abstract：:The recent pandemics of the SARS-Cov-2 has pushed physical activity (PA) and exercise at the forefront of the discussion, since PA is associated with a reduced risk of developing all the chronic diseases strongly associated with severe cases of SARS-Cov-2 and exercise is considered a complimentary therapeutics for the...

journal_title：Ageing research reviews

authors： de Souto Barreto P,Vellas B,Rolland Y

更新日期：2021-01-12 00:00:00

abstract：:The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first reported in Wuhan, China in December 2019, moved across the globe at an unprecedented speed, and is having a profound and yet still unfolding health and socioeconomic impacts. SARS-CoV-2, a β-coronavirus, is a highly contagious respira...

journal_title：Ageing research reviews

authors： Chen Y,Klein SL,Garibaldi BT,Li H,Wu C,Osevala NM,Li T,Margolick JB,Pawelec G,Leng SX

更新日期：2021-01-01 00:00:00

abstract：:Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but ...

journal_title：Ageing research reviews

authors： Kahroba H,Ramezani B,Maadi H,Sadeghi MR,Jaberie H,Ramezani F

更新日期：2021-01-01 00:00:00

abstract：:Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and are increasingly used to track organisms along their life-course. This allows investigation into how aging affects cellular transcriptomes, and how changes in transcriptomes may underlie aging, including chronic inflammation (infl...

journal_title：Ageing research reviews

authors： Uyar B,Palmer D,Kowald A,Murua Escobar H,Barrantes I,Möller S,Akalin A,Fuellen G

更新日期：2020-12-01 00:00:00

abstract：:The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...

journal_title：Ageing research reviews

authors： Guan SP,Seet RCS,Kennedy BK

更新日期：2020-12-01 00:00:00

abstract：:Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related t...

journal_title：Ageing research reviews

authors： Calderón-Larrañaga A,Dekhtyar S,Vetrano DL,Bellander T,Fratiglioni L

更新日期：2020-11-01 00:00:00

abstract：:Although ageing research increasingly incorporates resilience, a common notion on what resilience means is lacking. We aimed to give a comprehensive overview of the conceptual literature on resilience in older persons, identifying areas of consensus and variation/debate. A systematic search of eight databases from dif...

journal_title：Ageing research reviews

authors： Angevaare MJ,Roberts J,van Hout HPJ,Joling KJ,Smalbrugge M,Schoonmade LJ,Windle G,Hertogh CMPM

更新日期：2020-11-01 00:00:00

abstract：:In addition to its role in movement, human skeletal muscle also plays important roles in physiological activities related to metabolism and the endocrine system. Aging and disease onset and progression can induce the reduction of skeletal muscle mass and function, thereby exacerbating skeletal muscle atrophy. Recent s...

journal_title：Ageing research reviews

authors： Zhang H,Liang J,Chen N

更新日期：2020-11-01 00:00:00

abstract：:Fighting the current COVID-19 pandemic, we must not forget to prepare for the next. Since elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if possible. For example, it would take little effort to take additional swabs or dried blood spots. Such minimally-invasive samplin...

journal_title：Ageing research reviews

authors： Fuellen G,Liesenfeld O,Kowald A,Barrantes I,Bastian M,Simm A,Jansen L,Tietz-Latza A,Quandt D,Franceschi C,Walter M

更新日期：2020-09-01 00:00:00

abstract：:In our ever-aging world population, the risk of age-related neuropathies has been increasing, representing both a social and economic burden to society. Since the ability to regenerate in the adult mammalian central nervous system is very limited, brain trauma and neurodegeneration are often permanent. As a consequenc...

journal_title：Ageing research reviews

authors： Vanhunsel S,Beckers A,Moons L

更新日期：2020-09-01 00:00:00

abstract：:Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular senescence and organismal ageing and need to be protected in order to avoid being recognised as damaged DNA and activate DNA damage response pathways. Dysfunctional telomeres arise from critically short telomeres or altered t...

journal_title：Ageing research reviews

authors： Aguado J,d'Adda di Fagagna F,Wolvetang E

更新日期：2020-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is defined by a deficiency in specific behavioural and/or cognitive domains, pointing to selective vulnerabilities of specific neurons from different brain regions. These vulnerabilities can be compared across neuron subgroups to identify the most vulnerable neuronal types, regions, and time p...

journal_title：Ageing research reviews

authors： Wang ZT,Zhang C,Wang YJ,Dong Q,Tan L,Yu JT

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Influenza vaccination is a simple strategy recommended for the prevention of influenza infection and its complications. This meta-analysis aimed to provide current supportive evidence for the breadth and validity of the observed protective effects of influenza vaccination on cardiovascular and respiratory ad...

journal_title：Ageing research reviews

authors： Cheng Y,Cao X,Cao Z,Xu C,Sun L,Gao Y,Wang Y,Li S,Wu C,Li X,Wang Y,Leng SX

更新日期：2020-09-01 00:00:00

abstract：:The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...

journal_title：Ageing research reviews

authors： Elliott ML

更新日期：2020-08-01 00:00:00

abstract：:Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...

journal_title：Ageing research reviews

authors： Heiskanen V,Pfiffner M,Partonen T

更新日期：2020-08-01 00:00:00

abstract：:Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the pathogenesis of various chronic diseases and aging-related organ failure to fully control chronic wound-healing and restoring tissue function. The process of fibrosis is involved in the pathogenesis of the kidney, lung, live...

journal_title：Ageing research reviews

authors： Hu HH,Cao G,Wu XQ,Vaziri ND,Zhao YY

更新日期：2020-07-01 00:00:00

abstract：:The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets. To promote these goals, we performed a systematic review and analysis of human aging and proteomics studies. The systematic review includes 36 diffe...

journal_title：Ageing research reviews

authors： Johnson AA,Shokhirev MN,Wyss-Coray T,Lehallier B

更新日期：2020-07-01 00:00:00

abstract：:Aging is a major cause of many degenerative diseases. The most intuitive consequence of aging is mainly manifested on the skin, resulting in cumulative changes in skin structure, function and appearance, such as increased wrinkles, laxity, elastosis, telangiectasia, and aberrant pigmentation of the skin. Unlike other ...

journal_title：Ageing research reviews

authors： Gu Y,Han J,Jiang C,Zhang Y

更新日期：2020-05-01 00:00:00

abstract：:Aging effects have often been reported for spatial navigation performance. Moreover, navigation performance is thought to be an early marker of pathological aging. Yet, the cognitive complexity of navigation and large individual variation in healthy population make it difficult to pinpoint the precise aging mechanisms...

journal_title：Ageing research reviews

authors： van der Ham IJM,Claessen MHG

更新日期：2020-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are master post-transcriptional regulators of gene expression and their specific footprints reflect disease conditions. Over the last few years, several primary reports have described the deregulation of cell-free miRNAs in Parkinson's disease (PD), however, results have been rather inconsistent due...

journal_title：Ageing research reviews

authors： Doxakis E

更新日期：2020-03-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progr...

journal_title：Ageing research reviews

authors： Pereira CF,Santos AE,Moreira PI,Pereira AC,Sousa FJ,Cardoso SM,Cruz MT

更新日期：2019-12-01 00:00:00

abstract：:Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary theories of aging seek to explain why such stark longevity differences exist and why a deleterious process like aging evolved. The classical mutat...

journal_title：Ageing research reviews

authors： Johnson AA,Shokhirev MN,Shoshitaishvili B

更新日期：2019-11-01 00:00:00

abstract：:Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in the mitochondria and in the nucleus. Recently, accumulating evidence has uncovered a growing number of...

journal_title：Ageing research reviews

authors： Wang Y,Yang J,Hong T,Chen X,Cui L

更新日期：2019-11-01 00:00:00

abstract：:Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression. Interestingly, an enhancement of glucose uptake, glycolysis and pentose phosphate pathway occurs in both cancer cells and am...

journal_title：Ageing research reviews

authors： de Bari L,Atlante A,Armeni T,Kalapos MP

更新日期：2019-08-01 00:00:00

abstract：:Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signali...

journal_title：Ageing research reviews

authors： Yang Z,Jiang S,Shang J,Jiang Y,Dai Y,Xu B,Yu Y,Liang Z,Yang Y

更新日期：2019-07-01 00:00:00

abstract：:A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general dete...

journal_title：Ageing research reviews

authors： Johnson ND,Conneely KN

更新日期：2019-05-01 00:00:00

abstract：:Malnutrition plays a role in the development of poor physical performance, frailty and sarcopenia. The use of nutritional supplementations for improving physical performance and muscle strength parameters in older people is unclear. We therefore aimed to summarize the effect of nutritional supplementations compared to...

journal_title：Ageing research reviews

authors： Veronese N,Stubbs B,Punzi L,Soysal P,Incalzi RA,Saller A,Maggi S

更新日期：2019-05-01 00:00:00

abstract：:Population ageing is escalating rapidly now worldwide. This is an important time to determine if ageism or discrimination against older people is of concern, such as it being prevalent and/or increasing in prevalence. Over the years, many ageism measurement tools have been developed, with research findings from their ...

journal_title：Ageing research reviews

authors： Wilson DM,Errasti-Ibarrondo B,Low G

更新日期：2019-05-01 00:00:00

abstract：:Efferocytosis, the clearance of apoptotic cells (ACs), is a physiologic, multifaceted and dynamic process and a fundamental mechanism for the preservation of tissue homeostasis by avoiding unwanted inflammation and autoimmune responses through special phagocytic receptors. Defective efferocytosis is associated with sev...

journal_title：Ageing research reviews

authors： Tajbakhsh A,Gheibi Hayat SM,Butler AE,Sahebkar A

更新日期：2019-03-01 00:00:00

abstract：:Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding o...

journal_title：Ageing research reviews

authors： Lagunas-Rangel FA

更新日期：2018-11-01 00:00:00

abstract：:Autophagy is a lysosomal degradation process and protective housekeeping mechanism to eliminate damaged organelles, long-lived misfolded proteins and invading pathogens. Autophagy functions to recycle building blocks and energy for cellular renovation and homeostasis, allowing cells to adapt to stress. Modulation of a...

journal_title：Ageing research reviews

authors： Bagherniya M,Butler AE,Barreto GE,Sahebkar A

更新日期：2018-11-01 00:00:00

abstract：:Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role in the removal of reactive oxygen species, but rather mediated by oth...

journal_title：Ageing research reviews

authors： Detienne G,De Haes W,Mergan L,Edwards SL,Temmerman L,Van Bael S

更新日期：2018-07-01 00:00:00

abstract：:Recent findings suggest that both peripheral and central auditory system dysfunction occur in the prodromal stages of Alzheimer Disease (AD), and therefore may represent early indicators of the disease. In addition, loss of auditory function itself leads to communication difficulties, social isolation and poor quality...

journal_title：Ageing research reviews

authors： Swords GM,Nguyen LT,Mudar RA,Llano DA

更新日期：2018-07-01 00:00:00

abstract：:A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive tr...

journal_title：Ageing research reviews

authors： Cespón J,Miniussi C,Pellicciari MC

更新日期：2018-05-01 00:00:00

abstract：:The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...

journal_title：Ageing research reviews

authors： Navakkode S,Liu C,Soong TW

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent o...

journal_title：Ageing research reviews

authors： Zhang C,Wang X

更新日期：2017-11-01 00:00:00

abstract：:Neurons are highly energy demanding cells dependent on the mitochondrial oxidative phosphorylation system. Mitochondria generate energy via respiratory complexes that constitute the electron transport chain. Adenosine triphosphate depletion or glucose starvation act as a trigger for the activation of adenosine monopho...

journal_title：Ageing research reviews

authors： Shah SZA,Zhao D,Hussain T,Yang L

更新日期：2017-11-01 00:00:00

abstract：:As our world's population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial functio...

journal_title：Ageing research reviews

authors： LaRocca TJ,Martens CR,Seals DR

更新日期：2017-10-01 00:00:00

abstract：:The cognitive neuroscience of aging is a growing and stimulating research area. The development of neuroimaging techniques in the past two decades has considerably increased our understanding of the brain mechanisms that might underlie cognitive performance and resulting changes due to normal aging. Beside traditional...

journal_title：Ageing research reviews

authors： Agbangla NF,Audiffren M,Albinet CT

更新日期：2017-09-01 00:00:00

abstract：:We have long accepted that exercise is 'good for us'; that - put more rigorously - moderate exercise is associated with not just aerobic fitness but also reduced morbidity and reduced mortality from cardiovascular disease and even malignancies. Caloric restriction (moderate hunger) and our exposure to dietary phytoche...

journal_title：Ageing research reviews

authors： Kim B,Brandli A,Mitrofanis J,Stone J,Purushothuman S,Johnstone DM

更新日期：2017-08-01 00:00:00