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Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection.

Abstract：

:Hepatitis C virus (HCV) infection is a major cause of hepatocellular carcinoma (HCC) and chronic liver disease worldwide. Recent developments and advances in HCV replication systems in vitro and in vivo, transgenic animal models, and gene expression profiling approaches have provided novel insights into the mechanisms of HCV replication. They have also helped elucidate host cellular responses, including activated/inactivated signaling pathways, and the relationship between innate immune responses by HCV infection and host genetic traits. However, the mechanisms of hepatocyte malignant transformation induced by HCV infection are still largely unclear, most likely due to the heterogeneity of molecular paths leading to HCC development in each individual. In this review, we summarize recent advances in knowledge about the mechanisms of hepatocarcinogenesis induced by HCV infection.

journal_name

J Gastroenterol Hepatol

journal_title

Journal of gastroenterology and hepatology

authors

Yamashita T,Honda M,Kaneko S

doi

10.1111/j.1440-1746.2011.06723.x

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

960-4

issue

6

eissn

0815-9319

issn

1440-1746

journal_volume

26

pub_type

杂志文章,评审

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