Targeted delivery of mitochondria to the liver in rats.

abstract：BACKGROUND AND AIM:Hepatitis C virus (HCV)-infected patients who responded to interferon (IFN) treatment with clearance of serum HCV RNA may rarely develop hepatocellular carcinoma (HCC). The aim of the present study was to elucidate the risk factors for liver carcinogenesis among such patients. METHODS:In total, 126 ...

journal_title：Journal of gastroenterology and hepatology

authors： Tokita H,Fukui H,Tanaka A,Kamitsukasa H,Yagura M,Harada H,Okamoto H

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND AND AIM:The role of hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2α (HIF-2α) has been implicated in the clinical prognosis of hepatocellular carcinoma (HCC), but the results remain controversial. We aim to investigate the association of HIF-1α and HIF-2α overexpression with the prognosis...

journal_title：Journal of gastroenterology and hepatology

authors： Ding ZN,Dong ZR,Chen ZQ,Yang YF,Yan LJ,Li HC,Liu KX,Yao CY,Yan YC,Yang CC,Li T

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND AND AIMS:A prospective, non-randomized cohort study on long-term lamivudine treatment, comparing efficacy, drug resistance, and prognosis for various stages of chronic hepatitis B virus (HBV)-related liver disease was performed to elucidate the significance and indication of lamivudine for individual patient...

journal_title：Journal of gastroenterology and hepatology

authors： Nishida T,Kobashi H,Fujioka S,Fujio K,Takaguchi K,Ikeda H,Kawaguchi M,Ando M,Araki Y,Higashi T,Shoji B,Takaki A,Iwasaki Y,Sakaguchi K,Shiratori Y,Yamamoto K

更新日期：2008-05-01 00:00:00

abstract：:The effect of tauro-beta-muricholate (beta MC-tau) and tauro-alpha-muricholate (alpha MC-tau) on oestradiol-17 beta-glucuronide (E217G)-induced cholestasis was compared with that of tauroursodeoxycholate (UDC-tau) in rats. Like UDC-tau, alpha MC-tau and beta MC-tau infused at the rate of 0.2 mumol/min per 100 g bodywe...

journal_title：Journal of gastroenterology and hepatology

authors： Takikawa H,Sano N,Aiso M,Takamori Y,Yamanaka M

更新日期：1997-01-01 00:00:00

abstract：:There are approximately 277,000 new cases of pancreatic cancer and 266,000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk fact...

journal_title：Journal of gastroenterology and hepatology

authors： Pandol S,Gukovskaya A,Edderkaoui M,Dawson D,Eibl G,Lugea A

更新日期：2012-03-01 00:00:00

abstract：:Complete duplication of the entire large bowel with partial ileal involvement is very rare and diagnosis can often be difficult as illustrated by this case report. We also review the other clinical associations of this rare condition and briefly discuss the embryology of duplications of the gastrointestinal tract. ...

journal_title：Journal of gastroenterology and hepatology

authors： Jimenez SG,Oliver MR,Stokes KB,Morreau PN,Chow CW

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND AIM:Pathological grading is important in defining the therapeutic strategy in pancreatic neuroendocrine neoplasm (PNEN) but is difficult for unresectable cases. Endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) is useful in the diagnosis of PNEN, but its usefulness for pathological grading ...

journal_title：Journal of gastroenterology and hepatology

authors： Horiguchi S,Kato H,Shiraha H,Tsutsumi K,Yamamoto N,Matsumoto K,Tomoda T,Uchida D,Akimoto Y,Mizukawa S,Tanaka T,Ichimura K,Takaki A,Yagi T,Okada H

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIM:Same-day bidirectional endoscopy, including esophagogastroduodenoscopy (EGD) and colonoscopy, is frequently performed to screen for cancer and gastrointestinal bleeding. However, the optimal sequence for the procedures is unclear thus far. The aim of this study was to evaluate the optimal sequence fo...

journal_title：Journal of gastroenterology and hepatology

authors： Hsieh YH,Lin HJ,Tseng KC

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND AND AIM:Epithelial-mesenchymal transition (EMT) of biliary epithelial cells (BECs) plays an important role in biliary fibrosis. This study investigated the effects of simvastatin on the lipopolysaccharide (LPS)-induced EMT and related signal pathways in BECs. METHODS:Biliary epithelial cells were exposed to...

journal_title：Journal of gastroenterology and hepatology

authors： Kim Y,Lee EJ,Jang HK,Kim CH,Kim DG,Han JH,Park SM

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND AND AIM:Bacterial metabolites produced in the bowel are potentially related to the genesis of colorectal cancer. Butyrate is protective against cancer, whereas hydrogen sulfide and oxygen free radicals can be toxic to the epithelium. The present study was designed to quantitate Eubacterium rectale, Faecaliba...

journal_title：Journal of gastroenterology and hepatology

authors： Balamurugan R,Rajendiran E,George S,Samuel GV,Ramakrishna BS

更新日期：2008-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a member of the virus family Flaviviridae. At present HCV is classified into a discrete hepacivirus genus and is represented by six clades according to genome sequencing. Each clade is further divisible into subtypes, which may prove important for the study of clinical differences and epidem...

journal_title：Journal of gastroenterology and hepatology

authors： Howard CR

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND AIM:Pancreatic pseudocyst is a common complication of chronic pancreatitis. The identification of risk factors and development of a nomogram for pancreatic pseudocysts in chronic pancreatitis patients may contribute to the early diagnosis and intervention of pancreatic pseudocysts. METHODS:Patients with...

journal_title：Journal of gastroenterology and hepatology

authors： Hao L,Pan J,Wang D,Bi YW,Ji JT,Xin L,Liao Z,Du TT,Lin JH,Zhang D,Zeng XP,Ye B,Zou WB,Chen H,Xie T,Li BR,Zheng ZH,Hu LH,Li ZS

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND AND AIM:Although larger biopsies sample had been recommended for the study of non-invasive liver fibrosis assessment, few studies with larger biopsies for transient elastography (TE) detecting liver fibrosis had been reported. The present study tries to re-evaluate the performance of TE for detecting advance...

journal_title：Journal of gastroenterology and hepatology

authors： Chen YP,Liang XE,Zhang Q,Peng J,Zhu YF,Wen WQ,Hou JL

更新日期：2012-07-01 00:00:00

abstract：:Hepatic ischemia reperfusion (IR) injury is an important clinical problem complicating liver surgery and transplantation. The pathogenesis underlying reperfusion injury after warm ischemia is complex, encompassing a multitude of different cell types and signalling mechanisms innate and/or mobilized to the liver. Since...

journal_title：Journal of gastroenterology and hepatology

authors： Teoh NC

更新日期：2011-01-01 00:00:00

abstract：:The in vitro binding of 125I-labelled human alpha-interferon to peripheral blood mononuclear cells from 13 patients with chronic hepatitis B during interferon therapy was assayed in order to identify changes in the number of interferon receptors during treatment. Nine patients were treated with human alpha-interferon ...

journal_title：Journal of gastroenterology and hepatology

authors： Nakajima S,Kuroki T,Kurai O,Kobayashi K,Yamamoto S

更新日期：1989-09-01 00:00:00

abstract：:Primary sclerosing cholangitis (PSC), a chronic inflammatory process affecting the extrahepatic and/or medium to large bile ducts, is not rare in children. It has features suggesting an autoimmune pathogenesis, although the mechanism of tissue damage remains unknown. The clinical presentation of childhood primary scle...

journal_title：Journal of gastroenterology and hepatology

authors： Roberts EA

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Upper gastrointestinal endoscopy remains the gold standard for diagnosis of esophageal varices. Trans-abdominal ultrasound, as a noninvasive routine examination for the follow-up of cirrhosis patient, is safe, cheap, easy to perform, and plays an important role. In this study, we attempt to design a...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang CX,Xu JM,Li JB,Kong DR,Wang L,Xu XY,Zhao DM

更新日期：2016-01-01 00:00:00

abstract：:To investigate the efficacy of standard and low dosage of omeprazole in the healing of duodenal ulcer, 270 patients with endoscopically active duodenal ulcer were randomized to receive omeprazole, 10 mg or 20 mg every morning, or ranitidine, 150 mg twice daily, using the double-dummy technique. Forty-six potential pro...

journal_title：Journal of gastroenterology and hepatology

authors： Hui WM,Lam SK,Lau WY,Branicki FJ,Lok AS,Ng MM,Lai CL,Poon GP

更新日期：1989-01-01 00:00:00

abstract：:The focus on colorectal neoplasia has led to an exponential increase in the use of colonoscopy in many countries. Although colonoscopy facilitates the diagnosis and treatment of colonic disease, there are public health issues that include access, training, diagnostic accuracy, complications and additions to health-car...

journal_title：Journal of gastroenterology and hepatology

authors： Roberts-Thomson IC,Teo E

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND AIM:Thyroid dysfunction is the most common endocrinopathy associated with hepatitis C and its interferon-based treatment. When undergoing treatment, interferon and ribavirin synergize to potently stimulate the immune system in order to eradicate the virus. One of the innocent bystanders in this accentuat...

journal_title：Journal of gastroenterology and hepatology

authors： Tran HA,Malcolm Reeves GE,Gibson R,Attia JR

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age-related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all-cause mortality rates ...

journal_title：Journal of gastroenterology and hepatology

authors： Horsfall LJ,Nazareth I,Pereira SP,Petersen I

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND AND AIM:It has been reported that the branched-chain amino acid (BCAA) to tyrosine ratio (BTR) is a useful indicator of liver function and BCAA therapy is associated with a decreased incidence of hepatocellular carcinoma (HCC). However, there has not been sufficient research on the relationship between BTR a...

journal_title：Journal of gastroenterology and hepatology

authors： Tada T,Kumada T,Toyoda H,Kiriyama S,Tanikawa M,Hisanaga Y,Kanamori A,Kitabatake S,Yama T

更新日期：2015-09-01 00:00:00

abstract：:The production of interleukin-8 (CINC: cytokine-induced neutrophil chemo-attractant) from different cell populations in the rat liver was studied and cells related to the initiation of CINC production in lipopolysaccharide (LPS)-injected endotoxaemic rats were characterized. Sinusoidal endothelial cells (16.4 +/- 10.6...

journal_title：Journal of gastroenterology and hepatology

authors： Ohkubo K,Masumoto T,Horiike N,Onji M

更新日期：1998-07-01 00:00:00

abstract：AIMS:To investigate the relations between the formation of pigment gallstone and the function of the intestinal mucosal barrier, as well as the underlying mechanism. METHODS:Eighty guinea pigs were randomly divided into three groups in which they were respectively given normal diet, gallstone-causing diet, and gallsto...

journal_title：Journal of gastroenterology and hepatology

authors： Su Y,Wu S,Fan Y,Jin J,Zhang Z

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND AND AIM:There are few studies investigating the treatment of hepatitis C virus (HCV) infection in current and former drug users. With this in mind, we sought to evaluate the antiviral efficacy of interferon alpha-2b (IFN alpha-2b) or pegylated-interferon alpha-2b (PEG-IFN alpha-2b) and ribavirin (RBV) in inj...

journal_title：Journal of gastroenterology and hepatology

authors： Grebely J,Raffa JD,Meagher C,Duncan F,Genoway KA,Khara M,McLean M,Mead A,Viljoen M,DeVlaming S,Fraser C,Conway B

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND AND AIMS:We have shown previously that concentrations of stool decay-accelerating factor (DAF; CD55), a complement regulatory protein, in patients with ulcerative colitis (UC) are increased in relation to the severity of the colonic mucosal inflammation. In the present study, we evaluated the usefulness of s...

journal_title：Journal of gastroenterology and hepatology

authors： Kohno H,Mizuno M,Nasu J,Makidono C,Hiraoka S,Inaba T,Yamamoto K,Okada H,Fujita T,Shiratori Y

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study is to confirm the efficacy of multipolar ablation with a new simulator system, three-dimensional (3-D) sim-Navigator, for patients with hepatocellular carcinoma by assessing relapse-free survival and shape of the ablation volume under clinical conditions. METHODS:All participan...

journal_title：Journal of gastroenterology and hepatology

authors： Hirooka M,Koizumi Y,Imai Y,Nakamura Y,Yukimoto A,Watanabe T,Yoshida O,Tokumoto Y,Abe M,Hiasa Y

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND AIM:Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) of unknown etiology. We aimed to identify the etiological agent of CD using a molecular cloning strategy that was particularly focused on identifying agents causing immune abnormalities and infectious agents. METHODS:We constructed a...

journal_title：Journal of gastroenterology and hepatology

authors： Iizuka M,Nakagomi O,Nanjo H,Chiba M,Fukushima T,Sugita A,Sagara S,Horie Y,Watanabe S

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The clinical significance and prognosis of mixed adenocarcinoma in early gastric cancer (EGC) are incompletely understood. The aim of this study was to evaluate the clinicopathological characteristics and long-term outcomes of mixed adenocarcinoma diagnosed as EGC after endoscopic submucosal dissect...

journal_title：Journal of gastroenterology and hepatology

authors： Han JP,Hong SJ,Kim HK

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIM:To present the experience in management of inflammatory liver pseudotumors from a specialist surgical unit and to review the medical literature on this rare manifestation. METHODS:Between 1995 and 2008, four patients were identified with this type of tumor from a total of 108 resected benign liver l...

journal_title：Journal of gastroenterology and hepatology

authors： Milias K,Madhavan KK,Bellamy C,Garden OJ,Parks RW

更新日期：2009-09-01 00:00:00