PJ

更新日期：2000-11-01 00:00:00

abstract：:We have examined the role of CD26 (dipeptidyl peptidase IV) in the adhesion of resting and activated T lymphocytes to endothelial cells and fibroblasts. For this purpose, we ran a short-time adhesion assay under different strategies: Adhesion of T lymphocytes was determined in the presence of different anti-CD26 monoc...

journal_title：Immunobiology

authors： Mattern T,Reich C,Schönbeck U,Ansorge S,Demuth HU,Loppnow H,Ulmer AJ,Flad HD

更新日期：1998-02-01 00:00:00

abstract：:L-alanine was shown earlier to play a significant role for the proliferation of lymphocytes in vitro. In the present work the effect of L-alanine and some other amino acids on thymocyte proliferation was studied in vivo by local administration into one thymus lobe of guinea pigs. Proliferating cells were pulse labelle...

journal_title：Immunobiology

authors： Hägglund B,Sandberg G

更新日期：1993-06-01 00:00:00

abstract：:In bitches, the onset of pyometra, an infection of the uterus, characteristically occurs in the first half of the diestrous stage in the estrous cycle, in which the blood concentration of progesterone peaks and that of estradiol-17beta is lowest. To investigate the immunological mechanisms governing stage-specific ons...

journal_title：Immunobiology

authors： Sugiura K,Nishikawa M,Ishiguro K,Tajima T,Inaba M,Torii R,Hatoya S,Wijewardana V,Kumagai D,Tamada H,Sawada T,Ikehara S,Inaba T

更新日期：2004-01-01 00:00:00

abstract：:CD45RA monoclonal antibodies recognize the higher molecular weight isoforms (220 and 205 kDa) of leukocyte common antigen family (CD45), which are typically expressed on B cells and unstimulated T cells. We have found that there are at least three distinct CD45RA monoclonal antibodies which react with platelet 42 kDa ...

journal_title：Immunobiology

authors： Holada K,Dyr JE,Koubek K,Suttnar J,Simák J

更新日期：1995-02-01 00:00:00

abstract：:Toll-like receptors (TLR) initiate innate and often affect adaptive immune response. This study aimed to determine if TLR response and T regulatory cell (Treg) function in peripheral blood mononuclear cells (PBMC) correlate with clinical severity in non-infectious asthma. TLR1-9 expression and representative response ...

journal_title：Immunobiology

authors： Lee WI,Yao TC,Yeh KW,Chen LC,Ou LS,Huang JL,PATCH Study Group.

更新日期：2013-02-01 00:00:00

abstract：:The part played by MHC antigens on lymphocyte homing has been investigated by inducing modifications of their expression on lymphoid cells. A significant, though moderate, enhancement of H-2 antigen expression has been observed following in vitro treatment of lymphocytes with alpha-IFN. A decrease has been obtained af...

journal_title：Immunobiology

authors： Navarro J,El Ansary M,Royo C,de Maeyer E,Touraine JL

更新日期：1984-12-01 00:00:00

abstract：:Recently, it could be shown that Cyclosporin A (CsA) inhibited the activation of T and B lymphocytes by interfering with an early step of the activation, namely the stimulation of the plasma membrane-bound lysophosphatide acyltransferase. In this report, we compared three CsA-derivatives, Dihydro-Cyclosporin C (Dihydr...

journal_title：Immunobiology

authors： Kroggel R,Goppelt-Strübe M,Martin M,Resch K

更新日期：1987-09-01 00:00:00

abstract：:Neopterin is produced in large amounts specifically from macrophages upon stimulation with interferon-gamma (IFN-gamma). Measurement of neopterin allows a direct in vivo quantification of T cell activation. This is particularly useful, e.g., in early diagnosis of graft rejection. Since disease states with elevated neo...

journal_title：Immunobiology

authors： Fuchs D,Ebell W,Friedrich W,Hausen A,Reibnegger G,Werner ER,Wachter H

更新日期：1988-04-01 00:00:00

abstract：:Canine visceral leishmaniasis (CVL) is known to affect the cellular immunity of infected dogs, through impairing lymphoproliferation and microbicidal mechanisms. This study examined heme oxygenase-1 (HO-1) and its metabolites, oxidative stress and IL-10 levels in CVL and investigated correlations between these paramet...

journal_title：Immunobiology

authors： Almeida BF,Silva KL,Chiku VM,Leal AA,Venturin GL,Narciso LG,Fink MF,Eugênio FR,Santos PS,Ciarlini PC,Lima VM

更新日期：2017-05-01 00:00:00

abstract：:We studied immunohistological and biochemical aspects of the CD44 molecule with a mAb produced in our lab: GRHL-1. The characteristic expression of this antigen in cells of B lineage was analyzed. This mAb showed identical immunohistological patterns of reactivity to other mAbs included in CD44 cluster, on a variety l...

journal_title：Immunobiology

authors： Collado A,de Andres A,Cañadas E,Ruiz-Cabello F,Gomez O,Pedrinaci S,Garrido F

更新日期：1991-09-01 00:00:00

abstract：:Human T-lymphocyte clones showing proliferative and cytotoxic responses specific for HLA antigens were isolated. To obtain enriched numbers of functionally active colonies, the cells were first sensitized in vitro in a tertiary mixed lymphocyte culture (MLC), using 10 stimulating cells for each responding cell. To ass...

journal_title：Immunobiology

authors： Schendel DJ,Wank R

更新日期：1981-01-01 00:00:00

abstract：:Chitin and β-glucan are conserved throughout evolution in the fungal cell wall and are the most common polysaccharides in fungal species. Together, these two polysaccharides form a structural scaffold that is essential for the survival of the fungus. In the present study, we demonstrated that Aspergillus fumigatus alk...

journal_title：Immunobiology

authors： Dubey LK,Moeller JB,Schlosser A,Sorensen GL,Holmskov U

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Ficolins serve as soluble recognition molecules in the lectin pathway of complement. They are known to participate in the systemic host-response to infection but their role in local pulmonary defence is still incompletely understood. The purpose of this study was to clarify whether acute lung and systemic in...

journal_title：Immunobiology

authors： Plovsing RR,Berg RM,Munthe-Fog L,Konge L,Iversen M,Møller K,Garred P

更新日期：2016-05-01 00:00:00

abstract：:The phenotype frequency of the platelet-specific antigens P1A1/A2 ( = Zw(a,b)) in the German population (N = 711) is 97.75% and 2.25% respectively. The corresponding gene frequencies are P1A1 0.85; P1A2 0.15. The P1A1 determinant is codominantly inherited (19 families; 151 family members). There is a strong gene dosag...

journal_title：Immunobiology

authors： Mueller-Eckhardt C,Marks HJ,Baur MP,Mueller-Eckhardt G

更新日期：1982-02-01 00:00:00

abstract：:Complement component C6 is a part of the lytic membrane attack complex formed during complement activation. Animal modeling to define the role of C5a vs. C5b-9 in human disease has used rodents deficient in C6, yet the molecular basis for the deficiencies has not been ascertained. Oligonucleotides derived from a 493 b...

journal_title：Immunobiology

authors： Bhole D,Stahl GL

更新日期：2004-01-01 00:00:00

abstract：:T-lymphocytes, including Th17-cells and T-cells expressing acetylcholine (ACh), are key components of systemic inflammation in chronic obstructive pulmonary disease (COPD). We investigated whether ACh promotes Th17 cells in COPD. ACh, IL-17A, IL-22, RORγt, FOXP3 expression and AChIL-17A, AChIL-22, AChRORγt coexpressio...

journal_title：Immunobiology

authors： Profita M,Albano GD,Riccobono L,Di Sano C,Montalbano AM,Gagliardo R,Anzalone G,Bonanno A,Pieper MP,Gjomarkaj M

更新日期：2014-05-01 00:00:00