Role of aldosterone in the activation of primary mice hepatic stellate cell and liver fibrosis via NLRP3 inflammasome.

abstract：:Alcohol induces Ca(2+)-dependent intracellular trypsinogen activation in the apical granular area via non-oxidative metabolites, such as fatty acid ethyl esters and fatty acids. Intracellular trypsinogen activation is a crucial initiating event in the development of acute pancreatitis, but the specific organelle in wh...

journal_title：Journal of gastroenterology and hepatology

authors： Petersen OH

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND AND AIM:Early endoscopic intervention reduces morbidity and mortality for patients with high-risk gastrointestinal hemorrhage and gallstones causing pancreatitis or ascending cholangitis. For low-risk bleeds 'after-hours' endoscopy services allow risk stratification and early, safe discharge leading to reduc...

journal_title：Journal of gastroenterology and hepatology

authors： Gibson R,Hitchcock K,Duggan AE

更新日期：2006-03-01 00:00:00

abstract：:To study the replicative efficiency and pathogenicity of hepatitis B virus precore variant (A1896), anti-hepatitis B virus e antigen (HBe) titre was studied in naturally occurring wild-type virus infection, A1896 variant infection and dual infection. Higher titre of anti-HBe was found in patients with no virus replica...

journal_title：Journal of gastroenterology and hepatology

authors： Wen YM,Ma ZM,Tu G,Zhai WR,He LF,Yao X

更新日期：1998-11-01 00:00:00

abstract：:Infiltrating leucocytes are activated to generate reactive oxygen species or to produce several molecules in inflamed colonic mucosa. To clarify the phenotypical and functional properties of activating cells in colitic mucosa, 23 patients with ulcerative colitis and 13 controls were studied using a combined method for...

journal_title：Journal of gastroenterology and hepatology

authors： Oshitani N,Sawa Y,Hara J,Adachi K,Nakamura S,Matsumoto T,Arakawa T,Kuroki T

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role in HBV infection in humans has not been well characterized. In this study, we analyzed the frequency and cytokines secretion of circulating Th17 cells in HBV infected patients with different statuse...

journal_title：Journal of gastroenterology and hepatology

authors： Wu W,Li J,Chen F,Zhu H,Peng G,Chen Z

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Habitual alcohol intake is known to aggravate the clinical outcome of hepatitis C virus (HCV)-related chronic liver diseases and to increase the risk of hepatocellular carcinoma. METHODS:To investigate the possible mechanism of these effects by alcohol, we examined 31 cases of HCV-related chronic liver dise...

journal_title：Journal of gastroenterology and hepatology

authors： Takahashi K,Takahashi T,Takahashi S,Watanabe K,Boku S,Matsui S,Arai F,Asakura H

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND AND AIM:There have been few studies in Japan of the utility of quality of life (QOL) questionnaires as an evaluation of chemotherapy for gastrointestinal (GI) cancer. The present study investigated whether QOL can be an indicator of the clinical benefit of chemotherapy, by analyzing the changes in the QOL sc...

journal_title：Journal of gastroenterology and hepatology

authors： Kato J,Nagahara A,Iijima K,Yoshimura M,Osada T,Yoshizawa T,Watanabe S

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Lung injury is an important target for the systemic inflammatory response associated with intestinal ischemia/reperfusion (I/R). In the present study, the role of interleukin (IL)-18 in the development of acute pulmonary injury induced by intestinal I/R and its possible mechanism in relation to the ...

journal_title：Journal of gastroenterology and hepatology

authors： Yang YJ,Chen SH,Ge XR

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND AND AIM:Fully covered self-expandable metal stents (FCSEMS) may be better than plastic stents (PS) for preoperative biliary drainage (PBD) to relieve cholangitis or jaundice for resectable malignant biliary obstruction (MBO). However, modification of current FCSEMS designed originally for nonresectable MBO i...

journal_title：Journal of gastroenterology and hepatology

authors： Lee HW,Moon JH,Lee YN,Chung JC,Lee TH,Choi MH,Cha SW,Cho YD,Park SH

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Double-guidewire technique (DWT) has been successfully performed by experts in difficult biliary cannulation as an advanced technique. This study aimed to define the learning curve and safety of DWT by trainees during hands-on endoscopic retrograde cholangiopancreatography (ERCP) training. METHODS:...

journal_title：Journal of gastroenterology and hepatology

authors： Wang X,Ren G,Xi Y,Luo H,Liang S,Wang B,Tao Q,Luo B,Qin Q,Farrell JJ,Guo X,Wu K,Pan Y

更新日期：2020-05-30 00:00:00

abstract：BACKGROUND:Spontaneous bacterial peritonitis (SBP) is a serious complication of cirrhosis with ascites, having high recurrence despite antibiotic prophylaxis. Small bowel dysmotility and bacterial overgrowth have been documented to be related to SBP. The purpose of the present paper was (i) to study whether addition of...

journal_title：Journal of gastroenterology and hepatology

authors： Sandhu BS,Gupta R,Sharma J,Singh J,Murthy NS,Sarin SK

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Distinguishing Crohn's disease (CD) from intestinal tuberculosis (ITB) is a clinical challenge. This meta-analysis assessed the clinical usefulness of Interferon-gamma releasing assay (IGRA) and anti-Saccharomyces cerevisiae antibody (ASCA) in the diagnosis of ITB and CD, respectively. METHODS:Syst...

journal_title：Journal of gastroenterology and hepatology

authors： Ng SC,Hirai HW,Tsoi KK,Wong SH,Chan FK,Sung JJ,Wu JC

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND AND AIM:A subcirrhotic range of liver stiffness (sc-LS), assessed by transient elastography, is associated with better outcomes in patients with chronic hepatitis B (CHB). We investigated whether the achievement of sc-LS by antiviral therapy (AVT) reduced the risk of developing hepatocellular carcinoma (HCC)...

journal_title：Journal of gastroenterology and hepatology

authors： Kim BS,Seo YS,Kim YS,Lee CH,Lee HA,Um SH,Yoo JJ,Kim SG,Suh SJ,Jung YK,Ahn SH,Han KH,Yim HJ,Kim SU,Korean Transient Elastography Study Group.

更新日期：2018-02-01 00:00:00

abstract：:Brief periods of tissue ischemia produced tissue resistance to prolonged ischemia and reperfusion, a phenomenon called ischemic preconditioning. The mechanisms of ischemic preconditioning were examined in a rat warm ischemia-reperfusion model as well as the effect of ischemic preconditioning on liver regeneration. Isc...

journal_title：Journal of gastroenterology and hepatology

authors： Arai M,Tejima K,Ikeda H,Tomiya T,Yanase M,Inoue Y,Nagashima K,Nishikawa T,Watanabe N,Omata M,Fujiwara K

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND AND AIM:Whether an early use of azathioprine (AZA) can alter the natural history of Crohn's disease (CD) remains debated. The aim of this study is to evaluate the impact of AZA on disease progression in a cohort of patients with early CD. METHODS:This longitudinal cohort study examined patients with early C...

journal_title：Journal of gastroenterology and hepatology

authors： Qiu Y,Chen BL,Feng R,Zhang SH,He Y,Zeng ZR,Ben-Horin S,Peyrin-Biroulet L,Mao R,Chen MH

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND AIM:The vaccination against hepatitis B virus (HBV) is recommended in patients with inflammatory bowel disease (IBD). However, the response to this vaccine seems to be lower in IBD patients than in the general population. This study aims to evaluate the immunogenicity of the HBV vaccine in a cohort of pa...

journal_title：Journal of gastroenterology and hepatology

authors： Cossio-Gil Y,Martínez-Gómez X,Campins-Martí M,Rodrigo-Pendás JÁ,Borruel-Sainz N,Rodríguez-Frías F,Casellas-Jordà F

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The objective of this study was to describe the prevalence of pathogenic microorganisms in asymptomatic individuals in a community study in Melbourne, Australia. METHODS:The study population was a subset of 2803 individuals participating in the Water Quality Study; a community based randomized tria...

journal_title：Journal of gastroenterology and hepatology

authors： Hellard ME,Sinclair MI,Hogg GG,Fairley CK

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND AND AIM:Although the esophagus is a common site of opportunistic infection in AIDS patients, little is known about the impact of HIV as well as opportunistic infection in the esophageal mucosa. Our aim is to analyze the esophageal immune profile in HIV+ patients with different immunological status with and w...

journal_title：Journal of gastroenterology and hepatology

authors： Werneck-Silva AL,Pagliari C,Patzina RA,Takakura CFH,Duarte MI

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Cancer invasion and metastasis are critical events for patient prognosis; however, the most important step in the whole process of lymph node (LN) metastasis in gastric cancer remains obscure. In this study, the significance of cancer cell behaviors, such as cell detachment, stromal invasion and lym...

journal_title：Journal of gastroenterology and hepatology

authors： Kamata I,Ishikawa Y,Akishima-Fukasawa Y,Ito K,Akasaka Y,Uzuki M,Fujimoto A,Morita H,Tamai S,Maehara T,Ogata K,Shimokawa R,Igarashi Y,Miki K,Ishii T

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:The objective of three-dimensional (3-D) endoscopic ultrasonography (EUS) is to recognize lesions stereoscopically. METHODS AND RESULTS:We investigated a total of 43 lesions in the upper gastrointestinal (GI) tract by regenerating 3-D images in eight cases of oesophageal cancer, two cases of oesophageal sub...

journal_title：Journal of gastroenterology and hepatology

authors： Tokiyama H,Yanai H,Nakamura H,Takeo Y,Yoshida T,Okita K

更新日期：1999-12-01 00:00:00

abstract：:The growing numbers of potential transplant recipients on waiting lists is increasingly disproportionate to the supply of cadaveric donor organs. The hope for the next 20 years is that supply will satisfy demand. This requires both a reduction in indications for the procedure and an increase in the transplants perform...

journal_title：Journal of gastroenterology and hepatology

authors： Perera MT,Mirza DF,Elias E

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Because most of the characteristics of the portal hypertensive enteropathy can be explained on the basis of increased levels of mast cell mediators, the purpose of the present paper was to study mast cell splanchnic infiltration. METHODS:Duodenum, jejunum, ileum and mesenteric lymph node complex infiltratio...

journal_title：Journal of gastroenterology and hepatology

authors： Prieto I,Aller MA,Santamaría L,Nava MP,Madero R,Pérez-Robledo JP,Arias J

更新日期：2005-07-01 00:00:00

abstract：:Following partial hepatectomy (PH), there is a rapid and highly orchestrated series of biochemical events which occur prior to cellular proliferation. Some of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress related or required for the co...

journal_title：Journal of gastroenterology and hepatology

authors： Brenner DA

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND AND AIM:Little is known whether routine prophylaxis against Pneumocystis jirovecii pneumonia (PJP) is needed in patients with inflammatory bowel disease (IBD) on immunosuppression, especially in Asian populations. We, therefore, sought to investigate the incidence and risk factors of PJP in patients with IBD...

journal_title：Journal of gastroenterology and hepatology

authors： Nam K,Park SH,Lee J,Jo S,Kim SO,Noh S,Park JC,Kim JY,Kim J,Ham NS,Oh EH,Song EM,Hwang SW,Yang DH,Ye BD,Byeon JS,Myung SJ,Yang SK

更新日期：2020-02-01 00:00:00

abstract：:Wilson's disease is an autosomal recessive, inborn error of copper metabolism. The basic defect is unknown but decreased biliary excretion of copper is associated with copper accumulation and damage to the liver, brain and other organs with variable clinical expression. The gene for the disease has been mapped to band...

journal_title：Journal of gastroenterology and hepatology

authors： Frydman M

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND AND AIM:Intestinal failure (IF) is a rare but devastating complication of Crohn's disease (CD). The clinical and surgical factors that predispose to IF are poorly understood. The aim of this study was to define clinical factors that predispose to IF. METHODS:A retrospective case-control study was performed ...

journal_title：Journal of gastroenterology and hepatology

authors： Gearry RB,Kamm MA,Hart AL,Bassett P,Gabe SM,Nightingale JM

更新日期：2013-05-01 00:00:00

abstract：:Interferon-alpha (IFN-alpha) has been the only approved agent for the treatment of chronic hepatitis B in most countries, but this is rapidly changing. It is expensive, associated with frequent and unpleasant side effects, has limited efficacy and is ineffective in subjects with no/mild liver necro-inflammation. Loss ...

journal_title：Journal of gastroenterology and hepatology

authors： Guan R

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND AIM:Studies focused on the naturally occurring resistance mutation rate in treatment-naïve chronic hepatitis B (CHB) patients have set off a furious dispute. We conduct this meta-analysis to appraise the pooled incidence of spontaneous hepatitis B virus resistance mutations worldwide and its distribution...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang Q,Liao Y,Cai B,Li Y,Li L,Zhang J,An Y,Wang L

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIM:The present study was designed to investigate the expression of and humoral response against NY-ESO-1 in patients with hepatocellular carcinoma and to analyze the relationship between expression of NY-ESO-1 mRNA and clinicopathological features. METHODS:NY-ESO-1 mRNA and protein expression in surgic...

journal_title：Journal of gastroenterology and hepatology

authors： Nakamura S,Nouso K,Noguchi Y,Higashi T,Ono T,Jungbluth A,Chen YT,Old LJ,Nakayama E,Shiratori Y

更新日期：2006-08-01 00:00:00

abstract：BACKGROUNDS AND AIM:Clarithromycin (CAM)-resistant Helicobacter pylori sometimes offers serious problems with eradication by antibiotics. The aim of this study was to determine whether a probiotic can be an alternative therapy in CAM-resistant Hp infection. METHODS:The effects of Lactobacillus gasseri (strain OLL2716)...

journal_title：Journal of gastroenterology and hepatology

authors： Ushiyama A,Tanaka K,Aiba Y,Shiba T,Takagi A,Mine T,Koga Y

更新日期：2003-08-01 00:00:00