Abstract:
:Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a de novo genetic mutation that leads to the accumulation of a splicing isoform of lamin A termed progerin. Progerin expression alters the organization of the nuclear lamina and chromatin. The life expectancy of HGPS patients is severely reduced due to critical cardiovascular defects. Progerin also accumulates in an age-dependent manner in the vascular cells of adults that do not carry genetic mutations associated with HGPS. The molecular mechanisms that lead to vascular dysfunction in HGPS may therefore also play a role in vascular aging. The vascular phenotypic and molecular changes observed in HGPS are strikingly similar to those seen with age, including increased senescence, altered mechanotransduction and stem cell exhaustion. This article discusses the similarities and differences between age-dependent and HGPS-related vascular aging to highlight the relevance of HGPS as a model for vascular aging. Induced pluripotent stem cells derived from HGPS patients are suggested as an attractive model to study vascular aging in order to develop novel approaches to treat cardiovascular disease.
journal_name
Biogerontologyjournal_title
Biogerontologyauthors
Brassard JA,Fekete N,Garnier A,Hoesli CAdoi
10.1007/s10522-015-9602-zsubject
Has Abstractpub_date
2016-02-01 00:00:00pages
129-45issue
1eissn
1389-5729issn
1573-6768pii
10.1007/s10522-015-9602-zjournal_volume
17pub_type
杂志文章,评审相关文献
BIOGERONTOLOGY文献大全abstract::The effects of oxidative stress (OS) on the rat erythrocytes (RBCs) that were fractionated on the percoll/BSA gradient into young and old cells were studied to find out if the altered Na+/H+ and Cl⁻/ HCO3⁻ antiporters and in turn the intracellular pH (pHi) could act as one of the promoters of cell death. Old cells wer...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9212-8
更新日期:2009-12-01 00:00:00
abstract::Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-011-9343-6
更新日期:2011-12-01 00:00:00
abstract::Hormesis is any kind of biphasic dose-response when low doses of some agents are beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly investigated among all hormesis-like phenomena, in particular in biogerontology. In this review, we aimed to summarize research evidence supporting h...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-020-09908-5
更新日期:2021-01-09 00:00:00
abstract::Glycolysis and oxidative phosphorylation (OxPhos) are the two major mechanisms involved in brain energetics. In this article we propose that the sporadic forms of Alzheimer's disease (AD) are driven by age-related damage to macromolecules and organelles which results in the following series of dynamic processes. (1) M...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9403-6
更新日期:2012-12-01 00:00:00
abstract::Recent evidence suggests that high dose and/or long term use of proton pump inhibitors (PPIs) may increase the risk of adverse cardiovascular events in older patients, but mechanisms underlying these detrimental effects are not known. Taking into account that the senescent endothelial cells have been implicated in the...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9675-3
更新日期:2017-04-01 00:00:00
abstract::Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9251-1
更新日期:2010-06-01 00:00:00
abstract::During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9230-6
更新日期:2010-02-01 00:00:00
abstract::Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major public health issue. Sarcopenia is associated with an increased risk of falls, disability, dependency, institutionalization, hospital stay and early death. Finding interventions to stabilize, reverse or prevent sarcopenia is therefore a ke...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-09793-z
更新日期:2019-04-01 00:00:00
abstract::Chronic oxidative stress plays a central role in the pathogenesis of many diseases, including HIV-1 associated disorders. Concomitantly with the decline of endogenous antioxidant systems, it was reported that HIV-1-related proteins increase the production of radical species in cells and tissues that are not directly i...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9511-6
更新日期:2014-01-01 00:00:00
abstract::We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09848-9
更新日期:2020-04-01 00:00:00
abstract::Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9410-7
更新日期:2013-02-01 00:00:00
abstract::A reduced adaptation to cold is a prominent feature in aged mammals, including humans. The accelerated senescence-prone strain of mice (SAMP) has been studied as an animal model for several age-associated disorders and in the acceleration of senescence. Recent studies revealed that SAMP strains have dysfunctional hype...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-3499-x
更新日期:2005-01-01 00:00:00
abstract::Evolutionary theory leads to the general expectation that dietary restriction will often result in increased survival probabilities, and thus increased lifespan. The reaction norm is a basic tool of evolutionary analysis that quantifies the relationship between environmental parameters and functional characters, inclu...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-006-9005-2
更新日期:2006-06-01 00:00:00
abstract::Menopause marks the end of the reproductive life span of women and is characterized by a dramatic drop of circulating estrogen. Hormone replacement therapy (HRT) has been successfully used to treat the symptoms of menopause because estrogen has strong suppressive effects on climacteric complaints. As the hypothalamo-p...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-2623-2
更新日期:2005-01-01 00:00:00
abstract::Gene expression in aging kidney and pituitary was determined by subtractive hybridization, DNA microarrays and RT-PCR. Kidneys and pituitary were removed from 10- and 30-month-old female WAG/Rij rats, which were free from chronic progressive nephrosis and had a low incidence of pituitary tumors with age. From 350 cDNA...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1023/b:bgen.0000017685.91381.40
更新日期:2004-01-01 00:00:00
abstract::Complex diseases are major contributors to human mortality in old age. Paradoxically, many genetic variants that have been associated with increased risks of such diseases are found in genomes of long-lived people, and do not seem to compromise longevity. Here we argue that trade-off-like and conditional effects of ge...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-015-9600-1
更新日期:2016-02-01 00:00:00
abstract::In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9154-6
更新日期:2009-02-01 00:00:00
abstract::There are currently no reliable biomarkers of ageing. A biomarker should indicate biological age, that is, the amount of an animal's total lifespan it has lived and, therefore, the amount of time it has remaining. Some potential biomarkers cannot be validated as their measurement involves harm or death of the animal, ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9393-4
更新日期:2012-10-01 00:00:00
abstract::Considering that the phenomenon of accelerated ageing contributes to early onset of various chronic diseases, modelling of the relevant dysregulated systems or responses is vital for research aimed at identification of potential therapeutic targets. Here, we aimed to establish a model capable of simulating the redox a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09891-x
更新日期:2020-12-01 00:00:00
abstract::Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9271-x
更新日期:2010-08-01 00:00:00
abstract::In mammals suprachiasmatic nucleus (SCN), acts as a light entrainable master clock and by generation of temporal oscillations regulates the peripheral organs acting as autonomous clocks resulting in overt behavioral and physiological rhythms. SCN also controls synthesis and release of melatonin (hormonal message for d...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-016-9656-6
更新日期:2016-11-01 00:00:00
abstract::When mortality (μ), aging rate (γ) and age (t) are treated according to the Gompertz model μ(t) = μ0eγt (GM), any mean age corresponds to a manifold of paired reciprocally changing μ0 and γ. Therefore, any noisiness of data used to derive GM parameters makes them negatively correlated. Besides this artifactual factor ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09828-z
更新日期:2019-12-01 00:00:00
abstract::The senescence-accelerated mouse (SAM) prone 8 (SAMP8) has been demonstrated for muscular aging research including sarcopenia, but its underlying mechanisms remain scarce. Physiological indices and histology of skeletal muscle were analyzed in SAMP8 mice at different ages. SAMP8 mice exhibited typical features of sarc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-020-09867-x
更新日期:2020-06-01 00:00:00
abstract::Eusocial subterranean rodents of the Bathyergidae family have enormous longevity. The long lifespan of these species is associated with negligible senescence, that is, an absence of the signs of age-related deterioration in physical condition. The question arises as to whether these features are unique to eusocial Bat...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-015-9592-x
更新日期:2015-12-01 00:00:00
abstract::Age is the principal nonmodifiable risk factor for stroke. Over the past 10 years, suitable models for stroke in aged rats have been established. At genetic and cellular level there are significant differences in behavioral, cytological and genomics responses to injury in old animals as compared with the young ones. B...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9465-0
更新日期:2013-12-01 00:00:00
abstract::In the central nervous system (CNS), senescent astrocytes have been associated with neurodegeneration. Senescent cells secrete a complex mixture of pro-inflammatory factors, which are collectively called Senescence Associated Secretory Phenotype (SASP). The SASP components can vary depending on the cell type, senescen...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9767-3
更新日期:2018-10-01 00:00:00
abstract::The phytochemical epigallocatechin gallate (EGCG) has been reported to alleviate age-associated immune disorders and organ dysfunction. However, information regarding the mechanistic role of EGCG in the suppression of cellular senescence is limited. The present study thus assessed the effects and underlying mechanisms...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-018-9785-1
更新日期:2019-04-01 00:00:00
abstract::For a period of 6-15 days prior to death, the fecundity and virility of Drosophila melanogaster fall significantly below those of same-aged flies that are not near death. It is likely that other aspects of physiology may decline during this period. This study attempts to document changes in two physiological character...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9398-z
更新日期:2012-10-01 00:00:00
abstract::Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-019-09796-4
更新日期:2019-06-01 00:00:00
abstract::The hypoxia-inducible factor (HIF)-1 is a master transcriptional activator of oxygen-regulated genes involved in energy metabolism, angiogenesis, and erythropoiesis. HIF-1 is composed of the two subunits HIF-1alpha and HIF-1beta (also called ARNT). The destruction of HIF-1alpha in the presence of oxygen is initiated b...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-005-7950-9
更新日期:2005-01-01 00:00:00