abstract：:Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to aut...

journal_title：Neurotoxicology and teratology

authors： Dzwilewski KLC,Merced-Nieves FM,Aguiar A,Korrick SA,Schantz SL

更新日期：2020-01-01 00:00:00

abstract：:Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...

journal_title：Neurotoxicology and teratology

authors： Kwan LY,Eaton DL,Andersen SL,Dow-Edwards D,Levin ED,Talpos J,Vorhees CV,Li AA

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:General anesthetics (GAs) may exert harmful effects on the developing brain by disrupting neuronal circuit formation. Anesthetics that act on γ-aminobutyric acid (GABA) receptors can interfere with axonal growth cone guidance, a critical process in the assembly of neuronal circuitry. Here we investigate the ...

journal_title：Neurotoxicology and teratology

authors： Xu J,Xu M,Wang Y,Mathena RP,Wen J,Zhang P,Furmanski O,Mintz CD

更新日期：2019-01-01 00:00:00

abstract：:Adolescence is a period of dramatic neural reorganization creating a period of vulnerability and the possibility for the development of psychopathology. The maturation of various neural circuits during adolescence depends, to a large degree, on one's experiences both physical and psychosocial. This occurs through a pr...

journal_title：Neurotoxicology and teratology

authors： Dow-Edwards D,MacMaster FP,Peterson BS,Niesink R,Andersen S,Braams BR

更新日期：2019-01-01 00:00:00

abstract：:Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...

journal_title：Neurotoxicology and teratology

authors： Morris-Schaffer K,Sobolewski M,Welle K,Conrad K,Yee M,O'Reilly MA,Cory-Slechta DA

更新日期：2018-01-01 00:00:00

abstract：:Human exposure to organophosphate flame retardants (OPFRs) is widespread, including pregnant women and young children with whom developmental neurotoxic risk is a concern. Given similarities of OPFRs to organophosphate (OP) pesticides, research into the possible neurotoxic impacts of developmental OPFR exposure has be...

journal_title：Neurotoxicology and teratology

authors： Oliveri AN,Ortiz E,Levin ED

更新日期：2018-01-01 00:00:00

abstract：:Zebrafish behavioral model is a powerful tool for neuroscience research. Behavioral changes in the zebrafish are studied by administering drugs. With the aid of automated and open-source MATLAB program, high-accuracy tracking of zebrafish can be achieved, and the important behavioral parameters can be calculated. Alth...

journal_title：Neurotoxicology and teratology

authors： Biswas S,Balodia N,Bellare J

更新日期：2018-01-01 00:00:00

abstract：:In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedron...

journal_title：Neurotoxicology and teratology

authors： Naseri G,Fazel A,Golalipour MJ,Haghir H,Sadeghian H,Mojarrad M,Hosseini M,Shahrokhi Sabzevar S,Beheshti F,Ghorbani A

更新日期：2018-01-01 00:00:00

abstract：:Ethanol alters the homeostasis between excitatory and inhibitory neurotransmitters and its intoxication reveals adenosine as responsible to modify several responses including signal transduction. Zebrafish has been recently investigated for knowledge the prolonged effect of ethanol on behavioral and biochemical parame...

journal_title：Neurotoxicology and teratology

authors： Rico EP,Rosemberg DB,Berteli JFA,da Silveira Langoni A,Souto AA,Bogo MR,Bonan CD,Souza DO

更新日期：2018-01-01 00:00:00

abstract：:The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric ...

journal_title：Neurotoxicology and teratology

authors： Li AA,Sheets LP,Raffaele K,Moser V,Hofstra A,Hoberman A,Makris SL,Garman R,Bolon B,Kaufmann W,Auer R,Lau E,Vidmar T,Bowers WJ

更新日期：2017-09-01 00:00:00

abstract：:A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...

journal_title：Neurotoxicology and teratology

authors： Mesbah-Oskui L,Penna A,Orser BA,Horner RL

更新日期：2017-05-01 00:00:00

abstract：:Autism is a heterogeneous developmental disorder characterized by impaired social interaction, impaired communication skills, and restricted and repetitive behavior. The abnormal behaviors of these patients can make their anesthetic and perioperative management difficult. Evidence in the literature suggests that some ...

journal_title：Neurotoxicology and teratology

authors： Li C,Schaefer M,Gray C,Yang Y,Furmanski O,Liu S,Worley P,Mintz CD,Tao F,Johns RA

更新日期：2017-01-01 00:00:00

abstract：:Exposure to general anesthetic agents during development has been associated with neurotoxicity and long-term behavioral impairments in rodents and non-human primates. The phenotype of anesthetic-induced cognitive impairment has a robust learning and memory component, however less is known about other psychological do...

journal_title：Neurotoxicology and teratology

authors： Murphy KL,McGaughy J,Croxson PL,Baxter MG

更新日期：2017-01-01 00:00:00

abstract：:The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested have been shown to cause abnormal brain cell death in animals...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Liu F,Slikker W Jr,Wang C,Paule MG

更新日期：2017-01-01 00:00:00

abstract：:Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term effects of this drug on the central nervous system (CNS) are not well understood, we conducted microPET/CT scans on young adult male rhesus monkeys (n=4/group) to gather in...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Newport GD,Callicott R,Liu S,Thompson J,Berridge MS,Apana SM,Slikker W Jr,Wang C,Paule MG

更新日期：2016-07-01 00:00:00

abstract：:Chemical warfare nerve agents (CWNAs) are known to cause behavioral abnormalities in cases of human exposures and in animal models. The behavioral consequences of single exposures to CWNAs that cause observable toxic signs are particularly well characterized in animals; however, less is known regarding repeated smalle...

journal_title：Neurotoxicology and teratology

authors： Smith CD,Lee RB,Moran AV,Sipos ML

更新日期：2016-03-01 00:00:00

abstract：:Understanding the potentially harmful long term consequences of prenatal marijuana exposure is important given the increase in number of pregnant women smoking marijuana to relieve morning sickness. Altered executive functioning is one area of research that has suggested negative consequences of prenatal marijuana exp...

journal_title：Neurotoxicology and teratology

authors： Smith AM,Mioduszewski O,Hatchard T,Byron-Alhassan A,Fall C,Fried PA

更新日期：2016-01-01 00:00:00

abstract：:Cortical thickness abnormalities have been identified in youth using both alcohol and marijuana. However, limited studies have followed individuals pre- and post initiation of alcohol and marijuana use to help identify to what extent discrepancies in structural brain integrity are pre-existing or substance-related. Ad...

journal_title：Neurotoxicology and teratology

authors： Jacobus J,Castro N,Squeglia LM,Meloy MJ,Brumback T,Huestis MA,Tapert SF

更新日期：2016-01-01 00:00:00

abstract：:Amitraz is a formamidine pesticide that has been reported to be a neurotoxic compound that induces convulsions among other effects. Excitatory and inhibitory neurotransmission is mediated mainly by glutamate and GABA, respectively, so their alteration could be responsible for induction of seizures. In this regard, ami...

journal_title：Neurotoxicology and teratology

authors： Del Pino J,Frejo MT,Baselga MJ,Moyano P,Díaz MJ

更新日期：2015-07-01 00:00:00

abstract：:Methylphenidate (MPD) is a dopamine uptake inhibitor and the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder in children. Several studies have shown that such stimulants as cocaine and amphetamine that are administered during gestation and lactation may disrupt maternal beha...

journal_title：Neurotoxicology and teratology

authors： Ponchio RA,Teodorov E,Kirsten TB,Coelho CP,Oshiro A,Florio JC,Bernardi MM

更新日期：2015-07-01 00:00:00

abstract：:Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brai...

journal_title：Neurotoxicology and teratology

authors： Oliveira-Pinto J,Paes-Branco D,Cristina-Rodrigues F,Krahe TE,Manhães AC,Abreu-Villaça Y,Filgueiras CC

更新日期：2015-07-01 00:00:00

abstract：:Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...

journal_title：Neurotoxicology and teratology

authors： Habr SF,Macrini DJ,Florio JC,Bernardi MM

更新日期：2014-11-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are hypothesized to play a pathogenic role in aging and age-related neurodegenerative diseases such as Parkinson's disease (PD). In support of this, high levels of somatic mtDNA mutations in “POLG mutator” mice carrying a proofreading-deficient form of mtDNA polymerase ã (Polg(D257A...

journal_title：Neurotoxicology and teratology

authors： Dai Y,Clark J,Zheng K,Kujoth GC,Prolla TA,Simon DK

更新日期：2014-11-01 00:00:00

abstract：:Disruptive Behavior Disorders (DBD) exhibit a sex-biased prevalence rate favoring boys, and prenatal testosterone exposure appears to be part of the complex etiology of these disorders. The current study examines whether high prenatal testosterone exposure may heighten the risk for DBD symptoms in males by increasing ...

journal_title：Neurotoxicology and teratology

authors： Martel MM,Roberts BA

更新日期：2014-07-01 00:00:00

abstract：:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...

journal_title：Neurotoxicology and teratology

authors： Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Exposures to hydrogen sulfide gas (H2S) have been inconclusively linked to a variety of negative cognitive outcomes. We investigated possible effects on cognitive function in an urban population with chronic, low-level exposure to H2S. METHODS:Participants were 1637 adults, aged 18-65 years from Rotorua cit...

journal_title：Neurotoxicology and teratology

authors： Reed BR,Crane J,Garrett N,Woods DL,Bates MN

更新日期：2014-03-01 00:00:00

abstract：:The present study was designed to investigate the in vivo effects of monosodium glutamate (MSG) and aspartame (ASM) individually and in combination on the cognitive behavior and biochemical parameters like neurotransmitters and oxidative stress indices in the brain tissue of mice. Forty male Swiss albino mice were ran...

journal_title：Neurotoxicology and teratology

authors： Abu-Taweel GM,A ZM,Ajarem JS,Ahmad M

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:We have previously reported the inverse associations between in utero levels of lead (Pb), arsenic (As) (i.e., toxic elements), and neurodevelopmental indicators (i.e., motor and state regulation cluster score) measured by the Brazelton Neonatal Behavioral Assessment Scale, third edition (NBAS III) in this c...

journal_title：Neurotoxicology and teratology

authors： Parajuli RP,Fujiwara T,Umezaki M,Furusawa H,Watanabe C

更新日期：2014-01-01 00:00:00

abstract：:This population-based retrospective cohort study examined Structural Magnetic Resonance Imaging (MRI) of the brain in relation to prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water on Cape Cod, Massachusetts. Subjects were identified through birth records from 1969 through 1...

journal_title：Neurotoxicology and teratology

authors： Janulewicz PA,Killiany RJ,White RF,Martin BM,Winter MR,Weinberg JM,Aschengrau A

更新日期：2013-07-01 00:00:00

abstract：:Early-life exposures to brominated diphenyl ethers (BDEs) lead to neurobehavioral abnormalities later in life. Although these agents are thyroid disruptors, it is not clear whether this mechanism alone accounts for the adverse effects. We evaluated the impact of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) on PC12 cel...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Card J,Infante A,Seidler FJ

更新日期：2013-05-01 00:00:00

abstract：:Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic proj...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ

更新日期：2013-03-01 00:00:00

abstract：:Zebrafish provide a powerful model of the impacts of embryonic toxicant exposure on neural development that may result in long-term behavioral dysfunction. In this study, zebrafish embryos were treated with 1.5mM strychnine for short embryonic time windows to induce transient changes in inhibitory neural signaling, an...

journal_title：Neurotoxicology and teratology

authors： Roy NM,Arpie B,Lugo J,Linney E,Levin ED,Cerutti D

更新日期：2012-11-01 00:00:00

abstract：:The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms...

journal_title：Neurotoxicology and teratology

authors： de Esch C,Slieker R,Wolterbeek A,Woutersen R,de Groot D

更新日期：2012-11-01 00:00:00

abstract：:Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder, bent spine and yolk-sac...

journal_title：Neurotoxicology and teratology

authors： Chen J,Chen Y,Liu W,Bai C,Liu X,Liu K,Li R,Zhu JH,Huang C

更新日期：2012-11-01 00:00:00

abstract：:Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of various types of cancer. Patients undergoing cisplatin treatment often suffer from a condition known as "chemobrain", ototoxicity, peripheral neuropathy, weight loss, nausea, vomiting, nephrotoxicity, seizures, hearing loss and tinni...

journal_title：Neurotoxicology and teratology

authors： Gopal KV,Wu C,Shrestha B,Campbell KC,Moore EJ,Gross GW

更新日期：2012-09-01 00:00:00

abstract：:A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....

journal_title：Neurotoxicology and teratology

authors： Paule MG,Green L,Myerson J,Alvarado M,Bachevalier J,Schneider JS,Schantz SL

更新日期：2012-03-01 00:00:00

abstract：:In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM pCPA for 24h and subsequently rescued...

journal_title：Neurotoxicology and teratology

authors： Airhart MJ,Lee DH,Wilson TD,Miller BE,Miller MN,Skalko RG,Monaco PJ

更新日期：2012-01-01 00:00:00

abstract：:Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental ...

journal_title：Neurotoxicology and teratology

authors： Silva L,Zhao N,Popp S,Dow-Edwards D

更新日期：2012-01-01 00:00:00

abstract：:4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

journal_title：Neurotoxicology and teratology

authors： Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

更新日期：2011-11-01 00:00:00

abstract：:The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the...

journal_title：Neurotoxicology and teratology

authors： Win-Shwe TT,Kunugita N,Yoshida Y,Fujimaki H

更新日期：2011-09-01 00:00:00