abstract：:In the study here, the potential applicability of KMRC011 - an agonist of toll-like receptor-5 - as a countermeasure for radiation toxicities was evaluated. Following a single 5.5 Gy total body irradiation (TBI, surface absorbed dose = 7 Gy) of Co60 γ-rays, mortality rates and degrees of pathological lesions that deve...

journal_title：Journal of immunotoxicology

authors： Lee HS,Cho DW,Han JS,Han SC,Woo SK,Jun SY,Lee WJ,Yoon S,Pak SI,Lee SJ,Seong E,Park EJ

更新日期：2020-12-01 00:00:00

abstract：:There is increasing evidence that host inflammatory responses play an important role in the development and progression of cancers. There are some data that cancer is associated not only with inflammation at the site of the lesion, but also with dysregulations of the host overall systemic immune response. In the case ...

journal_title：Journal of immunotoxicology

authors： Vitkauskaite A,Urboniene D,Celiesiute J,Jariene K,Skrodeniene E,Nadisauskiene RJ,Vaitkiene D

更新日期：2020-12-01 00:00:00

abstract：:Glyphosate, or N-phosphomethyl(glycine), is an organophosphorus compound and a competitive inhibitor of the shikimate pathway that allows aromatic amino acid biosynthesis in plants and microorganisms. Its utilization in broad-spectrum herbicides, such as RoundUp®, has continued to increase since 1974; glyphosate, as w...

journal_title：Journal of immunotoxicology

authors： Peillex C,Pelletier M

更新日期：2020-12-01 00:00:00

abstract：:The programmed cell death 1 (PD-1) pathway represents a major immune checkpoint which may be engaged by cells in a tumor microenvironment to overcome active T-cell immune surveillance. Pembrolizumab (Keytruda®) is a potent and highly selective humanized monoclonal antibody (mAb) of the IgG4/κ isotype designed to direc...

journal_title：Journal of immunotoxicology

authors： Plitnick LM,Hutchins B,Dubey S,Li N,Amin RP,Born S,Mangadu R,Phillips JH,Sriram V,Herzyk DJ

更新日期：2020-12-01 00:00:00

abstract：:The present study aimed to investigate the protective effect of quercetin on polychlorinated biphenyls (PCB)-induced liver and embryo damage in pregnant Sprague-Dawley rats. Pregnant rats were divided into five groups, and then were orally gavaged daily with peanut oil (vehicle) or a commercial PCB mixture (Aroclor 12...

journal_title：Journal of immunotoxicology

authors： Xu L,Guo X,Li N,Pan Q,Ma YZ

更新日期：2019-12-01 00:00:00

abstract：:Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but compariso...

journal_title：Journal of immunotoxicology

authors： Nelson AJ,Roy SK,Warren K,Janike K,Thiele GM,Mikuls TR,Romberger DJ,Wang D,Swanson B,Poole JA

更新日期：2018-12-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDC) are widespread in the built and natural environments. Heightened public awareness of their potential danger has led to concern about whether EDC and their metabolites have significant negative biological effects. Studies have shown that EDC like DDT and other organochlorine pestici...

journal_title：Journal of immunotoxicology

authors： Leung-Gurung L,Escalante Cobb P,Mourad F,Zambrano C,Muscato Z,Sanchez V,Godde K,Broussard C

更新日期：2018-12-01 00:00:00

abstract：:Transferon, a human dialyzable leukocyte extract (hDLE), is a biotherapeutic that comprises a complex mixture of low-molecular-weight peptides (< 10 kDa) and is used to treat diseases with an inflammatory component. Some biotherapeutics, including those composed of peptides, can induce anti-drug antibodies (ADA) that ...

journal_title：Journal of immunotoxicology

authors： Avila S,Muñoz-García L,Vázquez-Leyva S,Salinas-Jazmín N,Medina-Rivero E,Pavón L,Mellado-Sánchez G,Chacón-Salinas R,Estrada-Parra S,Vallejo-Castillo L,Pérez-Tapia SM

更新日期：2017-12-01 00:00:00

abstract：:Preeclampsia is a pregnancy-specific condition manifested by new-onset maternal hypertension with systemic inflammation, including increased innate immune system complement activation. While exact pathophysiology is unknown, evidence suggests that inadequate spiral artery invasion and resulting utero-placental insuffi...

journal_title：Journal of immunotoxicology

authors： Laule CF,Wing CR,Odean EJ,Wilcox JA,Gilbert JS,Regal JF

更新日期：2017-12-01 00:00:00

abstract：:Many investigators have posited on the significant influence of lead on the immune system function. However, available data on this topic are not conclusive. Therefore, a study was undertaken to examine associations between lead exposure and levels of cytokines related to the T-helper (TH)-1, TH2, and TH17 types of im...

journal_title：Journal of immunotoxicology

authors： Dobrakowski M,Boroń M,Czuba ZP,Kasperczyk A,Machoń-Grecka A,Kasperczyk S

更新日期：2016-11-01 00:00:00

abstract：:Tungsten is a naturally occurring, high-tensile strength element that has been used in a number of consumer products. Tungsten has been detected in soil, waterways, groundwater, and human tissue and body fluids. Elevated levels of tungsten in urine were reported for populations exposed to tungstate in drinking water i...

journal_title：Journal of immunotoxicology

authors： Frawley RP,Smith MJ,White KL Jr,Elmore SA,Herbert R,Moore R,Staska LM,Behl M,Hooth MJ,Kissling GE,Germolec DR

更新日期：2016-09-01 00:00:00

abstract：:Trichloroethylene (TCE) is a major environmental pollutant. An immunological response is a newly-recognized mechanism for TCE-induced kidney damage. However, the role of the plasma kallikrein-kinin system (KKS) in immune-mediated kidney injury has never been examined. This study aimed to explore the role of the key co...

journal_title：Journal of immunotoxicology

authors： Wang H,Zhang JX,Ye LP,Li SL,Wang F,Zha WS,Shen T,Wu C,Zhu QX

更新日期：2016-07-01 00:00:00

abstract：:The development of immune-dependent drug hypersensitivity reactions (IDHR) is likely to involve activation of the innate immune system to stimulate neo-antigen specific T-cells. Previously it has been shown that, upon oral exposure to several drugs with immune-adjuvant capacity, mice developed T-cell-dependent respons...

journal_title：Journal of immunotoxicology

authors： Kwast L,Fiechter D,Kruijssen L,Bleumink R,Ludwig I,Bol-Schoenmakers M,Smit J,Pieters R

更新日期：2016-07-01 00:00:00

abstract：:Vanadium (V) is a transition metal often adhered to particulate matter and released into the atmosphere as vanadium pentoxide (V2O5) by the burning of fossil fuels. This air pollutant causes adverse effects in the immune system. Lymphocytosis and splenomegaly have been reported with increased white pulp in mice after ...

journal_title：Journal of immunotoxicology

authors： Rodriguez-Lara V,Muñiz-Rivera Cambas A,González Villalva A,Fortoul TI

更新日期：2016-07-01 00:00:00

abstract：:The objective of this study was to characterize the variability of rat lymphoid organ weights and morphology following treatment with a known immunotoxicant, with a focus on the usefulness of evaluating popliteal lymph node weight and histology. Cyclophosphamide was administered to male Sprague-Dawley rats by oral gav...

journal_title：Journal of immunotoxicology

authors： Lapointe JM,Valdez RA,Ryan AM,Haley PJ

更新日期：2016-07-01 00:00:00

abstract：:Gastric ulcer is a very common gastrointestinal disease that may lead to dangerous complications and even death. This study was conducted to evaluate the prophylactic effect of nebivolol against indomethacin [INDO]-induced gastric ulcer. Male Wistar rats were divided into four groups: normal control, ulcer control (IN...

journal_title：Journal of immunotoxicology

authors： El-Ashmawy NE,Khedr EG,El-Bahrawy HA,Selim HM

更新日期：2016-07-01 00:00:00

abstract：:Mercuric chloride (HgCl2) induces kidney damage, in part, through oxidative stress. A role for angiotensin II (Ang II) in pro-inflammatory events in a model of acute HgCl2-induced nephropathy was reported. Ang II is a potent oxidative stress inducer; however, its role in oxidative/anti-oxidative events in HgCl2-induce...

journal_title：Journal of immunotoxicology

authors： Peña C,Hernández-Fonseca JP,Pedreañez A,Viera N,Mosquera J

更新日期：2016-05-01 00:00:00

abstract：:The influence of size of nanoparticles (NP), especially in regard to pulmonary toxicity, has been widely investigated. In general, NP with smaller diameters are more pro-inflammatory in vivo, at least in terms of neutrophil influx. Nevertheless, the influence of size of NP on polymorphonuclear neutrophil (PMN) cell bi...

journal_title：Journal of immunotoxicology

authors： Poirier M,Simard JC,Girard D

更新日期：2016-05-01 00:00:00

abstract：:Exposure to subacute ozone (O3) causes pulmonary neutrophil recruitment. In mice, this recruitment requires IL-17A. Ozone also causes expression of IL-23 and IL-1, which can induce IL-17A. The purpose of this study was to examine the hypothesis that IL-23 and IL-1 contribute to IL-17A expression and subsequent neutrop...

journal_title：Journal of immunotoxicology

authors： Brand JD,Mathews JA,Kasahara DI,Wurmbrand AP,Shore SA

更新日期：2016-05-01 00:00:00

abstract：:The incidence of autoimmune Type 1 diabetes (T1D) has been steadily rising in developed countries. Although the exact cause of T1D remains elusive, it is known that both genetics and environmental factors play a role in its immunopathogenesis. Whereas a positive association between p,p'-DDE, a DDT metabolite, and Type...

journal_title：Journal of immunotoxicology

authors： Cetkovic-Cvrlje M,Olson M,Schindler B,Gong HK

更新日期：2016-01-01 00:00:00

abstract：:Tetanus is a highly fatal disease caused by tetanus neurotoxin (TeNT) and remains a major threat to human and animal health, despite preventive strategies. TeNT is composed of heavy and light chain linked by a disulfide bond. The antibody response to TeNT is polyclonal and directed to multiple epitopes within both the...

journal_title：Journal of immunotoxicology

authors： Yousefi M,Younesi V,Bayat AA,Jadidi-Niaragh F,Abbasi E,Razavi A,Khosravi-Eghbal R,Asgarian-Omran H,Shokri F

更新日期：2016-01-01 00:00:00

abstract：:First responders (FR) present at Ground Zero in the first 72 h after the World Trade Center (WTC) collapsed have progressively exhibited significant respiratory injuries. The few toxicology studies performed to date evaluated effects from just fine (< 2.5 µm) WTC dusts; none examined health effects/toxicities from atm...

journal_title：Journal of immunotoxicology

authors： Cohen MD,Vaughan JM,Garrett B,Prophete C,Horton L,Sisco M,Kodavanti UP,Ward WO,Peltier RE,Zelikoff J,Chen LC

更新日期：2015-04-01 00:00:00

abstract：:Curcumin has been found to possess anti-inflammatory activities and neutrophils, key players in inflammation, were previously found to be important targets to curcumin in a few studies. For example, curcumin was found to induce apoptosis in neutrophils by a p38 mitogen-activated protein kinase (MAPK)-dependent mechani...

journal_title：Journal of immunotoxicology

authors： Antoine F,Girard D

更新日期：2015-04-01 00:00:00

abstract：:In the past two decades, hematologic and immunologic disorders in humans have been increasingly reported as a result of pesticide exposures. Therefore, safety assessment is required to assess the effects on hematopoiesis and thus on the immune system in addition to routine toxicity evaluation. Currently, the data avai...

journal_title：Journal of immunotoxicology

authors： Mandarapu R,Prakhya BM

更新日期：2015-01-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-γ (PPARγ) has been reported to play important roles in carcinogenesis. The current study was carried out to assess the possible anti-tumor effects of pioglitazone (PIO), a PPARγ agonist, in a mouse mammary carcinoma model, i.e. a solid Ehrlich carcinoma (SEC). Effects of PIO ...

journal_title：Journal of immunotoxicology

authors： El-Sisi AE,Sokar SS,Salem TA,Abu Risha SE

更新日期：2015-01-01 00:00:00

abstract：:Isoniazid (INH) is associated with one of the highest incidences of idiosyncratic drug-induced liver failure of any commonly prescribed drug. The mechanism of this liver injury remains uncertain, and a valid animal model would greatly facilitate mechanistic studies. Most studies of INH-induced liver toxicity have been...

journal_title：Journal of immunotoxicology

authors： Metushi IG,Uetrecht J

更新日期：2014-10-01 00:00:00

abstract：:The concept of immunological surveillance implies that immunogenic variants of tumor cells arising in the organism can be recognized by the immune system. Tumor progression is provided by somatic evolution of tumor cells under the pressure of the immune system. The loss of MHC Class I molecules on the surface of tumor...

journal_title：Journal of immunotoxicology

authors： Silaeva YY,Grinenko TS,Vagida MS,Kalinina AA,Khromykh LM,Kazansky DB

更新日期：2014-10-01 00:00:00

abstract：:The elicitation of anti-drug antibodies (ADA) against biotherapeutics can have detrimental effects on drug safety, efficacy, and pharmacokinetics. The immunogenicity of biotherapeutics is, therefore, an important issue. There is evidence that protein aggregation can result in enhanced immunogenicity; however, the prec...

journal_title：Journal of immunotoxicology

authors： Ratanji KD,Derrick JP,Dearman RJ,Kimber I

更新日期：2014-04-01 00:00:00

abstract：:A number of immunomodulatory therapeutics increase the risk of disease associated with latent herpesviruses such as cytomegalovirus (CMV) and Epstein-Barr virus (EBV), a member of the lymphocryptovirus (LCV) family that infects humans. The diseases associated with loss of immunity to these viruses can have major impac...

journal_title：Journal of immunotoxicology

authors： Kamperschroer C,O'Donnell LM,Schneider PA,Li D,Roy M,Coskran TM,Kawabata TT

更新日期：2014-01-01 00:00:00

abstract：:Leukotrienes, divided into cysteinyl leukotrienes (CysLTs), which are important mediators of asthmatic responses, and leukotriene B4 (LTB4), a chemotactic and chemokinetic agent for leukocytes, are potent lipid mediators generated from arachidonic acid by 5-lipoxygenase (5-LO). Leukotrienes are also considered to have...

journal_title：Journal of immunotoxicology

authors： Inada T,Ueshima H,Shingu K

更新日期：2013-07-01 00:00:00

abstract：:Malignant melanoma is a very representative disease in terms of tumor progression processes. During its evolution, a series of events takes place; among these, the cells' 'out-of-control' growth and loss of homeostasis play crucial roles in the genesis of the tumor itself and its subsequent progression. These events i...

journal_title：Journal of immunotoxicology

authors： Botti G,Cerrone M,Scognamiglio G,Anniciello A,Ascierto PA,Cantile M

更新日期：2013-07-01 00:00:00

abstract：:The present study was designed to examine and compare the effects of three suppressors on the cytokine response in tandem with examining: the synthesis of inducible forms of heat shock proteins; HSP72 and HSP90α; activities of NF-κB and SAPK/JNK signaling pathways; and TLR4 expression. Pre-treatment with inhibitors of...

journal_title：Journal of immunotoxicology

authors： Glushkova OV,Parfenyuk SB,Khrenov MO,Novoselova TV,Lunin SM,Fesenko EE,Novoselova EG

更新日期：2013-04-01 00:00:00

abstract：:In recent decades, in the US and in Western and Northern Europe, there has been a significant increase in the prevalence of atopic allergic disease. Although that increase may now be slowing, or have already reached a plateau, there remains considerable interest in the factor or factors that may have caused this incre...

journal_title：Journal of immunotoxicology

authors： Kimber I,Pieters R

更新日期：2013-04-01 00:00:00

abstract：:Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic ri...

journal_title：Journal of immunotoxicology

authors： Terhune TD,Deth RC

更新日期：2013-04-01 00:00:00

abstract：:Warfarin is a Vitamin K (VK) antagonist that affects Vitamin K-dependent (VKD) processes, including blood coagulation, as well as processes unrelated to hemostasis such as bone growth, calcification, and growth of some cell types. In addition, warfarin exerts influence on some non-VKD-related activities, including ant...

journal_title：Journal of immunotoxicology

authors： Popov A,Belij S,Subota V,Zolotarevski L,Mirkov I,Kataranovski D,Kataranovski M

更新日期：2013-01-01 00:00:00

abstract：:As a new type of persistent organic pollutant, perfluorooctane sulfonate (PFOS) has raised great concern in recent years due to its ubiquitous distribution in the general environment and its long elimination half-life in humans. PFOS has toxic and carcinogenic effects in animals and humans, but the effects of PFOS on ...

journal_title：Journal of immunotoxicology

authors： Zhang YH,Wang J,Dong GH,Liu MM,Wang D,Zheng L,Jin YH

更新日期：2013-01-01 00:00:00

abstract：:Dimethyl carbonate (DMC) is an industrial chemical, used as a paint and adhesive solvent, with the potential for significant increases in production. Using select immune function assays, the purpose of these studies was to evaluate the immunotoxicity of DMC following dermal exposure using a murine model. Following a 2...

journal_title：Journal of immunotoxicology

authors： Anderson SE,Franko J,Anderson KL,Munson AE,Lukomska E,Meade BJ

更新日期：2013-01-01 00:00:00

abstract：:Skin exposure to sensitizing chemicals can induce allergic reactions. Certain chemicals, so called pro-sensitizers, need metabolic activation to become allergenic. Their metabolic activation occurs in skin cells such as keratinocytes or dendritic cells. These cell types are also incorporated into dermal in vitro test ...

journal_title：Journal of immunotoxicology

authors： Jäckh C,Fabian E,van Ravenzwaay B,Landsiedel R

更新日期：2012-10-01 00:00:00

abstract：:Immunotherapy in the treatment of cancer is increasing, particularly with the recent FDA approval of sipuleucel-T and ipilimumab. The efficacy of anti-tumor immunotherapies has been modest compared to their theoretical and pre-clinical promise. This review evaluates the promise and pitfalls of immunotherapy and highli...

journal_title：Journal of immunotoxicology

authors： Monjazeb AM,Hsiao HH,Sckisel GD,Murphy WJ

更新日期：2012-07-01 00:00:00

abstract：:Chronic exposure to organochlorine pesticides (OCP) has been suspected of causing immunoregulatory abnormalities that eventually lead to development and progression of systemic lupus erythematosus (SLE), but the role of these non-genetic stimuli has remained poorly understood. The objectives of the study were to quant...

journal_title：Journal of immunotoxicology

authors： Dar SA,Das S,Ramachandran VG,Bhattacharya SN,Mustafa MD,Banerjee BD,Verma P

更新日期：2012-01-01 00:00:00