abstract：OBJECTIVE:We investigated the semiology of focal onset bilateral motor (convulsive) seizure (FBMS) in patients with intractable focal epilepsy who underwent epilepsy surgery to understand its value in localizing the origin of the seizure. METHODS:The study included 20 patients who underwent resective surgery after int...

journal_title：Epilepsy research

authors： Punyawai P,Usui N,Kondo A,Ichikawa N,Tottori T,Terada K,Takahashi Y,Inoue Y

更新日期：2021-01-07 00:00:00

abstract：:Periventricular nodular heterotopia (PNH) is characterized by disabled neural migration and is usually associated with epilepsy. Despite awareness of PNH-related epilepsy, little is known about the brain-level underlying functional neural bases. Thus, we used functional magnetic resonance imaging (MRI) to examine the ...

journal_title：Epilepsy research

authors： Liu W,Yue Q,Tian Y,Gong Q,Zhou D,Wu X

更新日期：2021-01-05 00:00:00

abstract：PURPOSE:We retrospectively analyzed the seizure characteristics, EEG pattern, treatment, and outcome in a series of patients with self-limited epilepsy with centrotemporal spikes (SLECTS) who presented with unusual clinical manifestations. METHOD:A retrospective, descriptive, multicenter study was conducted evaluating...

journal_title：Epilepsy research

authors： Galicchio S,Espeche A,Cersosimo R,Chacon S,Gamboni B,Adi J,Fasulo L,Semprino M,Fortini S,Cachia P,Caraballo RH

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To assess the correlation between time of day and sleep-wake state prior to seizure onset for seizures recorded in an inpatient epilepsy monitoring unit. METHODS:We prospectively enrolled a consecutive series of patients undergoing inpatient epilepsy monitoring. For each epileptic seizure recorded, continuou...

journal_title：Epilepsy research

authors： Ha KH,Schomer AC,Leonardo J,Quigg M

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To study the pregnancy outcomes, including obstetric complications and fetal outcomes, in pregnant women with epilepsy (WWE) treated with direct brain-responsive neurostimulation (RNS System). METHODS:Retrospective review of obstetric outcomes and fetal outcomes in WWE treated with the RNS System at nine com...

journal_title：Epilepsy research

authors： Li Y,Eliashiv D,LaHue SC,Rao VR,Martini ML,Panov F,Oster JM,Yoshii-Contreras J,Skidmore CT,Kalayjian LA,Millett D,Meador KJ

更新日期：2021-01-01 00:00:00

abstract：:Fits of audiogenic seizures in rodents are considered as a model for generalized convulsive epilepsies in humans. The laminar distribution of the H3 histamine receptor binding densities was quantified in the motor cortex of two strains of rats with genetically determined generalized epilepsies, namely KM rats with aud...

journal_title：Epilepsy research

authors： Midzyanovskaya IS,Petrenko TE,Birioukova LM,Tuomisto LM

更新日期：2020-12-25 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated in the pathogenesis of epilepsy and consequently as targets for anticonvulsant drugs. Consistent with this, broad-spectrum block of HCN-mediated current (Ih) reduces seizure susceptibility in a variety of epilepsy models. However, ...

journal_title：Epilepsy research

authors： Kharouf Q,Pinares-Garcia P,Romanelli MN,Reid CA

更新日期：2020-12-01 00:00:00

abstract：:Interpreting electrocorticography (ECoG) in the context of neuroimaging requires that multimodal information be integrated accurately. However, the implantation of ECoG electrodes can shift the brain impacting the spatial interpretation of electrode locations in the context of pre-implant imaging. We characterized the...

journal_title：Epilepsy research

authors： Foldes ST,Munter BT,Appavu BL,Kerrigan JF,Adelson PD

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Epilepsy is among the more stigmatising diseases, leading to a negative impact on the quality of life (QoL) of people with epilepsy (PWE). Assessment of the QoL and stigma in PWE reflects the outcome of their disease, and the findings can be used to improve the management of epilepsy. To fill a gap in the li...

journal_title：Epilepsy research

authors： Mroueh L,Boumediene F,Jost J,Ratsimbazafy V,Preux PM,Salameh P,Al-Hajje A

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:The objectives of this study were to determine the inheritance pattern by which familial mesial temporal lobe epilepsy (FMTLE) is segregated in Mexican families, and to identify if there was an association between the clinical characteristics and the inheritance pattern. METHOD:We included a total of 25 famili...

journal_title：Epilepsy research

authors： Guzmán-Jiménez DE,Campos JB,Venegas-Vega CA,Sánchez MA,Velasco AL

更新日期：2020-11-01 00:00:00

abstract：:Post-stroke paroxysmal activity is a neurophysiological indicator of epileptogenesis and increase of seizure susceptibility, so treatments with neuroprotective activity and anti-paroxysmal activity can be more beneficial during post-ischemic period. The goal of this study was evaluation of levetiracetam (100 mg/kg, 7 ...

journal_title：Epilepsy research

authors： Litvinova SA,Kutepova IS,Voronina TA,Petrunina АА

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:Aphasic status epilepticus (ASE), although rare, may often remain underdiagnosed. We aimed to report the patients diagnosed with ASE and describe their clinical presentation, etiology, electrophysiological findings, neuroimaging, treatment options, and outcome. METHODS:We retrospectively analyzed a series of...

journal_title：Epilepsy research

authors： Azman F,Tezer FI,Saygi S

更新日期：2020-11-01 00:00:00

abstract：:The ketogenic diet has been used to treat intractable epilepsy for many years, yet the mechanism(s) underlying its effectiveness have not been completely elucidated. However, emerging evidence indicates that the ketogenic diet may correct or otherwise alter a 'dystopic' gut microbiota that exhibits altered fecal micro...

journal_title：Epilepsy research

authors： Pittman QJ

更新日期：2020-10-01 00:00:00

abstract：:Epilepsy affects about 1 % of the world population. Mesial temporal lobe epilepsy (mTLE) presents with seizures initiated in hippocampus and is the most frequent form of epilepsy. About 30 % of individuals with mTLE do not respond to conventional medications maintaining seizures and consequently new lesions on a daily...

journal_title：Epilepsy research

authors： Miranda DM,Rosa DV,Costa BS,Nicolau NF,Magno LAV,de Paula JJ,Romano-Silva MA

更新日期：2020-10-01 00:00:00

abstract：:Periodic lateralized epileptiform discharges (PLEDs) or lateralized periodic discharges (LPDs) are a well-known variant of pathological EEG activity. However, the mechanisms underpinning the appearance of this pattern are not completely understood. The heterogeneity of the features derived from LPDs patterns, and the ...

journal_title：Epilepsy research

authors： Chegodaev D,Pavlova NV,Pavlova P,Lvova O

更新日期：2020-10-01 00:00:00

abstract：:Vigabatrin increases GABA concentrations by inhibiting GABA transaminase. In previous studies, it was shown that vigabatrin increases the incidence of Spike and Wave Discharges (SWD) in the WAG/Rij rat model for absence epilepsy. Since following a single dose of vigabatrin GABA concentrations are known to be increased...

journal_title：Epilepsy research

authors： Perescis MFJ,van Luijtelaar G,van Rijn CM

更新日期：2020-09-01 00:00:00

abstract：:Quantifying epileptiform discharges before and after the initiation of treatment can be useful for evaluating the efficacy of antiepileptic drugs in generalized epilepsy. The aim of this study was to determine if the selective α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor antagonist perampanel ...

journal_title：Epilepsy research

authors： Montoya Gutiérrez FJ,Díaz Román M,Cerveró Albert D

更新日期：2020-09-01 00:00:00

abstract：:Although accumulating evidence indicates that the immunomodulatory medication thalidomide exerts anticonvulsant properties, the mechanisms underlying such effects of thalidomide are still unknown. Our previous preclinical study suggested that nitric oxide (NO) signaling may be involved in the anticonvulsant effects of...

journal_title：Epilepsy research

authors： Pourshadi N,Rahimi N,Ghasemi M,Faghir-Ghanesefat H,Sharifzadeh M,Dehpour AR

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:GRIN-related developmental-epileptic encephalopathies are associated with a spectrum of neurodevelopmental disorders, including intellectual disability, epilepsy including continuous spike-and-wave during sleep syndrome (CSWS), or epilepsy-aphasia spectrum phenotypes such as in Landau-Kleffner syndrome. Effi...

journal_title：Epilepsy research

authors： Hausman-Kedem M,Menascu S,Greenstein Y,Fattal-Valevski A

更新日期：2020-07-01 00:00:00

abstract：:Use of non-vitamin K antagonist oral anticoagulants (NOACs), including dabigatran etexilate, rivaroxaban, apixaban, edoxaban or betrixaban provides a safe and convenient alternative to the traditional anticoagulation with vitamin K antagonists or heparin derivatives. Many patients receiving long-term seizure prophylax...

journal_title：Epilepsy research

authors： Taha M,Li W,Schmidt CM,Gonzalez-Castellon M,Taraschenko O

更新日期：2020-05-01 00:00:00

abstract：:Seizures that occur during early development are associated with adverse neurodevelopmental outcomes. Causation and mechanisms are currently under investigation. Induction of an early life seizure by kainic acid (KA) in immature rats on post-natal day (P) 7 results in behavioral changes in the adult rat that reflect s...

journal_title：Epilepsy research

authors： O'Leary H,Vanderlinden L,Southard L,Castano A,Saba LM,Benke TA

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:To determine the feasibility of using epileptiform events detected by continuous electrocorticographic monitoring via a brain-responsive neurostimulation system to supplement patient-maintained seizure diaries. METHODS:Data were retrospectively analyzed from a randomized controlled trial of brain-responsive ne...

journal_title：Epilepsy research

authors： Quigg M,Skarpaas TL,Spencer DC,Fountain NB,Jarosiewicz B,Morrell MJ

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To assess functional organization of the motor cortex in patients with Unverricht-Lundborg disease (EPM1A) using a combined neurophysiologic and imaging approach. METHODS:EPM1A patients underwent transcranial magnetic stimulation (TMS)-based cortical mapping of the motor hand area. Moreover, they performed n...

journal_title：Epilepsy research

authors： Rossi Sebastiano D,Visani E,Contarino VE,Panzica F,Duran D,D'Incerti L,Franceschetti S,Canafoglia L

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Prior research has shown that people with epilepsy are at risk for a poorer health-related quality of life (HRQOL). However, patients differ greatly in how well they adjust to their epilepsy. To better understand these differences, the present study examined the role of personality. More specifically, we e...

journal_title：Epilepsy research

authors： Rassart J,Luyckx K,Verdyck L,Mijnster T,Mark RE

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:We aim to delineate the genetic and clinical features of SCN8A developmental and epileptic encephalopathy. METHODS:Nine patients with SCN8A developmental and epileptic encephalopathy were included in this study. Genetic and clinical features and effectiveness of sodium channel blockers were assessed in patie...

journal_title：Epilepsy research

authors： Kim HJ,Yang D,Kim SH,Kim B,Kim HD,Lee JS,Choi JR,Lee ST,Kang HC

更新日期：2019-12-01 00:00:00

abstract：:NMDA, AMPA, and kainate receptors are the principal excitatory receptors in the brain. These receptors have been considered as the main targets in the treatment of epilepsy in recent years. This work aimed to determine how the Ca2+ conductivity of ionotropic glutamate receptors and voltage-gated Ca2+ channels changes ...

journal_title：Epilepsy research

authors： Gaidin SG,Zinchenko VP,Teplov IY,Tuleukhanov ST,Kosenkov AM

更新日期：2019-12-01 00:00:00

abstract：:In the immature brain the neurotransmitter γ-amino butyric acid (GABA) mediates a membrane depolarization and can contribute to both, inhibition and excitation. Therefore the consequences of a positive modulation of GABA(A) receptors by neurosteroids on epileptiform activity are hard to predict. In order to analyze wh...

journal_title：Epilepsy research

authors： Sharopov S,Winkler P,Uehara R,Lombardi A,Halbhuber L,Okabe A,Luhmann HJ,Kilb W

更新日期：2019-11-01 00:00:00

abstract：OBJECTIVE:To describe the use of a population pharmacokinetic (PopPK) model incorporating weight and ontogeny to identify effective clobazam (CLB) dosing for use in a clinical trial in pediatric patients with Dravet syndrome. METHODS:Pharmacokinetic data were combined from 3 CLB trials (OV-1012, OV-1017, and study 301...

journal_title：Epilepsy research

authors： Tolbert D,Chu HM,Ette EI

更新日期：2019-11-01 00:00:00

abstract：AIM:Vitamin D (Vit D) has been considered as a neurosteroid and has a pivotal role in neuroprotection including epilepsy. Vit D regulator acts via a Vit D receptor (VDR). WAG/Rij rats have a genetically epileptic model of absence epilepsy with comorbidity of depression. The aim of the present study was to investigate t...

journal_title：Epilepsy research

authors： Aygun H,Ayyildiz M,Agar E

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:To study the extent and characteristics of dietary and herbal supplements use in a large cohort of adult patients with epilepsy. METHODS:This prospective study included 490 patients receiving care at a university epilepsy clinic. A number of variables, including demographics, characteristics of epilepsy and it...

journal_title：Epilepsy research

authors： Bosak M,Mołek P,Słowik A

更新日期：2019-10-01 00:00:00

abstract：:Infantile spasms (IS) is a developmental and epileptic encephalopathy with heterogeneous etiologies including many genetic causes. Genetic studies have identified pathogenic variants in over 30 genes as causes of IS. Many of these genetic causes are extremely rare, with only one reported incidence in an individual wit...

journal_title：Epilepsy research

authors： Muir AM,Myers CT,Nguyen NT,Saykally J,Craiu D,De Jonghe P,Helbig I,Hoffman-Zacharska D,Guerrini R,Lehesjoki AE,Marini C,Møller RS,Serratosa J,Štěrbová K,Striano P,von Spiczak S,Weckhuysen S,Mefford HC,EuroEPINOMICS-RE

更新日期：2019-10-01 00:00:00

abstract：:The epileptic baboon provides a natural model of idiopathic generalized epilepsy and sudden unexpected death in epilepsy (SUDEP). We sought to evaluate autonomic differences, including heart rate (HR), heart rate variability (HRV) and corrected QT-duration (QTc) between two epileptic (EB1, EB2) and one control (CB) ba...

journal_title：Epilepsy research

authors： de la Garza MA,Poldiak D,Shade R,Salinas FS,Papanastassiou AM,Szabó CÁ

更新日期：2019-09-01 00:00:00

abstract：:Ketamine, a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist, used as an anesthetic has been reported to induce seizures both in humans and baboons predisposed to epilepsy. In this study, we aimed to characterize the acute effects of ketamine on scalp (sc-EEG) and intracranial EEG (ic-EEG) in the baboon...

journal_title：Epilepsy research

authors： Gowda S,Szabó CÁ

更新日期：2019-08-01 00:00:00

abstract：:Neuromodulation therapies represent an important treatment arm for patients with drug-resistant epilepsy (DRE) who are not candidates for resective surgery. Vagus nerve stimulation (VNS) - the neurostimulation modality in focus in this review - was the first available neuromodulatory therapy for DRE and was followed b...

journal_title：Epilepsy research

authors： Dibué-Adjei M,Kamp MA,Vonck K

更新日期：2019-07-01 00:00:00

abstract：:Dietary supplements, herbal medicines, and other foods may affect the pharmacokinetics and/or pharmacodynamics of carbamazepine (CBZ), which may possibly lead to potential drug-drug/herb-drug interactions, as CBZ has a narrow therapeutic window. Sinapic acid (SA) is a bioactive phytoconstituent used as a dietary suppl...

journal_title：Epilepsy research

authors： Raish M,Ahmad A,Ansari MA,Alkharfy KM,Ahad A,Al-Jenoobi FI,Al-Mohizea AM,Khan A,Ali N

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:To assess the long-term safety and efficacy of eslicarbazepine acetate (ESL) monotherapy in adults with focal seizures (FS). METHODS:Study 050 was a long-term, multicenter, open-label (OL) safety extension of two conversion-to-ESL monotherapy studies in adults with refractory FS. After participating in Study...

journal_title：Epilepsy research

authors： Chung S,Sinha SR,Shah A,Stern JM,Cheng H,Jung J,Grinnell T,Blum D

更新日期：2019-07-01 00:00:00

abstract：:We retrospectively analyzed published studies to investigate historical trends in outcome of childhood absence epilepsy (CAE). We included patients based on onset of absence seizures in childhood, 3 Hz bilateral spike-wave discharges on EEG, and availability of seizure-free outcome data. The primary endpoint was seizu...

journal_title：Epilepsy research

authors： Morse E,Giblin K,Chung MH,Dohle C,Berg AT,Blumenfeld H

更新日期：2019-05-01 00:00:00

abstract：:Severe paediatric epilepsies such as CDKL5 Deficiency Disorder (CDD) are extremely debilitating, largely due to the early-onset and refractory nature of the seizures. Existing treatment options are often ineffective and associated with a host of adverse effects, causing those that are affected to seek alternative trea...

journal_title：Epilepsy research

authors： Dale T,Downs J,Olson H,Bergin AM,Smith S,Leonard H

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:There have been no validated Medicare claims-based algorithms available to identify epilepsy by discrete etiology of stroke (e.g., post-stroke epilepsy, PSE) in community-dwelling elderly individuals, despite the increasing availability of large datasets. Our objective was to validate algorithms that detect w...

journal_title：Epilepsy research

authors： Moura LMVR,Smith JR,Blacker D,Vogeli C,Schwamm LH,Hsu J

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Millions of individuals worldwide suffer from epilepsy, and up to 25% of patients have seizures that are resistant to currently available antiepileptic drugs. Hence, there continues to be a need for more seizure medications that are effective yet tolerable. Levodropropizine (LVDP) is an established antitussi...

journal_title：Epilepsy research

authors： Erdogan MA,Yusuf D,Erdogan A,Erbas O

更新日期：2019-02-01 00:00:00