Flow cytometric analysis of cell proliferation kinetics during duodenal ulcer healing.


:Cell proliferation in the gastroduodenal mucosa of patients with duodenal ulcers was evaluated using flow cytometry. Forty patients with duodenal ulcers and 12 normal subjects were investigated. Biopsy samples were obtained during endoscopic examination and subjected to DNA analysis by flow cytometry. Thirty patients with duodenal ulcers were healed within 3 months with H2 blockers (tractable or responsive ulcers), whereas 10 patients did not respond to treatment (intractable ulcers). The percentage of cells at the DNA-synthetic phase, an index of cell proliferation, was constant in the adjacent duodenal mucosa 2 cm from ulcer margin and antral mucosa during duodenal ulcer healing. The index at the margin of tractable ulcers was elevated during the active stage (12.9 +/- 1.3), peaked during the healing stage (15.4 +/- 2.8) and returned to the same level at the scarring stage (10.9 +/- 2.0) as normal controls (10.3 +/- 1.7). However, the index was not elevated in intractable ulcers (10.3 +/- 1.7 in the healing stage) and was smaller than in tractable ulcers. These data indicate that augmented mucosal cell proliferation at the ulcer margin plays an important role in duodenal ulcer healing and intractable ulcers are characterized by an abnormal failure to accelerate DNA synthesis to achieve ulcer repair.


Kobayashi I,Kawano S,Tsuji S,Nakama A,Sawaoka H,Masuda E,Nagano K,Fusamoto H,Kamada T




Has Abstract


1998-04-01 00:00:00












  • Ethanol administration generates oxidative stress in the pancreas and liver, but fails to induce heat-shock proteins in rats.

    abstract:BACKGROUND:Heat-shock proteins (HSP) play an essential role in the sequestration and reparation of denatured cellular proteins. Because ethanol treatment can result in oxidative stress-induced protein damage, it is possible that expression of HSP is altered after ethanol consumption. Dose-response and time-course studi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Rakonczay Z Jr,Boros I,Jármay K,Hegyi P,Lonovics J,Takacs T

    更新日期:2003-07-01 00:00:00

  • Epidemiology of colorectal cancer in Asia.

    abstract::The prevalence of colorectal cancer is increasing in Asia. However, the age-standardized rate has reached a plateau in some countries. Some studies have shown a male predominance difference and increasing risk in the elderly, but not in the younger population. 'Right shifting' of colorectal cancer, not accountable by ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Yee YK,Tan VP,Chan P,Hung IF,Pang R,Wong BC

    更新日期:2009-12-01 00:00:00

  • The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors.

    abstract:BACKGROUND/AIMS:Psychological factors and subtle histopathological changes have been implicated in irritable bowel syndrome (IBS). The aims of the present study were to investigate whether the numbers of enterochromaffin (EC) cells, mast cells, and lamina propria T lymphocytes are altered in IBS, and evaluate the relat...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lee KJ,Kim YB,Kim JH,Kwon HC,Kim DK,Cho SW

    更新日期:2008-11-01 00:00:00

  • Inhibition of TXA synthesis with OKY-046 improves liver preservation by prolonged hypothermic machine perfusion in rats.

    abstract:BACKGROUND AND AIM:We previously reported that hypothermic machine perfusion (HMP) for liver preservation is feasible, but hepatic microcirculatory dysfunction and significant liver damage remain major obstacles in its application when the preservation is extended to 24 h. The underlying injury mechanism is not well un...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Xu H,Lee CY,Clemens MG,Zhang JX

    更新日期:2008-07-01 00:00:00

  • Treatment with infliximab or azathioprine negatively impact the efficacy of hepatitis B vaccine in inflammatory bowel disease patients.

    abstract:BACKGROUND AND AIM:Immunization against hepatitis B virus (HBV) infection is recommended in patients with inflammatory bowel disease (IBD), particularly in those under immunosuppressive therapy. Limited data are available about IBD patient's response to HBV vaccination. We assessed the response rate to HBV vaccination ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Andrade P,Santos-Antunes J,Rodrigues S,Lopes S,Macedo G

    更新日期:2015-11-01 00:00:00

  • A protease inhibitor attenuates gastric erosions and microcirculatory disturbance in the early period after thermal injury in rats.

    abstract::The effects of camostat mesilate, a synthetic serine protease inhibitor on gastric microcirculation and active oxygen species generated by leucocytes from the gastric and jugular veins in the early period after thermal injury were assessed. Male Wistar rats were anaesthetized and a 30% full skin-thickness dorsal burn ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Yoshida M,Wakabayashi G,Ishikawa H,Otani Y,Shimazu M,Kubota T,Kumal K,Kurose I,Miura S,Ishii H,Kitajima M

    更新日期:1998-01-01 00:00:00

  • Adult intussuscepted Meckel's diverticulum presenting mainly lower gastrointestinal bleeding.

    abstract::Herein, we report on an adult with intussusception of an invaginated Meckel's diverticulum presenting mainly with acute intermittent lower gastrointestinal bleeding, whereas the common symptom of abdominal pain, indicating intussusception, was absent. Colonoscopy revealed a reducible polypoid lesion in the ileocecal a...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lu CL,Chen CY,Chiu ST,Chang FY,Lee SD

    更新日期:2001-04-01 00:00:00

  • Three-dimensional endoscopic ultrasonography of lesions of the upper gastrointestinal tract using a radial-linear switchable thin ultrasound probe.

    abstract:BACKGROUND:The objective of three-dimensional (3-D) endoscopic ultrasonography (EUS) is to recognize lesions stereoscopically. METHODS AND RESULTS:We investigated a total of 43 lesions in the upper gastrointestinal (GI) tract by regenerating 3-D images in eight cases of oesophageal cancer, two cases of oesophageal sub...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Tokiyama H,Yanai H,Nakamura H,Takeo Y,Yoshida T,Okita K

    更新日期:1999-12-01 00:00:00

  • Gastrointestinal manifestations of leukemia.

    abstract::Gastrointestinal (GI) manifestations of leukemia occur in up to 25% of patients at autopsy, generally during relapse. Its presence varies with the type of leukemia and has been decreasing over time due to improved chemotherapy. Gross leukemic lesions are most common in the stomach, ileum, and proximal colon. Leukemia ...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Ebert EC,Hagspiel KD

    更新日期:2012-03-01 00:00:00

  • Detection of interferon-alpha expression by PCR in patients with chronic hepatitis C and hepatitis non-A, non-B.

    abstract::The polymerase chain reaction (PCR) was used to examine expression of interferon-alpha (IFN A) genes in general and the expression of messenger RNA (mRNA) encoding the subtypes IFN-alpha-2 and IFN-alpha-4 in blood and liver biopsy samples from patients with chronic hepatitis C or hepatitis non-A, non-B (HC/HNANB) infe...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Brandt ER,Devenish RJ,Hertzog PJ,Dudley FJ,Linnane AW

    更新日期:1994-07-01 00:00:00

  • Emerging roles of microRNA in the intracellular signaling networks of hepatocellular carcinoma.

    abstract::MicroRNAs (miRNAs) are small non-coding RNAs of 19-23 nucleotides that negatively regulate gene expression through binding to the 3'-untranslated regions of target messenger RNAs (mRNAs). Although the miRNA family constitutes only a minor fraction of the human genome, they hold fundamental importance in diverse physio...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Law PT,Wong N

    更新日期:2011-03-01 00:00:00

  • Comparison of clinical features, treatment, and outcomes of collagenous sprue, celiac disease, and collagenous colitis.

    abstract:BACKGROUND:Collagenous sprue (CS) is a rare form of enteropathy that had been reported to be associated with celiac disease (CD) and collagenous colitis (CC). The aim of our study was to compare the clinical features, treatments, and outcomes of CS, CD, and CC. METHODS:All patients with histologic diagnosis of CS, CD,...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lan N,Shen B,Yuan L,Liu X

    更新日期:2017-01-01 00:00:00

  • Herpes simplex esophagitis from 1307 autopsy cases.

    abstract:BACKGROUND AND AIMS:The aim of the present study was to clarify relationship between macroscopic and microscopic features of herpes simplex esophagitis (HSE), and localization of herpes simplex virus type 1 (HSV-1)-infected cells in esophageal lesions from autopsy cases of histopathologically proven HSE. METHODS:The s...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Itoh T,Takahashi T,Kusaka K,Kawaura K,Nakagawa Y,Yamakawa J,Kanda T

    更新日期:2003-12-01 00:00:00

  • Decreased density of interstitial cells of Cajal and neuronal cells in patients with slow-transit constipation and acquired megacolon.

    abstract:BACKGROUND:The pathophysiology of constipation is not clearly identified as yet, and the interstital cells of Cajal (ICC), known to generate the slow wave activity and to be involved in intestinal neurotransmission and the enteric nervous system (ENS), are suspected to play an important role. The aims of the present st...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lee JI,Park H,Kamm MA,Talbot IC

    更新日期:2005-08-01 00:00:00

  • Fetal and infant exposure to the Chinese famine increases the risk of fatty liver disease in Chongqing, China.

    abstract:BACKGROUND AND AIM:Early life exposure to the famine may affect the susceptibility to the metabolic disorders. The objective of this study was to examine the associations of early life exposure to the Chinese Famine (1959-1961) with the risk of fatty liver disease, obesity, hypertension, and hyperglycemia in adulthood....

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Chen JP,Peng B,Tang L,Sun R,Hu S,Wen XY,Que P,Wang YH

    更新日期:2016-01-01 00:00:00

  • The significance of glypican-3 expression profiling in the tumor cellular origin theoretical system for hepatocellular carcinoma progression.

    abstract:BACKGROUND AND AIM:Glypican-3 (GPC3) expression is correlated with poor prognosis and progression in hepatocellular carcinoma (HCC). HCC progression can be associated with the differentiation status of tumor cell before malignant transformation. Our aim was to investigate the dynamic expression of GPC3 during tumor cel...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Xue R,Feng J,Meng Q,Lv F,Zhu Y,Yu H,Zhang S,Song C,Sun L,Yue Z,Feng S,Che R,Xiang Q,Jing X

    更新日期:2017-08-01 00:00:00

  • Liver metabolism of porphyrins and haem.

    abstract::The liver is an active site for the biosynthesis of haem and porphyrinogens/porphyrins, which are intermediates of the haem biosynthetic pathway, because haem is required for functional activity of the cytochrome P 450 system and other critical hepatic haemoproteins. The production of hepatic haem is regulated primari...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Bloomer JR

    更新日期:1998-03-01 00:00:00

  • Changes in prostaglandin and nitric oxide levels in the hyperdynamic circulation following liver resection.

    abstract:BACKGROUND AND AIMS:Significant changes in hepatic haemodynamics occur after major hepatectomy, but the pathogenesis of this phenomenon is unclear. This study investigates the serum profile of prostaglandin and nitric oxide in the hepatic and systemic circulation before and after hepatectomy and the temporal relationsh...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lai OF,Chow PK,Tan S,Song IC,Soo KC,Aw SE,Yu WK,Fook-Chong SM,Satchithanantham S,Chan ST

    更新日期:2000-08-01 00:00:00

  • Haemodynamic effects of enalaprilat on portal hypertension in patients with HBsAg-positive cirrhosis.

    abstract::It has been suggested that enalaprilat inhibits the renin-angiotensin-aldosterone system in plasma and tissue; it may therefore reduce portal vascular pressure owing to secondary hyperaldosteronism in patients with liver cirrhosis. In order to evaluate this concept, 20 patients with hepatitis B surface antigen (HBsAg)...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 临床试验,杂志文章


    authors: Chiang HT,Cheng JS,Lin M,Tseng WS,Chang JM,Lai KH

    更新日期:1995-05-01 00:00:00

  • Quantitative analysis of endosonographic parenchymal echogenicity in patients with chronic pancreatitis.

    abstract:BACKGROUND AND AIM:The aim of the study was to develop a method of quantitation of endoscopic ultrasonography (EUS) changes of chronic pancreatitis (CP). METHODS:Twenty-three patients with chronic pancreatitis by EUS were compared with nine normal subjects. Hyperechogenicity was evaluated as the size of the hyperechoi...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Irisawa A,Mishra G,Hernandez LV,Bhutani MS

    更新日期:2004-10-01 00:00:00

  • Cold activation of complement in sera from patients with persistent hepatitis C virus infection on interferon therapy.

    abstract::The loss of haemolytic activity in sera during storage at low temperature (the cold activation of complement) was observed in 136 of 184 (74%) patients with chronic liver disease associated with hepatitis C virus (HCV) infection. This was more frequent than observed in the three of 40 (8%) patients with chronic hepati...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Aikawa T,Kimura I,Kojima M,Ueno C,Miyamoto K,Tango T,Tanaka N

    更新日期:1996-04-01 00:00:00

  • Anti-neutrophil cytoplasmic antibodies in patients with chronic liver diseases: prevalence, antigen specificity and predictive value for diagnosis of autoimmune liver disease. Swedish Internal Medicine Liver Club (SILK)

    abstract:BACKGROUND:Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 are diagnostic of Wegener's granulomatosis, but ANCA occur also in patients with other inflammatory disorders, such as ulcerative colitis, primary sclerosing cholangitis (PSC) and autoimmune hepatitis. As their predictive value for autoimmune...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Lindgren S,Nilsson S,Nässberger L,Verbaan H,Wieslander J

    更新日期:2000-04-01 00:00:00

  • Increased esophageal mucosal/submucosal blood flow in patients with gastroesophageal reflux disease: normalization by treatment with a proton pump inhibitor.

    abstract:BACKGROUND AND AIM:Mucosal injury caused by gastroesophageal reflux may result in changes in esophageal mucosal blood flow. Little is known about esophageal mucosal blood flow in patients with gastroesophageal reflux disease (GERD). Here we examined esophageal mucosal blood flow and the effects of treatment in patients...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Mine S,Iida T,Tabata T,Okada Y,Tanaka Y

    更新日期:2008-02-01 00:00:00

  • Disparities in the treatment of hepatocellular carcinoma based on geographical region are decreasing.

    abstract:BACKGROUND AND AIM:Geographic differences have existed in the management of hepatocellular carcinoma (HCC), and efforts to reduce regional disparities have been initiated. The aim of this study is to use the Nationwide Inpatient Sample to determine if regional disparities in the treatment of HCC continue to exist. MET...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Sobotka LA,Hinton A,Conteh LF

    更新日期:2019-03-01 00:00:00

  • Genetic polymorphisms of CD14 and Toll-like receptor-2 (TLR2) in patients with ulcerative colitis.

    abstract:BACKGROUND AND AIM:Ulcerative colitis (UC) is a multifactorial disease resulting from a complex interaction of genetic and environmental factors. Identifying genetic variants that alter the innate immune response is highly relevant to understanding the pathogenesis of UC. The aim of this study was to investigate the as...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Wang F,Tahara T,Arisawa T,Shibata T,Nakamura M,Fujita H,Iwata M,Kamiya Y,Nagasaka M,Takahama K,Watanabe M,Hirata I,Nakano H

    更新日期:2007-06-01 00:00:00

  • Acute Budd-Chiari syndrome with liver failure: the experience of a policy of initial interventional radiological treatment using transjugular intrahepatic portosystemic shunt.

    abstract:BACKGROUND AND AIMS:The optimal management of acute Budd-Chiari syndrome (BCS) with liver failure is controversial. Options include anticoagulation, portal systemic shunting or liver transplantation. In recent years, transjugular intrahepatic portosystemic shunts (TIPS) have been tried in place of shunt surgery. We rep...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Kavanagh PM,Roberts J,Gibney R,Malone D,Hegarty J,McCormick PA

    更新日期:2004-10-01 00:00:00

  • A multicenter prospective study on the prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drugs-negative idiopathic peptic ulcers in Japan.

    abstract:BACKGROUND AND AIM:The prevalence of Helicobacter pylori-negative and nonsteroidal anti-inflammatory drug-negative peptic ulcers, commonly known as idiopathic peptic ulcers (IPUs), has been reported to be very low (0.9-2.6%) in Japan based on data from the 1990s. However, recent trends have yet to be been reported. Her...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,多中心研究


    authors: Kanno T,Iijima K,Abe Y,Yagi M,Asonuma S,Ohyauchi M,Ito H,Koike T,Shimosegawa T

    更新日期:2015-05-01 00:00:00

  • Difference in quasispecies of the hypervariable region 1 of hepatitis C virus between alcoholic and non-alcoholic patients.

    abstract:BACKGROUND:Habitual alcohol intake is known to aggravate the clinical outcome of hepatitis C virus (HCV)-related chronic liver diseases and to increase the risk of hepatocellular carcinoma. METHODS:To investigate the possible mechanism of these effects by alcohol, we examined 31 cases of HCV-related chronic liver dise...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Takahashi K,Takahashi T,Takahashi S,Watanabe K,Boku S,Matsui S,Arai F,Asakura H

    更新日期:2001-04-01 00:00:00

  • Genetic aspects of Wilson's disease.

    abstract::Wilson's disease is an autosomal recessive, inborn error of copper metabolism. The basic defect is unknown but decreased biliary excretion of copper is associated with copper accumulation and damage to the liver, brain and other organs with variable clinical expression. The gene for the disease has been mapped to band...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章,评审


    authors: Frydman M

    更新日期:1990-07-01 00:00:00

  • New diagnostic criteria for nutcracker esophagus using conventional water-perfused manometry: a comparison between nutcracker esophagus with and without gastroesophageal reflux disease.

    abstract:BACKGROUND AND AIM:Controversy continues as to whether nutcracker esophagus (NE) is a 'real' manometric disease due to its poor correlation with clinical symptoms such as chest pain or dysphagia. While new NE criteria were proposed in a recent study, that study included NE patients both with and without gastroesophagea...

    journal_title:Journal of gastroenterology and hepatology

    pub_type: 杂志文章


    authors: Jung KW,Jung HY,Yoon IJ,Kim DH,Chung JW,Oh HC,Choi KS,Choi KD,Song HJ,Lee GH,Kim JH

    更新日期:2010-07-01 00:00:00