听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览AGEING RESEARCH REVIEWS期刊下所有文献
  • Physical activity and exercise in the context of SARS-Cov-2: A perspective from geroscience field.

    abstract::The recent pandemics of the SARS-Cov-2 has pushed physical activity (PA) and exercise at the forefront of the discussion, since PA is associated with a reduced risk of developing all the chronic diseases strongly associated with severe cases of SARS-Cov-2 and exercise is considered a complimentary therapeutics for the...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2021.101258

    authors: de Souto Barreto P,Vellas B,Rolland Y

    更新日期:2021-01-12 00:00:00

  • The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease.

    abstract::Neurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101211

    authors: Kahroba H,Ramezani B,Maadi H,Sadeghi MR,Jaberie H,Ramezani F

    更新日期:2021-01-01 00:00:00

  • Aging in COVID-19: Vulnerability, immunity and intervention.

    abstract::The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic was first reported in Wuhan, China in December 2019, moved across the globe at an unprecedented speed, and is having a profound and yet still unfolding health and socioeconomic impacts. SARS-CoV-2, a β-coronavirus, is a highly contagious respira...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101205

    authors: Chen Y,Klein SL,Garibaldi BT,Li H,Wu C,Osevala NM,Li T,Margolick JB,Pawelec G,Leng SX

    更新日期:2021-01-01 00:00:00

  • Does eNOS derived nitric oxide protect the young from severe COVID-19 complications?

    abstract::The COVID-19 pandemic poses an imminent threat to humanity, especially to the elderly. The molecular mechanisms underpinning the age-dependent disparity for disease progression is not clear. COVID-19 is both a respiratory and a vascular disease in severe patients. The damage endothelial system provides a good explanat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101201

    authors: Guan SP,Seet RCS,Kennedy BK

    更新日期:2020-12-01 00:00:00

  • Single-cell analyses of aging, inflammation and senescence.

    abstract::Single-cell gene expression (transcriptomics) data are becoming robust and abundant, and are increasingly used to track organisms along their life-course. This allows investigation into how aging affects cellular transcriptomes, and how changes in transcriptomes may underlie aging, including chronic inflammation (infl...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101156

    authors: Uyar B,Palmer D,Kowald A,Murua Escobar H,Barrantes I,Möller S,Akalin A,Fuellen G

    更新日期:2020-12-01 00:00:00

  • Resilience in older persons: A systematic review of the conceptual literature.

    abstract::Although ageing research increasingly incorporates resilience, a common notion on what resilience means is lacking. We aimed to give a comprehensive overview of the conceptual literature on resilience in older persons, identifying areas of consensus and variation/debate. A systematic search of eight databases from dif...

    journal_title:Ageing research reviews

    pub_type: 杂志文章

    doi:10.1016/j.arr.2020.101144

    authors: Angevaare MJ,Roberts J,van Hout HPJ,Joling KJ,Smalbrugge M,Schoonmade LJ,Windle G,Hertogh CMPM

    更新日期:2020-11-01 00:00:00

  • Do not neglect the role of circadian rhythm in muscle atrophy.

    abstract::In addition to its role in movement, human skeletal muscle also plays important roles in physiological activities related to metabolism and the endocrine system. Aging and disease onset and progression can induce the reduction of skeletal muscle mass and function, thereby exacerbating skeletal muscle atrophy. Recent s...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101155

    authors: Zhang H,Liang J,Chen N

    更新日期:2020-11-01 00:00:00

  • COVID-19: risk accumulation among biologically and socially vulnerable older populations.

    abstract::Emerging data show that the health and economic impacts of COVID-19 are being disproportionately borne by individuals who are not only biologically, but also socially vulnerable. Based on preliminary data from Sweden and other reports, in this paper we propose a conceptual framework whereby different factors related t...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101149

    authors: Calderón-Larrañaga A,Dekhtyar S,Vetrano DL,Bellander T,Fratiglioni L

    更新日期:2020-11-01 00:00:00

  • Selective neuronal vulnerability in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is defined by a deficiency in specific behavioural and/or cognitive domains, pointing to selective vulnerabilities of specific neurons from different brain regions. These vulnerabilities can be compared across neuron subgroups to identify the most vulnerable neuronal types, regions, and time p...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101114

    authors: Wang ZT,Zhang C,Wang YJ,Dong Q,Tan L,Yu JT

    更新日期:2020-09-01 00:00:00

  • Designing neuroreparative strategies using aged regenerating animal models.

    abstract::In our ever-aging world population, the risk of age-related neuropathies has been increasing, representing both a social and economic burden to society. Since the ability to regenerate in the adult mammalian central nervous system is very limited, brain trauma and neurodegeneration are often permanent. As a consequenc...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101086

    authors: Vanhunsel S,Beckers A,Moons L

    更新日期:2020-09-01 00:00:00

  • Effects of influenza vaccination on the risk of cardiovascular and respiratory diseases and all-cause mortality.

    abstract:BACKGROUND:Influenza vaccination is a simple strategy recommended for the prevention of influenza infection and its complications. This meta-analysis aimed to provide current supportive evidence for the breadth and validity of the observed protective effects of influenza vaccination on cardiovascular and respiratory ad...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101124

    authors: Cheng Y,Cao X,Cao Z,Xu C,Sun L,Gao Y,Wang Y,Li S,Wu C,Li X,Wang Y,Leng SX

    更新日期:2020-09-01 00:00:00

  • Telomere transcription in ageing.

    abstract::Telomeres, the ends of eukaryotic chromosomes, play a central role in the control of cellular senescence and organismal ageing and need to be protected in order to avoid being recognised as damaged DNA and activate DNA damage response pathways. Dysfunctional telomeres arise from critically short telomeres or altered t...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101115

    authors: Aguado J,d'Adda di Fagagna F,Wolvetang E

    更新日期:2020-09-01 00:00:00

  • The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging).

    abstract::Fighting the current COVID-19 pandemic, we must not forget to prepare for the next. Since elderly and frail people are at high risk, we wish to predict their vulnerability, and intervene if possible. For example, it would take little effort to take additional swabs or dried blood spots. Such minimally-invasive samplin...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101091

    authors: Fuellen G,Liesenfeld O,Kowald A,Barrantes I,Bastian M,Simm A,Jansen L,Tietz-Latza A,Quandt D,Franceschi C,Walter M

    更新日期:2020-09-01 00:00:00

  • MRI-based biomarkers of accelerated aging and dementia risk in midlife: how close are we?

    abstract::The global population is aging, leading to an increasing burden of age-related neurodegenerative disease. Efforts to intervene against age-related dementias in older adults have generally proven ineffective. These failures suggest that a lifetime of brain aging may be difficult to reverse once widespread deterioration...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101075

    authors: Elliott ML

    更新日期:2020-08-01 00:00:00

  • Sunlight and health: shifting the focus from vitamin D3 to photobiomodulation by red and near-infrared light.

    abstract::Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast bod...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101089

    authors: Heiskanen V,Pfiffner M,Partonen T

    更新日期:2020-08-01 00:00:00

  • Systematic review and analysis of human proteomics aging studies unveils a novel proteomic aging clock and identifies key processes that change with age.

    abstract::The development of clinical interventions that significantly improve human healthspan requires robust markers of biological age as well as thoughtful therapeutic targets. To promote these goals, we performed a systematic review and analysis of human aging and proteomics studies. The systematic review includes 36 diffe...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.arr.2020.101070

    authors: Johnson AA,Shokhirev MN,Wyss-Coray T,Lehallier B

    更新日期:2020-07-01 00:00:00

  • Wnt signaling pathway in aging-related tissue fibrosis and therapies.

    abstract::Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the pathogenesis of various chronic diseases and aging-related organ failure to fully control chronic wound-healing and restoring tissue function. The process of fibrosis is involved in the pathogenesis of the kidney, lung, live...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101063

    authors: Hu HH,Cao G,Wu XQ,Vaziri ND,Zhao YY

    更新日期:2020-07-01 00:00:00

  • Biomarkers, oxidative stress and autophagy in skin aging.

    abstract::Aging is a major cause of many degenerative diseases. The most intuitive consequence of aging is mainly manifested on the skin, resulting in cumulative changes in skin structure, function and appearance, such as increased wrinkles, laxity, elastosis, telangiectasia, and aberrant pigmentation of the skin. Unlike other ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101036

    authors: Gu Y,Han J,Jiang C,Zhang Y

    更新日期:2020-05-01 00:00:00

  • How age relates to spatial navigation performance: Functional and methodological considerations.

    abstract::Aging effects have often been reported for spatial navigation performance. Moreover, navigation performance is thought to be an early marker of pathological aging. Yet, the cognitive complexity of navigation and large individual variation in healthy population make it difficult to pinpoint the precise aging mechanisms...

    journal_title:Ageing research reviews

    pub_type: 杂志文章

    doi:10.1016/j.arr.2020.101020

    authors: van der Ham IJM,Claessen MHG

    更新日期:2020-03-01 00:00:00

  • Cell-free microRNAs in Parkinson's disease: potential biomarkers that provide new insights into disease pathogenesis.

    abstract::MicroRNAs (miRNAs) are master post-transcriptional regulators of gene expression and their specific footprints reflect disease conditions. Over the last few years, several primary reports have described the deregulation of cell-free miRNAs in Parkinson's disease (PD), however, results have been rather inconsistent due...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2020.101023

    authors: Doxakis E

    更新日期:2020-03-01 00:00:00

  • Is Alzheimer's disease an inflammasomopathy?

    abstract::Alzheimer's disease (AD) is the most common form of dementia in the elderly and, despite the tremendous efforts researchers have put into AD research, there are no effective options for prevention and treatment of the disease. The best way to reach this goal is to clarify the mechanisms involved in the onset and progr...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100966

    authors: Pereira CF,Santos AE,Moreira PI,Pereira AC,Sousa FJ,Cardoso SM,Cruz MT

    更新日期:2019-12-01 00:00:00

  • Revamping the evolutionary theories of aging.

    abstract::Radical lifespan disparities exist in the animal kingdom. While the ocean quahog can survive for half a millennium, the mayfly survives for less than 48 h. The evolutionary theories of aging seek to explain why such stark longevity differences exist and why a deleterious process like aging evolved. The classical mutat...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100947

    authors: Johnson AA,Shokhirev MN,Shoshitaishvili B

    更新日期:2019-11-01 00:00:00

  • SIRT2: Controversy and multiple roles in disease and physiology.

    abstract::Sirtuin 2 (SIRT2) is an NAD+-dependent deacetylase that was under studied compared to other sirtuin family members. SIRT2 is the only sirtuin protein which is predominantly found in the cytoplasm but is also found in the mitochondria and in the nucleus. Recently, accumulating evidence has uncovered a growing number of...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100961

    authors: Wang Y,Yang J,Hong T,Chen X,Cui L

    更新日期:2019-11-01 00:00:00

  • Synthesis and metabolism of methylglyoxal, S-D-lactoylglutathione and D-lactate in cancer and Alzheimer's disease. Exploring the crossroad of eternal youth and premature aging.

    abstract::Both cancer and Alzheimer's disease (AD) are emerging as metabolic diseases in which aberrant/dysregulated glucose metabolism and bioenergetics occur, and play a key role in disease progression. Interestingly, an enhancement of glucose uptake, glycolysis and pentose phosphate pathway occurs in both cancer cells and am...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.100915

    authors: de Bari L,Atlante A,Armeni T,Kalapos MP

    更新日期:2019-08-01 00:00:00

  • LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging.

    abstract::Fibrosis is universally observed in multiple aging-related diseases and progressions and is characterized by excess accumulation of the extracellular matrix. Fibrosis occurs in various human organs and eventually results in organ failure. Noncoding RNAs (ncRNAs) have emerged as essential regulators of cellular signali...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.04.001

    authors: Yang Z,Jiang S,Shang J,Jiang Y,Dai Y,Xu B,Yu Y,Liang Z,Yang Y

    更新日期:2019-07-01 00:00:00

  • Where are we now in relation to determining the prevalence of ageism in this era of escalating population ageing?

    abstract::Population ageing is escalating rapidly now worldwide. This is an important time to determine if ageism or discrimination against older people is of concern, such as it being prevalent and/or increasing in prevalence. Over the years, many ageism measurement tools have been developed, with research findings from their ...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.03.001

    authors: Wilson DM,Errasti-Ibarrondo B,Low G

    更新日期:2019-05-01 00:00:00

  • The role of DNA methylation and hydroxymethylation in immunosenescence.

    abstract::A healthy functioning immune system is critical to stave off infectious diseases, but as humans and other organisms age, their immune systems decline. As a result, diseases that were readily thwarted in early life pose nontrivial harm and can even be deadly in late life. Immunosenescence is defined as the general dete...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.01.011

    authors: Johnson ND,Conneely KN

    更新日期:2019-05-01 00:00:00

  • Effect of nutritional supplementations on physical performance and muscle strength parameters in older people: A systematic review and meta-analysis.

    abstract::Malnutrition plays a role in the development of poor physical performance, frailty and sarcopenia. The use of nutritional supplementations for improving physical performance and muscle strength parameters in older people is unclear. We therefore aimed to summarize the effect of nutritional supplementations compared to...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.arr.2019.02.005

    authors: Veronese N,Stubbs B,Punzi L,Soysal P,Incalzi RA,Saller A,Maggi S

    更新日期:2019-05-01 00:00:00

  • Effect of soluble cleavage products of important receptors/ligands on efferocytosis: Their role in inflammatory, autoimmune and cardiovascular disease.

    abstract::Efferocytosis, the clearance of apoptotic cells (ACs), is a physiologic, multifaceted and dynamic process and a fundamental mechanism for the preservation of tissue homeostasis by avoiding unwanted inflammation and autoimmune responses through special phagocytic receptors. Defective efferocytosis is associated with sev...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2019.01.007

    authors: Tajbakhsh A,Gheibi Hayat SM,Butler AE,Sahebkar A

    更新日期:2019-03-01 00:00:00

  • Cancer-free aging: Insights from Spalax ehrenbergi superspecies.

    abstract::Cancer and ageing can be regarded as two different manifestations of the same underlying process-accumulation of cellular damage-and therefore both are closely linked. Nowadays, the ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities, and therefore the understanding o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.06.004

    authors: Lagunas-Rangel FA

    更新日期:2018-11-01 00:00:00

  • The effect of fasting or calorie restriction on autophagy induction: A review of the literature.

    abstract::Autophagy is a lysosomal degradation process and protective housekeeping mechanism to eliminate damaged organelles, long-lived misfolded proteins and invading pathogens. Autophagy functions to recycle building blocks and energy for cellular renovation and homeostasis, allowing cells to adapt to stress. Modulation of a...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.08.004

    authors: Bagherniya M,Butler AE,Barreto GE,Sahebkar A

    更新日期:2018-11-01 00:00:00

  • Auditory system dysfunction in Alzheimer disease and its prodromal states: A review.

    abstract::Recent findings suggest that both peripheral and central auditory system dysfunction occur in the prodromal stages of Alzheimer Disease (AD), and therefore may represent early indicators of the disease. In addition, loss of auditory function itself leads to communication difficulties, social isolation and poor quality...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.04.001

    authors: Swords GM,Nguyen LT,Mudar RA,Llano DA

    更新日期:2018-07-01 00:00:00

  • Beyond ROS clearance: Peroxiredoxins in stress signaling and aging.

    abstract::Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role in the removal of reactive oxygen species, but rather mediated by oth...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.03.005

    authors: Detienne G,De Haes W,Mergan L,Edwards SL,Temmerman L,Van Bael S

    更新日期:2018-07-01 00:00:00

  • Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity.

    abstract::A growing body of evidence suggests that healthy elderly individuals and patients with Alzheimer's disease retain an important potential for neuroplasticity. This review summarizes studies investigating the modulation of neural activity and structural brain integrity in response to interventions involving cognitive tr...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.03.001

    authors: Cespón J,Miniussi C,Pellicciari MC

    更新日期:2018-05-01 00:00:00

  • Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline.

    abstract::The rapid developments in science have led to an increase in human life expectancy and thus, ageing and age-related disorders/diseases have become one of the greatest concerns in the 21st century. Cognitive abilities tend to decline as we get older. This age-related cognitive decline is mainly attributed to aberrant c...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2018.01.001

    authors: Navakkode S,Liu C,Soong TW

    更新日期:2018-03-01 00:00:00

  • Initiation of the age-related decline of odor identification in humans: A meta-analysis.

    abstract:BACKGROUND:Aging is an important contributor to olfactory system deterioration in humans, leading to increased health and safety risks as well as affecting the quality of life. However, it is currently unknown when age-related olfactory deterioration begins in humans and thus when to initiate interventions to prevent o...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.arr.2017.08.004

    authors: Zhang C,Wang X

    更新日期:2017-11-01 00:00:00

  • Role of the AMPK pathway in promoting autophagic flux via modulating mitochondrial dynamics in neurodegenerative diseases: Insight into prion diseases.

    abstract::Neurons are highly energy demanding cells dependent on the mitochondrial oxidative phosphorylation system. Mitochondria generate energy via respiratory complexes that constitute the electron transport chain. Adenosine triphosphate depletion or glucose starvation act as a trigger for the activation of adenosine monopho...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.09.004

    authors: Shah SZA,Zhao D,Hussain T,Yang L

    更新日期:2017-11-01 00:00:00

  • Nutrition and other lifestyle influences on arterial aging.

    abstract::As our world's population ages, cardiovascular diseases (CVD) will become an increasingly urgent public health problem. A key antecedent to clinical CVD and many other chronic disorders of aging is age-related arterial dysfunction, characterized by increased arterial stiffness and impaired arterial endothelial functio...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2016.09.002

    authors: LaRocca TJ,Martens CR,Seals DR

    更新日期:2017-10-01 00:00:00

  • Use of near-infrared spectroscopy in the investigation of brain activation during cognitive aging: A systematic review of an emerging area of research.

    abstract::The cognitive neuroscience of aging is a growing and stimulating research area. The development of neuroimaging techniques in the past two decades has considerably increased our understanding of the brain mechanisms that might underlie cognitive performance and resulting changes due to normal aging. Beside traditional...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.07.003

    authors: Agbangla NF,Audiffren M,Albinet CT

    更新日期:2017-09-01 00:00:00

  • Remote tissue conditioning - An emerging approach for inducing body-wide protection against diseases of ageing.

    abstract::We have long accepted that exercise is 'good for us'; that - put more rigorously - moderate exercise is associated with not just aerobic fitness but also reduced morbidity and reduced mortality from cardiovascular disease and even malignancies. Caloric restriction (moderate hunger) and our exposure to dietary phytoche...

    journal_title:Ageing research reviews

    pub_type: 杂志文章,评审

    doi:10.1016/j.arr.2017.05.005

    authors: Kim B,Brandli A,Mitrofanis J,Stone J,Purushothuman S,Johnstone DM

    更新日期:2017-08-01 00:00:00

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