Abstract：
:The main goals of chronic hepatitis B treatment should be the long-term suppression of viral replication to minimize disease progression and the risk for the development of hepatocellular carcinoma. Treatment end-points, depending on surrogate markers alone, in particular hepatitis B e-antigen seroconversion, may not be ideal for patients who acquire the disease early in life. Currently-available drugs include interferons and oral nucleoside/nucleotide analogs. Although interferon therapy provides a finite treatment period, a significant proportion of patients may not respond, and long-term outcome is inconclusive. Long-term efficacy has been demonstrated for both lamivudine and adefovir. However, prolonged nucleoside/nucleotide analog therapy is associated with the emergence of drug-resistant mutations. Therefore, nucleoside/nucleotide analogs with a high genetic barrier and potent antiviral activity, such as entecavir, should be used to reduce the chance of developing drug-resistant mutations. Drugs with a low genetic barrier, including lamivudine and telbivudine, should be used in conjunction with early testing for antiviral response. This can predict favorable outcomes in the long term. The early detection of drug-resistant mutations should prompt clinicians to either add or switch to another agent with a different drug-resistance profile. There are currently no treatment models in the use of combination or sequential therapy in treatment-naïve patients. To date, long-term treatment appears to be the most effective option. Despite recent advances made with better understanding on the natural history of chronic hepatitis B infection and with newer antiviral drugs available, challenges remain with respect to treatment criteria, treatment end-points, and duration of treatment.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Fung J,Lai CL,Yuen MFdoi
10.1111/j.1440-1746.2008.05400.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
1182-92issue
8 Pt 1eissn
0815-9319issn
1440-1746pii
JGH5400journal_volume
23pub_type
杂志文章abstract：:The hepatitis C virus was first identified in 1989. It causes chronic hepatitis, cirrhosis and hepatocellular carcinoma. Global anti-HCV prevalence is 1-3%. Contaminated blood product, dirty needles and instruments, and injection drug use are the main parenteral routes of transmission. Cultural practices, such as acup...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1746.17.s1.13.x
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:Data on anorectal physiology in patients with disordered thyroid metabolism are lacking. This prospective study was performed to evaluate anorectal physiology in patients with either hyperthyroidism and diarrhoea, or hypothyroidism and constipation in order to assess slow transit in hypothyroid patients. ME...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.1999.01865.x
更新日期：1999-04-01 00:00:00
abstract：:Prostaglandin E1 (PGE1) has been reported to have, experimentally and clinically, a protective effect against liver damage. This effect may result from the relaxation of hepatic stellate cells, whose contraction induces vasoconstriction of hepatic sinusoids. However, prostaglandins are unstable and a new drug delivery...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：
更新日期：1998-09-01 00:00:00
abstract：BACKGROUND AND AIM:Hepatic fibrosis is a worldwide healthy burden associated with significant morbidity and mortality. It is caused by a variety of chronic liver injuries. There is currently no effective treatment for liver fibrosis. In this report, we tested an imidazolium salt, 1,3-diisopropylimidazolium tetrafluorob...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2012.07265.x
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND AND AIMS:The CLOtest and other rapid urease detection kits are widely used in the endoscopic diagnosis of Helicobacter pylori. A new formulation CLOtest has been developed with the goal of obtaining a positive result more rapidly. The aims of this study were to validate the sensitivity and specificity of the...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1046/j.1440-1746.2002.02563.x
更新日期：2002-02-01 00:00:00
abstract：:Bioactive food chemicals are substances present in food that are capable of interacting with living cells causing changes in physiological functions. Salicylic acid (SA), a plant hormone involved in plant immune response, is one such bioactive food chemical. Aspirin, a commercially available SA, might play beneficial ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/jgh.13702
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND AND AIM:Endoscopic resection is highly effective treatment option for rectal neuroendocrine tumors (NETs) as they usually present as small localized tumors. However, there are no well-established surveillance strategies following endoscopic resection. We established our own protocol for the surveillance of r...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.15231
更新日期：2020-08-31 00:00:00
abstract：:At Royal Perth Hospital, Western Australia in April 1982, spiral bacteria were first cultured from a gastric biopsy specimen. Several important taxonomic features were identified which indicated that these bacteria represented a new genus. In October 1989 the new genus name Helicobacter was published. Helicobacter pyl...
journal_title：Journal of gastroenterology and hepatology
pub_type： 历史文章,杂志文章
doi：10.1111/j.1440-1746.1994.tb01292.x
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Probucol is a lipid-lowering agent with anti-oxidant effects. Oxidative stress and inflammation are important in the pathophysiology of insulin resistance. We aimed to evaluate the effects of probucol on liver histological changes, serum and hepatic levels of adipokines in rats with high fat-induced...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2008.05719.x
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND AND AIM:Sniff test is a common method before unsedated transnasal esophago-gastro-duodenoscopy (UT-EGD) to select a nostril insertion site. Yet there is no objective method to select a more specific meatus insertion tract for anesthesia and insertion. We devised an endoscopic meatus scoring scale by anterior...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/jgh.13810
更新日期：2017-12-01 00:00:00
abstract：:Endoscopic variceal ligation (EVL) related complication is rarely reported. A case is presented of a 74 year old man with oesophageal variceal bleeding who developed oesophageal perforation following EVL and balloon tamponade. An oesophageal wall defect was induced by EVL and tissue repair was hindered by decompensate...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1994.tb01582.x
更新日期：1994-11-01 00:00:00
abstract：BACKGROUND AND AIM:The rate of fibrosis progression per year can predict the time for the development of cirrhosis in chronic hepatitis C (CHC). We assessed the rate of fibrosis progression and the predictors of disease severity in Indian CHC patients. METHODS:Of the 355 treatment-naïve, histologically-proven CHC pati...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2008.05649.x
更新日期：2009-04-01 00:00:00
abstract：BACKGROUND AND AIM:It has recently been reported that Toll-like receptor 4 (TLR4) is involved in cellular responses to lipopolysaccharides (LPS) and early liver injury induced by LPS. The aim of the present study was to investigate the alterations of TLR4 gene expression in liver tissues and Kupffer cells during the co...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2007.04896.x
更新日期：2007-06-01 00:00:00
abstract：:Changes in serum hyaluronic acid (HA) in 35 patients treated with interferon (IFN) were studied and the histological change in fibrosis was analysed. Serum HA levels and hepatitis C virus (HCV) RNA were followed from the start of therapy to 12 months after completion of treatment. Histological changes in pre- and post...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1996.tb00308.x
更新日期：1996-07-01 00:00:00
abstract：:Complete duplication of the entire large bowel with partial ileal involvement is very rare and diagnosis can often be difficult as illustrated by this case report. We also review the other clinical associations of this rare condition and briefly discuss the embryology of duplications of the gastrointestinal tract. ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.1999.01951.x
更新日期：1999-09-01 00:00:00
abstract：:The low Fermentable Oligosaccharides, Disaccharides, and Monosaccharides And Polyols (FODMAP) diet has been described, evaluated, and found efficacious for the treatment of patients with irritable bowel syndrome primarily in Western countries. The aim of this review was to address the applicability of this diet to Sou...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/jgh.13885
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 are diagnostic of Wegener's granulomatosis, but ANCA occur also in patients with other inflammatory disorders, such as ulcerative colitis, primary sclerosing cholangitis (PSC) and autoimmune hepatitis. As their predictive value for autoimmune...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2000.02078.x
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Microbial agents are a possible cause of ulcerative colitis. We have previously reported evidence of bacteria invading the colonic mucosa of patients with ulcerative colitis. We have isolated bacteria from inflamed colonic mucosa, examined the localization of the species in the mucosa, and assayed for serum ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2002.02834.x
更新日期：2002-08-01 00:00:00
abstract：:Wilson's disease is an autosomal recessive, inborn error of copper metabolism. The basic defect is unknown but decreased biliary excretion of copper is associated with copper accumulation and damage to the liver, brain and other organs with variable clinical expression. The gene for the disease has been mapped to band...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.1990.tb01427.x
更新日期：1990-07-01 00:00:00
abstract：:Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. This case of a 65-year-old Korean man with HCC and metastatic frontal bone mass that regressed after radiotherapy for frontal bone mass without any other therapeutic modalities is described. The clinical diagnosis of HCC was made because of...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2005.03243.x
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND AND AIM:Ecabet sodium is reported to have a bactericidal effect on Helicobacter pylori and inhibit urease activity in vitro. METHODS:Seven male volunteers (mean age, 51.3 years; range, 45-55 years) with H. pylori infection were medicated with 1 g ecabet sodium t.i.d. for 4 weeks. The urea breath test (UBT) ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2012.07080.x
更新日期：2012-04-01 00:00:00
abstract：:To ascertain whether acid inhibition or Helicobacter pylori (HP) colonization is the decisive factor in the healing of duodenal ulcer, we treated 54 patients with famotidine and carried out long-term follow-up. Helicobacter pylori colonization was found in 70.4% of patients before treatment. There were no differences ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1991.tb01454.x
更新日期：1991-03-01 00:00:00
abstract：:In 18 patients with cancers of the gastrointestinal tract, lymphokine-activated killer (LAK) cell activity was studied and compared with that of healthy subjects. After cultivation with 10(3) iu/mL of recombinant interleukin-2, the cytotoxicity of patients' lymphoid cells was increased from 13.6 +/- 6.8% to 76.2 +/- 1...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1990.tb01813.x
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND AND AIM:Approximately 42-95% of working channels have been reported to show the presence of residual fluid despite endoscope reprocessing. The aim of this study was to design two novel protocols for cleaning residual simethicone and demonstrate its efficiency by evaluating the residual fluid and cleanliness ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.15365
更新日期：2020-12-03 00:00:00
abstract：BACKGROUND AND AIM:Tumor thrombi in the bile duct caused by hepatocellular carcinoma (HCC), and cholangiocarcinoma show polypoid lesions on cholangiographic findings. This study prospectively compared the images of intraductal ultrasonography between HCC and polypoid cholangiocarcinoma. METHODS:In five patients with t...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2001.02527.x
更新日期：2001-07-01 00:00:00
abstract：:Following partial hepatectomy (PH), there is a rapid and highly orchestrated series of biochemical events which occur prior to cellular proliferation. Some of these events are presumably intimately linked with the eventual regeneration of the liver, whereas others are likely to be stress related or required for the co...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:To study the replicative efficiency and pathogenicity of hepatitis B virus precore variant (A1896), anti-hepatitis B virus e antigen (HBe) titre was studied in naturally occurring wild-type virus infection, A1896 variant infection and dual infection. Higher titre of anti-HBe was found in patients with no virus replica...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1998.tb01898.x
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND AND AIM:It has been reported that immunological factors, such as the T-helper cell (Th)1/Th2 ratio, play a part in the mechanisms for the antihepatitis C virus (HCV) effect of the interferon (IFN) alpha-2b plus ribavirin combination therapy. By using flow cytometry, we examined this ratio during a 24-week co...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2008.05320.x
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND AND AIM:Hepatocellular carcinoma (HCC) is characteristically a hypervascular tumor and its progression is known to be closely related to angiogenesis. In this study, we investigated angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF) levels in the hepatic vein draining from HCC, as well as i...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2007.05175.x
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:Clinical trials of probiotic treatment for Crohn's disease (CD) have yielded conflicting results. This study assessed the clinical usefulness of combined probiotic and prebiotic therapy in the treatment of active CD. METHOD:Ten active CD outpatients without history of operation for CD were enrolled. Their m...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1440-1746.2006.04535.x
更新日期：2007-08-01 00:00:00
