Tolerance to famotidine and ranitidine treatment after 14 days of administration in healthy subjects without Helicobacter pylori infection.

Abstract:

BACKGROUND AND AIM:The attenuated antisecretory activity observed during continuous administration of ranitidine has been described as tolerance. However, it remains unclear whether a similar phenomenon occurs with other histamine H2 receptor antagonists (H2RA). We investigated whether tolerance to famotidine, a stronger H2RA than ranitidine, occurs during long-term administration. METHODS:Seven healthy male Japanese subjects without Helicobacter pylori infection participated in a randomized cross-over study in which ranitidine and famotidine were administered for 14 days with a 4-week wash-out period. We performed 24-h intragastric pH monitoring on the first and 14th days of administration of each drug, and measured serum gastrin and plasma drug concentrations on the first, seventh and 14th days. RESULTS:The acid-inhibiting activity of ranitidine and famotidine declined during continuous administration. In particular, the potent nocturnal pH-increasing effect of the H2RA, which was observed on day 1, declined on day 14. Serum gastrin concentrations on day 14 were significantly lower than those on day 7, although plasma drug concentrations remained unchanged. CONCLUSION:Tolerance to famotidine occurs during continuous administration for 14 days, as previously shown in ranitidine studies.

authors

Komazawa Y,Adachi K,Mihara T,Ono M,Kawamura A,Fujishiro H,Kinoshita Y

doi

10.1046/j.1440-1746.2003.03041.x

subject

Has Abstract

pub_date

2003-06-01 00:00:00

pages

678-82

issue

6

eissn

0815-9319

issn

1440-1746

pii

3041

journal_volume

18

pub_type

临床试验,杂志文章,随机对照试验
  • Hepatic stellate cell contraction is inhibited by lipo-prostaglandin E1 in vitro.

    abstract::Prostaglandin E1 (PGE1) has been reported to have, experimentally and clinically, a protective effect against liver damage. This effect may result from the relaxation of hepatic stellate cells, whose contraction induces vasoconstriction of hepatic sinusoids. However, prostaglandins are unstable and a new drug delivery...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:

    authors: Wang XE,Watanabe S,Oide H,Hirose M,Itatsu T,Osada T,Takazakura Y,Yokoi Y,Sato N

    更新日期:1998-09-01 00:00:00

  • Resistance of Helicobacter pylori to quinolones and clarithromycin assessed by genetic testing in Japan.

    abstract:BACKGROUND AND AIM:As bacterial resistance to clarithromycin limits the efficacy of clarithromycin-based regimens for Helicobacter pylori infection, attention has turned to quinolone-based rescue therapies. Resistance of H. pylori to both clarithromycin and quinolone can be predicted by genetic testing. Here, we used t...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2011.06815.x

    authors: Yamade M,Sugimoto M,Uotani T,Nishino M,Kodaira C,Furuta T

    更新日期:2011-09-01 00:00:00

  • Generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen.

    abstract:BACKGROUND:Antibody against hepatitis B surface antigen (HBsAg) is used for passive immunotherapy in certain cases of hepatitis B infection. The authors have earlier reported a high-affinity mouse monoclonal (5S) against HBsAg. However, this mouse antibody cannot be used for therapeutic purposes because it may elicit a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04329.x

    authors: Bose B,Khanna N,Acharya SK,Sinha S

    更新日期:2006-09-01 00:00:00

  • Sphincter of Oddi: Function, dysfunction, and its management.

    abstract::The most common functional disorder of the biliary tract and pancreas relates to the activity of the Sphincter of Oddi. The Sphincter of Oddi is a small smooth muscle sphincter strategically placed at the junction of the bile duct, pancreatic duct, and duodenum. The sphincter controls flow of bile and pancreatic juice...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2009.06072.x

    authors: Toouli J

    更新日期:2009-10-01 00:00:00

  • Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3.

    abstract:BACKGROUND AND AIMS:Hepatic steatosis has been shown to be associated with lipid peroxidation and hepatic fibrosis in a variety of liver diseases including non-alcoholic fatty liver disease. However, the lobular distribution of lipid peroxidation associated with hepatic steatosis, and the influence of hepatic iron stor...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2001.02445.x

    authors: MacDonald GA,Bridle KR,Ward PJ,Walker NI,Houglum K,George DK,Smith JL,Powell LW,Crawford DH,Ramm GA

    更新日期:2001-06-01 00:00:00

  • Medical treatment of duodenal ulcer: acid inhibition or Helicobacter pylori eradication?

    abstract::To ascertain whether acid inhibition or Helicobacter pylori (HP) colonization is the decisive factor in the healing of duodenal ulcer, we treated 54 patients with famotidine and carried out long-term follow-up. Helicobacter pylori colonization was found in 70.4% of patients before treatment. There were no differences ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1991.tb01454.x

    authors: Lai KH,Chang FY,Tsay SH,Lu LC,Cheng JT,Jeng SS,Wu TC,Ng WW,Jeng JS,Lee SD

    更新日期:1991-03-01 00:00:00

  • Evaluation of platelet kinetics in patients with liver cirrhosis: similarity to idiopathic thrombocytopenic purpura.

    abstract:BACKGROUND:Thrombocytopenia is a common manifestation of liver cirrhosis (LC), but its underlying mechanism is not fully understood. The purpose of the present paper was to evaluate the platelet kinetics in LC patients by examining several non-invasive convenient markers. METHODS:Fifty-seven LC patients, 32 patients w...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04359.x

    authors: Kajihara M,Okazaki Y,Kato S,Ishii H,Kawakami Y,Ikeda Y,Kuwana M

    更新日期:2007-01-01 00:00:00

  • Incomplete type of intestinal metaplasia has the highest risk to progress to gastric cancer: results of the Spanish follow-up multicenter study.

    abstract:BACKGROUND AND AIM:In high or moderate risk populations, periodic surveillance of patients at risk of progression from gastric precursor lesions (PL) to gastric cancer (GC) is the most effective strategy for reducing the burden of GC. Incomplete type of intestinal metaplasia (IIM) may be considered as the best candidat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgh.13249

    authors: González CA,Sanz-Anquela JM,Companioni O,Bonet C,Berdasco M,López C,Mendoza J,Martín-Arranz MD,Rey E,Poves E,Espinosa L,Barrio J,Torres MÁ,Cuatrecasas M,Elizalde I,Bujanda L,Garmendia M,Ferrández Á,Muñoz G,Andreu V

    更新日期:2016-05-01 00:00:00

  • The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury.

    abstract::Previous research from this laboratory using a continuous enteral ethanol (EtOH) administration model demonstrated that Kupffer cells are pivotal in the development of EtOH-induced liver injury. When Kupffer cells were destroyed using gadolinium chloride (GdCl3 ) or the gut was sterilized with polymyxin B and neomycin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.1998.13.s1.39

    authors: Thurman RG,Bradford BU,Iimuro Y,Knecht KT,Arteel GE,Yin M,Connor HD,Wall C,Raleigh JA,Frankenberg MV,Adachi Y,Forman DT,Brenner D,Kadiiska M,Mason RP

    更新日期:1998-09-01 00:00:00

  • Seroepidemiological study on hepatitis delta virus infection in the Irabu Islands, Okinawa, Japan.

    abstract::A seroepidemiological study was performed to clarify the prevalence of hepatitis delta virus (HDV) infection among the general population in the Irabu islands, Okinawa, Japan. Of 2028 healthy people examined who had received their annual health check-up in 1994-95, 195 (9.6%) were positive for hepatitis B surface anti...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1997.tb00425.x

    authors: Sakugawa H,Nakasone H,Shokita H,Kawakami Y,Nakachi N,Adaniya H,Mizushima T,Nakayoshi T,Kinjo F,Saito A,Taira M,Takaesu H,Onga N

    更新日期:1997-04-01 00:00:00

  • Clinical outcomes of cryptogenic compared with non-cryptogenic cirrhosis: A retrospective cohort study.

    abstract:BACKGROUND AND AIM:The consequences of the association between the metabolic syndrome and cryptogenic cirrhosis are uncertain. We aimed to compare the differences in clinical outcomes between cryptogenic and non-cryptogenic cirrhosis. METHODS:A retrospective cohort study was conducted in a large, single academic cente...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.12978

    authors: Mohammed OK,Mahadeva S

    更新日期:2015-09-01 00:00:00

  • Molecular cloning reveals nearly half of patients with Crohn's disease have an antibody to peroxiredoxin 6-like protein.

    abstract:BACKGROUND AND AIM:Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) of unknown etiology. We aimed to identify the etiological agent of CD using a molecular cloning strategy that was particularly focused on identifying agents causing immune abnormalities and infectious agents. METHODS:We constructed a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2012.07147.x

    authors: Iizuka M,Nakagomi O,Nanjo H,Chiba M,Fukushima T,Sugita A,Sagara S,Horie Y,Watanabe S

    更新日期:2012-08-01 00:00:00

  • Antiviral efficacy of lamivudine versus entecavir in patients with hepatitis B virus-related advanced hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:Little information is available about the antiviral efficacy of lamivudine (LAM) and entecavir (ETV) in patients with hepatitis B virus (HBV)-related advanced hepatocellular carcinoma (HCC). Thus, we compared the antiviral efficacy of LAM and ETV in these patients. METHODS:The medical records of 134...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2012.07145.x

    authors: Shin HS,Kim SU,Park JY,Kim DY,Han KH,Chon CY,Baatarkhuu O,Ahn SH

    更新日期:2012-09-01 00:00:00

  • Predicting the efficacy of proton pump inhibitors in patients with non-erosive reflux disease before therapy using dual-channel 24-h esophageal pH monitoring.

    abstract:BACKGROUND AND AIM:We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). METHODS:Twenty-seven NERD patients who had experienced heartburn more than once a week within the previous month were enrolled. Intraeso...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1440-1746.2011.06975.x

    authors: Shimatani T,Sugimoto M,Nishino M,Adachi K,Furuta K,Ito M,Kurosawa S,Manabe N,Mannen K,Hongo M,Chiba T,Kinoshita Y,Acid-Related Symptom Research (ARS) Group.

    更新日期:2012-05-01 00:00:00

  • Segmental colonoscopic biopsies in the differentiation of ileocolic tuberculosis from Crohn's disease.

    abstract:BACKGROUND AND AIM:The differentiation between Crohn's disease (CD) and tuberculosis (TB) of the intestine can be difficult in areas where both diseases occur. The present study examined histological criteria that would enable the diagnosis in mucosal biopsies. METHODS:Colonoscopic biopsies from 33 patients with TB an...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2005.03814.x

    authors: Pulimood AB,Peter S,Ramakrishna B,Chacko A,Jeyamani R,Jeyaseelan L,Kurian G

    更新日期:2005-05-01 00:00:00

  • Preventing endoscopic retrograde cholangiopancreatography related sepsis: a randomized controlled trial comparing two antibiotic regimes.

    abstract::Current antibiotic prophylaxis for endoscopic retrograde cholangiopancreatography (ERCP) is not standardized and may be inadequate. We aimed to evaluate the efficacy of 3 days of additional oral antibiotics in the prevention of ERCP-related sepsis. One hundred and fifty-six patients were randomized prospectively to re...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Smith BC,Alqamish JR,Watson KJ,Shaw RG,Andrew JH,Desmond PV

    更新日期:1996-10-01 00:00:00

  • Choice of treatments for small hepatocellular carcinoma: hepatectomy, embolization or ethanol injection.

    abstract::The results of hepatectomy, percutaneous ethanol injection therapy and transcatheter arterial embolization for small hepatocellular carcinoma (HCC) of 3 cm or less in diameter from the published literature were compared with the authors' experiences with surgical treatment. The survival rates for those treated by hepa...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1991.tb00879.x

    authors: Yamasaki S,Hasegawa H,Makuuchi M,Takayama T,Kosuge T,Shimada K

    更新日期:1991-07-01 00:00:00

  • Role of apoptosis in Helicobacter pylori-associated gastric mucosal injury.

    abstract::Apoptosis, a programmed cell death, was ignored, just like Helicobacter pylori, only to reappear recently. However, the number of current publications dealing with apoptosis or H. pylori has increased exponentially. Although gastric epithelial apoptosis is a programmed physiological event in the superficial aspect of ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1440-1746.2000.02147.x

    authors: Suzuki H,Ishii H

    更新日期:2000-03-01 00:00:00

  • Signal transduction during liver regeneration.

    abstract::Following partial hepatectomy (PH), there is a rapid and highly orchestrated series of biochemical events which occur prior to cellular proliferation. Some of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress related or required for the co...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:

    authors: Brenner DA

    更新日期:1998-09-01 00:00:00

  • Directly observed therapy for the treatment of hepatitis C virus infection in current and former injection drug users.

    abstract:BACKGROUND AND AIM:There are few studies investigating the treatment of hepatitis C virus (HCV) infection in current and former drug users. With this in mind, we sought to evaluate the antiviral efficacy of interferon alpha-2b (IFN alpha-2b) or pegylated-interferon alpha-2b (PEG-IFN alpha-2b) and ribavirin (RBV) in inj...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1440-1746.2007.05032.x

    authors: Grebely J,Raffa JD,Meagher C,Duncan F,Genoway KA,Khara M,McLean M,Mead A,Viljoen M,DeVlaming S,Fraser C,Conway B

    更新日期:2007-09-01 00:00:00

  • Biology of hepatic cancer stem cells.

    abstract::Hepatocellular carcinoma (HCC) is the most commonly diagnosed malignancy of the liver and is the third most frequent cause of cancer death worldwide. Although advances in HCC detection and treatment have increased the likelihood of a cure at early stages of the disease, HCC remains largely incurable because of late pr...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2011.06762.x

    authors: Tong CM,Ma S,Guan XY

    更新日期:2011-08-01 00:00:00

  • Correlation between serum pepsinogen concentration and gastric acidity measured by 24 h pH monitoring.

    abstract::The relationship between the intragastric pH measured by 24 h pH monitoring system and the serum pepsinogen I/II ratio was studied in 68 cases. When pepsinogen I/II ratio was compared with pH 3.0 holding time (the percentage time during which the gastric pH is above 3.0), there was a negative correlation between these...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.1995.tb01070.x

    authors: Kinoshita Y,Yamashita Y,Kitajima N,Tojo M,Itoh T,Fukuzaki H,Chiba T

    更新日期:1995-03-01 00:00:00

  • IL-18 serum level and IL-18 promoter gene polymorphism in Iranian patients with gastrointestinal cancers.

    abstract:BACKGROUND AND AIM:Interleukin (IL)-18 level and association of its two promoter gene polymorphisms at -607 C/A and -137 G/C positions were investigated in Iranian patients with gastrointestinal (GI) cancers. METHODS:232 cases of GI cancers and 312 healthy controls were enrolled. Serum level of IL-18 was measured by e...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2009.05791.x

    authors: Haghshenas MR,Hosseini SV,Mahmoudi M,Saberi-Firozi M,Farjadian S,Ghaderi A

    更新日期:2009-06-01 00:00:00

  • Ischemic preconditioning in liver pathophysiology.

    abstract::Brief periods of tissue ischemia produced tissue resistance to prolonged ischemia and reperfusion, a phenomenon called ischemic preconditioning. The mechanisms of ischemic preconditioning were examined in a rat warm ischemia-reperfusion model as well as the effect of ischemic preconditioning on liver regeneration. Isc...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04656.x

    authors: Arai M,Tejima K,Ikeda H,Tomiya T,Yanase M,Inoue Y,Nagashima K,Nishikawa T,Watanabe N,Omata M,Fujiwara K

    更新日期:2007-06-01 00:00:00

  • Effect of Helicobacter pylori eradication on gastroesophageal function.

    abstract:BACKGROUND:To elucidate the cause of possible occurrence of reflux esophagitis after Helicobacter pylori eradication, gastric and esophageal function among H. pylori infected Japanese patients were evaluated both before and after eradication therapy. METHODS:Nine H. pylori-positive patients were studied before and 6 m...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2003.03301.x

    authors: Tanaka I,Tatsumi Y,Kodama T,Kato K,Fujita S,Mitsufuji S,Kashima K

    更新日期:2004-03-01 00:00:00

  • Involvement of RhoA in progression of human hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:The activation of Rho proteins has been shown to lead to loss of polarity in cancer cells, as well as reorganization of the cytoskeleton and facilitation of cell motility, possibly resulting in their malignant potential. The clinicopathological significance of RhoA, however, is not yet well known in ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2006.04534.x

    authors: Wang D,Dou K,Xiang H,Song Z,Zhao Q,Chen Y,Li Y

    更新日期:2007-11-01 00:00:00

  • Gastrointestinal manifestations of leukemia.

    abstract::Gastrointestinal (GI) manifestations of leukemia occur in up to 25% of patients at autopsy, generally during relapse. Its presence varies with the type of leukemia and has been decreasing over time due to improved chemotherapy. Gross leukemic lesions are most common in the stomach, ileum, and proximal colon. Leukemia ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1440-1746.2011.06908.x

    authors: Ebert EC,Hagspiel KD

    更新日期:2012-03-01 00:00:00

  • Androgen profiles among Egyptian adults considering liver status.

    abstract:BACKGROUND AND AIM:Hepatitis C virus (HCV) and environmental hepatotoxins may have an indirect influence on health by altering the synthesis and function of hormones, particularly reproductive hormones. We aimed to evaluate liver diseases and sex steroid hormones in Egypt, which has the highest prevalence of HCV worldw...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/j.1440-1746.2007.04949.x

    authors: Aguilar CE,Soliman AS,McConnell DS,Zekri AR,Banerjee M,Omar A,Sharawy M,Omar S,Raouf A,Sowers MR

    更新日期:2008-07-01 00:00:00

  • Late biliary tract complications after orthotopic liver transplantation: diagnostic and therapeutic role of endoscopic retrograde cholangiopancreatography.

    abstract:BACKGROUND:Biliary tract complications are frequent after orthotopic liver transplantation. Late biliary tract complications occurring after T-tube removal mostly include stones and strictures which may be associated with sepsis and worsening of the liver function. Endoscopic retrograde cholangiopancreatography (ERCP) ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1046/j.1440-1746.2000.02198.x

    authors: Mosca S,Militerno G,Guardascione MA,Amitrano L,Picciotto FP,Cuomo O

    更新日期:2000-06-01 00:00:00

  • Thiopurines prevented surgical recurrence in patients with Crohn's disease after intestinal resection: Strategy based on risk stratification.

    abstract:BACKGROUND AND AIM:Thiopurines (TPs) are effective in reducing clinical and endoscopic recurrence in postoperative patients with Crohn's disease (CD). However, whether TPs could prevent surgical recurrence (SR) remains unknown. We aimed to explore whether TPs could prevent SR and identify risk factors associated with S...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章

    doi:10.1111/jgh.13922

    authors: Guo J,Chen BL,Chen ZH,Luo XP,Qiu Y,Zhang SH,Feng R,He Y,Zeng ZR,Song XM,Ben-Horin S,Mao R,Chen MH

    更新日期:2018-03-01 00:00:00