Choice of treatments for small hepatocellular carcinoma: hepatectomy, embolization or ethanol injection.


:The results of hepatectomy, percutaneous ethanol injection therapy and transcatheter arterial embolization for small hepatocellular carcinoma (HCC) of 3 cm or less in diameter from the published literature were compared with the authors' experiences with surgical treatment. The survival rates for those treated by hepatectomy and ethanol injection were almost the same, being more than 90% at 1 year and 70% at 3 years. The overall results achieved by embolization were inferior to those achieved by the other two therapeutic modalities, although the 1 year survival rate was not worse. The cancer-free survival rates after hepatectomy and ethanol injection were also similar. Most of the patients with small HCC had associated liver cirrhosis or chronic active hepatitis, but the degree of liver dysfunction and the level of hepatic reserve varied. Anatomically, the number, size, and location of the cancer also varies. Choice of treatment for small HCC should be made based upon the degree of liver function and the anatomic status of the cancer. For example, a patient with multiple (more than four) cancer nodules is a good candidate for embolization. Ethanol injection is indicated for a small HCC, deeply seated in a severely diseased liver. Hepatectomy is the first choice for a small HCC situated near the surface of a liver with relatively good liver function.


Yamasaki S,Hasegawa H,Makuuchi M,Takayama T,Kosuge T,Shimada K




Has Abstract


1991-07-01 00:00:00












  • Factors affecting the mortality of pediatric fulminant hepatic failure in relation to hepatitis B virus infection.

    abstract:AIM:To investigate the factors affecting the outcome of fulminant hepatic failure (FHF) in children in relation to hepatitis B virus (HBV) infection. METHODS:Retrospective review of a total of 94 cases (61 males and 33 females, aged from 1 month to 15 years) recruited from nine tertiary referral centers in Taiwan from...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chan PC,Chen HL,Kong MS,Huang FC,Lee HC,Lin CC,Liu CC,Lee IH,Wu TC,Wu SF,Ni YH,Hsu HY,Chang MH

    更新日期:2005-08-01 00:00:00

  • Relationship between dietary patterns and non-alcoholic fatty liver disease: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease. Previous studies have investigated the association between dietary patterns and NAFLD, but their results are contradictory. Therefore, we carried out this meta-analysis to examine the association betw...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Hassani Zadeh S,Mansoori A,Hosseinzadeh M

    更新日期:2020-12-02 00:00:00

  • Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity.

    abstract::Constantly challenged by luminal bacteria, intestinal epithelium forms both a physical and biochemical defense against pathogens. Besides, intestinal epithelium senses dynamic and continuous changes in luminal environment and transmits signals to subjacent immune cells accordingly. It has been long accepted that adapt...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Lu JT,Xu AT,Shen J,Ran ZH

    更新日期:2017-05-01 00:00:00

  • Troglitazone prevents fatty changes of the liver in obese diabetic rats.

    abstract:BACKGROUND AND AIMS:Troglitazone is a newly developed antidiabetic drug and is indicated to be useful for the treatment of patients with type II diabetes mellitus. Recently, however, it became clear that troglitazone could cause liver dysfunction in some patients. In addition, a relationship between the activation of t...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Jia DM,Tabaru A,Akiyama T,Abe S,Otsuki M

    更新日期:2000-10-01 00:00:00

  • Duodenal tuberculosis with a choledocho-duodenal fistula.

    abstract::A 22-year-old man visited our hospital (National Cancer Center Hospital East) complaining of fatigue and anorexia. A laboratory investigation demonstrated a biochemical 'picture' of obstructive jaundice. An abdominal CT showed a low density mass in the retropancreatic area with multiple enlarged periportal lymph nodes...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Miyamoto S,Furuse J,Maru Y,Tajiri H,Muto M,Yoshino M

    更新日期:2001-02-01 00:00:00

  • Hyposplenism in alcoholic cirrhosis, facts or artifacts? A comparative analysis with non-alcoholic cirrhosis and extrahepatic portal venous obstruction.

    abstract:BACKGROUND AND AIMS:Hyposplenism has been described in patients with alcoholic cirrhosis (AC). However, no data are available regarding hyposplenism in patients with non-alcoholic cirrhosis (NAC) and other forms of portal hypertension such as extrahepatic portal venous obstruction (EHPVO). The aim is to study the splen...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Satapathy SK,Narayan S,Varma N,Dhiman RK,Varma S,Chawla Y

    更新日期:2001-09-01 00:00:00

  • Omeprazole and ranitidine in duodenal ulcer healing and subsequent relapse: a randomized double-blind study with weekly endoscopic assessment.

    abstract::To investigate the efficacy of standard and low dosage of omeprazole in the healing of duodenal ulcer, 270 patients with endoscopically active duodenal ulcer were randomized to receive omeprazole, 10 mg or 20 mg every morning, or ranitidine, 150 mg twice daily, using the double-dummy technique. Forty-six potential pro...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hui WM,Lam SK,Lau WY,Branicki FJ,Lok AS,Ng MM,Lai CL,Poon GP

    更新日期:1989-01-01 00:00:00

  • Effect of Helicobacter pylori eradication on gastroesophageal function.

    abstract:BACKGROUND:To elucidate the cause of possible occurrence of reflux esophagitis after Helicobacter pylori eradication, gastric and esophageal function among H. pylori infected Japanese patients were evaluated both before and after eradication therapy. METHODS:Nine H. pylori-positive patients were studied before and 6 m...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Tanaka I,Tatsumi Y,Kodama T,Kato K,Fujita S,Mitsufuji S,Kashima K

    更新日期:2004-03-01 00:00:00

  • Expression and prognostic significance of gastric-specific annexin A10 in diffuse- and intestinal-type gastric carcinoma.

    abstract:BACKGROUND AND AIMS:Annexin A10 (ANXA10) and its liver-specific short isoform (ANXA10S) had tissue-restricted expression. The downregulation of ANXA10S is correlated with tumor progression and poor prognosis in hepatocellular carcinoma. The aim of the present study was to validate the tissue distribution and explore th...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lu SH,Chen YL,Shun CT,Lai JN,Peng SY,Lai PL,Hsu HC

    更新日期:2011-01-01 00:00:00

  • Transcriptional regulation of stellate cell activation.

    abstract::The identification of activated hepatic stellate cells and related cell types as key fibrogenic effectors during liver injury has led to intense evaluation of transcriptional events underlying their behavior. While initial studies focused on characterizing interactions between transcription factors and regulatory regi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Friedman SL

    更新日期:2006-10-01 00:00:00

  • Marked retention of indocyanine green and sulfobromophthalein with chronic persistent hepatitis.

    abstract::A hepatitis B virus (HBV) carrier with marked retention of indocyanine green (ICG) and sulfobromophthalein (BSP) was admitted to our hospital for assessment of liver function. On admission, he was asymptomatic and blood chemistry tests showed normal values for transaminases and bilirubin. Serum hepatitis B surface ant...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Ikejima K,Ichikawa S,Kitamura T,Watanabe S,Hirose M,Yokoi Y,Uchida S,Oide H,Suzuki H,Kitami N

    更新日期:1993-09-01 00:00:00

  • Inducible nitric oxide synthase activity induced by sodium chloride solution prolongs luminal pH elevation in rat and mouse stomachs.

    abstract:BACKGROUND:Sodium chloride (NaCl) is a strong promoter of gastric cancer. We hypothesized that inducible nitric oxide synthase (iNOS) induced by NaCl may be involved in its promoting effects. We investigated iNOS expression by hypertonic NaCl solutions and its pathophysiological roles in the gastric mucosa of rats and ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Tatemichi M,Ogura T,Sakurazawa N,Nagata H,Sugita M,Esumi H

    更新日期:2003-09-01 00:00:00

  • Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody.

    abstract:BACKGROUND:Microbial agents are a possible cause of ulcerative colitis. We have previously reported evidence of bacteria invading the colonic mucosa of patients with ulcerative colitis. We have isolated bacteria from inflamed colonic mucosa, examined the localization of the species in the mucosa, and assayed for serum ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Ohkusa T,Sato N,Ogihara T,Morita K,Ogawa M,Okayasu I

    更新日期:2002-08-01 00:00:00

  • Prehepatic portal hypertension produces increased mast cell density in the small bowel and in mesenteric lymph nodes in the rat.

    abstract:BACKGROUND:Because most of the characteristics of the portal hypertensive enteropathy can be explained on the basis of increased levels of mast cell mediators, the purpose of the present paper was to study mast cell splanchnic infiltration. METHODS:Duodenum, jejunum, ileum and mesenteric lymph node complex infiltratio...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Prieto I,Aller MA,Santamaría L,Nava MP,Madero R,Pérez-Robledo JP,Arias J

    更新日期:2005-07-01 00:00:00

  • Ledipasvir/sofosbuvir fixed-dose combination tablet in Taiwanese patients with chronic genotype 1 hepatitis C virus.

    abstract:BACKGROUND AND AIM:Pegylated-interferon-alpha plus ribavirin is the current standard-of-care regimen for treating chronic hepatitis C virus (HCV) infection in Taiwan; however, interferon-based regimens can be poorly tolerated. The interferon-free, two-drug, fixed-dose combination tablet ledipasvir/sofosbuvir is approve...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究


    authors: Chuang WL,Chien RN,Peng CY,Chang TT,Lo GH,Sheen IS,Wang HY,Chen JJ,Yang JC,Knox SJ,Gao B,Garrison KL,Mo H,Pang PS,Hsu YC,Hu TH,Chu CJ,Kao JH

    更新日期:2016-07-01 00:00:00

  • Decreased anti-Saccharomyces cerevisiae antibody titer by mesalazine in patients with Crohn's disease.

    abstract:BACKGROUND:Saccharomyces cerevisiae may contribute to the pathophysiology of Crohn's disease. We determined serum anti-Saccharomyces cerevisiae antibody (ASCA) levels in patients with inflammatory bowel disease. METHODS AND RESULTS:Immunoglobulin G (IgG) ASCA was measured by using an ELISA in serum samples from 19 pat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Oshitani N,Hato F,Matsumoto T,Jinno Y,Sawa Y,Hara J,Nakamura S,Seki S,Arakawa T,Kitano A,Kitagawa S,Kuroki T

    更新日期:2000-12-01 00:00:00

  • Case report: hepatic adenoma with bone marrow metaplasia in a patient with glycogen storage disease type 1a.

    abstract::A 34 year old man with glycogen storage disease type 1a had two hepatic tumours since 18 years of age. They had continued to grow until he was 24 years old, but showed no further growth since then. He underwent a right hepatic trisegmentectomy with caudate lobectomy under veno-venous bypass. The tumour in the posterio...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Moriura S,Kuroda M,Kimura A,Iwatsuka Y,Ikeda S,Sakai T,Usui A

    更新日期:1996-06-01 00:00:00

  • Rapid elimination of Helicobacter pylori and reduction of histocompatibility leucocyte antigen-DR expression 12 h after a single dose of omeprazole, amoxycillin and metronidazole triple therapy.

    abstract:BACKGROUND:Studies of eradication of Helicobacter pylori and subsequent resolution of H. pylori-related gastritis, have focused mainly on medium and long-term change following eradication therapies. Results from those studies have shown that both acute and chronic inflammatory changes found in gastric mucosa eventually...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chen W,Shu D,Wilson IR,Tie A,Chadwick VS

    更新日期:1999-04-01 00:00:00

  • Relationship between local immune response to Helicobacter pylori and the diversity of disease: investigation of H. pylori-specific IgA in gastric juice.

    abstract::In order to evaluate the relationship between local immune response to Helicobacter pylori and the diversity of disease, 77 asymptomatic subjects who underwent a health examination were studied. Helicobacter pylori-specific IgG in serum and H. pylori-specific IgA in gastric juice were measured by ELISA, and the measur...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Watanabe T,Goto H,Arisawa T,Hase S,Niwa Y,Hayakawa T,Asai J

    更新日期:1997-10-01 00:00:00

  • Increased survival rates in gastric cancer, with a narrowing gender gap and widening socioeconomic status gap: A period analysis from 1984 to 2013.

    abstract:BACKGROUND AND AIM:Gastric cancer (GC) has the fifth highest incidence rate of all cancers and has a poor prognosis. However, no recent large-scale and long-term studies have evaluated the incidence and survival rates of individuals with GC. METHODS:In order to explore the change of GC incidence and survival rates by ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Sun F,Sun H,Mo X,Tang J,Liao Y,Wang S,Su Y,Ma H

    更新日期:2018-04-01 00:00:00

  • Hypothermia induced by adenosine 5'-monophosphate attenuates injury in an L-arginine-induced acute pancreatitis rat model.

    abstract:BACKGROUND AND AIM:This study sought to investigate the effects of hypothermia induced by adenosine 5'-monophosphate (5'-AMP) on L-arginine (L-Arg)-induced acute pancreatitis in rats. METHODS:The rats were divided into four groups: the control group, the acute pancreatitis group, the 5'-AMP pretreatment group, and the...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Wang Y,Guo W,Li Y,Pan X,Lv W,Cui L,Li C,Wang Y,Yan S,Zhang J,Liu B

    更新日期:2014-04-01 00:00:00

  • Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis.

    abstract:BACKGROUND AND AIM:By array-comparative genomic hybridization, we demonstrated cyclin E as one of seven genes associated with hepatocellular carcinoma (HCC) development in Ku70 DNA repair-deficient mice. We therefore explored the hypothesis that during hepatocarcinogenesis, cyclin E kinase can overcome the inhibitory e...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Pok S,Wen V,Shackel N,Alsop A,Pyakurel P,Fahrer A,Farrell GC,Teoh NC

    更新日期:2013-09-01 00:00:00

  • Endoscopic mucosal resection: not only therapeutic, but a diagnostic procedure for sessile gastric polyps.

    abstract:BACKGROUND AND AIMS:Histological examination of specimens obtained by forceps biopsy sampling of gastric lesions is of limited accuracy, and their management on this basis is therefore controversial. Endoscopic mucosal resection (EMR) was initially developed in Japan for the resection of early gastric cancer (EGC). The...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Szalóki T,Tóth V,Németh I,Tiszlavicz L,Lonovics J,Czakó L

    更新日期:2008-04-01 00:00:00

  • Case report: lymphangioma of the oesophagus endoscopically resected.

    abstract::Lymphangioma of the oesophagus is an extremely rare entity, with only nine cases having been reported worldwide. We report on a 52-year-old woman with oesophageal lymphangioma, diagnosed using endoscopic ultrasonography and endoscopically resected. No case of malignant transformation of the lymphangioma has been repor...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Suwa T,Ozawa S,Ando N,Shinozaki H,Tsujitsuka K,Miki H,Makuuchi H,Kitajima M

    更新日期:1996-08-01 00:00:00

  • A prospective and comparative cohort study on efficacy and drug resistance during long-term lamivudine treatment for various stages of chronic hepatitis B and cirrhosis.

    abstract:BACKGROUND AND AIMS:A prospective, non-randomized cohort study on long-term lamivudine treatment, comparing efficacy, drug resistance, and prognosis for various stages of chronic hepatitis B virus (HBV)-related liver disease was performed to elucidate the significance and indication of lamivudine for individual patient...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Nishida T,Kobashi H,Fujioka S,Fujio K,Takaguchi K,Ikeda H,Kawaguchi M,Ando M,Araki Y,Higashi T,Shoji B,Takaki A,Iwasaki Y,Sakaguchi K,Shiratori Y,Yamamoto K

    更新日期:2008-05-01 00:00:00

  • Interstitial tumour cell invasion in small hepatocellular carcinoma. Evaluation in microscopic and low magnification views.

    abstract::In order to study the process of hepatocellular carcinoma (HCC) development, and to search for a clue to histologic diagnosis of well-differentiated HCC (wd-HCC), interstitial invasion in small HCC was evaluated. The study material consisted of 35 cases of HCC that were smaller than 3 cm that comprised 17 cases of wd-...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kondo F,Kondo Y,Nagato Y,Tomizawa M,Wada K

    更新日期:1994-11-01 00:00:00

  • Akt expression may predict favorable prognosis in cholangiocarcinoma.

    abstract:BACKGROUND:Overexpression of signaling proteins including epidermal growth factor receptor (EGFR), Akt, mitogen activated protein kinase (MAPK) and cyclooxygenase-2 (COX-2) occurs in cholangiocarcinoma cell lines. However, the prognostic value of these markers is unknown. No prior study correlated the expression of the...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Javle MM,Yu J,Khoury T,Chadha KS,Iyer RV,Foster J,Kuvshinoff BW,Gibbs JF,Geradts J,Black JD,Brattain MG

    更新日期:2006-11-01 00:00:00

  • Factors associated with diagnostic accuracy, technical success and adverse events of endoscopic ultrasound-guided fine-needle biopsy: A systematic review and meta-analysis.

    abstract:BACKGROUND AND AIM:Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is used to diagnose lesions within or adjacent to the digestive tract. However, there is no report on the overall diagnostic accuracy, technical success, and adverse events of FNB. The aims of this study were to conduct a systematic review and...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,meta分析


    authors: Li DF,Wang JY,Yang MF,Xiong F,Zhang DG,Xu ZL,Luo MH,Jing ZD,Wang KX,Wang LS,Yao J

    更新日期:2020-08-01 00:00:00

  • Esophageal mucosa in HIV infection: A"deeper" look at this little spoken organ.

    abstract:BACKGROUND AND AIM:Although the esophagus is a common site of opportunistic infection in AIDS patients, little is known about the impact of HIV as well as opportunistic infection in the esophageal mucosa. Our aim is to analyze the esophageal immune profile in HIV+ patients with different immunological status with and w...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Werneck-Silva AL,Pagliari C,Patzina RA,Takakura CFH,Duarte MI

    更新日期:2017-11-01 00:00:00

  • Increased melibiose/rhamnose ratio in bile of rats with acute cholestasis.

    abstract:BACKGROUND AND AIM:Melibiose/rhamnose permeability test is used for noninvasive intestinal mucosa barrier testing. However, the possible escape route of the absorbed saccharides through either intact or impaired blood-biliary barriers has not so far been explored. The objective of the present study was therefore two-fo...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Tomsik P,Sispera L,Rezacova M,Niang M,Stoklasova A,Cerman J,Knizek J,Brcakova E,Cermanova J,Micuda S

    更新日期:2008-12-01 00:00:00