Effects of hypoxia-inducible factor-1α and hypoxia-inducible factor-2α overexpression on hepatocellular carcinoma survival: A systematic review with meta-analysis.


BACKGROUND AND AIM:The role of hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2α (HIF-2α) has been implicated in the clinical prognosis of hepatocellular carcinoma (HCC), but the results remain controversial. We aim to investigate the association of HIF-1α and HIF-2α overexpression with the prognosis and clinicopathological features of HCC. METHODS:A systematic search was conducted in PubMed, Embase, Scopus, Web of Science, and Cochrane Library until June 20, 2020. Meta-analysis was conducted to generate combined HRs with 95% confidence intervals (CI) for overall survival (OS) and disease-free survival (DFS). Odds ratios (ORs) with 95% CI were also derived by fixed or random effect model. RESULTS:Twenty-two studies involving 3238 patients were included. Combined data suggested that overexpression of HIF-1α in HCC was not only correlated with poorer OS [HR = 1.75 (95% CI: 1.53-2.00)] and DFS [HR = 1.64 (95% CI: 1.34-2.00)] but was also positively associated with vascular invasion [OR = 1.83 (95% CI: 1.36-2.48)], tumor size [OR = 1.36 (95% CI: 1.12-1.66)], and tumor number [1.74 (95% CI: 1.34-2.25)]. In contrast, HIF-2α overexpression was not associated with the prognosis and clinicopathological features of HCC. CONCLUSION:Our data provided compelling evidence of a worse prognosis of HCC in HIF-1α overexpression patients but not HIF-2α overexpression ones.


Ding ZN,Dong ZR,Chen ZQ,Yang YF,Yan LJ,Li HC,Liu KX,Yao CY,Yan YC,Yang CC,Li T




Has Abstract


2021-01-04 00:00:00






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    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


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    abstract:BACKGROUND AND AIM:The aim of this study was to assess the gastric histopathology and serum gastrin-17 and pepsinogens profiles in patients with duodenal ulcer before and after Helicobacter pylori eradication in a population with a very high prevalence of H. pylori. At the same time we assessed the role of H. pylori de...

    journal_title:Journal of gastroenterology and hepatology

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    abstract:BACKGROUND AND AIM:Portal-systemic collateral vascular resistance and vasoconstrictor responsiveness are crucial in portal hypertension and variceal bleeding control. Statins enhance vasodilators production, but their influence on collaterals is unknown. This study aimed to survey the effect of simvastatin on collatera...

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    abstract::A novel experimental model of submassive liver necrosis with impaired regeneration has been established. A novel lipid A analogue, FS-112, was injected intravenously into male BALB/c mice, followed 2 days later by a 70% partial hepatectomy. Over the next 9 days, mice became severely jaundiced, with a peak total biliru...

    journal_title:Journal of gastroenterology and hepatology

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    authors: Maeda T,Ohnishi H,Hayashi T,Ishiki Y,Moriwaki H,Muto Y

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  • Viral hepatitis and liver transplantation.

    abstract::This article highlights the importance of hepatotropic viruses as pathogens in patients undergoing transplantation, their contribution to morbidity and mortality after transplantation and the approach to treatment of these pathogens when they cause disease. Although many advances have been made in the management of vi...

    journal_title:Journal of gastroenterology and hepatology

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    authors: Bzowej NH,Wright TL

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  • Large-scale population analysis reveals an extremely low threshold for "non-healthy" alanine aminotransferase that predicts diabetes mellitus.

    abstract:BACKGROUND AND AIMS:Serum alanine aminotransferase (ALT) is commonly used to detect liver damage. Recent studies indicate that ALT levels at the upper range of normal limits are predictors of adverse outcomes, especially diabetes mellitus (DM) and the metabolic syndrome. The aim of our study was to define the ALT thres...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Shlomai A,Kariv R,Leshno M,Beth-or A,Sheinberg B,Halpern Z

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  • Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.

    abstract:BACKGROUND AND AIM:Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) of unknown etiology. We aimed to identify the etiological agent of CD using a molecular cloning strategy that was particularly focused on identifying agents causing immune abnormalities and infectious agents. METHODS:We constructed a...

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    pub_type: 杂志文章


    authors: Iizuka M,Nakagomi O,Nanjo H,Chiba M,Fukushima T,Sugita A,Sagara S,Horie Y,Watanabe S

    更新日期:2012-08-01 00:00:00

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    abstract:BACKGROUND AND AIM:This multinational (Taiwan, South Korea, Russia) phase 3 study evaluated the all-oral, ribavirin-free, fixed-dose combination (DCV-TRIO) of daclatasvir (NS5A inhibitor) 30 mg, asunaprevir (NS3 inhibitor) 200 mg, and beclabuvir (NS5B inhibitor) 75 mg, in patients with chronic hepatitis C virus genotyp...

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    journal_title:Journal of gastroenterology and hepatology

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    authors: Shiotani A,Honda K,Kawakami M,Nishi R,Murao T,Ishii M,Matsumoto H,Kusunoki H,Hata J,Haruma K

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    authors: Ramirez T,Tong M,Chen WC,Nguyen QG,Wands JR,de la Monte SM

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    authors: Bowden S

    更新日期:2001-02-01 00:00:00

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    authors: Takahashi H,Matsui T,Hisabe T,Hirai F,Takatsu N,Tsurumi K,Kanemitsu T,Sato Y,Kinjyo K,Yano Y,Takaki Y,Nagahama T,Yao K,Washio M

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    journal_title:Journal of gastroenterology and hepatology

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    authors: Haber G

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    pub_type: 杂志文章


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    journal_title:Journal of gastroenterology and hepatology

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    authors: Kohgo Y,Ohtake T,Ikuta K,Suzuki Y,Torimoto Y,Kato J

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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


    authors: Chen CJ,Yu MW,Liaw YF

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  • Effects of washout following indomethacin administration on electrical field stimulation-induced isolated rat gastric fundus strip contractions.

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    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Keshavarz M,Afshin S,Djahanguiri B

    更新日期:2007-09-01 00:00:00

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    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Puri AS,Khan EM,Kumar M,Pandey R,Choudhuri G

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    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Akiba Y,Kaunitz JD

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    pub_type: 杂志文章


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    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Tsikrikoni A,Rigopoulou EI,Zachou K,Liaskos C,Kyriakou D,Dalekos GN

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