Abstract：
:Much has been achieved in Helicobacter pylori research, to the point that the growth of new knowledge is bound to slow down. However, expectations for further developments remain high. Knowledge about the characteristic organism and behaviour is already extensive. Particularly intriguing are the differences in genetic make-up in the various geographical regions. Sadly, detailed knowledge on how the organism spreads is still lacking. The spectrum of clinical presentation in humans is largely known. Helicobacter pylori is disappearing worldwide, allowing the relative frequency of H. pylori-negative ulcer disease to increase. The extent to which H. pylori disappearance and eradication is responsible for decreasing prevalence of gastric cancer remains speculative. Antimicrobial therapy is dominated by proton pump inhibitor triple therapy as first line therapy, with quadruple therapy as second rescue line therapy. The long-term consequences of the rising resistance to the 'key' antimicrobials are so far unknown, because few data are available on therapeutic outcomes in routine practice outside pharmaceutical trials.
journal_name
J Gastroenterol Hepatoljournal_title
Journal of gastroenterology and hepatologyauthors
Tytgat Gdoi
10.1046/j.1440-1746.2000.02262.xsubject
Has Abstractpub_date
2000-10-01 00:00:00pages
G30-3eissn
0815-9319issn
1440-1746journal_volume
15 Supplpub_type
杂志文章,评审abstract：BACKGROUND:There are few detailed clinical reports about extrahepatic metastases of hepatocellular carcinoma (HCC). The purpose of the present study was to elucidate the clinical features of extrahepatic metastases of HCC. METHODS:The clinical records of 482 patients who had been diagnosed as having HCC during the per...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2005.03919.x
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND AND AIMS:The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type-1 autoimmune hepatitis (AIH) among patients from western India. METHODS:In 20 patients and 120 healthy controls, polymerase chain reaction ampli...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2004.03608.x
更新日期：2005-02-01 00:00:00
abstract：:The approach of a pediatric hepatologist in managing children with hepatitis C virus (HCV) differs from adult practice, because the pediatric hepatologist is dealing with the beginning of a chronic illness in which long-term outcomes will not occur for 20 or 40 years, and it is not possible to predict in the early sta...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1046/j.1440-1746.2002.02731.x
更新日期：2002-04-01 00:00:00
abstract：:To evaluate the pathophysiology underlying gastric mucosal lesions induced by lateral hypothalamic (LH) lesions, we investigated the changes in acid secretion, gastric mucosal blood flow, gastric mucus and mucosal integrity in the corpus during the 4 h period and 48 h after the production of bilateral electrolytic LH ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1995.tb01586.x
更新日期：1995-07-01 00:00:00
abstract：BACKGROUND AND AIM:The European evidence-based guidelines (EEG) and American College of Gastroenterology Guidelines (ACGG) have been published to guide the management of pancreatic cystic lesions. We aim to evaluate the value of both guidelines in predicting advanced pancreatic cystic lesions (A-PCLs) with preoperative...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.14973
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND AND AIM:We have previously found high incidence of inflammatory bowel disease (IBD) in Australia. A population-based registry was established to assess disease severity, frequency of complications, and prognostic factors. METHODS:Incident cases were prospectively identified over 4 years. Early disease sever...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.12967
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND AND AIM:Epimorphin is suggested to play a key role in the morphogenesis of epithelial cells. We focused on epimorphin and attempted to clarify the relationship between expression of this molecule and inflammatory bowel disease (IBD). METHODS:Colonic specimens were taken from 23 patients with ulcerative coli...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2003.02972.x
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND AND AIM:T-cell responses against hepatitis C are believed to be critical in achieving both natural and treatment-induced clearance. However, rapid clearance of antigen with early treatment of primary infection may result in reduced or poorly sustained cellular immunity. This study longitudinally examined Th1...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.12265
更新日期：2013-11-01 00:00:00
abstract：:High circulating serum immunoglobulin G4 (IgG4) levels have been proposed as a marker of autoimmune pancreatitis (AIP). The aim of the present study was to review the data existing in the English literature on the usefulness of the IgG4 serum levels in the diagnosis and follow up of patients with AIP. A total of 159 p...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1440-1746.2008.05676.x
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND AND AIMS:Aberrant right subclavian artery (ARSA) is the most common congenital anomaly of the aortic arch occurring in 0.4-2.0% of the general population. Instead of arising from the brachiocephalic artery, the ARSA arises as the last branch from the aortic arch. The aim of this study was to determine the pr...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2006.04622.x
更新日期：2007-11-01 00:00:00
abstract：:The in vitro binding of 125I-labelled human alpha-interferon to peripheral blood mononuclear cells from 13 patients with chronic hepatitis B during interferon therapy was assayed in order to identify changes in the number of interferon receptors during treatment. Nine patients were treated with human alpha-interferon ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1989.tb01739.x
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:The reasons for the viral persistence of hepatitis B virus infection (HBV) are unknown, but are probably related to host immune factors. Cytokines play a significant role in immune defense. The present study was undertaken to investigate the association between HBV infection and polymorphisms of tumor necros...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2006.04304.x
更新日期：2006-07-01 00:00:00
abstract：:Lauren's intestinal type of gastric cancer was proposed to be dependent on long-term environmental factors and is always preceded by chronic premalignant change. A cohort study was performed and demonstrated an increased cancer risk of gastric remnant after gastric surgery for benign disease. It is generally believed ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1997.tb00462.x
更新日期：1997-06-01 00:00:00
abstract：BACKGROUND AND AIM:To investigate a possible association between HLA genes with serum alanine aminotransferase (ALT) levels and evaluate whether the HLA-DQA1, DQB1, and DRB1 genes could influence the development of liver damage in chronic hepatitis C. METHODS:A total of 145 patients with chronic hepatitis C virus (HCV...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2007.05215.x
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND AND AIM:In hilar cholangiocarcinoma, an accurate assessment of preoperative resectability is important to optimize surgical resection. We investigated the accuracy of the combination of intraductal ultrasonography (IDUS) and percutaneous transhepatic cholangioscopy (PTCS) for evaluating longitudinal extent i...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2009.05944.x
更新日期：2010-02-01 00:00:00
abstract：:Typhoid fever is often associated with abnormal liver biochemical tests, but severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. There have been more than 150 cases of salmonella hepatitis reported from both developed and developing countries. The documented incidence varies w...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.1998.tb00726.x
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:This study aimed to describe the clinical features, manometric findings, prevalence and incidence of achalasia in Singapore. METHODS:A total of 615 new patients referred for oesophageal manometry between 1989 and 1996 were examined prospectively. Twenty-four men and 25 women fulfilled the manometric and cli...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.1999.01950.x
更新日期：1999-08-01 00:00:00
abstract：:Constantly challenged by luminal bacteria, intestinal epithelium forms both a physical and biochemical defense against pathogens. Besides, intestinal epithelium senses dynamic and continuous changes in luminal environment and transmits signals to subjacent immune cells accordingly. It has been long accepted that adapt...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/jgh.13723
更新日期：2017-05-01 00:00:00
abstract：:A case is described of a 58 year old Caucasian male with primary biliary cirrhosis (PBC) who first presented with acanthosis nigricans of both axillae, skin pigmentation, which was pronounced over the posterior surface of the neck, and generalized pruritus. Following orthotopic liver transplantation for progressive li...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1996.tb00025.x
更新日期：1996-11-01 00:00:00
abstract：:The main goals of chronic hepatitis B treatment should be the long-term suppression of viral replication to minimize disease progression and the risk for the development of hepatocellular carcinoma. Treatment end-points, depending on surrogate markers alone, in particular hepatitis B e-antigen seroconversion, may not ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2008.05400.x
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND AND AIM:Hepatitis B core-related antigen (HBcrAg) has been shown to correlate with various viral markers in chronic hepatitis B, but its role in defining natural history is not well studied. We aimed to investigate the use of HBcrAg to define different phases of chronic hepatitis B. METHODS:Stored residual ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.15058
更新日期：2020-04-15 00:00:00
abstract：BACKGROUND AND AIMS:Positron emission tomography with computed tomography (PET/CT) has been used to detect metastasis in the diagnosis of esophageal adenocarcinoma (EAC). However, the utility of PET/CT to assess primary tumor for endoscopic resectability and prognosis in early EAC remains unclear. We conducted a retros...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/jgh.12148
更新日期：2013-06-01 00:00:00
abstract：BACKGROUND AND AIM:The role of zinc in the nutrition and growth of children with chronic liver disease is poorly defined. The present study determined the serum zinc levels of children with compensated liver disease (CLD) and decompensated liver disease (DLD) and compared this with healthy children. Zinc levels were al...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2009.06003.x
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Australia receives many migrants from countries with a high prevalence of hepatitis C infection. General practitioners, who are often the first health professionals consulted, need to be aware of risk factors and complications associated with hepatitis C in this group. METHODS:Four hundred and forty-seven g...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2002.02701.x
更新日期：2002-03-01 00:00:00
abstract：:The structural analysis, replicative efficiency and immunogenicity of hepatitis B virus (HBV) full-length genomes isolated from different patients or asymptomatic carriers are presented in the present review. Data indicate the importance of viral genome-based studies in elucidating the pathogenesis of HBV infections. ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章,评审
doi：10.1111/j.1440-1746.2003.03158.x
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND AND AIMS:Troglitazone is a newly developed antidiabetic drug and is indicated to be useful for the treatment of patients with type II diabetes mellitus. Recently, however, it became clear that troglitazone could cause liver dysfunction in some patients. In addition, a relationship between the activation of t...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1046/j.1440-1746.2000.02316.x
更新日期：2000-10-01 00:00:00
abstract：BACKGROUND AND AIM:HFE mutations, a common cause of hereditary hemochromatosis (HH), are reportedly associated with hepatic iron overload, severe liver fibrosis, and good response to interferon treatment in European patients with chronic hepatitis C (CHC). HH shows ethnicity-based differences and little is known about ...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2011.06976.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND AND AIM:Little information is available about the antiviral efficacy of lamivudine (LAM) and entecavir (ETV) in patients with hepatitis B virus (HBV)-related advanced hepatocellular carcinoma (HCC). Thus, we compared the antiviral efficacy of LAM and ETV in these patients. METHODS:The medical records of 134...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.2012.07145.x
更新日期：2012-09-01 00:00:00
abstract：:Quantitative measurement of hepatitis C virus (HCV) RNA is useful in patients with chronic hepatitis C, especially with interferon treatment. We examined the clinical usefulness of the AMPLICOR monitor assay, a newly developed assay for quantitative measurement, by comparing it with two other assays with different pri...
journal_title：Journal of gastroenterology and hepatology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1440-1746.1997.tb00473.x
更新日期：1997-07-01 00:00:00
abstract：:The prevalence and potential value of the detection of signs of portal hypertension by duplex Doppler ultrasound (DDU) of the ligamentum teres and portal vein in patients with known or suspected chronic liver disease and/or portal hypertension was studied in 136 consecutive patients undergoing clinical assessment incl...
journal_title：Journal of gastroenterology and hepatology
pub_type： 杂志文章
doi：10.1111/j.1440-1746.1991.tb01147.x
更新日期：1991-01-01 00:00:00
