Flow cytometric analysis of cell proliferation kinetics during duodenal ulcer healing.


:Cell proliferation in the gastroduodenal mucosa of patients with duodenal ulcers was evaluated using flow cytometry. Forty patients with duodenal ulcers and 12 normal subjects were investigated. Biopsy samples were obtained during endoscopic examination and subjected to DNA analysis by flow cytometry. Thirty patients with duodenal ulcers were healed within 3 months with H2 blockers (tractable or responsive ulcers), whereas 10 patients did not respond to treatment (intractable ulcers). The percentage of cells at the DNA-synthetic phase, an index of cell proliferation, was constant in the adjacent duodenal mucosa 2 cm from ulcer margin and antral mucosa during duodenal ulcer healing. The index at the margin of tractable ulcers was elevated during the active stage (12.9 +/- 1.3), peaked during the healing stage (15.4 +/- 2.8) and returned to the same level at the scarring stage (10.9 +/- 2.0) as normal controls (10.3 +/- 1.7). However, the index was not elevated in intractable ulcers (10.3 +/- 1.7 in the healing stage) and was smaller than in tractable ulcers. These data indicate that augmented mucosal cell proliferation at the ulcer margin plays an important role in duodenal ulcer healing and intractable ulcers are characterized by an abnormal failure to accelerate DNA synthesis to achieve ulcer repair.


Kobayashi I,Kawano S,Tsuji S,Nakama A,Sawaoka H,Masuda E,Nagano K,Fusamoto H,Kamada T




Has Abstract


1998-04-01 00:00:00












  • Expression and immunogenicity of NY-ESO-1 in hepatocellular carcinoma.

    abstract:BACKGROUND AND AIM:The present study was designed to investigate the expression of and humoral response against NY-ESO-1 in patients with hepatocellular carcinoma and to analyze the relationship between expression of NY-ESO-1 mRNA and clinicopathological features. METHODS:NY-ESO-1 mRNA and protein expression in surgic...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Nakamura S,Nouso K,Noguchi Y,Higashi T,Ono T,Jungbluth A,Chen YT,Old LJ,Nakayama E,Shiratori Y

    更新日期:2006-08-01 00:00:00

  • Brachyspira aalborgi infection in four Australian children.

    abstract:AIM:The clinical presentation of four children and adolescents (two males and two females with a mean age of 12.4 years; range 9-16 years) with colorectal spirochetosis is discussed. RESULTS:Symptoms included persistent diarrhea (n = 2), rectal bleeding (n = 1) and abdominal pain (n = 2). In all patients, colorectal s...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Heine RG,Ward PB,Mikosza AS,Bennett-Wood V,Robins-Browne RM,Hampson DJ

    更新日期:2001-08-01 00:00:00

  • Radiology of pancreatic adenocarcinoma: current status of imaging.

    abstract::Pancreatic adenocarcinoma is one of the leading causes of cancer death in the West, with a poor overall 5-year survival rate of only 4%. Late clinical presentation with an advanced disease results in a low rate of surgical intervention. Tumor serum marker CA 19-9 is sensitive, although not specific for the diagnosis o...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Sahani DV,Shah ZK,Catalano OA,Boland GW,Brugge WR

    更新日期:2008-01-01 00:00:00

  • Profile of hepatocellular carcinoma in India: an insight into the possible etiologic associations.

    abstract:BACKGROUND:Several etiologic factors including hepatitis viruses, alcohol and aflatoxin have been implicated in the pathogenesis of hepatocellular carcinoma (HCC). There is, however, limited information from the Indian subcontinent. METHODS:Seventy-four consecutive cases of HCC were studied. A detailed history, tests ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Sarin SK,Thakur V,Guptan RC,Saigal S,Malhotra V,Thyagarajan SP,Das BC

    更新日期:2001-06-01 00:00:00

  • Hepatocellular carcinoma in the Asia pacific region.

    abstract::Primary liver cancer, particularly hepatocellular carcinoma (HCC) remains a significant disease worldwide. It is among the top three causes of cancer death in the Asia Pacific region because of the high prevalence of its main etiological agents, chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. I...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Yuen MF,Hou JL,Chutaputti A,Asia Pacific Working Party on Prevention of Hepatocellular Carcinoma.

    更新日期:2009-03-01 00:00:00

  • Pharyngeal observation via transoral endoscopy using a lip cover-type mouthpiece.

    abstract:BACKGROUND AND AIM:Simultaneous and metachronous head and neck cancers are likely to develop in patients with current or previous esophageal cancer. The Valsalva maneuver facilitates the visualization of the hypopharyngeal area during endoscopic observation, but it requires transnasal endoscopy. We developed a novel Va...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Iwatsubo T,Ishihara R,Nakagawa K,Ohmori M,Iwagami H,Matsuno K,Inoue S,Nakahira H,Matsuura N,Shichijo S,Maekawa A,Kanesaka T,Yamamoto S,Takeuchi Y,Higashino K,Uedo N,Higuchi K

    更新日期:2019-08-01 00:00:00

  • Endoscopic diagnosis of early squamous neoplasia of the esophagus with iodine staining: high-grade intra-epithelial neoplasia turns pink within a few minutes.

    abstract:BACKGROUND AND AIM:The ability to detect early squamous neoplasia of the esophagus can be enhanced considerably by iodine staining during endoscopic examination; however, there has been no study on distinguishing high-grade intra-epithelial squamous neoplasia from low-grade dysplasia by endoscopic examination. We assum...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Shimizu Y,Omori T,Yokoyama A,Yoshida T,Hirota J,Ono Y,Yamamoto J,Kato M,Asaka M

    更新日期:2008-04-01 00:00:00

  • Non-steroid anti-inflammatory drug associated ulcer: epidemiology, causation and treatment.

    abstract::Epidemiological evidence consistently indicates that aspirin or non-aspirin non-steroidal anti-inflammatory drug use is associated with the occurrence of gastric ulceration, gastric and ulcer bleeding, and ulcer death. Evidence on duodenal ulcer occurrence conflicts, possibly because of differences in study population...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,随机对照试验,评审


    authors: Langman MJ,Brooks P,Hawkey CJ,Silverstein F,Yeomans N

    更新日期:1991-09-01 00:00:00

  • Inflammatory pseudotumors of the liver: experience of a specialist surgical unit.

    abstract:BACKGROUND AND AIM:To present the experience in management of inflammatory liver pseudotumors from a specialist surgical unit and to review the medical literature on this rare manifestation. METHODS:Between 1995 and 2008, four patients were identified with this type of tumor from a total of 108 resected benign liver l...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Milias K,Madhavan KK,Bellamy C,Garden OJ,Parks RW

    更新日期:2009-09-01 00:00:00

  • Analysis of tolvaptan non-responders and outcomes of tolvaptan treatment of ascites.

    abstract:BACKGROUND AND AIM:The goals of the study were to identify an effective treatment for ascites and to examine the influence of tolvaptan on outcomes by investigating non-responders to tolvaptan and comparing outcomes of hepatic cirrhosis in patients treated with and without tolvaptan. METHODS:In Study 1, of 145 patient...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Iwamoto T,Maeda M,Saeki I,Hidaka I,Tajima K,Ishikawa T,Takami T,Sakaida I

    更新日期:2019-07-01 00:00:00

  • Gilbert's syndrome and the risk of death: a population-based cohort study.

    abstract:BACKGROUND AND AIMS:Gilbert's syndrome is a common familial hyperbilirubinemia that may reduce the risk of various age-related diseases because of the antioxidant properties of bilirubin. We conducted a large cohort study using The Health Improvement Network primary care database and compared all-cause mortality rates ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Horsfall LJ,Nazareth I,Pereira SP,Petersen I

    更新日期:2013-10-01 00:00:00

  • Precore stop codon mutation of hepatitis B virus is associated with low breakthrough rate following long-term lamivudine therapy.

    abstract:BACKGROUND:Frequent viral breakthroughs limit the usefulness of lamivudine in the treatment of chronic hepatitis B (CHB). The purpose of the present study was to evaluate the effects of precore stop codon mutation (G to A mutation at nucleotide 1896; A(1896)) of hepatitis B virus (HBV) on the occurrence of viral breakt...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Shin JW,Chung YH,Choi MH,Kim JA,Ryu SH,Jang MK,Kim IS,Park NH,Lee HC,Lee YS,Suh DJ

    更新日期:2005-06-01 00:00:00

  • Hepatitis C in childhood.

    abstract::The approach of a pediatric hepatologist in managing children with hepatitis C virus (HCV) differs from adult practice, because the pediatric hepatologist is dealing with the beginning of a chronic illness in which long-term outcomes will not occur for 20 or 40 years, and it is not possible to predict in the early sta...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Hardikar W

    更新日期:2002-04-01 00:00:00

  • Antiviral therapy in advanced chronic liver disease due to hepatitis C virus infection: pilot study.

    abstract:BACKGROUND:Antiviral therapy has not been adequately evaluated in patients with hepatitis C virus (HCV)-related advanced liver disease due to apprehensions of adverse events and intolerance. The titrable dose of interferon (IFN)-alpha and ribavirin was evaluated in a flexible regimen in a pilot study. METHODS:Twenty-f...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kumar R,Kumar S,Sharma BC,Singh J,Sarin SK

    更新日期:2005-04-01 00:00:00

  • Case report: hepatic adenoma with bone marrow metaplasia in a patient with glycogen storage disease type 1a.

    abstract::A 34 year old man with glycogen storage disease type 1a had two hepatic tumours since 18 years of age. They had continued to grow until he was 24 years old, but showed no further growth since then. He underwent a right hepatic trisegmentectomy with caudate lobectomy under veno-venous bypass. The tumour in the posterio...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Moriura S,Kuroda M,Kimura A,Iwatsuka Y,Ikeda S,Sakai T,Usui A

    更新日期:1996-06-01 00:00:00

  • Elevation of serum aminotransferase activity increases risk of carotid atherosclerosis in patients with non-alcoholic fatty liver disease.

    abstract:BACKGROUND AND AIM:Patients with non-alcoholic fatty liver disease (NAFLD) have an increased risk of atherosclerosis and alanine aminotransferase (ALT) is associated with insulin resistance independently of metabolic factors. The aim of the present study was to investigate whether NAFLD patients with ALT elevation had ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Wang CC,Lin SK,Tseng YF,Hsu CS,Tseng TC,Lin HH,Wang LY,Kao JH

    更新日期:2009-08-01 00:00:00

  • Hepatitis C virus infection facilitates gallstone formation.

    abstract:BACKGROUND:Bile duct damage and hepatic steatosis are two characteristic histological findings in hepatitis C virus infection; and high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma. The purpose of the present study was to examine the relationship between biliary diseases and hepatitis...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chang TS,Lo SK,Shyr HY,Fang JT,Lee WC,Tai DI,Sheen IS,Lin DY,Chu CM,Liaw YF

    更新日期:2005-09-01 00:00:00

  • Clinical characterization and mutation spectrum in patients with familial adenomatous polyposis in China.

    abstract:BACKGROUND AND AIM:Familial adenomatous polyposis (FAP) is the most common adenomatous polyposis syndrome. Patients with FAP are screened for germline mutations of two genes, APC and MUTYH. However, limited data exist on the clinical characterization and genotypic spectrum of FAP in China. This study was aimed to deter...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Li N,Kang Q,Yang L,Zhao XJ,Xue LJ,Wang X,Li AQ,Li CG,Sheng JQ

    更新日期:2019-09-01 00:00:00

  • Risk of alanine aminotransferase flare-up among asymptomatic hepatitis C virus RNA carriers: a 10-year follow-up study.

    abstract:AIMS:The aim of this study was to determine the cumulative rate of flare-up of serum alanine aminotransferase (ALT) level during a 10-year follow-up period, and characterize the clinical, virologic features in 120 hepatitis C virus (HCV) RNA-positive asymptomatic carriers with persistently normal ALT levels for 6 month...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Tsuji K,Yamasaki K,Yamanishi M,Kawakami M,Shirahama S

    更新日期:2001-05-01 00:00:00

  • Inhibition of TXA synthesis with OKY-046 improves liver preservation by prolonged hypothermic machine perfusion in rats.

    abstract:BACKGROUND AND AIM:We previously reported that hypothermic machine perfusion (HMP) for liver preservation is feasible, but hepatic microcirculatory dysfunction and significant liver damage remain major obstacles in its application when the preservation is extended to 24 h. The underlying injury mechanism is not well un...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Xu H,Lee CY,Clemens MG,Zhang JX

    更新日期:2008-07-01 00:00:00

  • Assessment of cytology and mucin 2 in colorectal mucus collected from patients with inflammatory bowel disease: Results of a pilot trial.

    abstract:BACKGROUND AND AIM:Non-invasive diagnosis of colorectal disease remains problematic, fecal biomarkers presenting the only current option. Colorectal mucus is the diagnostically informative element of stool samples, but its separation from stool is difficult. We aimed to: (i) test a novel method of non-invasive colorect...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Loktionov A,Chhaya V,Bandaletova T,Poullis A

    更新日期:2016-02-01 00:00:00

  • Hepatitis B vaccine boosters: is there a clinical need in high endemicity populations?

    abstract::The Steering Committee for the Prevention and Control of Infectious Diseases in Asia recently conducted a survey of primary-care physicians in Asia, which revealed that many physicians administer boosters in their clinical practice and that there is considerable variation and uncertainty among physicians regarding thi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: John TJ,Cooksley G,Steering Committee for the Prevention and Control of Infectious Diseases in Asia.

    更新日期:2005-01-01 00:00:00

  • Spectrum of histopathologic findings in patients with achalasia reflects different etiologies.

    abstract:BACKGROUND:The etiology of achalasia is still unknown. The aim of the present study was to elucidate its underlying pathologies and their chronology by investigation of esophageal specimens in patients undergoing surgery (esophageal resection or myotomy) for achalasia. METHODS:In 17 patients with achalasia, histopatho...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Gockel I,Bohl JR,Doostkam S,Eckardt VF,Junginger T

    更新日期:2006-04-01 00:00:00

  • Association between chronic hepatitis B virus infection and interleukin-10, tumor necrosis factor-alpha gene promoter polymorphisms.

    abstract:BACKGROUND:The reasons for the viral persistence of hepatitis B virus infection (HBV) are unknown, but are probably related to host immune factors. Cytokines play a significant role in immune defense. The present study was undertaken to investigate the association between HBV infection and polymorphisms of tumor necros...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Cheong JY,Cho SW,Hwang IL,Yoon SK,Lee JH,Park CS,Lee JE,Hahm KB,Kim JH

    更新日期:2006-07-01 00:00:00

  • Impact of immunomodulator use on treatment persistence in patients with ulcerative colitis: A claims database analysis.

    abstract:BACKGROUND AND AIM:It is unclear how adding an anti-tumor necrosis factor alpha agent to immunomodulator (IM) treatment, as a step-up strategy, affects long-term outcomes in ulcerative colitis. This retrospective study investigated persistence associated with biologic anti-tumor necrosis factor alpha agents combined wi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kobayashi T,Udagawa E,Uda A,Hibi T,Hisamatsu T

    更新日期:2020-02-01 00:00:00

  • Extended indication of endoscopic resection for mucosal early gastric cancer: analysis of a single center experience.

    abstract:BACKGROUND:Endoscopic resection (ER) has become an important therapeutic option for early gastric cancer (EGC). Some investigators have suggested that this indication should be extended. We aimed to compare the extended indication of ER for intramucosal EGC based on data from a large, single-center study. METHODS:We a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chung JW,Jung HY,Choi KD,Song HJ,Lee GH,Jang SJ,Park YS,Yook JH,Oh ST,Kim BS,Kim JH

    更新日期:2011-05-01 00:00:00

  • Reutilization of accessories in gastrointestinal endoscopic practice.

    abstract::The key issues that determine the decision between reusable versus disposable accessories are cost and functionality. In most health-care systems the availability and dissemination of endoscopic services relates directly to the resources (i.e. budget) of that system. Given the limitations of health-care budgets, acces...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Haber G

    更新日期:2000-10-01 00:00:00

  • Role of interleukin-18 in the development of acute pulmonary injury induced by intestinal ischemia/reperfusion and its possible mechanism.

    abstract:BACKGROUND AND AIMS:Lung injury is an important target for the systemic inflammatory response associated with intestinal ischemia/reperfusion (I/R). In the present study, the role of interleukin (IL)-18 in the development of acute pulmonary injury induced by intestinal I/R and its possible mechanism in relation to the ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Yang YJ,Chen SH,Ge XR

    更新日期:2007-02-01 00:00:00

  • Structural and functional analysis of full-length hepatitis B virus genomes in patients: implications in pathogenesis.

    abstract::The structural analysis, replicative efficiency and immunogenicity of hepatitis B virus (HBV) full-length genomes isolated from different patients or asymptomatic carriers are presented in the present review. Data indicate the importance of viral genome-based studies in elucidating the pathogenesis of HBV infections. ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Wen YM

    更新日期:2004-05-01 00:00:00

  • Which should go first during same-day bidirectional endosocopy with propofol sedation?

    abstract:BACKGROUND AND AIM:Same-day bidirectional endoscopy, including esophagogastroduodenoscopy (EGD) and colonoscopy, is frequently performed to screen for cancer and gastrointestinal bleeding. However, the optimal sequence for the procedures is unclear thus far. The aim of this study was to evaluate the optimal sequence fo...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,随机对照试验


    authors: Hsieh YH,Lin HJ,Tseng KC

    更新日期:2011-10-01 00:00:00