Effect of tauro-alpha-muricholate and tauro-beta-muricholate on oestradiol-17 beta-glucuronide-induced cholestasis in rats.

Abstract:

:The effect of tauro-beta-muricholate (beta MC-tau) and tauro-alpha-muricholate (alpha MC-tau) on oestradiol-17 beta-glucuronide (E217G)-induced cholestasis was compared with that of tauroursodeoxycholate (UDC-tau) in rats. Like UDC-tau, alpha MC-tau and beta MC-tau infused at the rate of 0.2 mumol/min per 100 g bodyweight (BW) completely inhibited the cholestasis induced by E217G infused at the rate of 0.06 mumol/min per 100 g BW for 20 min. These findings indicate that beta MC-tau and alpha MC-tau are useful in protecting against various types of experimental cholestasis, as well as against bile acid-induced cholestasis.

authors

Takikawa H,Sano N,Aiso M,Takamori Y,Yamanaka M

doi

10.1111/j.1440-1746.1997.tb00352.x

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

84-6

issue

1

eissn

0815-9319

issn

1440-1746

journal_volume

12

pub_type

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