abstract：BACKGROUND AND AIM:Hepatocellular carcinoma (HCC) remains a serious cause of cancer-related deaths worldwide. Developing new therapeutic strategies is urgently needed to improve the outcomes of HCC patients. Dendritic cell (DC)-based vaccines and programmed death 1 (PD-1) immune checkpoint inhibitors have been regarded...

journal_title：Journal of gastroenterology and hepatology

authors： Teng CF,Wang T,Shih FY,Shyu WC,Jeng LB

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND AND AIM:The role of hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2α (HIF-2α) has been implicated in the clinical prognosis of hepatocellular carcinoma (HCC), but the results remain controversial. We aim to investigate the association of HIF-1α and HIF-2α overexpression with the prognosis...

journal_title：Journal of gastroenterology and hepatology

authors： Ding ZN,Dong ZR,Chen ZQ,Yang YF,Yan LJ,Li HC,Liu KX,Yao CY,Yan YC,Yang CC,Li T

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND AND AIM:Single-nucleotide polymorphisms (SNPs) in long non-coding RNAs (lncRNAs) are potential biomarkers for cancer risk, but their association with hepatocellular carcinoma (HCC) is unclear. We examined the association of lncRNA-related SNPs with HCC susceptibility and explored the optimal genetic models f...

journal_title：Journal of gastroenterology and hepatology

authors： Li Y,He HC,Zhou DL,Liu Q,Zhang X,Yang XH,Ye ZL,Peng JL,Tang T,Su X,He CY

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND AND AIM:Although endoscopic ultrasound-guided fine-needle biopsy is widely applied, there is no clear consensus on the optimal biopsy technique. We described a modified wet suction technique (MWEST) with the aim to compare the efficacy and safety between MWEST and the dry suction technique (DST). METHODS:In...

journal_title：Journal of gastroenterology and hepatology

authors： Tong T,Tian L,Deng M,Liu Y,Yang Y,Yin H,Long X,Pan S,Yang Z,Luo W,Nie K,Meng X,Xiao M,Wu X,Zhang C,Wang X

更新日期：2020-12-08 00:00:00

abstract：:Dysbiosis in the gut microbiota composition due to environmental or genetic variations can disrupt the immune system and may promote several diseases such as colorectal cancer (CRC). Gut microbiota can alter the toxicity and efficiency of an extensive range of CRC treatment methods, especially surgery, chemotherapy, r...

journal_title：Journal of gastroenterology and hepatology

authors： Taghinezhad-S S,Mohseni AH,Fu X

更新日期：2020-12-08 00:00:00

abstract：BACKGROUND AND AIM:Approximately 42-95% of working channels have been reported to show the presence of residual fluid despite endoscope reprocessing. The aim of this study was to design two novel protocols for cleaning residual simethicone and demonstrate its efficiency by evaluating the residual fluid and cleanliness ...

journal_title：Journal of gastroenterology and hepatology

authors： Peng CL,Liu TC,Wang HP,Chang WK

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND AND AIM:Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. Previous studies have investigated the association between dietary patterns and NAFLD, but their results are contradictory. Therefore, we carried out this meta-analysis to examine the association betw...

journal_title：Journal of gastroenterology and hepatology

authors： Hassani Zadeh S,Mansoori A,Hosseinzadeh M

更新日期：2020-12-02 00:00:00

abstract：BACKGROUND AND AIM:Fusobacterium nucleatum (Fn) is involved in colorectal cancer (CRC) growth and is a biomarker for patient prognosis and management. However, the ecology of Fn in CRC and the distribution of intratumoral Fn are unknown. METHODS:We evaluated Fn and the status of KRAS and BRAF in 200 colorectal neoplas...

journal_title：Journal of gastroenterology and hepatology

authors： Yamamoto S,Kinugasa H,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Harada K,Hiraoka S,Nouso K,Tanaka T,Teraishi F,Fujiwara T,Okada H

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND AND AIM:Real-world data on sofosbuvir/velpatasvir with and without ribavirin (SOF/VEL ± RBV), particularly among patients with genotype 3 (GT3) decompensated cirrhosis, prior treatment, coinfection, and hepatocellular carcinoma (HCC), are scarce. We aimed to assess the efficacy and safety of SOF/VEL ± RBV in...

journal_title：Journal of gastroenterology and hepatology

authors： Wong YJ,Thurairajah PH,Kumar R,Tan J,Fock KM,Law NM,Li W,Kwek A,Tan YB,Koh J,Lee ZC,Kumar LS,Teo EK,Ang TL

更新日期：2020-11-20 00:00:00

abstract：BACKGROUND AND AIM:This study was designed to determine whether non-alcoholic fatty liver disease (NAFLD), with or without metabolic syndrome (MetS), is a risk factor for cancer development. METHODS:We conducted a retrospective longitudinal study at the Center for Preventive Medicine, St. Luke's International Hospital...

journal_title：Journal of gastroenterology and hepatology

authors： Yamamoto K,Ikeya T,Okuyama S,Fukuda K,Kobayashi D

更新日期：2020-11-17 00:00:00

abstract：BACKGROUND AND AIM:This study investigated the usefulness of near-focus narrowband imaging (NF-NBI) for determining gastric tumor margins compared with indigo carmine chromoendoscopy (ICC) before endoscopic submucosal dissection (ESD). METHODS:This prospective randomized controlled trial was conducted at seven teachin...

journal_title：Journal of gastroenterology and hepatology

authors： Kim JW,Jung Y,Jang JY,Kim GH,Bang BW,Park JC,Choi HS,Cho JH,Research Group for Endoscopic Instruments and Stents of Korean Society of Gastrointestinal Endoscopy.

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND AIM:Fecal microbiota transplantation (FMT) has proven to be very effective in recurrent Clostridium difficile infection (CDI) when compared with standard antibiotic therapy. However, given the lack of validated criteria, decision regarding number and timing of infusions is currently based on the clinicia...

journal_title：Journal of gastroenterology and hepatology

authors： Gallo A,Cancelli C,Ceron E,Covino M,Capoluongo E,Pocino K,Ianiro G,Cammarota G,Gasbarrini A,Montalto M

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND AND AIM:The number of colonoscopies required to reach satisfactory adenoma detection rate (ADR) is not well established. The aim of this study was to identify the appropriate number of procedures required to attain satisfactory ADR for those well-trained endoscopists who have a cecal intubation rate (CIR) ≥ ...

journal_title：Journal of gastroenterology and hepatology

authors： Dong Z,Sun H,Li B,Zhang Q,Sun K,Wang Z,Qian X,Wang J,Zhan T,Jiang Y,Chen Y,Xu S

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND AND AIM:Since the advent of direct-acting antiviral (DAA) therapy, the total eradication of hepatitis C virus has been achievable with the recovery of hepatic reserve after achievement of sustained virologic response (SVR). Hence, here, we examined the factors affecting the recovery of hepatic reserve. METH...

journal_title：Journal of gastroenterology and hepatology

authors： Nakajima T,Karino Y,Hige S,Suii H,Tatsumi R,Yamaguchi M,Arakawa T,Kuwata Y,Hasegawa T,Toyota J

更新日期：2020-09-29 00:00:00

abstract：:Artificial liver systems are used to bridge between transplantation or to allow a patient's liver to recover. They are used in patients with acute liver failure (ALF) and acute-on-chronic liver failure. There are five artificial systems currently in use: molecular adsorbent recirculating system (MARS), single-pass alb...

journal_title：Journal of gastroenterology and hepatology

authors： Tandon R,Froghi S

更新日期：2020-09-12 00:00:00

abstract：BACKGROUND AND AIM:Intubation of the terminal ileum (TI) demonstrates a complete colonoscopy, but its clinical value during screening exams is unknown. We aimed to determine whether TI intubation during screening colonoscopy is associated with colonoscopy quality measures or identifies subclinical pathology. METHODS:W...

journal_title：Journal of gastroenterology and hepatology

authors： Leiman DA,Jawitz NG,Lin L,Wood RK,Gellad ZF

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND AIM:The European evidence-based guidelines (EEG) and American College of Gastroenterology Guidelines (ACGG) have been published to guide the management of pancreatic cystic lesions. We aim to evaluate the value of both guidelines in predicting advanced pancreatic cystic lesions (A-PCLs) with preoperative...

journal_title：Journal of gastroenterology and hepatology

authors： Sun L,Wang W,Wang Y,Jiang F,Peng L,Jin G,Jin Z

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic resection is highly effective treatment option for rectal neuroendocrine tumors (NETs) as they usually present as small localized tumors. However, there are no well-established surveillance strategies following endoscopic resection. We established our own protocol for the surveillance of r...

journal_title：Journal of gastroenterology and hepatology

authors： Chung HG,Goh MJ,Kim ER,Hong SN,Kim TJ,Chang DK,Kim YH

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND AND AIM:Nonattendance of outpatient colonoscopy leads to inefficient use of health-care resources. We aimed to study the effectiveness of using Short Message Service (SMS) reminder prior in patients scheduled for outpatient colonoscopy on their nonattendance rate. METHODS:Patients who scheduled for an outpa...

journal_title：Journal of gastroenterology and hepatology

authors： Lam TYT,Hui AJ,Sia F,Wong MY,Lee CCP,Chung KW,Lau JYW,Wu PI,Sung JJY

更新日期：2020-08-16 00:00:00

abstract：:Two intertwined compartments coexisting in nonpolypoid conventional (i.e. tubular or villous) adenomas are highlighted in this review: one built of dysplastic tissue on top and the other portraying crypts with irregular, corrupted shapes, albeit lined with normal epithelium, below. The latter compartment has remained ...

journal_title：Journal of gastroenterology and hepatology

authors： Rubio CA

更新日期：2020-08-05 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic resection is feasible for superficial tumors in patients with ulcerative colitis; however, endoscopic resection options have not been evaluated comprehensively. We evaluated the efficacy and safety of endoscopic submucosal dissection and endoscopic mucosal resection, and decision making re...

journal_title：Journal of gastroenterology and hepatology

authors： Nishio M,Hirasawa K,Ozeki Y,Sawada A,Ikeda R,Fukuchi T,Kobayashi R,Makazu M,Sato C,Kunisaki R,Maeda S

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND AND AIMS:Epidemics pose a great challenge to health care of patients. However, the impact of unprecedented situation of COVID-19 outbreak on health care of inflammatory bowel disease (IBD) patients in real-world setting has seldom been investigated. METHODS:We performed an observational study in a tertiary ...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang YF,Qiu Y,He JS,Tan JY,Li XZ,Zhu LR,Chen Y,Liu ZJ,Iacucci M,Chen BL,He Y,Ben-Horin S,Shen B,Zeng ZR,Ghosh S,Chen MH,Mao R

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND AIM:Lipids play important roles in inflammation and may be involved in the pathophysiology of inflammatory bowel disease (IBD). Here, we evaluated the characteristics of the plasma lipid profile in patients with IBD. METHODS:Plasma samples were collected from 20 patients with Crohn's disease (CD), 20 pa...

journal_title：Journal of gastroenterology and hepatology

authors： Iwatani S,Iijima H,Otake Y,Amano T,Tani M,Yoshihara T,Tashiro T,Tsujii Y,Inoue T,Hayashi Y,Takeda K,Hayashi A,Fujita S,Shinzaki S,Takehara T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND AIM:DNA methylation is an important epigenetic modification that can promote the development of various cancers. The STAT1 and SOCS3 have been observed to be hypermethylated in tumor tissues and peripheral blood. This study aimed to explore the relationship between the methylation status of the STAT1 and...

journal_title：Journal of gastroenterology and hepatology

authors： Han Q,Zhou H,Xie W,Sun T,Wei R,Nie C,Hong J,Zhu L,Tian W

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND AIM:At present, there is no recognized diagnostic criteria for gastric low-grade intraepithelial neoplasia (LGIN). The purpose of this study was to determine whether an "endoscopic acanthosis nigricans appearance (EANA)" could be a useful endoscopic marker for distinguishing LGIN lesions from peripheral ...

journal_title：Journal of gastroenterology and hepatology

authors： Cheng J,Xu X,Zhuang Q,Luo S,Gong X,Wu X,Wan X,Zhou H

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is used to diagnose lesions within or adjacent to the digestive tract. However, there is no report on the overall diagnostic accuracy, technical success, and adverse events of FNB. The aims of this study were to conduct a systematic review and...

journal_title：Journal of gastroenterology and hepatology

authors： Li DF,Wang JY,Yang MF,Xiong F,Zhang DG,Xu ZL,Luo MH,Jing ZD,Wang KX,Wang LS,Yao J

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND AND AIM:We elucidated the clinical significance of distal contractile integral-to-esophageal impedance integral (EII) ratio (DCIIR) in ineffective esophageal motility (IEM) adult patients. METHODS:We recruited 101 patients with IEM (48.38 ± 1.58 years) and 42 matched healthy volunteers (44.28 ± 1.85 years) ...

journal_title：Journal of gastroenterology and hepatology

authors： Wu JF,Tsai IJ,Tong TW,Lin YC,Yang CH,Tseng PH

更新日期：2020-08-01 00:00:00

abstract：:Affecting one fourth of the global population, non-alcoholic fatty liver disease (NAFLD) is the commonest chronic liver disorder. It encompasses the simple liver fat accumulation to more progressive steatosis, inflammation, and fibrosis characterized as non-alcoholic steatohepatitis (NASH) and in some cases cirrhosis ...

journal_title：Journal of gastroenterology and hepatology

authors： Chrysavgis L,Papatheodoridi AM,Chatzigeorgiou A,Cholongitas E

更新日期：2020-07-27 00:00:00

abstract：BACKGROUND AND AIM:Exogenous 8-hydroxydeoxyguanosine (8-OHdG) was suggested as an inhibitor of Rac1 and NADPH oxidase (NOX). The aim of this study was to evaluate the effects of the exogenous 8-OHdG on hepatic fibrogenesis in vitro and in vivo model of liver fibrosis. METHODS:Adult Sprague-Dawley rats were allocated t...

journal_title：Journal of gastroenterology and hepatology

authors： Shin SK,Kim KO,Kim SH,Kwon OS,Choi CS,Jeong SH,Kim YS,Kim JH,Chung MH

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Emerging evidence suggests aldosterone (aldo) and NLRP3 inflammasome are important factors for HSC activation and liver fibrosis. However, the interaction between aldo and NLRP3 inflammasome in HSC activation and liver fibrosis remains largely unknown. The aim of this study is to investigate the rel...

journal_title：Journal of gastroenterology and hepatology

authors： Li Y,Zhang Y,Chen T,Huang Y,Zhang Y,Geng S,Li X

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND AND AIM:Currently, endoscopic drainage (ED) and percutaneous drainage (PD) are both widely used effective interventions in the management of patients with symptomatic pancreatic fluid collections (PFCs). This study aimed to compare the clinical effectiveness and safety of ED to those of PD in the treatment o...

journal_title：Journal of gastroenterology and hepatology

authors： Wan J,Wu D,He W,Zhu Y,Zhu Y,Zeng H,Liu P,Xia L,Lu N

更新日期：2020-05-30 00:00:00

abstract：BACKGROUND AND AIMS:Double-guidewire technique (DWT) has been successfully performed by experts in difficult biliary cannulation as an advanced technique. This study aimed to define the learning curve and safety of DWT by trainees during hands-on endoscopic retrograde cholangiopancreatography (ERCP) training. METHODS:...

journal_title：Journal of gastroenterology and hepatology

authors： Wang X,Ren G,Xi Y,Luo H,Liang S,Wang B,Tao Q,Luo B,Qin Q,Farrell JJ,Guo X,Wu K,Pan Y

更新日期：2020-05-30 00:00:00

abstract：BACKGROUND AND AIM:Mitochondrial damage is commonly involved in liver injury. We have previously shown that normal mitochondria can be coated with a carrier protein to form complexes that are specifically taken up by liver cells in culture. The aim of the current study was to determine whether mitochondrial complexes c...

journal_title：Journal of gastroenterology and hepatology

authors： Liu X,Khouri-Farah N,Wu CH,Wu GY

更新日期：2020-05-09 00:00:00

abstract：BACKGROUND AND AIM:The effect of solid debris on walled-off necrosis (WON) drainage remains unknown. Our study evaluated the role of solid debris in endoscopic ultrasound (EUS)-guided drainage of WON compared lumen-apposing metal stent (LAMS) with double-pigtail plastic stent (DPPS). METHODS:We retrospectively evaluat...

journal_title：Journal of gastroenterology and hepatology

authors： Zhu H,Xie P,Wang Y,Jin Z,Li Z,Du Y

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND AND AIM:Hepatitis B core-related antigen (HBcrAg) has been shown to correlate with various viral markers in chronic hepatitis B, but its role in defining natural history is not well studied. We aimed to investigate the use of HBcrAg to define different phases of chronic hepatitis B. METHODS:Stored residual ...

journal_title：Journal of gastroenterology and hepatology

authors： Chan HLY,Yasuda S,Wong GLH,Tada T,Chan CKM,Kumada T,Tse YK,Wong VWS,Toyoda H

更新日期：2020-04-15 00:00:00

abstract：:The incidence of inflammatory bowel diseases (IBD) in East has risen over the past decade to become a global disease. The increasing number of studies on the incidence and course of IBD in East has enabled us to explore East versus West differences in the epidemiology of IBD which could enhance our understanding of th...

journal_title：Journal of gastroenterology and hepatology

authors： Mak WY,Zhao M,Ng SC,Burisch J

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND AIM:Although several techniques for improved outcomes in endoscopic ultrasound (EUS)-guided tissue acquisition have been reported, the reported diagnostic yield for pancreatic masses is not satisfactory. The effects of novel technique (torque method) on twisting the scope in the clockwise or counterclock...

journal_title：Journal of gastroenterology and hepatology

authors： Park SW,Lee SS,Song TJ,Koh DH,Hyun B,Chung D,Lee J,Shin E,Hong SM,Park CH

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study is to evaluate the epidemiology and impact of bacterial infections at admission in patients with acute decompensation (AD) of cirrhosis. METHODS:A cohort with AD of cirrhosis (European Association for the Study of the Liver criteria) admitted at a tertiary center was evaluated ...

journal_title：Journal of gastroenterology and hepatology

authors： Gupta T,Lochan D,Verma N,Rathi S,Agrawal S,Duseja A,Taneja S,Chawla YK,Dhiman RK

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND AND AIM:Little is known whether routine prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is needed in patients with inflammatory bowel disease (IBD) on immunosuppression, especially in Asian populations. We, therefore, sought to investigate the incidence and risk factors of PJP in patients with IBD...

journal_title：Journal of gastroenterology and hepatology

authors： Nam K,Park SH,Lee J,Jo S,Kim SO,Noh S,Park JC,Kim JY,Kim J,Ham NS,Oh EH,Song EM,Hwang SW,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND AND AIM:It is unclear how adding an anti-tumor necrosis factor alpha agent to immunomodulator (IM) treatment, as a step-up strategy, affects long-term outcomes in ulcerative colitis. This retrospective study investigated persistence associated with biologic anti-tumor necrosis factor alpha agents combined wi...

journal_title：Journal of gastroenterology and hepatology

authors： Kobayashi T,Udagawa E,Uda A,Hibi T,Hisamatsu T

更新日期：2020-02-01 00:00:00