解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Accumulating studies have argued that the mitochondrial unfolded protein response (UPRmt) is a mitochondrial stress response that promotes longevity in model organisms. In the present study, we screened an off-patent drug library to identify compounds that activate UPRmt using a mitochondrial chaperone hsp-6::GFP repo...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09907-6
更新日期:2021-02-01 00:00:00
abstract::The current linear no-threshold paradigm assumes that any exposure to ionizing radiation carries some risk, thus every effort should be made to maintain the exposures as low as possible. We examined whether background radiation impacts human longevity and cancer mortality. Our data covered the entire US population of ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09909-4
更新日期:2021-01-22 00:00:00
abstract::Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-020-09908-5
更新日期:2021-01-09 00:00:00
abstract::Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09891-x
更新日期:2020-12-01 00:00:00
abstract::Regular exercise is an important part of a healthy lifestyle, as it helps maintain a healthy weight and reduces the risk of chronic diseases. We explored the effects of lifelong exercise and aging on rat metabolism through a metabolomics approach. Thirty-six rats were divided into four equal groups: exercise during th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09871-1
更新日期:2020-10-01 00:00:00
abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09867-x
更新日期:2020-06-01 00:00:00
abstract::The present study aimed at evaluating the role of senescent cell microenvironment as an extrinsic causal factor for altered age-associated macrophage functions, and that whether such changes could be ameliorated by the application of tea catechin epigallocatechin gallate (EGCG). To ascertain this, we analyzed the impa...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09861-3
更新日期:2020-06-01 00:00:00
abstract::We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09848-9
更新日期:2020-04-01 00:00:00
abstract::With advancing age, memory declines through different mechanisms including dysregulation of expression of synaptic plasticity genes in hippocampus. Increasing evidences suggest that these synaptic plasticity genes are regulated through epigenetic modifications. Recently we have reported that the neuronal immediate ear...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09850-1
更新日期:2020-04-01 00:00:00
abstract::When mortality (μ), aging rate (γ) and age (t) are treated according to the Gompertz model μ(t) = μ0eγt (GM), any mean age corresponds to a manifold of paired reciprocally changing μ0 and γ. Therefore, any noisiness of data used to derive GM parameters makes them negatively correlated. Besides this artifactual factor ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09828-z
更新日期:2019-12-01 00:00:00
abstract::Longevity is mainly conditioned by genetic, epigenetic and environmental factors. Different genetic modifications seem to be positively associated to longevity, including SNPs in SIRT1, APOE, FOXO3A, ACE, ATM, NOS1 and NOS2 gene. Epigenetic changes as DNA hyper- and hypo-methylation influence significantly human longe...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09824-3
更新日期:2019-10-01 00:00:00
abstract::Cell senescence, a state of cell cycle arrest and altered metabolism with enhanced pro-inflammatory secretion, underlies at least some aspects of organismal ageing. The sirtuin family of deacetylases has been implicated in preventing premature ageing; sirtuin overexpression or resveratrol-mediated activation of sirtui...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09792-0
更新日期:2019-06-01 00:00:00
abstract::Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09796-4
更新日期:2019-06-01 00:00:00
abstract::An increasing amount of data implicate immunity-mostly innate immunity-in the ageing process; both during healthy ageing as well as in neurodegenerative diseases. Despite the aetiology however, the underlying mechanisms are poorly understood. Here we review what we know from model organisms (worms, flies and mice) on ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-019-09801-w
更新日期:2019-06-01 00:00:00
abstract::Senescence-associated secretory phenotype (SASP) plays a role in aging adipose tissue dysfunction by directly promoting chronic inflammation. The JNK/p53 pathway was reported as a potential mechanism that mediates SASP. In this study, we investigated the effects of L-carnitine, an inhibitor of the JNK/p53 pathway in a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9787-z
更新日期:2019-04-01 00:00:00
abstract::The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9785-1
更新日期:2019-04-01 00:00:00
abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09793-z
更新日期:2019-04-01 00:00:00
abstract::Ageing leads to dramatic changes in the physiology of many different tissues resulting in a spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven by highly conserved cell intrinsic processes, and a set of unifying hallmarks of ageing has been defined. Here, we survey reports of age-l...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9750-z
更新日期:2018-12-01 00:00:00
abstract::High-throughput molecular studies are greatly advancing our knowledge of the human microbiome and its specific role in governing health and disease states. A myriad of ongoing studies aim at identifying links between microbial community disequilibria (dysbiosis) and human diseases. However, due to the inherent complex...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9752-x
更新日期:2018-12-01 00:00:00
abstract::CD4+ T cells are important for generating high quality and robust immune responses to influenza infection. Immunosenescence that occurs with aging, however, compromises the ability of CD4+ T cells to differentiate into functional subsets resulting in a multitude of dysregulated responses namely, delayed viral clearanc...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9754-8
更新日期:2018-12-01 00:00:00
abstract::In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9767-3
更新日期:2018-10-01 00:00:00
abstract::Parametric models for survival data help to differentiate aging from other lifespan determinants. However, such inferences suffer from small sizes of experimental animal samples and variable animals handling by different labs. We analyzed control data from a single laboratory where interventions in murine lifespan wer...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9759-3
更新日期:2018-10-01 00:00:00
abstract::In the last decades, studies about ageing have become more essential as our population grows older. The incidence of age-related diseases increases, which pose challenges both for societies and individuals in terms of life quality and economic impact. Understanding ageing and ageing-related processes will help us to s...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-018-9748-6
更新日期:2018-07-01 00:00:00
abstract::Accumulation of advanced glycation end products (AGEs) is accompanied by increased free radical activity which contributes to ageing and the development or worsening of degenerative diseases. Apart from other physiological factors, AGEs are also an important biomarker for premature ageing. Here we report protein modif...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9733-5
更新日期:2018-02-01 00:00:00
abstract::Researchers working in the area of ageing have found numerous manifestations of this process at the molecular biological level, including DNA and protein damage, accumulation of metabolic by-products, lipids peroxidation, macromolecular cross-linking, non-enzymatic glycosylation, anti-oxidant/pro-oxidant misbalance, r...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9728-2
更新日期:2018-02-01 00:00:00
abstract::Aging is associated with changes in several basic parameters of circadian timing system (CTS) in mammals leading to circadian dysfunction. We had reported earlier that upon aging and in rotenone induced Parkinson's disease (RIPD) rat model there were significant alterations in the core clock genes expression levels an...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9711-y
更新日期:2017-08-01 00:00:00
abstract::Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular respon...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-017-9718-4
更新日期:2017-08-01 00:00:00
abstract::Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9675-3
更新日期:2017-04-01 00:00:00
abstract::An organism's well-being is facilitated by numerous molecular and biochemical pathways that ensure homeostasis within cells and tissues. Aging causes a gradual let-down in the maintenance of homeostasis due to various endogenous and environmental challenges, leading to amassing of damages, functional deterioration of ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-016-9670-8
更新日期:2017-02-01 00:00:00
abstract::Deterioration of adipocyte function due to increased oxidative stress predisposes patients to metabolic disorders in advanced age. However, the roles of tumor suppressors in such conditions remain largely unknown. Therefore, we aimed to address their dynamics in aged adipocytes using a long-term culture model. We comp...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9661-9
更新日期:2017-02-01 00:00:00
abstract::Death-associated protein 6 (DAXX) is a ubiquitous protein implicated in various cellular processes such as apoptosis, tumorigenesis, development and transcription. The role of DAXX is however ambiguous and many contradictory results regarding its function in apoptosis upon various cellular stresses are described in th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9651-y
更新日期:2016-11-01 00:00:00
abstract::In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9656-6
更新日期:2016-11-01 00:00:00
abstract::Behavioral symptoms of sickness, such as fever and motor activity are a coordinated set of changes that develop during infection. The aim of study was to compare the sickness behaviour (SB) in healthy old and young rats treated with pyrogenic dose of endotoxin and to check their glutathione level. Before experimentati...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9636-x
更新日期:2016-08-01 00:00:00
abstract::Obesity is associated with functional limitations in muscle performance and increased likelihood of developing a functional disability such as mobility, strength, postural and dynamic balance limitations. The consensus is that obese individuals, regardless of age, have a greater absolute maximum muscle strength compar...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9626-4
更新日期:2016-06-01 00:00:00
abstract::FVB/N wild type and transgenic HER-2/neu FVB/N female mice breed at N.N. Petrov Research Institute of Oncology were under observation until natural death without any special treatment. Age-related dynamics of body weight, food consumption and parameters of carbohydrate and lipid metabolism, level of nitric oxide, malo...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9611-y
更新日期:2016-04-01 00:00:00
abstract::Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of ge...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9600-1
更新日期:2016-02-01 00:00:00
abstract::Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed progerin. Progerin expression alters the organization of the nuclear lamina and chromatin. The life expectancy of HGPS patients is severe...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9602-z
更新日期:2016-02-01 00:00:00
abstract::Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9592-x
更新日期:2015-12-01 00:00:00
abstract::Our previous findings indicate that the gastrocnemius muscle of aging rats exhibits impairments of muscle quality (force/unit muscle tissue) and autophagy and increased sarcoplasmic reticulum stress. The purpose of this study was to examine age-related changes in soleus muscle contractility and in markers of autophagy...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9598-4
更新日期:2015-12-01 00:00:00
abstract::The theory that accumulation of reactive oxygen species (ROS) in internal organs is a major promoter of aging has been considered negatively. However, it is still controversial whether overexpression of superoxide dismutases (SODs), which remove ROS, extends the lifespan in Drosophila adults. We examined whether ROS a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9570-3
更新日期:2015-08-01 00:00:00