Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.

abstract：:Hepatitis C virus (HCV) leads to chronic liver disease in at least 50-60% of infected people and approximately 40-50% of these patients will go on to develop cirrhosis due to chronic hepatitis C (HCV-C). The pathogenic mechanisms that result in HCV-C are unknown. Sixty Japanese patients with HCV-C were examined for HL...

journal_title：Journal of gastroenterology and hepatology

authors： Higashi Y,Kamikawaji N,Suko H,Ando M

更新日期：1996-03-01 00:00:00

abstract：:In order to study the process of hepatocellular carcinoma (HCC) development, and to search for a clue to histologic diagnosis of well-differentiated HCC (wd-HCC), interstitial invasion in small HCC was evaluated. The study material consisted of 35 cases of HCC that were smaller than 3 cm that comprised 17 cases of wd-...

journal_title：Journal of gastroenterology and hepatology

authors： Kondo F,Kondo Y,Nagato Y,Tomizawa M,Wada K

更新日期：1994-11-01 00:00:00

abstract：:Although the incidence of bleeding from gastric varices is relatively low (10%-36%), the bleeding is massive once it has occurred and it increases the patient's mortality. The management of esophageal variceal bleeding is highly differentiated with several effective treatments available. In contrast, bleeding from gas...

journal_title：Journal of gastroenterology and hepatology

authors： Hashizume M,Akahoshi T,Tomikawa M

更新日期：2011-01-01 00:00:00

abstract：:Advances in technology have made possible the clinical application of magnetic resonance cholangiography, endoscopic, intra-operative and laparoscopic ultrasound in the study of the biliary tree, in addition to conventional magnetic resonance imaging and transabdominal ultrasound. The role of the conventional, as well...

journal_title：Journal of gastroenterology and hepatology

authors： Chan YL

更新日期：1998-11-01 00:00:00

abstract：:It was recently reported that mutations in the precore and core promoter region of hepatitis B virus (HBV) are associated with fulminant hepatitis. The aim of this study was to investigate the association of mutations in the precore and core promoter region of HBV with fulminant and severe acute hepatitis. We studied ...

journal_title：Journal of gastroenterology and hepatology

authors： Aritomi T,Yatsuhashi H,Fujino T,Yamasaki K,Inoue O,Koga M,Kato Y,Yano M

更新日期：1998-11-01 00:00:00

abstract：:Pancreatic adenocarcinoma is one of the leading causes of cancer death in the West, with a poor overall 5-year survival rate of only 4%. Late clinical presentation with an advanced disease results in a low rate of surgical intervention. Tumor serum marker CA 19-9 is sensitive, although not specific for the diagnosis o...

journal_title：Journal of gastroenterology and hepatology

authors： Sahani DV,Shah ZK,Catalano OA,Boland GW,Brugge WR

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND AND AIM:Palliative endoscopic or percutaneous biliary drainage is used for unresectable advanced hilar cancer (HC). The best option for drainage in Bismuth type III or IV HC has not been established. The aims of this study are to identify factors predictive of endoscopic stenting failure and evaluate the eff...

journal_title：Journal of gastroenterology and hepatology

authors： Jang SI,Hwang JH,Lee KH,Yu JS,Kim HW,Yoon CJ,Lee YS,Paik KH,Lee SH,Lee DK

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Outer membrane proteins of Helicobacter pylori mediate important pathogen-host interactions such as colonization, adhesion and the inflammatory response. hopQ genotypes have been suggested to be associated with increased risk of peptic ulcer. The aim of this study was to test the relation of hopQ ge...

journal_title：Journal of gastroenterology and hepatology

authors： Ohno T,Sugimoto M,Nagashima A,Ogiwara H,Vilaichone RK,Mahachai V,Graham DY,Yamaoka Y

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic assessment of mucosal healing in ulcerative colitis (UC) is increasingly accepted as a measure of disease activity, therapeutic goal, and the key prognostic indicator. While regular endoscopy evaluates appearance of the mucosal surface, confocal laser endomicroscopy (CLE) enables in vivo v...

journal_title：Journal of gastroenterology and hepatology

authors： Macé V,Ahluwalia A,Coron E,Le Rhun M,Boureille A,Bossard C,Mosnier JF,Matysiak-Budnik T,Tarnawski AS

更新日期：2015-03-01 00:00:00

abstract：:Autoimmune hepatitis (AIH) is an inflammatory liver disease with diverse clinical spectrum, which predominantly affects females. This review provides detailed comparisons of epidemiology, genetic predispositions, clinical features, risk factors of hepatocellular carcinoma, and mortality in AIH patients between eastern...

journal_title：Journal of gastroenterology and hepatology

authors： Yang F,Wang Q,Bian Z,Ren LL,Jia J,Ma X

更新日期：2015-08-01 00:00:00

abstract：AIM:The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9-16 years) with colorectal spirochetosis is discussed. RESULTS:Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal s...

journal_title：Journal of gastroenterology and hepatology

authors： Heine RG,Ward PB,Mikosza AS,Bennett-Wood V,Robins-Browne RM,Hampson DJ

更新日期：2001-08-01 00:00:00

abstract：BACKGROUND:Depth of invasion beyond the muscularis propria (MP) by T3 rectal cancer can vary. The purpose of the present paper was to determine if depth of invasion beyond MP, as assessed by preoperative endoscopic ultrasound (EUS), can predict tumor recurrence in patients with T3 rectal tumors. METHODS:Patients with ...

journal_title：Journal of gastroenterology and hepatology

authors： Harewood GC,Kumar KS,Clain JE,Levy MJ,Nelson H

更新日期：2004-07-01 00:00:00

abstract：BACKGROUND:It has been reported that cathepsin E (CTSE) is a non-secretory and intracellular aspartic proteinase found in the superficial epithelial cells of the stomach and that it is also expressed in pancreatic ductal adenocarcinoma. We evaluated the diagnostic value of CTSE in the pancreatic juice in the diagnosis ...

journal_title：Journal of gastroenterology and hepatology

authors： Uno K,Azuma T,Nakajima M,Yasuda K,Hayakumo T,Mukai H,Sakai T,Kawai K

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:Thrombocytopenia is a common manifestation of liver cirrhosis (LC), but its underlying mechanism is not fully understood. The purpose of the present paper was to evaluate the platelet kinetics in LC patients by examining several non-invasive convenient markers. METHODS:Fifty-seven LC patients, 32 patients w...

journal_title：Journal of gastroenterology and hepatology

authors： Kajihara M,Okazaki Y,Kato S,Ishii H,Kawakami Y,Ikeda Y,Kuwana M

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND AND AIMS:To evaluate and compare laparoscopic splenectomy and partial splenic embolization as supportive intervention for cirrhotic patients with hypersplenism to overcome peripheral cytopenia before the initiation of and during interferon therapy or anticancer therapy for hepatocellular carcinoma. METHODS:...

journal_title：Journal of gastroenterology and hepatology

authors： Tomikawa M,Akahoshi T,Sugimachi K,Ikeda Y,Yoshida K,Tanabe Y,Kawanaka H,Takenaka K,Hashizume M,Maehara Y

更新日期：2010-02-01 00:00:00

abstract：AIM:To determine whether liver biopsy might be useful in the diagnosis of visceral leishmaniasis when bone marrow examination and serologic tests are inconclusive. METHODS:Over a 10-year period, liver biopsy was performed in five children with suspected visceral leishmaniasis when indirect hemagglutination tests and b...

journal_title：Journal of gastroenterology and hepatology

authors： Artan R,Yilmaz A,Akçam M,Aksoy NH

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role in HBV infection in humans has not been well characterized. In this study, we analyzed the frequency and cytokines secretion of circulating Th17 cells in HBV infected patients with different statuse...

journal_title：Journal of gastroenterology and hepatology

authors： Wu W,Li J,Chen F,Zhu H,Peng G,Chen Z

更新日期：2010-04-01 00:00:00

abstract：:High circulating serum immunoglobulin G4 (IgG4) levels have been proposed as a marker of autoimmune pancreatitis (AIP). The aim of the present study was to review the data existing in the English literature on the usefulness of the IgG4 serum levels in the diagnosis and follow up of patients with AIP. A total of 159 p...

journal_title：Journal of gastroenterology and hepatology

authors： Morselli-Labate AM,Pezzilli R

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND AND AIM:The attenuated antisecretory activity observed during continuous administration of ranitidine has been described as tolerance. However, it remains unclear whether a similar phenomenon occurs with other histamine H2 receptor antagonists (H2RA). We investigated whether tolerance to famotidine, a strong...

journal_title：Journal of gastroenterology and hepatology

authors： Komazawa Y,Adachi K,Mihara T,Ono M,Kawamura A,Fujishiro H,Kinoshita Y

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of the present study was to compare the therapeutic efficacy of three different regimens in childhood chronic hepatitis B (CHB) infection. METHODS:A total of 182 children with CHB infection were prospectively allocated to three random groups. Sixty-two patients in the first group received hi...

journal_title：Journal of gastroenterology and hepatology

authors： Dikici B,Ozgenc F,Kalayci AG,Targan S,Ozkan T,Selimoglu A,Doganci T,Kansu A,Tosun S,Arslan N,Kasirga E,Bosnak M,Haspolat K,Buyukgebiz B,Aydogdu S,Girgin N,Yagci RV

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND AIM:T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1...

journal_title：Journal of gastroenterology and hepatology

authors： Flynn JK,Dore GJ,Hellard M,Yeung B,Rawlinson WD,White PA,Kaldor JM,Lloyd AR,Ffrench RA,ATAHC Study Group.

更新日期：2013-11-01 00:00:00

abstract：:The prevalence of colorectal cancer is increasing in Asia. However, the age-standardized rate has reached a plateau in some countries. Some studies have shown a male predominance difference and increasing risk in the elderly, but not in the younger population. 'Right shifting' of colorectal cancer, not accountable by ...

journal_title：Journal of gastroenterology and hepatology

authors： Yee YK,Tan VP,Chan P,Hung IF,Pang R,Wong BC

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND AIM:Some patients with chronic hepatitis C experience virologic relapse even after achieving an end of treatment response. Prolonged therapy can be effective for helping such high-risk patients to avoid relapse. We aimed to identify factors predictive of virologic relapse in chronic hepatitis C patients ...

journal_title：Journal of gastroenterology and hepatology

authors： Shin SR,Sinn DH,Gwak GY,Choi MS,Lee JH,Koh KC,Yoo BC,Paik SW

更新日期：2010-05-01 00:00:00

abstract：:To evaluate the pathophysiology underlying gastric mucosal lesions induced by lateral hypothalamic (LH) lesions, we investigated the changes in acid secretion, gastric mucosal blood flow, gastric mucus and mucosal integrity in the corpus during the 4 h period and 48 h after the production of bilateral electrolytic LH ...

journal_title：Journal of gastroenterology and hepatology

authors： Saita H,Murakami M,Kita T

更新日期：1995-07-01 00:00:00

abstract：:Lymphocytic (microscopic) colitis is a disease of unknown aetiology which manifests as long-standing intermittent diarrhoea. Diagnosis is confirmed on histological examination of the colon. An association of this uncommon disease with tropical sprue is described. Tetracycline therapy resulted in a favourable clinical ...

journal_title：Journal of gastroenterology and hepatology

authors： Puri AS,Khan EM,Kumar M,Pandey R,Choudhuri G

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND AND AIM:Ethnic differences in non-alcoholic steatohepatitis (NASH) are well-documented, but there has been no study on the prognosis of Japanese NASH patients with cirrhosis. Accordingly, we compared cirrhotic NASH with liver cirrhosis caused by chronic hepatitis C (LC-C) to clarify its clinical features and...

journal_title：Journal of gastroenterology and hepatology

authors： Yatsuji S,Hashimoto E,Tobari M,Taniai M,Tokushige K,Shiratori K

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND AND AIM:Tumor thrombi in the bile duct caused by hepatocellular carcinoma (HCC), and cholangiocarcinoma show polypoid lesions on cholangiographic findings. This study prospectively compared the images of intraductal ultrasonography between HCC and polypoid cholangiocarcinoma. METHODS:In five patients with t...

journal_title：Journal of gastroenterology and hepatology

authors： Tamada K,Isoda N,Wada S,Tomiyama T,Ohashi A,Satoh Y,Ido K,Sugano K

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:The objective of three-dimensional (3-D) endoscopic ultrasonography (EUS) is to recognize lesions stereoscopically. METHODS AND RESULTS:We investigated a total of 43 lesions in the upper gastrointestinal (GI) tract by regenerating 3-D images in eight cases of oesophageal cancer, two cases of oesophageal sub...

journal_title：Journal of gastroenterology and hepatology

authors： Tokiyama H,Yanai H,Nakamura H,Takeo Y,Yoshida T,Okita K

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND AND AIM:Endoscopic papillary balloon dilation (EPBD) has been advocated as an alternative therapy to endoscopic sphincterotomy for bile duct stones. However, studies have shown that EPBD may increase the risk for pancreatitis. Pancreatitis after EPBD is believed to be related to papillary damage after balloo...

journal_title：Journal of gastroenterology and hepatology

authors： Tsujino T,Kawabe T,Isayama H,Sasaki T,Kogure H,Togawa O,Arizumi T,Ito Y,Matsubara S,Yamamoto N,Nakai Y,Sasahira N,Hirano K,Toda N,Komatsu Y,Tada M,Yoshida H,Omata M

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Epidemics pose a great challenge to health care of patients. However, the impact of unprecedented situation of COVID-19 outbreak on health care of inflammatory bowel disease (IBD) patients in real-world setting has seldom been investigated. METHODS:We performed an observational study in a tertiary ...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang YF,Qiu Y,He JS,Tan JY,Li XZ,Zhu LR,Chen Y,Liu ZJ,Iacucci M,Chen BL,He Y,Ben-Horin S,Shen B,Zeng ZR,Ghosh S,Chen MH,Mao R

更新日期：2020-08-01 00:00:00