当前位置： SCI文献检索 > JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY期刊下所有文献 > Distribution of liver stiffness in non-alcoholic fatty liver disease with higher fibrosis-4 index than low cut-off index.

Distribution of liver stiffness in non-alcoholic fatty liver disease with higher fibrosis-4 index than low cut-off index.

Abstract：

BACKGROUND AND AIM:In the condition of high prevalence of non-alcoholic fatty liver disease (NAFLD), a new diagnostic algorithm to efficiently identify NAFLD patients with significant fibrosis is urgently required. We evaluated the predictive ability of the fibrosis-4 index (FIB-4 index) for significant liver fibrosis (F ≥ 2) in a cohort of Japanese patients with NAFLD. METHODS:We prospectively calculated the FIB-4 index in patients who were incidentally diagnosed as fatty liver in medical checkups and then conducted liver stiffness measurement by vibration-controlled transient elastography (VCTE) only in patients in whom the FIB-4 index was more than the low cut-off index (> 1.45). RESULTS:Of the 5929 people who underwent medical checkups, a total of 1374 people were identified as having fatty liver. Among these, we performed VCTE in 106 patients in whom the FIB-4 index was higher than 1.45. The distribution of the fibrosis stage as estimated by VCTE in the patients was as follows: F0, 52.8%; F1, 10.3%; F2, 21.6%; F3, 11.3%; and F4, 3.7%. The positive predictive value of the FIB-4 index for detecting NAFLD with significant fibrosis was 36.6%. The minimum value of the FIB-4 index was constant for each estimated fibrosis stage. CONCLUSIONS:This is the first prospective study to evaluate the usefulness of the FIB-4 index as the first step to screen NAFLD patients with significant fibrosis. In Japan, addition of one further step that combined with the FIB-4 index is necessary to meaningfully reduce the number of patients needing liver stiffness measurement or liver biopsy.

journal_name

J Gastroenterol Hepatol

journal_title

Journal of gastroenterology and hepatology

authors

Tomeno W,Imajo K,Kuwada Y,Ogawa Y,Kikuchi M,Honda Y,Kato T,Kessoku T,Kirikoshi H,Yoneda M,Kitahora T,Saito S,Ozawa Y,Nakajima A

doi

10.1111/jgh.14559

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

1411-1416

issue

8

eissn

0815-9319

issn

1440-1746

journal_volume

34

pub_type

杂志文章

相关文献

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY文献大全
  • Usefulness of a novel and rapid assay system for fecal calprotectin in pediatric patients with inflammatory bowel diseases.

    abstract：BACKGROUND AND AIM:Fecal calprotectin (FC) has become a reliable biomarker for intestinal inflammation in inflammatory bowel diseases (IBDs). However, a simple and rapid assay to replace conventional ELISA is necessary for wider use in clinical practice. In this study, we investigated the usefulness of a novel method f...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.12578

    authors： Inoue K,Aomatsu T,Yoden A,Okuhira T,Kaji E,Tamai H

    更新日期：2014-01-01 00:00:00

  • A commentary on: career paths for basic scientists in medical research.

    abstract：:For basic scientists, the choice of starting a career in medical research is one made through a genuine interest in understanding the human disease processes and a desire to be at the forefront of new knowledge acquisition. However, more often than not, this decision is made without a great understanding of the career...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.1996.tb00099.x

    authors： Ramm GA

    更新日期：1996-09-01 00:00:00

  • Alcoholic liver disease: pathogenesis, management, and novel targets for therapy.

    abstract：:Alcohol use is a leading cause of preventable morbidity and mortality worldwide, with much of its negative impact as the result of alcoholic liver disease (ALD). ALD is a broad term that encompasses a spectrum of phenotypes ranging from simple steatosis to steatohepatitis, progressive fibrosis, cirrhosis, and hepatoce...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1111/jgh.12030

    authors： Orman ES,Odena G,Bataller R

    更新日期：2013-08-01 00:00:00

  • Effects of clarithromycin, omeprazole and leminoprazole on gastric ulcer healing in Helicobacter pylori-infected rats.

    abstract：:We examined whether a single inoculation of Helicobacter pylori can colonize the stomachs of ulcerated rats and delay their healing and whether an antibiotic drug and acid pump inhibitors can enhance the ulcer healing in infected rats. Ulcers were produced by a submucosal injection of acetic acid solution into the gas...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.1998.tb01874.x

    authors： Li T,Okabe S

    更新日期：1998-11-01 00:00:00

  • Fetal and infant exposure to the Chinese famine increases the risk of fatty liver disease in Chongqing, China.

    abstract：BACKGROUND AND AIM:Early life exposure to the famine may affect the susceptibility to the metabolic disorders. The objective of this study was to examine the associations of early life exposure to the Chinese Famine (1959-1961) with the risk of fatty liver disease, obesity, hypertension, and hyperglycemia in adulthood....

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.13044

    authors： Chen JP,Peng B,Tang L,Sun R,Hu S,Wen XY,Que P,Wang YH

    更新日期：2016-01-01 00:00:00

  • Glucose-6-phosphatase gene mutations in 20 adult Japanese patients with glycogen storage disease type 1a with reference to hepatic tumors.

    abstract：BACKGROUND AND AIMS:A few cases are reported of liver neoplasms observed in patients with glycogen storage disease type 1a (GSD1a). Genetic analysis was carried out in adult Japanese patients with GSD1a and their family members, and hepatic tumors were also investigated in these patients. METHODS:DNA was extracted fro...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.2001.02645.x

    authors： Nakamura T,Ozawa T,Kawasaki T,Nakamura H,Sugimura H

    更新日期：2001-12-01 00:00:00

  • Frequency of rebleeding events in obscure gastrointestinal bleeding with negative capsule endoscopy.

    abstract：BACKGROUND AND AIMS:Although capsule endoscopy (CE) is widely used as a first-line diagnostic modality for obscure gastrointestinal bleeding (OGIB), the rebleeding rate after negative CE varies according to different studies. We tried to elucidate the outcomes after negative CE for OGIB and to determine the risk factor...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.12145

    authors： Kim JB,Ye BD,Song Y,Yang DH,Jung KW,Kim KJ,Byeon JS,Myung SJ,Yang SK,Kim JH

    更新日期：2013-05-01 00:00:00

  • Acute hepatitis C transmitted by needlestick accident despite short duration interferon treatment.

    abstract：:Hepatitis C virus (HCV) transmission by needlestick accidents involving hospital employees has become an important problem. The present report is of a case of acute hepatitis C that developed after a needlestick injury, despite short duration interferon treatment performed just after the accident in a trial effort to ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.1995.tb01355.x

    authors： Nakano Y,Kiyosawa K,Sodeyama T,Tanaka E,Matsumoto A,Ichijo T,Mizokami M,Furuta S

    更新日期：1995-09-01 00:00:00

  • An unusual cause of rectal bleeding in a patient with cystic fibrosis.

    abstract：:Here we identify a previously unreported cause of rectal bleeding (juvenile polyposis) in a patient with cystic fibrosis (CF). We believe this patient most likely has two coexisting genetic diseases. It also raises many issues about organ transplantation in a patient with medical conditions that individually increase ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.1999.01849.x

    authors： Treepongkaruna S,Hardikar W,Chow CW,Smith AL,Oliver MR

    更新日期：1999-03-01 00:00:00

  • Echo-Doppler measurements of portal vein and superior mesenteric artery blood flow in humans: inter- and intra-observer short-term reproducibility.

    abstract：:The reproducibility of echo-Doppler measurements of portal vein and superior mesenteric artery blood flow has not been extensively studied. In the present study, two groups of subjects were examined to test inter- and intra-observer reproducibility. Each study population consisted of 15 nonportal hypertensive and 15 p...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.1996.tb00008.x

    authors： Iwao T,Toyonaga A,Shigemori H,Oho K,Sumino M,Sato M,Tanikawa K

    更新日期：1996-01-01 00:00:00

  • Evaluation of a new formulation CLOtest.

    abstract：BACKGROUND AND AIMS:The CLOtest and other rapid urease detection kits are widely used in the endoscopic diagnosis of Helicobacter pylori. A new formulation CLOtest has been developed with the goal of obtaining a positive result more rapidly. The aims of this study were to validate the sensitivity and specificity of the...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1046/j.1440-1746.2002.02563.x

    authors： Viiala CH,Windsor HM,Forbes GM,Chairman SO,Marshall BJ,Mollison LC

    更新日期：2002-02-01 00:00:00

  • Hepatic resection for benign tumours of the liver.

    abstract：:The most frequent benign tumours of the liver include haemangioma, liver cell adenoma and focal nodular hyperplasia. Patients may undergo hepatic resection because of a preoperative diagnosis of malignancy or uncertainty in diagnosis despite an extensive work-up. ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1046/j.1440-1746.2000.02167.x

    authors： Chen MF

    更新日期：2000-06-01 00:00:00

  • Hepatitis C virus infection facilitates gallstone formation.

    abstract：BACKGROUND:Bile duct damage and hepatic steatosis are two characteristic histological findings in hepatitis C virus infection; and high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma. The purpose of the present study was to examine the relationship between biliary diseases and hepatitis...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2005.03915.x

    authors： Chang TS,Lo SK,Shyr HY,Fang JT,Lee WC,Tai DI,Sheen IS,Lin DY,Chu CM,Liaw YF

    更新日期：2005-09-01 00:00:00

  • Secreted protein acidic and rich in cysteine promotes epithelial-mesenchymal transition of hepatocellular carcinoma cells and acquisition of cancerstem cell phenotypes.

    abstract：BACKGROUND AND AIM:Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that plays a significant role in tumor development. SPARC has been indicated that promotes tumorigenesis, metastasis, and poor prognosis in prostate cancer and lung cancer. Therefore, we sought to investigate the mol...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.14692

    authors： Jiang X,Liu F,Wang Y,Gao J

    更新日期：2019-10-01 00:00:00

  • Role of enhanced multi-detector-row computed tomography before urgent endoscopy in acute upper gastrointestinal bleeding.

    abstract：BACKGROUND AND AIM:Multi-detector-row computed tomography (MDCT) has been reported to be a potentially useful modality for detection of the bleeding origin in patients with acute upper massive gastrointestinal (GI) bleeding. The purpose of this study is to investigate the efficacy of MDCT as a routine method for detect...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.12447

    authors： Miyaoka Y,Amano Y,Ueno S,Izumi D,Mikami H,Yazaki T,Okimoto E,Sonoyama T,Ito S,Fujishiro H,Kohge N,Imaoka T

    更新日期：2014-04-01 00:00:00

  • Utility and limitations of noninvasive fibrosis markers for predicting prognosis in biopsy-proven Japanese non-alcoholic fatty liver disease patients.

    abstract：BACKGROUND AND AIM:The fibrosis stage of non-alcoholic fatty liver disease (NAFLD) is closely associated with long-term prognosis, including liver-related mortality. However, it is not yet clear whether noninvasive fibrosis markers can predict the incidence of non-liver-related complications in Japanese NAFLD. In this ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.14448

    authors： Ito T,Ishigami M,Ishizu Y,Kuzuya T,Honda T,Hayashi K,Nishimura D,Toyoda H,Kumada T,Goto H,Hirooka Y

    更新日期：2019-01-01 00:00:00

  • Vitamin C deficiency increases the binucleation of hepatocytes in SMP30 knock-out mice.

    abstract：BACKGROUND AND AIMS:The binucleation of hepatocytes, which was known as an important feature of liver growth and physiology, has been reported to be increased during the chronic oxidative injury stage and has been regarded as an age-related change of hepatic structures. Therefore, we investigated the binuclearity patte...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2010.06239.x

    authors： Park JK,Hong IH,Ki MR,Chung HY,Ishigami A,Ji AR,Goo MJ,Kim DH,Kwak JH,Min CW,Lee SS,Jeong KS

    更新日期：2010-11-01 00:00:00

  • Protective effect of OK-432 (streptococcal preparation) on murine fulminant hepatitis following mouse hepatitis virus infection.

    abstract：:The effects of OK-432 (streptococcal preparation) on murine fulminant hepatitis were investigated. Hepatitis was induced by injection of mouse hepatitis virus type 2 (MHV-2) at a strength of either 1 x 10(3) or 1 x 10(4) plaque-forming units (PFU). Mice without OK-432 treatment died within 5 days, whereas mice preinoc...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.1990.tb01416.x

    authors： Shirai M,Watanabe S,Nishioka M

    更新日期：1990-07-01 00:00:00

  • Sphincter of Oddi: Function, dysfunction, and its management.

    abstract：:The most common functional disorder of the biliary tract and pancreas relates to the activity of the Sphincter of Oddi. The Sphincter of Oddi is a small smooth muscle sphincter strategically placed at the junction of the bile duct, pancreatic duct, and duodenum. The sphincter controls flow of bile and pancreatic juice...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1440-1746.2009.06072.x

    authors： Toouli J

    更新日期：2009-10-01 00:00:00

  • Coincident increase in periportal expression of iron proteins in the iron-loaded rat liver.

    abstract：BACKGROUND:The liver is the major iron storage organ in the body and, as a result, total body iron stores closely regulate hepatocyte iron uptake, storage and release. Transferrin, transferrin receptor and ferritin facilitate these processes. METHODS:Expression of the three proteins was localized by immunohistochemist...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.1999.01932.x

    authors： Basclain KA,Jeffrey GP

    更新日期：1999-07-01 00:00:00

  • Effects of ammonia solution on the gastric mucosa in cirrhotic rats and therapeutic effects of geranylgeranylacetone.

    abstract：BACKGROUND:We designed an animal model in order to clarify whether Helicobacter pylori infection causes the gastric mucosal lesion frequently seen in cirrhotic patients. METHODS:Ammonia (NH3) solution was given to rats with carbon tetrachloride-induced cirrhosis. The gastric mucosal hexosamine (Hx) content and histopa...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.1999.01910.x

    authors： Sugimoto M,Machida Y,Ito K

    更新日期：1999-06-01 00:00:00

  • Case report: acanthosis nigricans in association with primary biliary cirrhosis: resolution after liver transplantation.

    abstract：:A case is described of a 58 year old Caucasian male with primary biliary cirrhosis (PBC) who first presented with acanthosis nigricans of both axillae, skin pigmentation, which was pronounced over the posterior surface of the neck, and generalized pruritus. Following orthotopic liver transplantation for progressive li...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.1996.tb00025.x

    authors： Pham TH,Kaushik S,Lin BP,Jones DB

    更新日期：1996-11-01 00:00:00

  • Adult intussuscepted Meckel's diverticulum presenting mainly lower gastrointestinal bleeding.

    abstract：:Herein, we report on an adult with intussusception of an invaginated Meckel's diverticulum presenting mainly with acute intermittent lower gastrointestinal bleeding, whereas the common symptom of abdominal pain, indicating intussusception, was absent. Colonoscopy revealed a reducible polypoid lesion in the ileocecal a...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.2001.02335.x

    authors： Lu CL,Chen CY,Chiu ST,Chang FY,Lee SD

    更新日期：2001-04-01 00:00:00

  • Evaluation of hernia repair operation in Child-Turcotte-Pugh class C cirrhosis and refractory ascites.

    abstract：BACKGROUND AND AIM:Abdominal wall hernia is a common feature of decompensated liver cirrhosis and frequently causes life-threatening complications or severe pain. However, there have been no data reported on postoperative mortality, hepatic functional deterioration and recurrence rate according to Child-Turcotte-Pugh (...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2006.04458.x

    authors： Park JK,Lee SH,Yoon WJ,Lee JK,Park SC,Park BJ,Jung YJ,Kim BG,Yoon JH,Kim CY,Ha J,Park KJ,Kim YJ

    更新日期：2007-03-01 00:00:00

  • New paradigms for the treatment of chronic hepatitis B.

    abstract：:The main goals of chronic hepatitis B treatment should be the long-term suppression of viral replication to minimize disease progression and the risk for the development of hepatocellular carcinoma. Treatment end-points, depending on surrogate markers alone, in particular hepatitis B e-antigen seroconversion, may not ...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2008.05400.x

    authors： Fung J,Lai CL,Yuen MF

    更新日期：2008-08-01 00:00:00

  • Hepatic stellate cell contraction is inhibited by lipo-prostaglandin E1 in vitro.

    abstract：:Prostaglandin E1 (PGE1) has been reported to have, experimentally and clinically, a protective effect against liver damage. This effect may result from the relaxation of hepatic stellate cells, whose contraction induces vasoconstriction of hepatic sinusoids. However, prostaglandins are unstable and a new drug delivery...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：

    authors： Wang XE,Watanabe S,Oide H,Hirose M,Itatsu T,Osada T,Takazakura Y,Yokoi Y,Sato N

    更新日期：1998-09-01 00:00:00

  • Validation of the Asia Pacific Colorectal Screening (APCS) score in a Western population: An alternative screening tool.

    abstract：BACKGROUND AND AIM:Colorectal cancer (CRC) screening is based on colonoscopy or fecal occult blood tests, but is imperfect and costly. The Asia Pacific Colorectal Screening Score (APCS) is derived from age, sex, family history of CRC, and smoking history and has been validated in Asian populations. Validation in a West...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.13196

    authors： Corte C,Zhang L,Chen J,Westbury S,Shaw J,Yeoh KG,Leong R

    更新日期：2016-02-01 00:00:00

  • Learning curve of double-guidewire technique by trainees during hands-on endoscopic retrograde cholangiopancreatography training.

    abstract：BACKGROUND AND AIMS:Double-guidewire technique (DWT) has been successfully performed by experts in difficult biliary cannulation as an advanced technique. This study aimed to define the learning curve and safety of DWT by trainees during hands-on endoscopic retrograde cholangiopancreatography (ERCP) training. METHODS:...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/jgh.15120

    authors： Wang X,Ren G,Xi Y,Luo H,Liang S,Wang B,Tao Q,Luo B,Qin Q,Farrell JJ,Guo X,Wu K,Pan Y

    更新日期：2020-05-30 00:00:00

  • Factors that influence cecal intubation rate during colonoscopy in deeply sedated patients.

    abstract：BACKGROUND AND AIM:The technical performance of colonoscopy performed in deeply sedated patients differs from that performed without sedation or under minimal to moderate sedation. The aim of this study is to evaluate the factors affecting cecal intubation during colonoscopy performed under deep sedation. METHODS:A to...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1111/j.1440-1746.2011.06795.x

    authors： Hsu CM,Lin WP,Su MY,Chiu CT,Ho YP,Chen PC

    更新日期：2012-01-01 00:00:00

  • Long-term outcome of autoimmune hepatitis in children.

    abstract：BACKGROUND AND AIM:Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology, which usually progresses to cirrhosis if not diagnosed and treated promptly. Data on long-term follow up in children with AIH are scant. The aim of this study is to assess the long-term outcome of autoimmune hepatitis in children wi...

    journal_title：Journal of gastroenterology and hepatology

    pub_type： 杂志文章

    doi：10.1046/j.1440-1746.2001.02615.x

    authors： Saadah OI,Smith AL,Hardikar W

    更新日期：2001-11-01 00:00:00