Changes in the Th1/Th2 ratio during a 24-week course of an interferon alpha-2b plus ribavirin combination therapy for patients with chronic hepatitis C.

abstract：:Wilson's disease is an autosomal recessive, inborn error of copper metabolism. The basic defect is unknown but decreased biliary excretion of copper is associated with copper accumulation and damage to the liver, brain and other organs with variable clinical expression. The gene for the disease has been mapped to band...

journal_title：Journal of gastroenterology and hepatology

authors： Frydman M

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:The parasympathetic nervous system (PNS), via neurotransmitter acetylcholine (ACh), modulates fibrogenesis in animal models. However, the role of ACh in human hepatic fibrogenesis is unclear. AIMS:We aimed to determine the fibrogenic responses of human hepatic stellate cells (hHSC) to ACh and the relevance ...

journal_title：Journal of gastroenterology and hepatology

authors： Morgan ML,Sigala B,Soeda J,Cordero P,Nguyen V,McKee C,Mouraliderane A,Vinciguerra M,Oben JA

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Data on risk of hepatocellular carcinoma (HCC) in patients with Wilson disease are scarce. We determine HCC risk in a well-defined cohort of Wilson patients. METHODS:All patients with a confirmed diagnosis of Wilson disease (Leipzig score ≥ 4) in three Dutch university referral hospitals were inclu...

journal_title：Journal of gastroenterology and hepatology

authors： van Meer S,de Man RA,van den Berg AP,Houwen RH,Linn FH,van Oijen MG,Siersema PD,van Erpecum KJ

更新日期：2015-03-01 00:00:00

abstract：:The immunogenicity and adverse reaction of an inactivated hepatitis A (HA) vaccine were investigated. Sixty healthy adult volunteers who lacked antibody to HA virus (anti-HAV) received three doses of vaccine containing 720 enzyme-linked immunosorbent assay (ELISA) units (EL.U) according to a 0, 1 and 6 month schedule....

journal_title：Journal of gastroenterology and hepatology

authors： Horng YC,Chang MH,Lee CY,Safary A,Andre FE,Chen DS

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND AND AIM:At present, there is no recognized diagnostic criteria for gastric low-grade intraepithelial neoplasia (LGIN). The purpose of this study was to determine whether an "endoscopic acanthosis nigricans appearance (EANA)" could be a useful endoscopic marker for distinguishing LGIN lesions from peripheral ...

journal_title：Journal of gastroenterology and hepatology

authors： Cheng J,Xu X,Zhuang Q,Luo S,Gong X,Wu X,Wan X,Zhou H

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:The epidemiology of lower gastrointestinal bleeding (LGIB) in Western populations has been reported; however, there are scant Asian reports. The aim of the present study was to determine the etiology of LGIB in a Chinese population by reporting a retrospective case series and a systematic analysis of Chinese...

journal_title：Journal of gastroenterology and hepatology

authors： Bai Y,Peng J,Gao J,Zou DW,Li ZS

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate the influence of a younger age at the time of ileal pouch-anal anastomosis (IPAA) on functional outcome and quality of life in patients with familial adenomatous polyposis (FAP). METHOD:A total of 105 patients with FAP who had undergone IPAA were retrieved from a...

journal_title：Journal of gastroenterology and hepatology

authors： Erkek AB,Church JM,Remzi FH

更新日期：2007-05-01 00:00:00

abstract：:Extracorporeal liver assist devices have been used for more than five decades to support patients with liver failure. Numerous modifications have been made to both biological as well as mechanical liver assist devices. Possibly, an ideal liver assist device would be one that would perform optimal detoxification and sy...

journal_title：Journal of gastroenterology and hepatology

authors： Kapoor D

更新日期：2002-12-01 00:00:00

abstract：:Constantly challenged by luminal bacteria, intestinal epithelium forms both a physical and biochemical defense against pathogens. Besides, intestinal epithelium senses dynamic and continuous changes in luminal environment and transmits signals to subjacent immune cells accordingly. It has been long accepted that adapt...

journal_title：Journal of gastroenterology and hepatology

authors： Lu JT,Xu AT,Shen J,Ran ZH

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND AND AIMS:The clinical significance and prognosis of mixed adenocarcinoma in early gastric cancer (EGC) are incompletely understood. The aim of this study was to evaluate the clinicopathological characteristics and long-term outcomes of mixed adenocarcinoma diagnosed as EGC after endoscopic submucosal dissect...

journal_title：Journal of gastroenterology and hepatology

authors： Han JP,Hong SJ,Kim HK

更新日期：2015-02-01 00:00:00

abstract：:Maintaining high levels of intracellular cyclic AMP (cAMP) is known to inhibit the growth of various proliferating cells including hepatocytes. We show here that transient (30 min) elevations of cAMP induced by addition of 8-bromo-cAMP (1 mmol/L) to rat hepatocytes in primary culture at three time points (12 h, 16 h a...

journal_title：Journal of gastroenterology and hepatology

authors： Kikukawa M,Okamoto Y,Nakano H

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND AND AIM:The fibrosis stage of non-alcoholic fatty liver disease (NAFLD) is closely associated with long-term prognosis, including liver-related mortality. However, it is not yet clear whether noninvasive fibrosis markers can predict the incidence of non-liver-related complications in Japanese NAFLD. In this ...

journal_title：Journal of gastroenterology and hepatology

authors： Ito T,Ishigami M,Ishizu Y,Kuzuya T,Honda T,Hayashi K,Nishimura D,Toyoda H,Kumada T,Goto H,Hirooka Y

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIM:As bacterial resistance to clarithromycin limits the efficacy of clarithromycin-based regimens for Helicobacter pylori infection, attention has turned to quinolone-based rescue therapies. Resistance of H. pylori to both clarithromycin and quinolone can be predicted by genetic testing. Here, we used t...

journal_title：Journal of gastroenterology and hepatology

authors： Yamade M,Sugimoto M,Uotani T,Nishino M,Kodaira C,Furuta T

更新日期：2011-09-01 00:00:00

abstract：:Differentiation between gastric adenomas and type IIa early gastric cancer by macroscopic and histologic examinations is often difficult. This study has shown that there are differences in the distribution of S-phase cells in these two types of tumour, and these differences can be exploited to differentiate between th...

journal_title：Journal of gastroenterology and hepatology

authors： Miwa H,Wada R,Abe H,Ohkura R,Yang SW,Watanabe H,Ogihara T,Hamada T,Sato N

更新日期：1993-03-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) and chronic liver disease worldwide. Recent developments and advances in HCV replication systems in vitro and in vivo, transgenic animal models, and gene expression profiling approaches have provided novel insights into the mechanisms...

journal_title：Journal of gastroenterology and hepatology

authors： Yamashita T,Honda M,Kaneko S

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:To elucidate the cause of possible occurrence of reflux esophagitis after Helicobacter pylori eradication, gastric and esophageal function among H. pylori infected Japanese patients were evaluated both before and after eradication therapy. METHODS:Nine H. pylori-positive patients were studied before and 6 m...

journal_title：Journal of gastroenterology and hepatology

authors： Tanaka I,Tatsumi Y,Kodama T,Kato K,Fujita S,Mitsufuji S,Kashima K

更新日期：2004-03-01 00:00:00

abstract：:A randomized controlled trial was designed to investigate whether a high dose of terlipressin could control acute variceal haemorrhage more effectively than a low dose of terlipressin. Forty cirrhotic patients with bleeding oesophageal varices were included, with low-dose terlipressin in 21 patients and high-dose terl...

journal_title：Journal of gastroenterology and hepatology

authors： Chang TT,Lee FY,Tsai YT,Lai KH,Chao Y,Hsia HC,Lin HC,Wang SS,Lee SD,Lo KJ

更新日期：1991-09-01 00:00:00

abstract：:Worldwide the need for effective therapy for chronic hepatitis B is similar to that for chronic hepatitis C. Current licensed treatment for chronic hepatitis B (interferon (IFN)-alpha, lamivudine) does not significantly alter the natural history of the disease because the frequency of sustained response is too low; ho...

journal_title：Journal of gastroenterology and hepatology

authors： Schalm SW,De Man RA,Janssen HL

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatitis C virus (HCV)-infected patients who responded to interferon (IFN) treatment with clearance of serum HCV RNA may rarely develop hepatocellular carcinoma (HCC). The aim of the present study was to elucidate the risk factors for liver carcinogenesis among such patients. METHODS:In total, 126 ...

journal_title：Journal of gastroenterology and hepatology

authors： Tokita H,Fukui H,Tanaka A,Kamitsukasa H,Yagura M,Harada H,Okamoto H

更新日期：2005-05-01 00:00:00

abstract：:Cell proliferation in the gastroduodenal mucosa of patients with duodenal ulcers was evaluated using flow cytometry. Forty patients with duodenal ulcers and 12 normal subjects were investigated. Biopsy samples were obtained during endoscopic examination and subjected to DNA analysis by flow cytometry. Thirty patients ...

journal_title：Journal of gastroenterology and hepatology

authors： Kobayashi I,Kawano S,Tsuji S,Nakama A,Sawaoka H,Masuda E,Nagano K,Fusamoto H,Kamada T

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND AND AIM:Exportin 4 (XPO4) is a recently-discovered candidate tumor-suppressor gene identified in a liver cancer mouse model. To investigate the role of XPO4 in hepatocellular carcinoma (HCC) pathogenesis, we determined XPO4 expression and its correlation to prognosis in human primary HCC. METHODS:The XPO4 m...

journal_title：Journal of gastroenterology and hepatology

authors： Liang XT,Pan K,Chen MS,Li JJ,Wang H,Zhao JJ,Sun JC,Chen YB,Ma HQ,Wang QJ,Xia JC

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND AIM:Nonalcoholic fatty liver disease (NAFLD) is becoming an increasingly important health issue. However, there are no data on the change in prevalence of NAFLD within a population over time, especially in the mainland of China. The goal of this study was to estimate the pooled prevalence of NAFLD in the...

journal_title：Journal of gastroenterology and hepatology

authors： Li Z,Xue J,Chen P,Chen L,Yan S,Liu L

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:Physicians use different scales and questionnaires to assess the severity of clinical symptoms in patients with functional gastrointestinal disorders. The current study aimed to validate the "7 × 7" questionnaire for assessment of severity of the symptoms as a tool for the efficacy of treatment of fu...

journal_title：Journal of gastroenterology and hepatology

authors： Ivashkin V,Sheptulin A,Shifrin O,Poluektova E,Pavlov C,Ivashkin K,Drozdova A,Lyashenko O,Korolev A

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND AND AIM:T-cell activation, mediated by the interaction with major histocompatibility complex (MHC)-peptide complexes and B7 costimulatory molecules on antigen-presenting cells, is an essential event in the pathogenesis of inflammatory bowel disease (IBD). We investigated the expression of B7 costimulatory mo...

journal_title：Journal of gastroenterology and hepatology

authors： Grose RH,Howarth GS,Xian CJ,Hohmann AW

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND AND AIM:The stool antigen test, the HpSA test, has been validated mainly in Western countries, but not properly in the Chinese population. Recently, another stool antigen test, the Apollo test, was developed, but its accuracy has rarely been validated. The aim of this study is to compare the accuracy of thes...

journal_title：Journal of gastroenterology and hepatology

authors： Wong BC,Xia HH,Cheung HK,Ng FH,Wong SY,Chow KC,Lin SK,Yin Y,Wong WM,Yuen MF,Lam SK

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND AND AIM:We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). METHODS:Twenty-seven NERD patients who had experienced heartburn more than once a week within the previous month were enrolled. Intraeso...

journal_title：Journal of gastroenterology and hepatology

authors： Shimatani T,Sugimoto M,Nishino M,Adachi K,Furuta K,Ito M,Kurosawa S,Manabe N,Mannen K,Hongo M,Chiba T,Kinoshita Y,Acid-Related Symptom Research (ARS) Group.

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND AND AIM:There are few studies investigating the treatment of hepatitis C virus (HCV) infection in current and former drug users. With this in mind, we sought to evaluate the antiviral efficacy of interferon alpha-2b (IFN alpha-2b) or pegylated-interferon alpha-2b (PEG-IFN alpha-2b) and ribavirin (RBV) in inj...

journal_title：Journal of gastroenterology and hepatology

authors： Grebely J,Raffa JD,Meagher C,Duncan F,Genoway KA,Khara M,McLean M,Mead A,Viljoen M,DeVlaming S,Fraser C,Conway B

更新日期：2007-09-01 00:00:00

abstract：:The preferred treatment for patients with chronic hepatitis C, either treatment-naive, relapsers or nonresponders to IFN monotherapy, is now IFN-ribavirin combination treatment. The adverse effects of IFN are well established and familiar to hepatologists all over the world. More than 25,000 patients worldwide have be...

journal_title：Journal of gastroenterology and hepatology

authors： Chutaputti A

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND AND AIM:There is scanty data on the occurrence of celiac disease in patients with type 1 diabetes mellitus in South Asia. Our aim was to study the prevalence and clinical profile of celiac disease in patients with type 1 diabetes mellitus in a tertiary care referral centre in north India. METHODS:Consecutiv...

journal_title：Journal of gastroenterology and hepatology

authors： Bhadada SK,Kochhar R,Bhansali A,Dutta U,Kumar PR,Poornachandra KS,Vaiphei K,Nain CK,Singh K

更新日期：2011-02-01 00:00:00

abstract：:The prevalence and potential value of the detection of signs of portal hypertension by duplex Doppler ultrasound (DDU) of the ligamentum teres and portal vein in patients with known or suspected chronic liver disease and/or portal hypertension was studied in 136 consecutive patients undergoing clinical assessment incl...

journal_title：Journal of gastroenterology and hepatology

authors： Gibson PR,Gibson RN,Donlan JD,Ditchfield MR,Bhathal PS

更新日期：1991-01-01 00:00:00