Two histologic compartments in nonpolypoid conventional colon adenomas.

Abstract:

:Two intertwined compartments coexisting in nonpolypoid conventional (i.e. tubular or villous) adenomas are highlighted in this review: one built of dysplastic tissue on top and the other portraying crypts with irregular, corrupted shapes, albeit lined with normal epithelium, below. The latter compartment has remained unattended in the literature. Recently, however, the histologic characteristics of the nondysplastic compartment in nonpolypoid conventional adenomas were closely examined, and some of its biological attributes were unveiled. Studies with the proliferation marker ki67 showed that the crypts with irregular, corrupted shapes in the nondysplastic compartment displayed haphazardly distributed proliferating cell-domains. Given that the proliferating cells are generated by stem cells, the relocation of proliferating cell-domains in those crypts seems to be the result of a reorganization of the stem cells within the crypts. The abnormal distribution of proliferating cells, the finding of p53-upregulated cells, and of crypts in asymmetric fission suggest that the crypts in that compartment are histo-biologically altered, probably somatically mutated. This new information might contribute to unravel the riddle of crypto-histogenesis of nonpolypoid conventional adenomas of the colon. More research along these lines is necessary, before the biology of the crypts in the nondysplastic compartment can be fully translated into molecular terms.

authors

Rubio CA

doi

10.1111/jgh.15210

subject

Has Abstract

pub_date

2020-08-05 00:00:00

eissn

0815-9319

issn

1440-1746

pub_type

杂志文章,评审
  • Oesophageal perforation following endoscopic variceal ligation and balloon tamponade.

    abstract::Endoscopic variceal ligation (EVL) related complication is rarely reported. A case is presented of a 74 year old man with oesophageal variceal bleeding who developed oesophageal perforation following EVL and balloon tamponade. An oesophageal wall defect was induced by EVL and tissue repair was hindered by decompensate...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1994.tb01582.x

    authors: Hou MC,Lin HC,Chang FY,Lee FY,Chen TS,Lee SD

    更新日期:1994-11-01 00:00:00

  • Heterogeneous distribution of Fusobacterium nucleatum in the progression of colorectal cancer.

    abstract:BACKGROUND AND AIM:Fusobacterium nucleatum (Fn) is involved in colorectal cancer (CRC) growth and is a biomarker for patient prognosis and management. However, the ecology of Fn in CRC and the distribution of intratumoral Fn are unknown. METHODS:We evaluated Fn and the status of KRAS and BRAF in 200 colorectal neoplas...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15361

    authors: Yamamoto S,Kinugasa H,Hirai M,Terasawa H,Yasutomi E,Oka S,Ohmori M,Yamasaki Y,Inokuchi T,Harada K,Hiraoka S,Nouso K,Tanaka T,Teraishi F,Fujiwara T,Okada H

    更新日期:2020-11-26 00:00:00

  • Prognostic value of hepatocyte nuclear factors 4α and 1α identified by tissue microarray in resectable hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:This study aimed to investigate the prognostic value of expression of hepatocyte nuclear factors (HNFs) involved in hepatic gene transcription in patients undergoing curative resection for hepatocellular carcinoma (HCC). METHODS:We performed immunohistochemical analyses on microarrays of the tumors ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12371

    authors: Shim JH,Kang HJ,Han S,Lee YJ,Lee SG,Yu E,Lee HC

    更新日期:2014-03-01 00:00:00

  • Salmonella hepatitis.

    abstract::Typhoid fever is often associated with abnormal liver biochemical tests, but severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. There have been more than 150 cases of salmonella hepatitis reported from both developed and developing countries. The documented incidence varies w...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.1998.tb00726.x

    authors: Pramoolsinsap C,Viranuvatti V

    更新日期:1998-07-01 00:00:00

  • Comparison of clinical features, treatment, and outcomes of collagenous sprue, celiac disease, and collagenous colitis.

    abstract:BACKGROUND:Collagenous sprue (CS) is a rare form of enteropathy that had been reported to be associated with celiac disease (CD) and collagenous colitis (CC). The aim of our study was to compare the clinical features, treatments, and outcomes of CS, CD, and CC. METHODS:All patients with histologic diagnosis of CS, CD,...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13592

    authors: Lan N,Shen B,Yuan L,Liu X

    更新日期:2017-01-01 00:00:00

  • Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. Previous studies have investigated the association between dietary patterns and NAFLD, but their results are contradictory. Therefore, we carried out this meta-analysis to examine the association betw...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15363

    authors: Hassani Zadeh S,Mansoori A,Hosseinzadeh M

    更新日期:2020-12-02 00:00:00

  • Efficacy and safety of sofosbuvir/velpatasvir in a real-world chronic hepatitis C genotype 3 cohort.

    abstract:BACKGROUND AND AIM:Real-world data on sofosbuvir/velpatasvir with and without ribavirin (SOF/VEL ± RBV), particularly among patients with genotype 3 (GT3) decompensated cirrhosis, prior treatment, coinfection, and hepatocellular carcinoma (HCC), are scarce. We aimed to assess the efficacy and safety of SOF/VEL ± RBV in...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15324

    authors: Wong YJ,Thurairajah PH,Kumar R,Tan J,Fock KM,Law NM,Li W,Kwek A,Tan YB,Koh J,Lee ZC,Kumar LS,Teo EK,Ang TL

    更新日期:2020-11-20 00:00:00

  • Development of thyroid diseases in the treatment of chronic hepatitis C with alpha-interferon may be a good prognosticator in achieving a sustained virological response: a meta-analysis.

    abstract:BACKGROUND AND AIM:Thyroid dysfunction is the most common endocrinopathy associated with hepatitis C and its interferon-based treatment. When undergoing treatment, interferon and ribavirin synergize to potently stimulate the immune system in order to eradicate the virus. One of the innocent bystanders in this accentuat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/j.1440-1746.2009.05874.x

    authors: Tran HA,Malcolm Reeves GE,Gibson R,Attia JR

    更新日期:2009-07-01 00:00:00

  • The clinicopathological differences of sporadic non-ampullary duodenal epithelial neoplasm depending on tumor location.

    abstract:BACKGROUND AND AIM:Although sporadic non-ampullary duodenal adenoma is speculated to be precancerous lesion, the relationship between adenoma and carcinoma remains unclear due to their rarity. Previous studies on sporadic non-ampullary duodenal epithelial neoplasm (SNADEN) have mainly targeted superficial tumors, like ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgh.14640

    authors: Matsueda K,Kanzaki H,Matsueda K,Nasu J,Yoshioka M,Nakagawa M,Inoue M,Inaba T,Imagawa A,Takatani M,Takenaka R,Suzuki S,Tomoda J,Yagi T,Fujiwara T,Tanaka T,Okada H

    更新日期:2019-09-01 00:00:00

  • Cold activation of complement in sera from patients with persistent hepatitis C virus infection on interferon therapy.

    abstract::The loss of haemolytic activity in sera during storage at low temperature (the cold activation of complement) was observed in 136 of 184 (74%) patients with chronic liver disease associated with hepatitis C virus (HCV) infection. This was more frequent than observed in the three of 40 (8%) patients with chronic hepati...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1996.tb01381.x

    authors: Aikawa T,Kimura I,Kojima M,Ueno C,Miyamoto K,Tango T,Tanaka N

    更新日期:1996-04-01 00:00:00

  • Confocal laser endomicroscopy: a new gold standard for the assessment of mucosal healing in ulcerative colitis.

    abstract:BACKGROUND AND AIM:Endoscopic assessment of mucosal healing in ulcerative colitis (UC) is increasingly accepted as a measure of disease activity, therapeutic goal, and the key prognostic indicator. While regular endoscopy evaluates appearance of the mucosal surface, confocal laser endomicroscopy (CLE) enables in vivo v...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12748

    authors: Macé V,Ahluwalia A,Coron E,Le Rhun M,Boureille A,Bossard C,Mosnier JF,Matysiak-Budnik T,Tarnawski AS

    更新日期:2015-03-01 00:00:00

  • Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome.

    abstract:BACKGROUND AND AIMS:Emerging evidence suggests aldosterone (aldo) and NLRP3 inflammasome are important factors for HSC activation and liver fibrosis. However, the interaction between aldo and NLRP3 inflammasome in HSC activation and liver fibrosis remains largely unknown. The aim of this study is to investigate the rel...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14961

    authors: Li Y,Zhang Y,Chen T,Huang Y,Zhang Y,Geng S,Li X

    更新日期:2020-06-01 00:00:00

  • Role of enhanced multi-detector-row computed tomography before urgent endoscopy in acute upper gastrointestinal bleeding.

    abstract:BACKGROUND AND AIM:Multi-detector-row computed tomography (MDCT) has been reported to be a potentially useful modality for detection of the bleeding origin in patients with acute upper massive gastrointestinal (GI) bleeding. The purpose of this study is to investigate the efficacy of MDCT as a routine method for detect...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12447

    authors: Miyaoka Y,Amano Y,Ueno S,Izumi D,Mikami H,Yazaki T,Okimoto E,Sonoyama T,Ito S,Fujishiro H,Kohge N,Imaoka T

    更新日期:2014-04-01 00:00:00

  • An endoscopic treatment strategy for superficial tumors in patients with ulcerative colitis.

    abstract:BACKGROUND AND AIM:Endoscopic resection is feasible for superficial tumors in patients with ulcerative colitis; however, endoscopic resection options have not been evaluated comprehensively. We evaluated the efficacy and safety of endoscopic submucosal dissection and endoscopic mucosal resection, and decision making re...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15207

    authors: Nishio M,Hirasawa K,Ozeki Y,Sawada A,Ikeda R,Fukuchi T,Kobayashi R,Makazu M,Sato C,Kunisaki R,Maeda S

    更新日期:2020-08-04 00:00:00

  • Hepatic resection for benign tumours of the liver.

    abstract::The most frequent benign tumours of the liver include haemangioma, liver cell adenoma and focal nodular hyperplasia. Patients may undergo hepatic resection because of a preoperative diagnosis of malignancy or uncertainty in diagnosis despite an extensive work-up. ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1746.2000.02167.x

    authors: Chen MF

    更新日期:2000-06-01 00:00:00

  • Implications of culture positivity in acute pancreatitis: does the source matter?

    abstract:BACKGROUND AND AIMS:Sepsis is an important complication and cause of morbidity and mortality in acute pancreatitis (AP). The source of sepsis may be infected pancreatic and peripancreatic collections and/or necrosis or extrapancreatic including infections in the bloodstream or respiratory and urinary tracts. We studied...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12161

    authors: Rao C,Bhasin DK,Rana SS,Gupta R,Gautam V,Singh K

    更新日期:2013-05-01 00:00:00

  • Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.

    abstract::Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease (ALD). ALD is a broad term that encompasses a spectrum of phenotypes ranging from simple steatosis to steatohepatitis, progressive fibrosis, cirrhosis, and hepatoce...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/jgh.12030

    authors: Orman ES,Odena G,Bataller R

    更新日期:2013-08-01 00:00:00

  • Pathogenesis of centrilobular necrosis following congestion of the liver.

    abstract::The exact pathogenesis of centrilobular necrosis following congestion of the liver is still unknown. We reviewed the clinical data related to systemic circulatory disturbance and histopathology of the liver and the gut in 320 autopsy subjects. Congestion of the liver alone was associated only with atrophy and loss of ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1993.tb01647.x

    authors: Shibayama Y,Urano T,Asaka S,Hashimoto K,Nakata K

    更新日期:1993-11-01 00:00:00

  • Antiviral therapy in advanced chronic liver disease due to hepatitis C virus infection: pilot study.

    abstract:BACKGROUND:Antiviral therapy has not been adequately evaluated in patients with hepatitis C virus (HCV)-related advanced liver disease due to apprehensions of adverse events and intolerance. The titrable dose of interferon (IFN)-alpha and ribavirin was evaluated in a flexible regimen in a pilot study. METHODS:Twenty-f...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03760.x

    authors: Kumar R,Kumar S,Sharma BC,Singh J,Sarin SK

    更新日期:2005-04-01 00:00:00

  • Echo-Doppler measurements of portal vein and superior mesenteric artery blood flow in humans: inter- and intra-observer short-term reproducibility.

    abstract::The reproducibility of echo-Doppler measurements of portal vein and superior mesenteric artery blood flow has not been extensively studied. In the present study, two groups of subjects were examined to test inter- and intra-observer reproducibility. Each study population consisted of 15 nonportal hypertensive and 15 p...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1996.tb00008.x

    authors: Iwao T,Toyonaga A,Shigemori H,Oho K,Sumino M,Sato M,Tanikawa K

    更新日期:1996-01-01 00:00:00

  • Role of the longitudinal smooth muscle coat in the ileal motile activity: evidence of ileo-ileal inhibitory reflex.

    abstract:BACKGROUND:All gut movements are claimed to be activated essentially by the concentric contraction of the circular muscle, moving the chyme aborally. The role of the longitudinal smooth muscle of the small intestine in gut motility is poorly understood; this point was investigated in the current study. METHODS:The abd...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2002.02870.x

    authors: Shafik A,Shafik AA,Ahmed I

    更新日期:2002-12-01 00:00:00

  • Reduced risk of hepatocellular carcinoma by achieving a subcirrhotic liver stiffness through antiviral agents in hepatitis B virus-related advanced fibrosis or cirrhosis.

    abstract:BACKGROUND AND AIM:A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients with chronic hepatitis B (CHB). We investigated whether the achievement of sc-LS by antiviral therapy (AVT) reduced the risk of developing hepatocellular carcinoma (HCC)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13854

    authors: Kim BS,Seo YS,Kim YS,Lee CH,Lee HA,Um SH,Yoo JJ,Kim SG,Suh SJ,Jung YK,Ahn SH,Han KH,Yim HJ,Kim SU,Korean Transient Elastography Study Group.

    更新日期:2018-02-01 00:00:00

  • Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats.

    abstract:BACKGROUND AND AIMS:Probucol is a lipid-lowering agent with anti-oxidant effects. Oxidative stress and inflammation are important in the pathophysiology of insulin resistance. We aimed to evaluate the effects of probucol on liver histological changes, serum and hepatic levels of adipokines in rats with high fat-induced...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05719.x

    authors: Zhang X,Li Z,Liu D,Xu X,Shen W,Mei Z

    更新日期:2009-06-01 00:00:00

  • Gene profile in the spleen under massive partial hepatectomy using complementary DNA microarray and pathway analysis.

    abstract:BACKGROUND AND AIM:In general, the spleen is one of the abdominal organs connected by the portal system, and a splenectomy improves hepatic functions in the settings of partial hepatectomy (Hx) for portal hypertensive cases or living donor liver transplantation with excessive portal vein flow. Those precise mechanisms ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12573

    authors: Arakawa Y,Shimada M,Utsunomiya T,Imura S,Morine Y,Ikemoto T,Mori H,Kanamoto M,Iwahashi S,Saito Y,Takasu C

    更新日期:2014-08-01 00:00:00

  • The association between non-alcoholic fatty liver disease (with or without metabolic syndrome) and extrahepatic cancer development.

    abstract:BACKGROUND AND AIM:This study was designed to determine whether non-alcoholic fatty liver disease (NAFLD), with or without metabolic syndrome (MetS), is a risk factor for cancer development. METHODS:We conducted a retrospective longitudinal study at the Center for Preventive Medicine, St. Luke's International Hospital...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15350

    authors: Yamamoto K,Ikeya T,Okuyama S,Fukuda K,Kobayashi D

    更新日期:2020-11-17 00:00:00

  • Narrowband imaging with near-focus magnification for discriminating the gastric tumor margin before endoscopic resection: A prospective randomized multicenter trial.

    abstract:BACKGROUND AND AIM:This study investigated the usefulness of near-focus narrowband imaging (NF-NBI) for determining gastric tumor margins compared with indigo carmine chromoendoscopy (ICC) before endoscopic submucosal dissection (ESD). METHODS:This prospective randomized controlled trial was conducted at seven teachin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.15109

    authors: Kim JW,Jung Y,Jang JY,Kim GH,Bang BW,Park JC,Choi HS,Cho JH,Research Group for Endoscopic Instruments and Stents of Korean Society of Gastrointestinal Endoscopy.

    更新日期:2020-11-01 00:00:00

  • Signal transduction during liver regeneration.

    abstract::Following partial hepatectomy (PH), there is a rapid and highly orchestrated series of biochemical events which occur prior to cellular proliferation. Some of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress related or required for the co...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Brenner DA

    更新日期:1998-09-01 00:00:00

  • Secreted protein acidic and rich in cysteine promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells and acquisition of cancerstem cell phenotypes.

    abstract:BACKGROUND AND AIM:Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that plays a significant role in tumor development. SPARC has been indicated that promotes tumorigenesis, metastasis, and poor prognosis in prostate cancer and lung cancer. Therefore, we sought to investigate the mol...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.14692

    authors: Jiang X,Liu F,Wang Y,Gao J

    更新日期:2019-10-01 00:00:00

  • Artemisia asiatica extracts protect against ethanol-induced injury in gastric mucosa of rats.

    abstract:BACKGROUND AND AIM:Based on our previous studies that Artemisia asiatica extracts exert either antioxidative or cytoprotective actions against non-steroidal anti-inflammatory drugs or Helicobacter pylori-induced gastric mucosal injury, or imposes qualified ulcer healing in an acetic acid-induced gastric ulcer model, we...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2008.05333.x

    authors: Park SW,Oh TY,Kim YS,Sim H,Park SJ,Jang EJ,Park JS,Baik HW,Hahm KB

    更新日期:2008-06-01 00:00:00

  • Clinical outcomes and factors for response prediction after the first course of corticosteroid therapy in patients with active ulcerative colitis.

    abstract:BACKGROUND AND AIMS:Both clinical outcomes and factors predictive for poor response after an initial course of corticosteroids have not yet been well established in the treatment of moderate to severe ulcerative colitis (UC). We therefore evaluated the short- and long-term effects of corticosteroids and prognostic fact...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.06688.x

    authors: Yoon JY,Cheon JH,Park JJ,Hong SP,Kim TI,Kim WH

    更新日期:2011-07-01 00:00:00