听力与言语-语言病理学

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医学伦理学

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  • The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity.

    abstract::Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2020.1804492

    authors: Peillex C,Pelletier M

    更新日期:2020-12-01 00:00:00

  • KMRC011, an agonist of toll-like receptor 5, mitigates irradiation-induced tissue damage and mortality in cynomolgus monkeys.

    abstract::In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2019.1699617

    authors: Lee HS,Cho DW,Han JS,Han SC,Woo SK,Jun SY,Lee WJ,Yoon S,Pak SI,Lee SJ,Seong E,Park EJ

    更新日期:2020-12-01 00:00:00

  • Circulating inflammatory markers in cervical cancer patients and healthy controls.

    abstract::There is increasing evidence that host inflammatory responses play an important role in the development and progression of cancers. There are some data that cancer is associated not only with inflammation at the site of the lesion, but also with dysregulations of the host overall systemic immune response. In the case ...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2020.1755397

    authors: Vitkauskaite A,Urboniene D,Celiesiute J,Jariene K,Skrodeniene E,Nadisauskiene RJ,Vaitkiene D

    更新日期:2020-12-01 00:00:00

  • A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model.

    abstract::The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2020.1826020

    authors: Plitnick LM,Hutchins B,Dubey S,Li N,Amin RP,Born S,Mangadu R,Phillips JH,Sriram V,Herzyk DJ

    更新日期:2020-12-01 00:00:00

  • Effects of quercetin on Aroclor 1254-induced expression of CYP450 and cytokines in pregnant rats.

    abstract::The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 12...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2019.1604585

    authors: Xu L,Guo X,Li N,Pan Q,Ma YZ

    更新日期:2019-12-01 00:00:00

  • Sex differences impact the lung-bone inflammatory response to repetitive inhalant lipopolysaccharide exposures in mice.

    abstract::Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but compariso...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2018.1460425

    authors: Nelson AJ,Roy SK,Warren K,Janike K,Thiele GM,Mikuls TR,Romberger DJ,Wang D,Swanson B,Poole JA

    更新日期:2018-12-01 00:00:00

  • Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice.

    abstract::Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pestici...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2018.1474978

    authors: Leung-Gurung L,Escalante Cobb P,Mourad F,Zambrano C,Muscato Z,Sanchez V,Godde K,Broussard C

    更新日期:2018-12-01 00:00:00

  • Transferon™, a peptide mixture with immunomodulatory properties is not immunogenic when administered with various adjuvants.

    abstract::Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2017.1346009

    authors: Avila S,Muñoz-García L,Vázquez-Leyva S,Salinas-Jazmín N,Medina-Rivero E,Pavón L,Mellado-Sánchez G,Chacón-Salinas R,Estrada-Parra S,Vallejo-Castillo L,Pérez-Tapia SM

    更新日期:2017-12-01 00:00:00

  • Effect of nicotine on placental ischemia-induced complement activation and hypertension in the rat.

    abstract::Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insuffi...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2017.1394934

    authors: Laule CF,Wing CR,Odean EJ,Wilcox JA,Gilbert JS,Regal JF

    更新日期:2017-12-01 00:00:00

  • Cytokines related to three major types of cell-mediated immunity in short- and long-term exposures to lead compounds.

    abstract::Many investigators have posited on the significant influence of lead on the immune system function. However, available data on this topic are not conclusive. Therefore, a study was undertaken to examine associations between lead exposure and levels of cytokines related to the T-helper (TH)-1, TH2, and TH17 types of im...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.1080/1547691X.2016.1184360

    authors: Dobrakowski M,Boroń M,Czuba ZP,Kasperczyk A,Machoń-Grecka A,Kasperczyk S

    更新日期:2016-11-01 00:00:00

  • Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water.

    abstract::Tungsten is a naturally occurring, high-tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water i...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2016.1154118

    authors: Frawley RP,Smith MJ,White KL Jr,Elmore SA,Herbert R,Moore R,Staska LM,Behl M,Hooth MJ,Kissling GE,Germolec DR

    更新日期:2016-09-01 00:00:00

  • Evaluation of the utility of popliteal lymph node examination in a cyclophosphamide model of immunotoxicity in the rat.

    abstract::The objective of this study was to characterize the variability of rat lymphoid organ weights and morphology following treatment with a known immunotoxicant, with a focus on the usefulness of evaluating popliteal lymph node weight and histology. Cyclophosphamide was administered to male Sprague-Dawley rats by oral gav...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2015.1122117

    authors: Lapointe JM,Valdez RA,Ryan AM,Haley PJ

    更新日期:2016-07-01 00:00:00

  • Oral exposure to immunostimulating drugs results in early changes in innate immune parameters in the spleen.

    abstract::The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent respons...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2016.1139643

    authors: Kwast L,Fiechter D,Kruijssen L,Bleumink R,Ludwig I,Bol-Schoenmakers M,Smit J,Pieters R

    更新日期:2016-07-01 00:00:00

  • Plasma Kallikrein-Kinin system mediates immune-mediated renal injury in trichloroethylene-sensitized mice.

    abstract::Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2016.1142019

    authors: Wang H,Zhang JX,Ye LP,Li SL,Wang F,Zha WS,Shen T,Wu C,Zhu QX

    更新日期:2016-07-01 00:00:00

  • Sex-based differences in lymphocyte proliferation in the spleen after vanadium inhalation.

    abstract::Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after ...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2015.1134731

    authors: Rodriguez-Lara V,Muñiz-Rivera Cambas A,González Villalva A,Fortoul TI

    更新日期:2016-07-01 00:00:00

  • Nebivolol prevents indomethacin-induced gastric ulcer in rats.

    abstract::Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2016.1142488

    authors: El-Ashmawy NE,Khedr EG,El-Bahrawy HA,Selim HM

    更新日期:2016-07-01 00:00:00

  • Silver nanoparticles of 70 nm and 20 nm affect differently the biology of human neutrophils.

    abstract::The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2015.1106622

    authors: Poirier M,Simard JC,Girard D

    更新日期:2016-05-01 00:00:00

  • Regulation of IL-17A expression in mice following subacute ozone exposure.

    abstract::Exposure to subacute ozone (O3) causes pulmonary neutrophil recruitment. In mice, this recruitment requires IL-17A. Ozone also causes expression of IL-23 and IL-1, which can induce IL-17A. The purpose of this study was to examine the hypothesis that IL-23 and IL-1 contribute to IL-17A expression and subsequent neutrop...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2015.1120829

    authors: Brand JD,Mathews JA,Kasahara DI,Wurmbrand AP,Shore SA

    更新日期:2016-05-01 00:00:00

  • Renal oxidative stress and renal CD8(+) T-cell infiltration in mercuric chloride-induced nephropathy in rats: role of angiotensin II.

    abstract::Mercuric chloride (HgCl2) induces kidney damage, in part, through oxidative stress. A role for angiotensin II (Ang II) in pro-inflammatory events in a model of acute HgCl2-induced nephropathy was reported. Ang II is a potent oxidative stress inducer; however, its role in oxidative/anti-oxidative events in HgCl2-induce...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2015.1089960

    authors: Peña C,Hernández-Fonseca JP,Pedreañez A,Viera N,Mosquera J

    更新日期:2016-05-01 00:00:00

  • Comparative human and mouse antibody responses against tetanus toxin at clonal level.

    abstract::Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2015.1046572

    authors: Yousefi M,Younesi V,Bayat AA,Jadidi-Niaragh F,Abbasi E,Razavi A,Khosravi-Eghbal R,Asgarian-Omran H,Shokri F

    更新日期:2016-01-01 00:00:00

  • Exposure to DDT metabolite p,p'-DDE increases autoimmune type 1 diabetes incidence in NOD mouse model.

    abstract::The incidence of autoimmune Type 1 diabetes (T1D) has been steadily rising in developed countries. Although the exact cause of T1D remains elusive, it is known that both genetics and environmental factors play a role in its immunopathogenesis. Whereas a positive association between p,p'-DDE, a DDT metabolite, and Type...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2015.1017060

    authors: Cetkovic-Cvrlje M,Olson M,Schindler B,Gong HK

    更新日期:2016-01-01 00:00:00

  • Acute high-level exposure to WTC particles alters expression of genes associated with oxidative stress and immune function in the lung.

    abstract::First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2014.914609

    authors: Cohen MD,Vaughan JM,Garrett B,Prophete C,Horton L,Sisco M,Kodavanti UP,Ward WO,Peltier RE,Zelikoff J,Chen LC

    更新日期:2015-04-01 00:00:00

  • Curcumin increases gelatinase activity in human neutrophils by a p38 mitogen-activated protein kinase (MAPK)-independent mechanism.

    abstract::Curcumin has been found to possess anti-inflammatory activities and neutrophils, key players in inflammation, were previously found to be important targets to curcumin in a few studies. For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechani...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2014.917749

    authors: Antoine F,Girard D

    更新日期:2015-04-01 00:00:00

  • PPARγ-dependent anti-tumor and immunomodulatory actions of pioglitazone.

    abstract::Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2014.978055

    authors: El-Sisi AE,Sokar SS,Salem TA,Abu Risha SE

    更新日期:2015-01-01 00:00:00

  • In vitro myelotoxic effects of cypermethrin and mancozeb on human hematopoietic progenitor cells.

    abstract::In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2014.880535

    authors: Mandarapu R,Prakhya BM

    更新日期:2015-01-01 00:00:00

  • Immune selection of tumor cells in TCR β-chain transgenic mice.

    abstract::The concept of immunological surveillance implies that immunogenic variants of tumor cells arising in the organism can be recognized by the immune system. Tumor progression is provided by somatic evolution of tumor cells under the pressure of the immune system. The loss of MHC Class I molecules on the surface of tumor...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2013.861548

    authors: Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB

    更新日期:2014-10-01 00:00:00

  • Isoniazid-induced liver injury and immune response in mice.

    abstract::Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2013.860644

    authors: Metushi IG,Uetrecht J

    更新日期:2014-10-01 00:00:00

  • Immunogenicity of therapeutic proteins: influence of aggregation.

    abstract::The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the prec...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/1547691X.2013.821564

    authors: Ratanji KD,Derrick JP,Dearman RJ,Kimber I

    更新日期:2014-04-01 00:00:00

  • Measuring T-cell responses against LCV and CMV in cynomolgus macaques using ELISPOT: potential application to non-clinical testing of immunomodulatory therapeutics.

    abstract::A number of immunomodulatory therapeutics increase the risk of disease associated with latent herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), a member of the lymphocryptovirus (LCV) family that infects humans. The diseases associated with loss of immunity to these viruses can have major impac...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2013.766287

    authors: Kamperschroer C,O'Donnell LM,Schneider PA,Li D,Roy M,Coskran TM,Kawabata TT

    更新日期:2014-01-01 00:00:00

  • Intravenous anesthetic propofol suppresses leukotriene production in murine dendritic cells.

    abstract::Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2012.712066

    authors: Inada T,Ueshima H,Shingu K

    更新日期:2013-07-01 00:00:00

  • Microenvironment and tumor progression of melanoma: new therapeutic prospectives.

    abstract::Malignant melanoma is a very representative disease in terms of tumor progression processes. During its evolution, a series of events takes place; among these, the cells' 'out-of-control' growth and loss of homeostasis play crucial roles in the genesis of the tumor itself and its subsequent progression. These events i...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/1547691X.2012.723767

    authors: Botti G,Cerrone M,Scognamiglio G,Anniciello A,Ascierto PA,Cantile M

    更新日期:2013-07-01 00:00:00

  • How aluminum adjuvants could promote and enhance non-target IgE synthesis in a genetically-vulnerable sub-population.

    abstract::Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/1547691X.2012.708366

    authors: Terhune TD,Deth RC

    更新日期:2013-04-01 00:00:00

  • Household chemicals, immune function, and allergy: a commentary.

    abstract::In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2012.707696

    authors: Kimber I,Pieters R

    更新日期:2013-04-01 00:00:00

  • Inhibitors of TLR-4, NF-κB, and SAPK/JNK signaling reduce the toxic effect of lipopolysaccharide on RAW 264.7 cells.

    abstract::The present study was designed to examine and compare the effects of three suppressors on the cytokine response in tandem with examining: the synthesis of inducible forms of heat shock proteins; HSP72 and HSP90α; activities of NF-κB and SAPK/JNK signaling pathways; and TLR4 expression. Pre-treatment with inhibitors of...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2012.700652

    authors: Glushkova OV,Parfenyuk SB,Khrenov MO,Novoselova TV,Lunin SM,Fesenko EE,Novoselova EG

    更新日期:2013-04-01 00:00:00

  • Mechanism of perfluorooctanesulfonate (PFOS)-induced apoptosis in the immunocyte.

    abstract::As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2012.691123

    authors: Zhang YH,Wang J,Dong GH,Liu MM,Wang D,Zheng L,Jin YH

    更新日期:2013-01-01 00:00:00

  • Immunotoxicity and allergic potential induced by topical application of dimethyl carbonate (DMC) in a murine model.

    abstract::Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 2...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2012.691124

    authors: Anderson SE,Franko J,Anderson KL,Munson AE,Lukomska E,Meade BJ

    更新日期:2013-01-01 00:00:00

  • Oral warfarin affects peripheral blood leukocyte IL-6 and TNFα production in rats.

    abstract::Warfarin is a Vitamin K (VK) antagonist that affects Vitamin K-dependent (VKD) processes, including blood coagulation, as well as processes unrelated to hemostasis such as bone growth, calcification, and growth of some cell types. In addition, warfarin exerts influence on some non-VKD-related activities, including ant...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2012.684159

    authors: Popov A,Belij S,Subota V,Zolotarevski L,Mirkov I,Kataranovski D,Kataranovski M

    更新日期:2013-01-01 00:00:00

  • Relevance of xenobiotic enzymes in human skin in vitro models to activate pro-sensitizers.

    abstract::Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/1547691X.2012.664578

    authors: Jäckh C,Fabian E,van Ravenzwaay B,Landsiedel R

    更新日期:2012-10-01 00:00:00

  • The role of antigen-specific and non-specific immunotherapy in the treatment of cancer.

    abstract::Immunotherapy in the treatment of cancer is increasing, particularly with the recent FDA approval of sipuleucel-T and ipilimumab. The efficacy of anti-tumor immunotherapies has been modest compared to their theoretical and pre-clinical promise. This review evaluates the promise and pitfalls of immunotherapy and highli...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章,评审

    doi:10.3109/1547691X.2012.685527

    authors: Monjazeb AM,Hsiao HH,Sckisel GD,Murphy WJ

    更新日期:2012-07-01 00:00:00

  • Alterations in T-lymphocyte sub-set profiles and cytokine secretion by PBMC of systemic lupus erythematosus patients upon in vitro exposure to organochlorine pesticides.

    abstract::Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...

    journal_title:Journal of immunotoxicology

    pub_type: 杂志文章

    doi:10.3109/1547691X.2011.642103

    authors: Dar SA,Das S,Ramachandran VG,Bhattacharya SN,Mustafa MD,Banerjee BD,Verma P

    更新日期:2012-01-01 00:00:00

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