Distribution of liver stiffness in non-alcoholic fatty liver disease with higher fibrosis-4 index than low cut-off index.


BACKGROUND AND AIM:In the condition of high prevalence of non-alcoholic fatty liver disease (NAFLD), a new diagnostic algorithm to efficiently identify NAFLD patients with significant fibrosis is urgently required. We evaluated the predictive ability of the fibrosis-4 index (FIB-4 index) for significant liver fibrosis (F ≥ 2) in a cohort of Japanese patients with NAFLD. METHODS:We prospectively calculated the FIB-4 index in patients who were incidentally diagnosed as fatty liver in medical checkups and then conducted liver stiffness measurement by vibration-controlled transient elastography (VCTE) only in patients in whom the FIB-4 index was more than the low cut-off index (> 1.45). RESULTS:Of the 5929 people who underwent medical checkups, a total of 1374 people were identified as having fatty liver. Among these, we performed VCTE in 106 patients in whom the FIB-4 index was higher than 1.45. The distribution of the fibrosis stage as estimated by VCTE in the patients was as follows: F0, 52.8%; F1, 10.3%; F2, 21.6%; F3, 11.3%; and F4, 3.7%. The positive predictive value of the FIB-4 index for detecting NAFLD with significant fibrosis was 36.6%. The minimum value of the FIB-4 index was constant for each estimated fibrosis stage. CONCLUSIONS:This is the first prospective study to evaluate the usefulness of the FIB-4 index as the first step to screen NAFLD patients with significant fibrosis. In Japan, addition of one further step that combined with the FIB-4 index is necessary to meaningfully reduce the number of patients needing liver stiffness measurement or liver biopsy.


Tomeno W,Imajo K,Kuwada Y,Ogawa Y,Kikuchi M,Honda Y,Kato T,Kessoku T,Kirikoshi H,Yoneda M,Kitahora T,Saito S,Ozawa Y,Nakajima A




Has Abstract


2019-08-01 00:00:00












  • Post-partum acute exacerbation of chronic hepatitis in a hepatitis C-carrier mother.

    abstract::Hepatitis C virus infection is a global health problem; however, the interaction between pregnancy and chronic hepatitis C remains controversial. A Taiwanese woman with chronic hepatitis C had an uncomplicated pregnancy and gave birth to a female baby through spontaneous vaginal delivery. The serum levels of alanine a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chen JD,Chung JL,Kao JH,Chen DS

    更新日期:2001-06-01 00:00:00

  • Prehepatic portal hypertension produces increased mast cell density in the small bowel and in mesenteric lymph nodes in the rat.

    abstract:BACKGROUND:Because most of the characteristics of the portal hypertensive enteropathy can be explained on the basis of increased levels of mast cell mediators, the purpose of the present paper was to study mast cell splanchnic infiltration. METHODS:Duodenum, jejunum, ileum and mesenteric lymph node complex infiltratio...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Prieto I,Aller MA,Santamaría L,Nava MP,Madero R,Pérez-Robledo JP,Arias J

    更新日期:2005-07-01 00:00:00

  • Application of the combined FibroMeter vibration-controlled transient elastography algorithm in Chinese patients with non-alcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:The FibroMeter vibration-controlled transient elastography (FM VCTE) is a new formula combining the serum test FM and liver stiffness measurement (LSM) by VCTE. We tested the accuracy and utility of FM VCTE for fibrosis staging in patients with non-alcoholic fatty liver disease (NAFLD). METHODS:Two ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Loong TC,Wei JL,Leung JC,Wong GL,Shu SS,Chim AM,Chan AW,Choi PC,Tse YK,Chan HL,Wong VW

    更新日期:2017-07-01 00:00:00

  • Pancreatitis-associated protein-I mRNA expression in mouse pancreas is upregulated by lipopolysaccharide independent of cerulein-pancreatitis.

    abstract:BACKGROUND AND AIMS:It is well known that endotoxemia, which is caused by a bacterial infection, can exacerbate acute pancreatitis, whereas pancreatitis-associated protein (PAP) has the ability to induce bacterial aggregation. Pancreatitis-associated protein is supposed to protect the tissue from infection during infla...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Wang X,Wang B,Wu J

    更新日期:2001-01-01 00:00:00

  • Extraesophageal and atypical manifestations of GERD.

    abstract::Extraesophageal manifestations of gastroesophageal reflux disease (GERD) are essentially complications of GERD that primarily involve organs that are in proximity to the esophagus. Non-cardiac chest pain (NCCP) is an atypical manifestation of GERD, because symptoms originate in essence from the esophagus. In both atyp...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Wong WM,Fass R

    更新日期:2004-09-01 00:00:00

  • Simvastatin effects on portal-systemic collaterals of portal hypertensive rats.

    abstract:BACKGROUND AND AIM:Portal-systemic collateral vascular resistance and vasoconstrictor responsiveness are crucial in portal hypertension and variceal bleeding control. Statins enhance vasodilators production, but their influence on collaterals is unknown. This study aimed to survey the effect of simvastatin on collatera...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Huang HC,Wang SS,Lee JY,Chen YC,Lee FY,Lin HC,Chang CC,Lee SD

    更新日期:2010-08-01 00:00:00

  • Hepatic microsomal protein and cytochrome P-450 in BALB/c mice infected with Leishmania.

    abstract::The effects of infection of mice with Leishmania major on liver microsomal protein and cytochrome P-450 were examined. The levels of hepatic microsomal protein and cytochrome P-450 were monitored at 6, 7, 9 and 12 weeks post-infection. The results indicated that the amount of hepatic microsomal protein and cytochrome ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: al-Mofleh IA,al-Khuwaitir SA,Mahmoud AA,Kyegombe DB,al-Tuwaijri AS

    更新日期:1989-11-01 00:00:00

  • Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Sri Lankan population.

    abstract:BACKGROUND AND AIMS:Non-alcoholic fatty liver disease (NAFLD) is an emerging problem in the Asia-Pacific region. However, its prevalence and risk factors in Asian (especially South Asian) communities is poorly studied. In this study, the aim was to determine the community prevalence and risk factors for NAFLD among adu...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Dassanayake AS,Kasturiratne A,Rajindrajith S,Kalubowila U,Chakrawarthi S,De Silva AP,Makaya M,Mizoue T,Kato N,Wickremasinghe AR,de Silva HJ

    更新日期:2009-07-01 00:00:00

  • Practical difficulties in the management of hepatitis B in the Asia-Pacific region.

    abstract::The Asia-Pacific Expert Committee on Hepatitis B Management recently reviewed the impact of hepatitis B in the region and assessed the differences and similarities observed in the practical management of the disease in individual Asia-Pacific countries. Hepatitis B is a major health concern in the Asia-Pacific region,...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Mohamed R,Desmond P,Suh DJ,Amarapurkar D,Gane E,Guangbi Y,Hou JL,Jafri W,Lai CL,Lee CH,Lee SD,Lim SG,Guan R,Phiet PH,Piratvisuth T,Sollano J,Wu JC

    更新日期:2004-09-01 00:00:00

  • Acetylcholine induces fibrogenic effects via M2/M3 acetylcholine receptors in non-alcoholic steatohepatitis and in primary human hepatic stellate cells.

    abstract:BACKGROUND:The parasympathetic nervous system (PNS), via neurotransmitter acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear. AIMS:We aimed to determine the fibrogenic responses of human hepatic stellate cells (hHSC) to ACh and the relevance ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Morgan ML,Sigala B,Soeda J,Cordero P,Nguyen V,McKee C,Mouraliderane A,Vinciguerra M,Oben JA

    更新日期:2016-02-01 00:00:00

  • Prevalence of Helicobacter pylori infection and the effect of its eradication on symptoms of functional dyspepsia in Kashmir, India.

    abstract:BACKGROUND AND AIM:Epidemiology of Helicobacter pylori infection has regional variation. Effect of eradication of H. pylori on symptoms of functional dyspepsia is uncertain, and the data in Asian scenario are scanty. The study aimed to see H. pylori positivity rate in patients of functional dyspepsia and the effect of ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Sodhi JS,Javid G,Zargar SA,Tufail S,Shah A,Khan BA,Yattoo GN,Gulzar GM,Khan MA,Lone MI,Saif Ru,Parveen S,Shoukat A

    更新日期:2013-05-01 00:00:00

  • Prolonged azathioprine treatment reduces the need for surgery in early Crohn's disease.

    abstract:BACKGROUND AND AIM:Whether an early use of azathioprine (AZA) can alter the natural history of Crohn's disease (CD) remains debated. The aim of this study is to evaluate the impact of AZA on disease progression in a cohort of patients with early CD. METHODS:This longitudinal cohort study examined patients with early C...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Qiu Y,Chen BL,Feng R,Zhang SH,He Y,Zeng ZR,Ben-Horin S,Peyrin-Biroulet L,Mao R,Chen MH

    更新日期:2018-03-01 00:00:00

  • Hepatic steatosis in chronic hepatitis C virus infection: prevalence and clinical correlation.

    abstract:BACKGROUND AND AIMS:Hepatic steatosis is a histological characteristic in patients with chronic hepatitis C virus (HCV) infection. The aim of this study was to evaluate the prevalence of hepatic steatosis in Chinese patients with chronic hepatitis C, and to look for possible correlation with various histopathological c...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Hwang SJ,Luo JC,Chu CW,Lai CR,Lu CL,Tsay SH,Wu JC,Chang FY,Lee SD

    更新日期:2001-02-01 00:00:00

  • Clinical outcomes of cryptogenic compared with non-cryptogenic cirrhosis: A retrospective cohort study.

    abstract:BACKGROUND AND AIM:The consequences of the association between the metabolic syndrome and cryptogenic cirrhosis are uncertain. We aimed to compare the differences in clinical outcomes between cryptogenic and non-cryptogenic cirrhosis. METHODS:A retrospective cohort study was conducted in a large, single academic cente...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Mohammed OK,Mahadeva S

    更新日期:2015-09-01 00:00:00

  • Expression and prognostic significance of gastric-specific annexin A10 in diffuse- and intestinal-type gastric carcinoma.

    abstract:BACKGROUND AND AIMS:Annexin A10 (ANXA10) and its liver-specific short isoform (ANXA10S) had tissue-restricted expression. The downregulation of ANXA10S is correlated with tumor progression and poor prognosis in hepatocellular carcinoma. The aim of the present study was to validate the tissue distribution and explore th...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lu SH,Chen YL,Shun CT,Lai JN,Peng SY,Lai PL,Hsu HC

    更新日期:2011-01-01 00:00:00

  • Clinical significance of SEN-virus on interferon response in chronic hepatitis C patients.

    abstract:BACKGROUND AND AIM:A novel virus, SEN-virus (SENV), was recently discovered. It has been reported as a candidate for a non-A-E hepatitis virus. However, much is still unknown about the clinical significance of SENV. The aim of the present study was to clarify the clinical significance of SENV in patients coinfected wit...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lin JG,Goto T,Nakane K,Miura K,Mikami K,Ohshima S,Yoneyama K,Watanabe S

    更新日期:2003-10-01 00:00:00

  • Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients.

    abstract:BACKGROUND AND AIMS:Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role in HBV infection in humans has not been well characterized. In this study, we analyzed the frequency and cytokines secretion of circulating Th17 cells in HBV infected patients with different statuse...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Wu W,Li J,Chen F,Zhu H,Peng G,Chen Z

    更新日期:2010-04-01 00:00:00

  • Changing aetiologic patterns of acute viral hepatitis in Taiwanese children.

    abstract::During 1981-86, 76 children were diagnosed as having acute viral hepatitis at the Department of Pediatrics, National Taiwan University Hospital, which is a major referral centre for hepatitis in children in northern Taiwan. The majority (64%) of children had acute hepatitis B which had occurred mainly during infancy. ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Huang LM,Chang MH,Hong JY,Lee CY,Chen DS

    更新日期:1989-07-01 00:00:00

  • Clinicopathological staging for colorectal cancer: an International Documentation System (IDS) and an International Comprehensive Anatomical Terminology (ICAT).

    abstract::The purpose of tumour staging for colorectal cancer (CRC) is to help define clinical management, facilitate communication between physicians, provide a basis for stratification and analysis of treatment results in prospective studies, and provide some prognostic information for patients and their families. The World C...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Fielding LP,Arsenault PA,Chapuis PH,Dent O,Gathright B,Hardcastle JD,Hermanek P,Jass JR,Newland RC

    更新日期:1991-07-01 00:00:00

  • Non-steroid anti-inflammatory drug associated ulcer: epidemiology, causation and treatment.

    abstract::Epidemiological evidence consistently indicates that aspirin or non-aspirin non-steroidal anti-inflammatory drug use is associated with the occurrence of gastric ulceration, gastric and ulcer bleeding, and ulcer death. Evidence on duodenal ulcer occurrence conflicts, possibly because of differences in study population...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: Langman MJ,Brooks P,Hawkey CJ,Silverstein F,Yeomans N

    更新日期:1991-09-01 00:00:00

  • Prevalence and risk of colorectal adenoma in asymptomatic Koreans aged 40-49 years undergoing screening colonoscopy.

    abstract:BACKGROUND AND AIM:Colorectal cancer screening is recommended for average-risk persons beginning at age 50. However, information about the incidence and risk factors of precursor adenoma in preceding decades is limited. The aim of this study was to determine the prevalence and risk factors of colorectal adenoma in pers...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chung SJ,Kim YS,Yang SY,Song JH,Park MJ,Kim JS,Jung HC,Song IS

    更新日期:2010-03-01 00:00:00

  • Absolute lymphocyte count recovery at 1 month after transplantation predicts favorable outcomes of patients with hepatocellular carcinoma.

    abstract:BACKGROUND AND AIMS:Absolute lymphocyte count (ALC) and the recovery of ALC after treatment have been identified as a prognostic biomarker for several malignancies. In this study, we aimed to investigate the prognostic role of peritransplant ALC and ALC recovery after liver transplantation (LT) in hepatocellular carcin...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Zheng Z,Lin B,Zhang J,Yang Z,Xie H,Zhou L,Zhang M,Zheng S

    更新日期:2015-04-01 00:00:00

  • The ion exchange properties of human post-mortem caecal and colonic mucus: the effect of sodium butyrate.

    abstract::This study examined Na+/H+ ion exchange of caecal and colonic mucus. Two distinct Na+/H+ ion exchange populations of caecal mucus were identified, one group being a cation exchanger and the other an anion exchanger, suggesting that caecal mucus has ampholyte properties responsive to changing physical and chemical prop...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Duncan CE,Tasman-Jones C

    更新日期:1992-01-01 00:00:00

  • Crosstalk between intestinal epithelial cell and adaptive immune cell in intestinal mucosal immunity.

    abstract::Constantly challenged by luminal bacteria, intestinal epithelium forms both a physical and biochemical defense against pathogens. Besides, intestinal epithelium senses dynamic and continuous changes in luminal environment and transmits signals to subjacent immune cells accordingly. It has been long accepted that adapt...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Lu JT,Xu AT,Shen J,Ran ZH

    更新日期:2017-05-01 00:00:00

  • The antiangiogenic effect of thalidomide on occult liver metastases: an in vivo study in mice.

    abstract:AIM:To investigate the morphological changes of intratumoral microvessels after administration of thalidomide in occult hepatic metastases. METHODS:Twenty mice with hepatic metastases created by injection of colon-26 tumor cells into the spleen were enrolled. Ten mice were treated with thalidomide (200 mg/kg) by intra...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Liu Y,Li H,Matsui O

    更新日期:2009-06-01 00:00:00

  • Inflammatory pseudotumors of the liver: experience of a specialist surgical unit.

    abstract:BACKGROUND AND AIM:To present the experience in management of inflammatory liver pseudotumors from a specialist surgical unit and to review the medical literature on this rare manifestation. METHODS:Between 1995 and 2008, four patients were identified with this type of tumor from a total of 108 resected benign liver l...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Milias K,Madhavan KK,Bellamy C,Garden OJ,Parks RW

    更新日期:2009-09-01 00:00:00

  • Correlation of transforming growth factor beta-1 gene polymorphisms C-509T and T869C and the risk of gastric cancer in China.

    abstract:BACKGROUND AND AIM:As an important cytokine that modulate the cell cycle, the involvement of transforming growth factor beta-1 (TGF-beta1) in carcinogenesis has been extensively studied for many years. Literatures have demonstrated that TGF-beta1 gene polymorphisms may alter the risk of various cancers, such as lung, p...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Li T,Cao BW,Dai Y,Cui H,Yang HL,Xu CQ

    更新日期:2008-04-01 00:00:00

  • Hepatitis C in childhood.

    abstract::The approach of a pediatric hepatologist in managing children with hepatitis C virus (HCV) differs from adult practice, because the pediatric hepatologist is dealing with the beginning of a chronic illness in which long-term outcomes will not occur for 20 or 40 years, and it is not possible to predict in the early sta...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Hardikar W

    更新日期:2002-04-01 00:00:00

  • Advanced glycation end products augment experimental hepatic fibrosis.

    abstract:BACKGROUND AND AIMS:Advanced glycation end products (AGEs) are nonenzymatic modifications of proteins by reducing sugars. These compounds accumulate in a number of chronic disease states, contributing to tissue injury via several mechanisms, including activation of the receptor for advanced glycation end products (RAGE...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Goodwin M,Herath C,Jia Z,Leung C,Coughlan MT,Forbes J,Angus P

    更新日期:2013-02-01 00:00:00

  • Trans fatty acids in diets act as a precipitating factor for gut inflammation?

    abstract::Fatty acids in our daily diet are broadly classified into cis and trans fatty acids (TFAs). TFAs are formed during the manufacturing process of hydrogenated vegetable oils such as margarine. Modern diets such as deep-fried products, frozen foods, and packaged snacks commonly include large quantities of margarine conta...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Okada Y,Tsuzuki Y,Ueda T,Hozumi H,Sato S,Hokari R,Kurihara C,Watanabe C,Tomita K,Komoto S,Kawaguchi A,Nagao S,Miura S

    更新日期:2013-12-01 00:00:00