abstract：:The transcription factor Blimp-1 is necessary for the B cell differentiation toward immunoglobulin-secreting plasma cells. However, the immunopathological mechanisms of Blimp-1 that regulates B cell differentiation remain unclear in MG. The purpose of this study was to perform a quantitative and functional analysis of...

journal_title：Immunologic research

authors： Xu Y,Huang X,Li F,Liu T,Yang T,Chen F,Zhu J,Pan M,Zhang Y,Wang Y,Fu L,Xiao C,Geng D

更新日期：2020-11-03 00:00:00

abstract：:Anti-rods and rings (anti-RR) antibody induction is related to the combination of interferon and ribavirin in the treatment of hepatitis C virus (HCV) infection. If the main factor leading to this autoimmune reaction is the combination of these drugs, is not well known, but in vitro studies shows that ribavirin alone ...

journal_title：Immunologic research

authors： da Silva Sacerdote AB,Filgueira NA,de Barros Barreto S,Batista AD,Lopes EP

更新日期：2020-06-01 00:00:00

abstract：:Aberrant T helper-2 (Th2) responses play a critical role in the pathogenesis of allergic diseases. The underlying mechanism is to be further investigated. It is reported that soluble CD83 (sCD83) has immune-regulatory effects. This study aims to investigate the role of sCD83 in the regulation of Th2 polarization. Bloo...

journal_title：Immunologic research

authors： Song W,Li H,Jia B,Wang Z,Liu Q,Yang G,Li X

更新日期：2020-06-01 00:00:00

abstract：:The etiology of polyarteritis nodosa (PAN) and localized PAN, including cutaneous arteritis (CA), remains unknown; however, initial endothelial damage has been implicated. The intima of the vasculitis lesions is predominantly infiltrated by innate-like bystander-activated CD8 T cells, in addition to the macrophages. M...

journal_title：Immunologic research

authors： Kobayashi M,Matsumoto Y,Satomi H,Tateishi A,Ohya M,Ito I,Kanno H

更新日期：2020-06-01 00:00:00

abstract：:The coexistence of alopecia areata (AA) and systemic lupus erythematosus (SLE) has been described, but the association between these conditions is yet to be firmly established. We aimed to evaluate the association between AA and SLE using a large-scale real-life computerized database. A cross-sectional study was condu...

journal_title：Immunologic research

authors： Kridin K,Shalom G,Comaneshter D,Cohen AD

更新日期：2020-02-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) disorders compromise lymphocyte numbers and/or function. One subset of SCID typically affects T cell and Natural Killer (NK) cell development in tandem (T-B+NK-) due to mutations arising in the genes encoding the common γ chain or Janus Kinase 3 (JAK3). In rare circumstances, mu...

journal_title：Immunologic research

authors： Khanolkar A,Wilks JD,Liu G,Simpson BM,Caparelli EA,Kirschmann DA,Bergerson J,Fuleihan RL

更新日期：2020-02-01 00:00:00

abstract：:With several different CAR T cell therapies under advanced phases of clinical trials, and the first FDA-approved CAR treatments in 2017 (Yescarta and Kymriah), CAR T cell therapy has become one of the most promising therapies for the treatment of certain types of cancer. This success has bred an opportunity to optimiz...

journal_title：Immunologic research

authors： Townsend MH,Bennion K,Robison RA,O'Neill KL

更新日期：2020-02-01 00:00:00

abstract：:The Cluster of differentiation 226(CD226)/T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif domain (TIGIT) axis plays an important role in the balance of the immune response. A previous study showed that CD226 is involved in CD4+ T cell differentiation and that blocking CD226 may attenuate expe...

journal_title：Immunologic research

authors： Wang N,Liang S,Jin J,Fang L,Ma Q,Wang X,Song Y,Chen L

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study was to determine whether interleukin-10 (IL-10) polymorphisms are associated with susceptibility to Behcet's disease (BD). A meta-analysis was conducted, examining the associations between the IL-10 - 1082 G/A, - 819 C/T, and - 592 C/A polymorphisms and BD in various ethnic groups. Fourteen studi...

journal_title：Immunologic research

authors： Lee YH,Song GG

更新日期：2019-10-01 00:00:00

abstract：:Limited protective effects of commercially available vaccines necessitate the development of novel pneumococcal vaccines. We recently reported a pneumococcal systemic vaccine containing two proteins, Pneumococcal surface protein A (PspA of family 1 and 2) and a bacterium-like particle-based pneumococcal mucosal vaccin...

journal_title：Immunologic research

authors： Zhang Y,Guo X,Guo M,Chen X,Li B,Yu J,Gu T,Kong W,Wu Y

更新日期：2019-10-01 00:00:00

abstract：:Previous studies showed that interleukin (IL)-28B gene polymorphisms were associated with hepatitis C Virus (HCV) infection and treatment outcomes. We tested whether single-nucleotide polymorphisms (SNPs) in IL-28A and IL-28B are associated with HCV infection among Egyptians with HCV genotype 4 infections. We enrolled...

journal_title：Immunologic research

authors： Zakaria ZA,Knapp S,Hashem M,Zaghla H,Thursz M,Waked I,Abdelwahab S

更新日期：2019-02-01 00:00:00

abstract：:Corn, soybean, spinach leaf, and tomato aquaporins have been shown to share homology with human aquaporin-4, which is abundantly expressed by brain astrocytic endfeet. Thus, antibodies formed against the dietary aquaporins may potentially cross-react with brain aquaporin, leading to blood-brain barrier permeability an...

journal_title：Immunologic research

authors： Lambert J,Mejia S,Vojdani A

更新日期：2019-02-01 00:00:00

abstract：:In all eukaryotes, the cell shape depends on the actin filament cytoskeleton, which is regulated by the small GTPase RhoA. It is well known that the cell shape determines cell function and behavior. Inversely, any change in the cell behavior and/or function reverberates at the cell shape. In this review, we describe h...

journal_title：Immunologic research

authors： Wosik J,Suarez-Villagran M,Miller JH Jr,Ghobrial RM,Kloc M

更新日期：2019-02-01 00:00:00

abstract：:EBV (Epstein-Barr Virus) and other human DNA viruses are associated with autoimmune syndromes in epidemiologic studies. In this work, immunoglobulin G response to EBV-encoded proteins which share regions with human immune response proteins from the human host including ZEBRA (BZLF-1 encoded protein), BALF-2 recombinas...

journal_title：Immunologic research

authors： Dreyfus DH,Farina A,Farina GA

更新日期：2018-12-01 00:00:00

abstract：:The "X chromosome-nucleolus nexus" hypothesis provides a comprehensive explanation of how autoantibodies can develop following cellular stress. The hypothesis connects autoimmune diseases with the impact of environmental factors, such as viruses, through epigenetic disruption. The inactive X chromosome, a major epigen...

journal_title：Immunologic research

authors： Brooks WH

更新日期：2018-12-01 00:00:00

abstract：:Schizophrenia is considered to be of the severe psychiatric disorders characterized by chronic debilitating course marked with frequent relapses and high clinical and financial burden. Aberrations of thyroid hormone levels have been documented in several psychiatric conditions including bipolar disease. The aim of thi...

journal_title：Immunologic research

authors： Sharif K,Tiosano S,Watad A,Comaneshter D,Cohen AD,Shoenfeld Y,Amital H

更新日期：2018-12-01 00:00:00

abstract：:The distinction that in areas where helminthic infections are common, autoimmune diseases are less prevalent, led to the investigation of immune modulatory properties of helminths and their derivatives. Such are phosphorylcholine (PC) moieties which are a component of secreted products of helminths. PC has been broadl...

journal_title：Immunologic research

authors： Segal Y,Blank M,Shoenfeld Y

更新日期：2018-12-01 00:00:00

abstract：:T follicular regulatory (Tfr) cell is a CXCR5+Foxp3+ subset of T regulatory (Treg) cell with critical roles in regulating germinal center responses and modulating the immune environment in the lymph nodes. Studies have shown that the proportion of Tfr cells may increase during acute inflammation. In this study, we inv...

journal_title：Immunologic research

authors： Li H,Zhou R,Wang C,Li Y,Zheng G,Jiang S,Dong T,Bai J,Xu S

更新日期：2018-08-01 00:00:00

abstract：:IgA nephropathy (IgAN) is an autoimmune disease associated with complement activation. It is unclear whether the ratio of serum C3 and C4 concentrations (C3/C4 ratio) can predict renal outcomes in IgAN patients. A total of 1503 patients diagnosed with IgAN via renal biopsy were recorded in this study. Poor renal outco...

journal_title：Immunologic research

authors： Pan M,Zhou Q,Zheng S,You X,Li D,Zhang J,Chen C,Xu F,Li Z,Zhou Z,Zhang J

更新日期：2018-06-01 00:00:00

abstract：:Primary immunodeficiencies (PI) are genetic defects of the immune system that result in chronic, serious, and often life-threatening infections, if not diagnosed and treated. Many patients with PI are undiagnosed, underdiagnosed, or misdiagnosed. In fact, recent studies have shown that PI may be more common than previ...

journal_title：Immunologic research

authors： Modell V,Orange JS,Quinn J,Modell F

更新日期：2018-06-01 00:00:00

abstract：:The purpose of this article is to study the involvement of inflammatory mast cells (MCs) in depression which may be inhibited by IL-37. We evaluate mast cells in depression on the basis of our previous experimental data, and using the most relevant studies reported in the literature. Dysfunction of mood, feelings, and...

journal_title：Immunologic research

authors： Conti P,Caraffa A,Ronconi G,Conti CM,Kritas SK,Mastrangelo F,Tettamanti L,Theoharides TC

更新日期：2018-06-01 00:00:00

abstract：:This study investigated nitro-oxidative stress in patients with systemic lupus erythematosus (SLE) in association with disease activity, immune-inflammatory biomarkers, and adhesion molecules. Two-hundred-four patients with SLE and 256 healthy volunteers were enrolled in this case-control study, which measured nitro-o...

journal_title：Immunologic research

authors： Scavuzzi BM,Simão ANC,Iriyoda TMV,Lozovoy MAB,Stadtlober NP,Franchi Santos LFDR,Flauzino T,de Medeiros FA,de Sá MC,Consentin L,Reiche EMV,Maes M,Dichi I

更新日期：2018-02-01 00:00:00

abstract：:Natural killer cells play a major role in innate immunity against tumor and virus-infected cells. NK cells express activating and inhibitory receptors to regulate their function. It has been established that modulation in the NK cell receptor profile results in altered function of NK cell against target cells. Here, w...

journal_title：Immunologic research

authors： Sharma R,Das A

更新日期：2018-02-01 00:00:00

abstract：:Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and m...

journal_title：Immunologic research

authors： Alijotas-Reig J,Esteve-Valverde E,Gil-Aliberas N,Garcia-Gimenez V

更新日期：2018-02-01 00:00:00

abstract：:Increased numbers of CD8+CD28neg. T cells have been detected in the peripheral blood of patients with several types of malignancies. However, the role of these cells in anticancer immunity are not yet clear and CD8+CD28neg. T cells are a controversially discussed subpopulation reported both as immunosuppressive and cy...

journal_title：Immunologic research

authors： Hashimoto H,Sterk M,Schilbach K

更新日期：2018-02-01 00:00:00

abstract：:The key role of T cells in hepatitis C virus (HCV) elimination and the ability of dendritic cells (DCs) to induce antiviral T cell responses suggest that DC vaccines could be a promising approach in the treatment of chronic HCV infection. The aim of our study was to evaluate, whether immunotherapy with DCs is safe and...

journal_title：Immunologic research

authors： Chernykh E,Leplina O,Oleynik E,Tikhonova M,Tyrinova T,Starostina N,Ostanin A

更新日期：2018-02-01 00:00:00

abstract：:Human α-fucosidase (EC 3.2.1.51) is an enzyme (hydrolase) of particular biological and medical interest, as the inherited deficiency in its activity leads to fucosidosis, a pathology belonging to severe glycoprotein lysosomal storage disorders. Although its importance has increased in latest years, data about its plas...

journal_title：Immunologic research

authors： Endreffy I,Bjørklund G,Szerafin L,Chirumbolo S,Urbina MA,Endreffy E

更新日期：2017-10-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an intractable multifaceted disease with high mortality. Although its pathogenesis is not fully understood, recent studies have advanced our knowledge on SSc. The cardinal pathological features of SSc are autoimmunity, vasculopathy, and fibrosis. The B cells in SSc are constitutively activa...

journal_title：Immunologic research

authors： Furue M,Mitoma C,Mitoma H,Tsuji G,Chiba T,Nakahara T,Uchi H,Kadono T

更新日期：2017-08-01 00:00:00

abstract：:Tumor necrosis factor (TNF) inhibitors have been found to exhibit certain efficacy in treating refractory Takayasu arteritis (TA) in clinic despite severe adverse effects. The aim of this study is to investigate a natural anti-TNF compound, curcumin, its function, and its potential as treatment against TA. In total, 2...

journal_title：Immunologic research

authors： Shao N,Jia H,Li Y,Li J

更新日期：2017-08-01 00:00:00

abstract：:Dendritic cells (DCs) are considered a very promising arm to activate the immune system in immunotherapeutic strategies against cancer. DCs are the most powerful antigen-presenting cells (APCs), being highly efficient at generating robust immune responses. They are also considered the center of the immune system, sinc...

journal_title：Immunologic research

authors： Constantino J,Gomes C,Falcão A,Neves BM,Cruz MT

更新日期：2017-08-01 00:00:00

abstract：:Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protec...

journal_title：Immunologic research

authors： Lv Y,Mattson E,Bhadurihauck A,Garcia K,Li L,Xiao Z

更新日期：2017-08-01 00:00:00

abstract：:Liver injury after experimental acetaminophen treatment is mediated both by direct hepatocyte injury through a P450-generated toxic metabolite and indirectly by activated liver Kupffer cells and neutrophils. This study was designed to investigate the role of Notch signaling in the regulation of innate immune responses...

journal_title：Immunologic research

authors： Jiang L,Ke M,Yue S,Xiao W,Yan Y,Deng X,Ying QL,Li J,Ke B

更新日期：2017-06-01 00:00:00

abstract：:Contrasting results have been reported about the prevalence of thyroid autoimmunity (AT) and dysfunction (TD) in patients with psoriatic arthritis (PsA). In this study, we pointed to evaluate the incidence of new cases of clinical and subclinical TD in a broad group of patients with PsA versus a control group, matched...

journal_title：Immunologic research

authors： Fallahi P,Ferrari SM,Ruffilli I,Elia G,Miccoli M,Sedie AD,Riente L,Antonelli A

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to examine the role and mechanism of interleukin-10 (IL-10)-producing regulatory B cells (B10 cells) in the pathogenesis of Henoch-Schönlein purpura nephritis (HSPN). We examined the percentage of B10 cells, CD19+CD24hiCD38hi B cells, CD19+CD24hiCD27+ B cells, Th17 cells, and T regulat...

journal_title：Immunologic research

authors： Yang B,Tan X,Xiong X,Wu D,Zhang G,Wang M,Dong S,Liu W,Yang H,Li Q

更新日期：2017-06-01 00:00:00

abstract：:Anti-nuclear antibody (ANA) positivity suggests CTD but can also lead to a diagnosis of UCTD when a patient does not fulfill the CTD diagnostic criteria. An anti-dense fine speckled (DFS) immunofluorescence (IIF) pattern can be observed when using an ANA test on HEp-2 cells and is due to the presence of antibodies to ...

journal_title：Immunologic research

authors： Infantino M,Meacci F,Grossi V,Manfredi M,Li Gobbi F,Sarzi-Puttini P,Atzeni F,Benucci M

更新日期：2017-02-01 00:00:00

abstract：:A 20-year-old man developed severe abdominal pain 1 week after being vaccinated with the first dose of quadrivalent human papillomavirus (HPV) vaccine (Gardasil®). Despite ongoing symptoms of nausea and pain, he received the second dose of the vaccine. Only 10 days later, laboratory results revealed significantly elev...

journal_title：Immunologic research

authors： Bizjak M,Bruck O,Praprotnik S,Dahan S,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:Anti-HMGCR antibodies represent a characteristic serological feature of statin-exposed and statin-unexposed patients with immune-mediated necrotizing myopathy (IMNM). We assessed anti-HMGCR antibodies in patients with suspected IMNM following statin exposure and patients with other autoimmune rheumatic diseases. We ev...

journal_title：Immunologic research

authors： Shovman O,Gilburd B,Chayat C,Lazar AD,Amital H,Blank M,Bentow C,Mahler M,Shoenfeld Y

更新日期：2017-02-01 00:00:00

abstract：:Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder characterized by repeated episodes of apnea and hypopnea during sleep. Continuous positive airway pressure (CPAP) is the most effective method for treating OSAS and alleviating the patients' symptoms. The aim of this study was to assess the effect of 3...

journal_title：Immunologic research

authors： Can M,Uygur F,Tanrıverdi H,Acıkgoz B,Alper B,Guven B

更新日期：2016-12-01 00:00:00

abstract：:Neutrophils are key effector cells of the innate immune system and are involved in the host defense against invading pathogens such as viruses. Recently, it was reported that HIV-1-neutrophil interaction triggers neutrophil activation and promotes expression of Toll-like receptors (TLRs). Here, we assessed the role of...

journal_title：Immunologic research

authors： Giraldo DM,Hernandez JC,Urcuqui-Inchima S

更新日期：2016-12-01 00:00:00

abstract：:A complex interplay between pathogen and host determines the immune response during viral infection. A set of cytosolic sensors are expressed by immune cells to detect viral infection. NOD-like receptors (NLRs) comprise a large family of intracellular pattern recognition receptors. Members of the NLR family assemble i...

journal_title：Immunologic research

authors： Shrivastava G,León-Juárez M,García-Cordero J,Meza-Sánchez DE,Cedillo-Barrón L

更新日期：2016-12-01 00:00:00