abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) imposes a large burden on the global population and even more so for the elderly who face significant obstacles in the diagnosis, management, and psychosocial effects of the disease. This review describes the current challenges and key points in the managem...

journal_title：Current opinion in pulmonary medicine

authors： Allen B,Aboussouan LS

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review and compare the constellations of causes and consequences of the two current pandemics, Covid-19 and climate change. RECENT FINDINGS:There has been a transient counterbalancing, in which the response to Covid-19 has briefly mitigated pollution and greenhouse gasses. This divergence belies m...

journal_title：Current opinion in pulmonary medicine

authors： Joshi M,Caceres J,Ko S,Epps SM,Bartter T

更新日期：2021-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Disorders of glucose metabolism, including insulin resistance, prediabetes, and diabetes, have been identified as risk factors for worsened asthma. This review summarizes emerging evidence for their role as modifiable risk factors in asthma, including the potential benefit of diabetes medications on a...

journal_title：Current opinion in pulmonary medicine

authors： Wu TD

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer...

journal_title：Current opinion in pulmonary medicine

authors： Abd-Elaziz K,Jesenak M,Vasakova M,Diamant Z

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the recent findings of the last 2 years on the epidemiology and phenotypes of occupational asthma, as well as new developments in its diagnosis and management. RECENT FINDINGS:Data from nine longitudinal studies showed a population attributable fraction for the occupational contribution t...

journal_title：Current opinion in pulmonary medicine

authors： Quirce S,Domínguez-Ortega J,Luna JA

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Obstructive sleep apnea (OSA) has historically been considered as a male disease. As a result, female individuals with OSA were often under-diagnosed and under-treated compared with male individuals. However, recent data suggest that several OSA-associated adverse cardiovascular outcomes are more pron...

journal_title：Current opinion in pulmonary medicine

authors： Schiza SE,Bouloukaki I

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Diagnosis of sleep apnoea was performed in sleep laboratories with polysomnography. This requires a room with supervision and presence of technologists and trained sleep experts. Today, clinical guidelines in most countries recommend home sleep apnoea testing with simple systems using six signals only...

journal_title：Current opinion in pulmonary medicine

authors： Penzel T,Fietze I,Glos M

更新日期：2020-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Need for intensive care in the patient with pulmonary arterial hypertension is associated with high mortality. This review will provide an overview of causes of ICU admission for patients with pulmonary hypertension and provide guidance on management. RECENT FINDINGS:There is a paucity of evidence-ba...

journal_title：Current opinion in pulmonary medicine

authors： Aryal S,King CS

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In previous years, there was limited research related to the role of sleep in interstitial lung diseases (ILDs). Physicians treating ILD patients tended to focus mainly on the daily disabling symptoms overlooking the possible significant role of coexisting sleep disorders, such as obstructive sleep ap...

journal_title：Current opinion in pulmonary medicine

authors： Schiza SE,Bouloukaki I,Bolaki M,Antoniou KM

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Sarcoidosis is a granulomatous systemic disease of unknown cause where the lung is the most frequently affected organ. Therapeutic management of the disease is challenging as clinical presentation and prognosis are very heterogeneous. In the present review, we will summarize the main advances in sarco...

journal_title：Current opinion in pulmonary medicine

authors： Sellarés J,Francesqui J,Llabres M,Hernandez-Gonzalez F,Baughman RP

更新日期：2020-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Patients with lung cancer are particularly vulnerable to lung injury associated with immune checkpoint inhibition and often present with more frequent and more severe manifestations of lung disease compared to patients with other tumor types. The present review explores the reasons for increased susce...

journal_title：Current opinion in pulmonary medicine

authors： Shannon VR

更新日期：2020-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This manuscript reviews the recent literature related to new developments in the understanding of existing and novel virulence factors of the pneumococcus that are of potential importance in the development of novel preventive and therapeutic strategies. RECENT FINDINGS:The pneumococcal capsule and p...

journal_title：Current opinion in pulmonary medicine

authors： Feldman C,Anderson R

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Asthma is a chronic inflammatory disease in which changes in macrophage polarization have been shown to contribute to the pathogenesis. The present review discusses the contribution of changes in macrophage function to asthma related to polarization changes and elaborates on possible therapeutic strat...

journal_title：Current opinion in pulmonary medicine

authors： van der Veen TA,de Groot LES,Melgert BN

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the implementation of precision medicine, based on treatable traits and mechanisms, in the daily clinical management of chronic airways diseases. RECENT FINDINGS:Recent insights into the complex and heterogeneous nature of chronic airway diseases including chronic obstructive ...

journal_title：Current opinion in pulmonary medicine

authors： Ulrik CS,Vijverberg S,Hanania NA,Diamant Z

更新日期：2020-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Obstructive sleep apnea (OSA) is heterogeneous in terms of contributing pathophysiological mechanisms, clinical presentation, and consequences. Different study models from animal models of intermittent hypoxia over case-control, cohort, and population-based observational studies to uncontrolled interv...

journal_title：Current opinion in pulmonary medicine

authors： Schwarz EI

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Pulmonary hypertension has been reported to complicate the course of a number of fibrotic lung diseases, including idiopathic pulmonary fibrosis, chronic hypersensitivity pneumonitis and nonspecific interstitial pneumonitis. Most commonly, mild elevations in the mean pulmonary artery pressure are seen...

journal_title：Current opinion in pulmonary medicine

authors： King CS,Nathan SD

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Malignant pleural effusion is a common cause of breathlessness and signifies advanced disease. Common options for definitive pleural intervention include insertion of an indwelling pleural catheter (IPC) or talc pleurodesis. RECENT FINDINGS:Administration of graded talc through an IPC offers an incre...

journal_title：Current opinion in pulmonary medicine

authors： Dipper A,Bhatnagar R,Maskell N

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the current use of oral corticosteroids (OCS) as a chronic treatment in patients with severe asthma and as a rescue treatment for patients presenting with acute exacerbations. RECENT FINDINGS:Airways disease is responsible for the bulk of OCS use in the community and considerable OCS-assoc...

journal_title：Current opinion in pulmonary medicine

authors： Pavord ID

更新日期：2019-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this article is to provide understanding of renal sarcoidosis, the different types of renal sarcoidosis, disease burden of renal involvement, and treatment options. RECENT FINDINGS:The frequency of renal involvement seems to be underestimated, but renal sarcoidosis represents a relevan...

journal_title：Current opinion in pulmonary medicine

authors： Bergner R,Löffler C

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Telomere attrition has been proposed as one of the aging hallmarks in pulmonary fibrosis. Telomere shortening and telomerase gene mutations have been widely evaluated in recent years. Reduced telomere length may be identified in a quarter of patients with sporadic idiopathic pulmonary fibrosis (IPF) a...

journal_title：Current opinion in pulmonary medicine

authors： Molina-Molina M,Borie R

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:A relatively new class of CD4 expressing T cells that also express and release interleukin-17 (Th17 cells) is gaining attention based on their capacity to regulate inflammatory responses in a spectrum of chronic autoimmune diseases. The purpose of this review is to consider recent studies relating to ...

journal_title：Current opinion in pulmonary medicine

authors： Crouser ED

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Accurate diagnosis of interstitial lung diseases (ILDs) can be challenging, and a substantial percentage of ILD patients remain unclassifiable even after thorough assessment by an experienced multidisciplinary team. In this review, we summarize the recent literature on the definition, prevalence, diag...

journal_title：Current opinion in pulmonary medicine

authors： Guler SA,Ryerson CJ

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Pleural infection remains an important pulmonary disease, causing significant morbidity and mortality. There is a resurgence of disease burden despite introduction of antibiotics and pneumococcal vaccines. A revisit of the pathogenesis and update on intervention may improve the care of pleural infecti...

journal_title：Current opinion in pulmonary medicine

authors： Chan KP,Fitzgerald DB,Lee YCG

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Pleural effusions in patients with hematologic malignancy may represent malignant pleural effusion (MPE) or occur secondary to infection, treatment effects, and other common causes. The impact of MPE on prognosis in this cohort remains unclear. Indwelling pleural catheters (IPCs) are routinely placed ...

journal_title：Current opinion in pulmonary medicine

authors： Vakil E,Jimenez CA,Faiz SA

更新日期：2018-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the current understanding and clinical applicability of severity scoring systems in pneumonia management. RECENT FINDINGS:Severity scores in community-acquired pneumonia are strong markers of mortality, but are not necessarily clinical decision-aid tools. The use of severity scores to sup...

journal_title：Current opinion in pulmonary medicine

authors： Ranzani OT,Taniguchi LU,Torres A

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Chronic obstructive pulmonary disease (COPD) affects over 12 million adults in the United States and is the third leading cause of 30-day readmissions. COPD is costly with almost $50 billion in direct costs annually. Total COPD costs can be up to double the identified direct costs because of comorbid ...

journal_title：Current opinion in pulmonary medicine

authors： Press VG,Konetzka RT,White SR

更新日期：2018-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The article aims to provide an updated and evidence-based review of the innovative electronic health interventions to monitor and improve inhaler technique and adherence to recommended therapy in asthma. RECENT FINDINGS:Out of the 290 articles identified by the search strategy, 23 manuscripts fulfill...

journal_title：Current opinion in pulmonary medicine

authors： Bonini M,Usmani OS

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In cystic fibrosis (CF) patients with end-stage pulmonary disease, lung transplantation (LTx) remains a life-extending therapy with good outcome in most patients. Despite early concern about chronic pretransplantation infections in the context of posttransplantation immunosuppression, typical CF-assoc...

journal_title：Current opinion in pulmonary medicine

authors： Dupont L

更新日期：2017-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Historically, pleural effusions have been attributed to a single cause. There is growing recognition that a substantial proportion of pleural effusions may have more than one underlying cause. The purpose of this review is to summarise recent findings regarding the diagnosis and treatment of effusions...

journal_title：Current opinion in pulmonary medicine

authors： Walker S,Maskell N

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Pleural effusions are frequent in the context of acute idiopathic pericarditis and following pericardiotomy, but they have seldom been characterized. This review summarizes their most relevant clinical features. RECENT FINDINGS:In acute idiopathic pericarditis, pleural effusions tend to be left-sided...

journal_title：Current opinion in pulmonary medicine

authors： Porcel JM

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:After 'curative' resection, many patients are still at risk for further lung cancer, either as a recurrence or a new metachronous primary. In theory, close follow-up should improve survival by catching relapse early - but in reality, many experts feel that surveillance for recurrence is of uncertain v...

journal_title：Current opinion in pulmonary medicine

authors： Chang CF,Gould M

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although currently available drugs to treat asthma are effective in most patients, a proportion of patients do not respond or experience side-effects; which is partly genetically determined. Pharmacogenetics is the study of how genetic variations influence drug response. In this review, we summarize p...

journal_title：Current opinion in pulmonary medicine

authors： Kersten ET,Koppelman GH

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Glucocorticosteroids (GCSs) remain the cornerstone of therapy for treating the inflammatory component of asthma. Clinical response to GCS is heterogeneous, varying both within asthma 'endotypes', as well as the same individual. Different factors and micro-environment can alter the canonical GCS-induce...

journal_title：Current opinion in pulmonary medicine

authors： Mukherjee M,Svenningsen S,Nair P

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Poor adherence to asthma controller medications, particularly inhaled corticosteroids, has been well known for decades and is a major cause of uncontrolled asthma and increased healthcare utilization. This review presents recent evidence on factors leading to nonadherence in specific age groups, paren...

journal_title：Current opinion in pulmonary medicine

authors： Blake KV

更新日期：2017-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article explains the high comorbidity of craniofacial pain (chronic face pain, temporomandibular disorders, and primary headaches) with obstructive sleep breathing disorders and obstructive sleep apnea (OSA). It is recommended that physicians treating OSA should be aware of the concurrent chronic...

journal_title：Current opinion in pulmonary medicine

authors： Olmos SR

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to summarize recent advances in our understanding of the impact sleep disturbances have on our health, with particular focus on the brain. The present review considers the influence of sleep disturbance on the neurovascular unit; the role of sleep disturbance in neurodege...

journal_title：Current opinion in pulmonary medicine

authors： Aguirre CC

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The immunopathogenesis of sarcoidosis is considered to involve contributions from both adaptive and innate immune responses. Although the identification of adaptive responses to candidate pathogenic antigens will elucidate mechanisms that regulate inflammation in sarcoidosis, innate mechanisms likely ...

journal_title：Current opinion in pulmonary medicine

authors： Chen ES

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Medical thoracoscopy provides the physician a window into the pleural space. The procedure allows biopsy of the parietal pleura under direct visualization with good accuracy. In addition, it achieves therapeutic goals of fluid drainage, guided chest tube placement, and pleurodesis. RECENT FINDINGS:Co...

journal_title：Current opinion in pulmonary medicine

authors： Lee P,Mathur PN

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Coal mine workers are at risk for a range of chronic respiratory diseases including coal workers' pneumoconiosis, diffuse dust-related fibrosis, and chronic obstructive pulmonary disease. The purpose of this review is to describe coal mining processes and associated exposures to inform the diagnostic ...

journal_title：Current opinion in pulmonary medicine

authors： Go LH,Krefft SD,Cohen RA,Rose CS

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Classic descriptions of chronic obstructive pulmonary disease (COPD) centered on its impact on respiratory function. It is currently recognized that comorbidities contribute to the severity of symptoms and COPD progression. Understanding COPD-comorbidities associations could provide innovative treatme...

journal_title：Current opinion in pulmonary medicine

authors： Brown JP,Martinez CH

更新日期：2016-03-01 00:00:00